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    GABAergic system in the endocrine pancreas: a new target for diabetes treatment by Wan Y, Wang Q, Prud’homme GJ

    Published 2015-02-01
    “…Yun Wan,1 Qinghua Wang,1–3 Gerald J Prud’homme4,5 1Department of Endocrinology and Metabolism, Huashan Hospital, Medical College, Fudan University, Shanghai, People’s Republic of China; 2Division of Endocrinology and Metabolism, Keenan Research Centre for Biomedical Science of St Michael’s Hospital, 3Departments of Physiology and Medicine, Faculty of Medicine, 4Department of Laboratory Medicine and Pathobiology, University of Toronto, 5Department of Laboratory Medicine, Keenan Research Centre for Biomedical Science, St Michael’s Hospital, Toronto, ON, Canada Abstract: Excessive loss of functional pancreatic β-cell mass, mainly due to apoptosis, is a major factor in the development of hyperglycemia in both type 1 and type 2 diabetes (T1D and T2D). …”
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