Implementing a pragmatic clinical trial to tailor opioids for acute pain on behalf of the IGNITE ADOPT PGx investigators by Larisa H. Cavallari, Emily Cicali, Kristin Wiisanen, Roger B. Fillingim, Hrishikesh Chakraborty, Rachel A. Myers, Kathryn V. Blake, Bolanle Asiyanbola, Jordan F. Baye, Wesley H. Bronson, Kelsey J. Cook, Erica N. Elwood, Chancellor F. Gray, Yan Gong, Lindsay Hines, Joseph Kannry, Natalie Kucher, Sheryl Lynch, Khoa A. Nguyen, Aniwaa Owusu Obeng, Victoria M. Pratt, Hernan A. Prieto, Michelle Ramos, Azita Sadeghpour, Rajbir Singh, Marc Rosenman, Petr Starostik, Cameron D. Thomas, Emma Tillman, Paul R. Dexter, Carol R. Horowitz, Lori A. Orlando, Josh F. Peterson, Todd C. Skaar, Sara L. Van Driest, Simona Volpi, Deepak Voora, Hari K. Parvataneni, Julie A. Johnson, for the IGNITE Pragmatic Trials Network

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I-SPY COVID adaptive platform trial for COVID-19 acute respiratory failure: rationale, design and operations by Carolyn S Calfee, Michael A Matthay, Paul Henderson, Martin Eklund, Laura J Esserman, Chirag Patel, Angela Haczku, Michelle Jung, Tony Oliver, Alessio Crippa, Andrea Discacciati, Kathleen D Liu, Ellen L Burnham, Nuala J Meyer, Fady A Youssef, Derek W Russell, Julie Lang, Kevin W Gibbs, Daniel C Files, Sheetal Gandotra, Purnema Madahar, Nathan K Cobb, Timothy E Albertson, Rajiv Sonti, John P Reilly, Alejandra Jauregui, Iván García, Luis E Huerta, Daniel Clark Files, Neil R Aggarwal, Adam L Asare, Jeremy R Beitler, Paul A Berger, George Cimino, Melissa H Coleman, Paul T Henderson, Caroline A G Ittner, Kashif T Khan, Jonathan L Koff, Mary LaRose, Joe Levitt, Ruixiao Lu, Jeffrey D McKeehan, Karl W Thomas, Aaron M Mittel, Albert F Yen, Alexis E Suarez, Alexis L Serra, Alpesh N Amin, Amanda Rosen, Amy L Dzierba, Anna D Barker, Ariel R Weisman, Brian M Daniel, Brian M Morrissey, Caroline AG Ittner, Chayse Jones, Christina Creel-Bulos, Christina M Angelucci, Diana Ng, Fredy Chaparro-Rojas, Gavin H Harris, Harsh V Barot, Heny Su, Jacqueline B Sutter, Jamal Dodin, Jerry S Lee, John Kazianis, Joshua F Detelich, Julie E Lang, Justin Muir, Katarzyna Gosek, Katherine L Nugent, Kimberly Yee, Laura G Rodrigues, Laura R Macias, Lindsey A Orr, Lindsie L Boerger, Lissette Rosario-Remigio, Lucia Kufa, Maged Tanios, Maria B Reyes, Max W Adelman, Maya M Juarez, Michelle Meyers, Mitchell P Sternlieb, Neil Aggarwal, Nilam S Mangalmurti, Patrice Jones, Paul L Saban, Peter S Marshall, Philiip A Robinson, Philip Yang, Rahul Nair, Richard Anthony Lee, Richard G Wunderink, Romina Wahab, Roxana A Lupu, Santhi I Kumar, Sara C Auld, Scott Fields, Se Fum Wong, Skyler J Pearson, Spencer Whealon, Timothy F Obermiller, Anita Darmanian, John Schicchi, Esmeralda Martinez, Farjad Sarafian, Julie Nguyen, Bethany Weiler-Lisowski, Jaime Wyatt, Daniel Blevins, Marylee Melendrez, Brenda Lopez, Hiwet Tzehaie, Omowunmi Amosu, Austin Simonson, Erin Hardy, Brett Lindgren, Gregory Peterfreund, Leigha Landreth, Lisa Parks

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Toward standardization, harmonization, and integration of social determinants of health data: A Texas Clinical and Translational Science Award institutions collaboration by Catherine K. Craven, Linda Highfield, Mujeeb Basit, Elmer V. Bernstam, Byeong Yeob Choi, Robert L. Ferrer, Jonathan A. Gelfond, Sandi L. Pruitt, Vaishnavi Kannan, Paula K. Shireman, Heidi Spratt, Kayla J. Torres Morales, Chen-Pin Wang, Zhan Wang, Meredith N. Zozus, Edward C. Sankary, Susanne Schmidt

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Association Between Acid-Sensing Ion Channel 3 Gene Variants and Balance Impairment in People With Mild Traumatic Brain Injury by Hsun-Hua Lee, Hsun-Hua Lee, Hsun-Hua Lee, Hsun-Hua Lee, Hon-Ping Ma, Hon-Ping Ma, Hon-Ping Ma, Ju-Chi Ou, Jiann Ruey Ong, Jiann Ruey Ong, Kai-Yun Chen, Chung-Che Wu, Wen-Ta Chiu, Kuo-Hsing Liao, Chien-Min Lin, Shu-Yu Lin, Dean Wu, Dean Wu, Dean Wu, Dean Wu, Yao-Hsien Huang, Yao-Hsien Huang, Yao-Hsien Huang, Yuan-Hung Wang, Chaur-Jong Hu, Chaur-Jong Hu, Chaur-Jong Hu, Chien-Tai Hong, Chien-Tai Hong, Chien-Tai Hong

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Host KIR/HLA-C Genotypes Determine HIV-Mediated Changes of the NK Cell Repertoire and Are Associated With Vpu Sequence Variations Impacting Downmodulation of HLA-C by Sarah Vollmers, Annabelle Lobermeyer, Annika Niehrs, Pia Fittje, Daniela Indenbirken, Jacqueline Nakel, Sanamjeet Virdi, Sebastien Brias, Sebastien Brias, Timo Trenkner, Gabriel Sauer, Sven Peine, Georg M.N. Behrens, Clara Lehmann, Clara Lehmann, Clara Lehmann, Anja Meurer, Ramona Pauli, Nils Postel, Julia Roider, Julia Roider, Stefan Scholten, Christoph D. Spinner, Christoph D. Spinner, Christoph Stephan, Eva Wolf, Christoph Wyen, Christoph Wyen, Laura Richert, Paul J. Norman, Paul J. Norman, Jürgen Sauter, Alexander H. Schmidt, Alexander H. Schmidt, Angelique Hoelzemer, Angelique Hoelzemer, Angelique Hoelzemer, Marcus Altfeld, Marcus Altfeld, Christian Körner

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Baseline Characteristics of Mitochondrial DNA and Mutations Associated With Short-Term Posttreatment CD4+T-Cell Recovery in Chinese People With HIV by Anni Liu, Anni Liu, Anni Liu, Qian Wei, Qian Wei, Haijiang Lin, Haijiang Lin, Haijiang Lin, Yingying Ding, Yingying Ding, Yan V. Sun, Yan V. Sun, Dan Zhao, Dan Zhao, Jiayu He, Jiayu He, Zhonghui Ma, Zhonghui Ma, Feihu Li, Sujuan Zhou, Sujuan Zhou, Xiaoxiao Chen, Weiwei Shen, Meiyang Gao, Meiyang Gao, Na He, Na He, Na He

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Brown marmorated stink bug, Halyomorpha halys (Stål), genome: putative underpinnings of polyphagy, insecticide resistance potential and biology of a top worldwide pest by Michael E. Sparks, Raman Bansal, Joshua B. Benoit, Michael B. Blackburn, Hsu Chao, Mengyao Chen, Sammy Cheng, Christopher Childers, Huyen Dinh, Harsha Vardhan Doddapaneni, Shannon Dugan, Elena N. Elpidina, David W. Farrow, Markus Friedrich, Richard A. Gibbs, Brantley Hall, Yi Han, Richard W. Hardy, Christopher J. Holmes, Daniel S. T. Hughes, Panagiotis Ioannidis, Alys M. Cheatle Jarvela, J. Spencer Johnston, Jeffery W. Jones, Brent A. Kronmiller, Faith Kung, Sandra L. Lee, Alexander G. Martynov, Patrick Masterson, Florian Maumus, Monica Munoz-Torres, Shwetha C. Murali, Terence D. Murphy, Donna M. Muzny, David R. Nelson, Brenda Oppert, Kristen A. Panfilio, Débora Pires Paula, Leslie Pick, Monica F. Poelchau, Jiaxin Qu, Katie Reding, Joshua H. Rhoades, Adelaide Rhodes, Stephen Richards, Rose Richter, Hugh M. Robertson, Andrew J. Rosendale, Zhijian Jake Tu, Arun S. Velamuri, Robert M. Waterhouse, Matthew T. Weirauch, Jackson T. Wells, John H. Werren, Kim C. Worley, Evgeny M. Zdobnov, Dawn E. Gundersen-Rindal

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Admission Cardiac Diagnostic Testing with Electrocardiography and Troponin Measurement Prognosticates Increased 30‐Day Mortality in COVID‐19 by Timothy J. Poterucha, Pierre Elias, Sneha S. Jain, Gabriel Sayer, Bjorn Redfors, Daniel Burkhoff, Hannah Rosenblum, Ersilia M. DeFilippis, Aakriti Gupta, Matthew Lawlor, Mahesh V. Madhavan, Jan Griffin, Jayant Raikhelkar, Justin Fried, Kevin J. Clerkin, Andrea Kim, Adler Perotte, Mathew S. Maurer, Deepak Saluja, José Dizon, Frederick A. Ehlert, John P. Morrow, Hirad Yarmohammadi, Angelo B. Biviano, Hasan Garan, LeRoy Rabbani, Martin B Leon, Allan Schwartz, Nir Uriel, Elaine Y. Wan

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Therapeutic HDAC inhibition in hypermutant diffuse intrinsic pontine glioma by Alyssa Noll, Carrie Myers, Matthew C. Biery, Michael Meechan, Sophie Tahiri, Asmitha Rajendran, Michael E. Berens, Danyelle Paine, Sara Byron, Jiaming Zhang, Conrad Winter, Fiona Pakiam, Sarah E.S. Leary, Bonnie L. Cole, Evangeline R. Jackson, Matthew D. Dun, Jessica B. Foster, Myron K. Evans, Siobhan S. Pattwell, James M. Olson, Nicholas A. Vitanza

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Characterization of the gut microbiota among Veterans with unique military-related exposures and high prevalence of chronic health conditions: A United States-Veteran Microbiome Pr... by Maggie A. Stanislawski, Christopher E. Stamper, Kelly A. Stearns-Yoder, Andrew J. Hoisington, Diana P. Brostow, Jeri E. Forster, Teodor T. Postolache, Christopher A. Lowry, Lisa A. Brenner

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Impacto de la pandemia de COVID-19 en la seguridad del paciente percibida por los pacientes en Atención Primaria by Maria A. Fiol-deRoque, Maria J. Serrano-Ripol, Montserrat Gens-Barberà, Encarna Sánchez, Miguel A. Mayer, Francisco Martín-Luján, José M. Valderas, Ignacio Ricci-Cabello

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Addressing the clinical unmet needs in primary Sjögren’s Syndrome through the sharing, harmonization and federated analysis of 21 European cohorts by Vasileios C. Pezoulas, Andreas Goules, Fanis Kalatzis, Luke Chatzis, Konstantina D. Kourou, Aliki Venetsanopoulou, Themis P. Exarchos, Saviana Gandolfo, Konstantinos Votis, Evi Zampeli, Jan Burmeister, Thorsten May, Manuel Marcelino Pérez, Iryna Lishchuk, Thymios Chondrogiannis, Vassiliki Andronikou, Theodora Varvarigou, Nenad Filipovic, Manolis Tsiknakis, Chiara Baldini, Michele Bombardieri, Hendrika Bootsma, Simon J. Bowman, Muhammad Shahnawaz Soyfoo, Dorian Parisis, Christine Delporte, Valérie Devauchelle-Pensec, Jacques-Olivier Pers, Thomas Dörner, Elena Bartoloni, Roberto Gerli, Roberto Giacomelli, Roland Jonsson, Wan-Fai Ng, Roberta Priori, Manuel Ramos-Casals, Kathy Sivils, Fotini Skopouli, Witte Torsten, Joel A. G. van Roon, Mariette Xavier, Salvatore De Vita, Athanasios G. Tzioufas, Dimitrios I. Fotiadis

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Admixture mapping of peripheral artery disease in a Dominican population reveals a putative risk locus on 2q35 by Sinead Cullina, Sinead Cullina, Genevieve L. Wojcik, Ruhollah Shemirani, Derek Klarin, Derek Klarin, Bryan R. Gorman, Bryan R. Gorman, Elena P. Sorokin, Christopher R. Gignoux, Christopher R. Gignoux, Christopher R. Gignoux, Gillian M. Belbin, Gillian M. Belbin, Saiju Pyarajan, Saiju Pyarajan, Samira Asgari, Samira Asgari, Philip S. Tsao, Scott M. Damrauer, Scott M. Damrauer, Scott M. Damrauer, Noura S. Abul-Husn, Noura S. Abul-Husn, Eimear E. Kenny, Eimear E. Kenny, Eimear E. Kenny, Eimear E. Kenny

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Mosaic chromosomal alterations in peripheral blood leukocytes of children in sub-Saharan Africa by Weiyin Zhou, Anja Fischer, Martin D. Ogwang, Wen Luo, Patrick Kerchan, Steven J. Reynolds, Constance N. Tenge, Pamela A. Were, Robert T. Kuremu, Walter N. Wekesa, Nestory Masalu, Esther Kawira, Tobias Kinyera, Isaac Otim, Ismail D. Legason, Hadijah Nabalende, Leona W. Ayers, Kishor Bhatia, James J. Goedert, Mateus H. Gouveia, Nathan Cole, Belynda Hicks, Kristine Jones, Michael Hummel, Mathias Schlesner, George Chagaluka, Nora Mutalima, Eric Borgstein, George N. Liomba, Steve Kamiza, Nyengo Mkandawire, Collins Mitambo, Elizabeth M. Molyneux, Robert Newton, Selina Glaser, Helene Kretzmer, Michelle Manning, Amy Hutchinson, Ann W. Hsing, Yao Tettey, Andrew A. Adjei, Stephen J. Chanock, Reiner Siebert, Meredith Yeager, Ludmila Prokunina-Olsson, Mitchell J. Machiela, Sam M. Mbulaiteye

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Computable phenotypes for cohort identification: core content for a new class of FAIR Digital Objects by Marisa Conte, Allen Flynn, Peter Boisvert, Zach Landis-Lewis, Rachel Richesson, Charles Friedman

“…In this abstract, we describe our work to develop a FDO carrying a computable phenotype.Defining computable phenotypesIn biomedical informatics, 'phenotyping' describes a data-driven approach to identifying a group of individuals sharing observable characteristics of interest, generally related to a disease or condition, and a 'computable phenotype' (CP) is a machine-processable expression of a phenotypic pattern of these characteristics (Hripcsak and Albers 2018). …”
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Development and validation of a trans-ancestry polygenic risk score for type 2 diabetes in diverse populations by Tian Ge, Marguerite R. Irvin, Amit Patki, Vinodh Srinivasasainagendra, Yen-Feng Lin, Hemant K. Tiwari, Nicole D. Armstrong, Barbara Benoit, Chia-Yen Chen, Karmel W. Choi, James J. Cimino, Brittney H. Davis, Ozan Dikilitas, Bethany Etheridge, Yen-Chen Anne Feng, Vivian Gainer, Hailiang Huang, Gail P. Jarvik, Christopher Kachulis, Eimear E. Kenny, Atlas Khan, Krzysztof Kiryluk, Leah Kottyan, Iftikhar J. Kullo, Christoph Lange, Niall Lennon, Aaron Leong, Edyta Malolepsza, Ayme D. Miles, Shawn Murphy, Bahram Namjou, Renuka Narayan, Mark J. O’Connor, Jennifer A. Pacheco, Emma Perez, Laura J. Rasmussen-Torvik, Elisabeth A. Rosenthal, Daniel Schaid, Maria Stamou, Miriam S. Udler, Wei-Qi Wei, Scott T. Weiss, Maggie C. Y. Ng, Jordan W. Smoller, Matthew S. Lebo, James B. Meigs, Nita A. Limdi, Elizabeth W. Karlson

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Dynamic altruistic cooperation within breast tumors by Muhammad Sufyan Bin Masroni, Kee Wah Lee, Victor Kwan Min Lee, Siok Bian Ng, Chao Teng Law, Kok Siong Poon, Bernett Teck-Kwong Lee, Zhehao Liu, Yuen Peng Tan, Wee Ling Chng, Steven Tucker, Lynette Su-Mien Ngo, George Wai Cheong Yip, Min En Nga, Susan Swee Shan Hue, Thomas Choudary Putti, Boon Huat Bay, Qingsong Lin, Lihan Zhou, Mikael Hartman, Tze Ping Loh, Manikandan Lakshmanan, Sook Yee Lee, Vinay Tergaonkar, Huiwen Chua, Adeline Voon Hui Lee, Eric Yew Meng Yeo, Mo-Huang Li, Chan Fong Chang, Zizheng Kee, Karen Mei-Ling Tan, Soo Yong Tan, Evelyn Siew-Chuan Koay, Marco Archetti, Sai Mun Leong

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Impact of pathological response on oncological outcomes in patients with upper tract urothelial cancer receiving neo-adjuvant chemotherapy by Chih-Chin Yu, Chao-Hsiang Chang, Jen-Kai Fang, Steven K. Huang, Wen-Hsin Tseng, Hsiang-Ying Lee, Hsin-Chih Yeh, I-Hsuan Alan Chen, Jen-Tai Lin, Pi-Che Chen, Ian-Seng Cheong, Thomas Y. Hsueh, Yuan-Hong Jiang, Yu-Khun Lee, Wei-Chieh Chen, Shih-Hsiu Lo, Po-Hung Lin, Shian-Shiang Wang, Chao-Yuan Huang, Chia-Chang Wu, Jen-Shu Tseng, Shu-Yu Wu, Yao-Chou Tsai

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Impact of individual level uncertainty of lung cancer polygenic risk score (PRS) on risk stratification by Xinan Wang, Ziwei Zhang, Yi Ding, Tony Chen, Lorelei Mucci, Demetrios Albanes, Maria Teresa Landi, Neil E. Caporaso, Stephen Lam, Adonina Tardon, Chu Chen, Stig E. Bojesen, Mattias Johansson, Angela Risch, Heike Bickeböller, H-Erich Wichmann, Gadi Rennert, Susanne Arnold, Paul Brennan, James D. McKay, John K. Field, Sanjay S. Shete, Loic Le Marchand, Geoffrey Liu, Angeline S. Andrew, Lambertus A. Kiemeney, Shan Zienolddiny-Narui, Annelie Behndig, Mikael Johansson, Angie Cox, Philip Lazarus, Matthew B. Schabath, Melinda C. Aldrich, Rayjean J. Hung, Christopher I. Amos, Xihong Lin, David C. Christiani

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Alpha-1 antitrypsin limits neutrophil extracellular trap disruption of airway epithelial barrier function by K. M. Hudock, K. M. Hudock, K. M. Hudock, M. S. Collins, M. A. Imbrogno, E. L. Kramer, E. L. Kramer, J. J. Brewington, J. J. Brewington, A. Ziady, A. Ziady, N. Zhang, N. Zhang, J. Snowball, Y. Xu, Y. Xu, Y. Xu, B. C. Carey, B. C. Carey, Y. Horio, Y. Horio, S. M. O’Grady, S. M. O’Grady, E. J. Kopras, J. Meeker, H. Morgan, A. J. Ostmann, E. Skala, M. E. Siefert, C. L. Na, C. R. Davidson, K. Gollomp, K. Gollomp, N. Mangalmurti, N. Mangalmurti, B. C. Trapnell, B. C. Trapnell, B. C. Trapnell, J. P. Clancy

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