Comparison of the Malignant Predictors in Intrahepatic and Extrahepatic Intraductal Papillary Neoplasm of the Bile Duct by Sung Yong Han, Dong Uk Kim, Hyeong Seok Nam, Dae Hwan Kang, Sung Ill Jang, Dong Ki Lee, Dong Woo Shin, Kwang Bum Cho, Min Jae Yang, Jae Chul Hwang, Jin Hong Kim, Hoonsub So, Sung Jo Bang, Min Je Sung, Chang-Il Kwon, Dong Wook Lee, Chang-Min Cho, Jae Hee Cho

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Group A Streptococcus Induces LAPosomes via SLO/β1 Integrin/NOX2/ROS Pathway in Endothelial Cells That Are Ineffective in Bacterial Killing and Suppress Xenophagy by Yi-Lin Cheng, Chih-Feng Kuo, Shiou-Ling Lu, Hiroko Omori, Ya-Na Wu, Cheng-Lu Hsieh, Takeshi Noda, Shang-Rung Wu, Robert Anderson, Chiou-Feng Lin, Chia-Ling Chen, Jiunn-Jong Wu, Yee-Shin Lin

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Genomic Landscape of Young-Onset Bladder Cancer and Its Prognostic Implications on Adult Bladder Cancer by Sun-Wha Im, Chang Ohk Sung, Kun Suk Kim, Nam Hoon Cho, Young Min Kim, Ghee Young Kwon, Kyung Chul Moon, Song-Yi Choi, Jae Sung Lim, Yeong Jin Choi, Soo Jin Jung, So Dug Lim, Sung Hyun Paick, Ok-Jun Lee, Ho Won Kang, Seo Hee Rha, Hee Sang Hwang, Ja-Min Park, Sun Young Yoon, Jeesoo Chae, Jaeyong Choi, Jong-Il Kim, Yong Mee Cho

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Type I Interferons induce endothelial destabilization in Systemic Lupus Erythematosus in a Tie2-dependent manner by Carlos Rafael-Vidal, Carlos Rafael-Vidal, Sara Martínez-Ramos, Sara Martínez-Ramos, Beatriz Malvar-Fernández, Beatriz Malvar-Fernández, Irene Altabás-González, Irene Altabás-González, Coral Mouriño, Douglas J. Veale, Douglas J. Veale, Achilleas Floudas, Ursula Fearon, Ursula Fearon, José María Pego Reigosa, José María Pego Reigosa, Samuel García, Samuel García

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Clinical phenotypes of cardiogenic shock survivors: insights into late host responses and long‐term outcomes by Sabri Soussi, Mojtaba Ahmadiankalati, Jacob C. Jentzer, John C. Marshall, Patrick R. Lawler, Margaret Herridge, Alexandre Mebazaa, Etienne Gayat, Zihang Lu, Claudia C. dosSantos, the French and European Outcome Registry in Intensive Care Units (FROG‐ICU) and CCCTBG trans‐trial group study for InFACT – the International Forum for Acute Care Trialists

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Prospective longitudinal analysis of antibody response after standard and booster doses of SARS-COV2 vaccination in patients with early breast cancer by Jinyong Kim, Jiyun Jeong, Jiyun Jeong, Chan Mi Lee, Dae-Won Lee, Chang Kyung Kang, Pyeong Gyun Choe, Nam Joong Kim, Myoung-don Oh, Chang-Han Lee, Chang-Han Lee, Chang-Han Lee, Chang-Han Lee, Wan Beom Park, Kyung-Hun Lee, Kyung-Hun Lee, Seock-Ah Im, Seock-Ah Im

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Upregulation of the Oct3/4 Network in Basal Breast Cancer Is Associated with Its Metastatic Potential and Shows Tissue Dependent Variability by Robin G. Rajan, Raisa I. Krutilina, Tatyana N. Ignatova, Zoran S. Pavicevich, Galina M. Dulatova, Maria A. Lane, Arindam R. Chatterjee, Robert J. Rooney, Mymoon Antony, Vivian R. Hagerty, Nickolay V. Kukekov, Khalid A. Hanafy, Frank D. Vrionis

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Longitudinal association between eating alone and deterioration in frailty status: The Korean Frailty and Aging Cohort Study by Junhee Park, Hyung Eun Shin, Miji Kim, Chang Won Won, Yun-Mi Song

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Moderate Vaccine Effectiveness against Severe Acute Respiratory Infection Caused by A(H1N1)pdm09 Influenza Virus and No Effectiveness against A(H3N2) Influenza Virus in the 2018/20... by Caterina Rizzo, Francesco Gesualdo, Daniela Loconsole, Elisabetta Pandolfi, Antonino Bella, Andrea Orsi, Giulia Guarona, Donatella Panatto, Giancarlo Icardi, Christian Napoli, Giovanni Battista Orsi, Ilaria Manini, Emanuele Montomoli, Ilaria Campagna, Luisa Russo, Valeria Alfonsi, Simona Puzelli, Antonino Reale, Umberto Raucci, Livia Piccioni, Carlo Concato, Marta Luisa Ciofi Degli Atti, Alberto Villani, Maria Chironna, Alberto Eugenio Tozzi

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Medullary astrocytes mediate irregular breathing patterns generation in chronic heart failure through purinergic P2X7 receptor signalling by Camilo Toledo, Esteban Díaz-Jara, Hugo S. Diaz, Karla G. Schwarz, Katherin V. Pereyra, Alexandra Las Heras, Angélica Rios-Gallardo, David C. Andrade, Thiago Moreira, Ana Takakura, Noah J. Marcus, Rodrigo Del Rio

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Ticagrelor as an Alternative Antiplatelet Therapy in Cardiac Patients Non-Sensitive to Aspirin by Hamzah Khan, Reid Gallant, Shubha Jain, Mohammed Al-Omran, Charles De Mestral, Elisa Greco, Mark Wheatcroft, Ashraf Alazonni, Rawand Abdin, Margaret L. Rand, Heyu Ni, Mohammad Qadura

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Patient perspectives on home-spirometry in interstitial lung disease: a qualitative co-designed study by Sarah Lines, Michael Gibbons, Rebecca Shuttleworth, Anne-Marie Russell, Graham Brown, Anna Duckworth, Alex Berry, Jessica Mandizha, Joseph W Lanario, Ana Paiva, Victoria Elworthy, Veena Muraleedharan, Ana Jorge Da Ponte, Howard Almond, Carole Bond, Maureen Cosby, Joanne Dallas, Marium Naqvi, Adam David Russell, Christopher J Scotton

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Chemistry, Biosynthesis and Pharmacology of Streptonigrin: An Old Molecule with Future Prospects for New Drug Design, Development and Therapy by Nabihah Nasir N, Sekar M, Ravi S, Wong LS, Sisinthy SP, Gan SH, Subramaniyan V, Chidambaram K, Mat Rani NNI, Begum MY, Ramar M, Safi SZ, Selvaraj S, Chinna Maruthu SK, Fuloria S, Fuloria NK, Lum PT, Djearamane S

“…Naurah Nabihah Nasir,1 Mahendran Sekar,2,3 Subban Ravi,4 Ling Shing Wong,5 Sreenivas Patro Sisinthy,6 Siew Hua Gan,2 Vetriselvan Subramaniyan,7 Kumarappan Chidambaram,8 Nur Najihah Izzati Mat Rani,6 M Yasmin Begum,9 Mohankumar Ramar,10 Sher Zaman Safi,11 Siddharthan Selvaraj,12 Senthil Kumar Chinna Maruthu,13 Shivkanya Fuloria,14 Neeraj Kumar Fuloria,14 Pei Teng Lum,1 Sinouvassane Djearamane15 1Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Health Sciences, Royal College of Medicine Perak, Universiti Kuala Lumpur, Ipoh, Perak, 30450, Malaysia; 2School of Pharmacy, Monash University Malaysia, Bandar Sunway, Selangor, 47500, Malaysia; 3Center for Transdisciplinary Research, Department of Pharmacology, Saveetha Institute of Medical and Technical Sciences, Saveetha Dental College and Hospital, Saveetha University, Chennai, Tamil Nadu, 600077, India; 4Department of Chemistry, Karpagam Academy of Higher Education, Coimbatore, Tamil Nadu, 641021, India; 5Faculty of Health and Life Sciences, INTI International University, Nilai, 71800, Malaysia; 6Faculty of Pharmacy and Health Sciences, Royal College of Medicine Perak, Universiti Kuala Lumpur, Ipoh, Perak, 30450, Malaysia; 7Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Bandar Sunway, Subang Jaya, Selangor, Malaysia; 8Department of Pharmacology, College of Pharmacy, King Khalid University, Abha, 62529, Saudi Arabia; 9Department of Pharmaceutics, College of Pharmacy, King Khalid University, Abha, 61421, Saudi Arabia; 10Department of Surgical Research, Rhode Island Hospital, Alpert Medical School, Brown University, Providence, RI, 02903, USA; 11Faculty of Medicine, Bioscience and Nursing, MAHSA University, Jenjarom, Selangor, 42610, Malaysia; 12Faculty of Dentistry, AIMST University, Bedong, Kedah, 08100, Malaysia; 13Department of Pharmacology, Karpagam College of Pharmacy, Coimbatore, Tamilnadu, 641032, India; 14Faculty of Pharmacy, AIMST University, Bedong, Kedah, 08100, Malaysia; 15Department of Biomedical Science, Faculty of Science, Universiti Tunku Abdul Rahman, Kampar, Perak, 31900, MalaysiaCorrespondence: Ling Shing Wong, Faculty of Health and Life Sciences, INTI International University, Nilai, 71800, Malaysia, Tel +6014 – 3034057, Email lingshing.wong@newinti.edu.my Sinouvassane Djearamane, Department of Biomedical Science, Faculty of Science, Universiti Tunku Abdul Rahman, Kampar, 31900, Perak, Malaysia, Tel +6016 – 4037685, Email biochsinouvas07@gmail.comAbstract: Streptonigrin is an aminoquinone alkaloid isolated from Streptomyces flocculus and is gaining attention as a drug molecule owing to its potential antitumor and antibiotic effects. …”
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Gut Epithelial Inositol Polyphosphate Multikinase Alleviates Experimental Colitis via Governing Tuft Cell HomeostasisSummary by Seung Eun Park, Dongeun Lee, Jae Woong Jeong, Su-Hyung Lee, Seung Ju Park, Jaeseung Ryu, Se Kyu Oh, Hanseul Yang, Sungsoon Fang, Seyun Kim

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Improving measurement of blood-brain barrier permeability with reduced scan time using deep-learning-derived capillary input function by Jonghyun Bae, Chenyang Li, Arjun Masurkar, Yulin Ge, Sungheon Gene Kim

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Brain metastases in Japanese NSCLC patients: prognostic assessment and the use of osimertinib and immune checkpoint inhibitors—retrospective study by Hajime Higaki, Kentaro Nishioka, Manami Otsuka, Noboru Nishikawa, Motoyasu Shido, Hideki Minatogawa, Yukiko Nishikawa, Rikiya Takashina, Takayuki Hashimoto, Norio Katoh, Hiroshi Taguchi, Rumiko Kinoshita, Koichi Yasuda, Takashi Mori, Yusuke Uchinami, Fuki Koizumi, Yoshihiro Fujita, Shuhei Takahashi, Takahiro Hattori, Noriaki Nishiyama, Hidefumi Aoyama

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Geographical variation of common childhood illness and its associated factors among under-five children in Ethiopia: spatial and multilevel analysis by Dagmawi Chilot, Mengistie Diress, Yibeltal Yismaw Gela, Deresse Sinamaw, Wudneh Simegn, Amare Agmas Andualem, Abdulwase Mohammed Seid, Desalegn Anmut Bitew, Mohammed Abdu Seid, Habitu Birhan Eshetu, Anteneh Ayelign Kibret, Daniel Gashaneh Belay

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A 2-Min Transient Ischemia Confers Cerebral Ischemic Tolerance in Non-Obese Gerbils, but Results in Neuronal Death in Obese Gerbils by Increasing Abnormal mTOR Activation-Mediated... by Joon Ha Park, Ji Hyeon Ahn, Minah Song, Hyunjung Kim, Cheol Woo Park, Young Eun Park, Tae-Kyeong Lee, Jae-Chul Lee, Dae Won Kim, Choong-Hyun Lee, In Koo Hwang, Bing Chun Yan, Sungwoo Ryoo, Young-Myeong Kim, Il Jun Kang, Moo-Ho Won, Soo Young Choi

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Phylogenetic distribution of malonate semialdehyde decarboxylase (MSAD) genes among strains within the genus Mycobacterium: evidence of MSAD gene loss in the evolution of pathogeni... by Duhyung Lee, Duhyung Lee, Dong Hyun Kim, Dong Hyun Kim, Hyejun Seo, Hyejun Seo, Hyejun Seo, Seaone Choi, Seaone Choi, Seaone Choi, Bum-Joon Kim, Bum-Joon Kim, Bum-Joon Kim, Bum-Joon Kim, Bum-Joon Kim, Bum-Joon Kim

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Choline PET/CT in recurrent prostate cancer by Beatrice Detti, Maria Grazia Carnevale, Sara Lucidi, Luca Burchini, Saverio Caini, Carolina Orsatti, Niccolò Bertini, Manuele Roghi, Vanessa di Cataldo, Simona Fondelli, Gianluca Ingrosso, Giulio Francolini, Daniele Scartoni, Angela Sardaro, Antonio Pisani, Silvia Scoccianti, Cynthia Aristei, Lorenzo Livi

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