Integrated lipids biomarker of the prediabetes and type 2 diabetes mellitus Chinese patients by Jiaying Yang, Jiaying Yang, Mei Wang, Dawei Yang, Han Yan, Zhigang Wang, Dan Yan, Na Guo

“…Network analyses of the biomarkers associated with this biosignature suggested that the most profoundly affected lipid metabolism pathways in the context of diabetes include de novo ceramide synthesis, sphingomyelin metabolism, and additional pathways associated with phosphatidylcholine synthesis. …”
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A pilot metabolomics study of tuberculosis immune reconstitution inflammatory syndrome by Carlos A.M. Silva, Barbara Graham, Kristofor Webb, Laura Vari Ashton, Marisa Harton, Annie F. Luetkemeyer, Samantha Bokatzian, Reem Almubarak, Sebabrata Mahapatra, Laura Hovind, Michelle A. Kendall, Diane Havlir, John T. Belisle, Mary Ann De Groote

“…Keywords: AIDS, Tuberculosis, IRIS, Metabolomics, Biosignature features…”
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Heightened Plasma Levels of Transforming Growth Factor Beta (TGF-β) and Increased Degree of Systemic Biochemical Perturbation Characterizes Hepatic Steatosis in Overweight Pediatri... by Junaura R. Barretto, Ney Boa-Sorte, Caian L. Vinhaes, Hayna Malta-Santos, Jessica Rebouças-Silva, Camila F. Ramos, Monica A. S. Torres-Nascimento, Valeria M. Borges, Bruno B. Andrade

“…Our data reveal that HS patients exhibit a distinct biosignature of biochemical parameters and imply TGF-β as an important biomarker to evaluate risk of steatosis development.…”
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Gene expression analysis in Kawasaki disease; bioinformatics and experimental approach by Yazdan Rahmati, Hasan Mollanoori, Naser Kakavandi, Alireza Nateghian, Shirin Sayyahfar, Vahid Babaei, Sajad Esmaeili, Shahram Teimourian

“…Real-time PCR results validated candidate genes and miRNAs as KD transcriptional biosignatures and biomarkers, respectively. Our studies have shown MyD88, KREMEN1, TLR5, ALPK1, IRAK4, PFKFB3, HK3, CREB, CR1, SLC2A14, and FPR1 as the most important genes involved in KD. …”
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Cross-Species Meta-Analysis of Transcriptomic Data in Combination With Supervised Machine Learning Models Identifies the Common Gene Signature of Lactation Process by Mohammad Farhadian, Seyed A. Rafat, Karim Hasanpur, Mansour Ebrahimi, Esmaeil Ebrahimie, Esmaeil Ebrahimie, Esmaeil Ebrahimie, Esmaeil Ebrahimie

“…Interestingly, 10 genes, including MRPS18B, SF1, UQCRC1, NUCB1, RNF126, ADSL, TNNC1, FIS1, HES5 and THTPA, were not detected in original studies that highlights meta-analysis power in biosignature discovery. Common target and regulator analysis highlighted the high connectivity of CTNNB1, CDD4 and LPL as gene network hubs. …”
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Environmental conditions and microbial community structure during the Great Ordovician Biodiversification Event; a multi-disciplinary study from the Canning Basin, Western Australi... by Spaak, Gemma, Edwards, Dianne S., Foster, Clinton B., Pagès, Anais, Summons, Roger E, Sherwood, Neil, Grice, Kliti

“…The correlation of a strong G. prisca biosignature with high 3-methylhopane indices and 13 C depleted G. prisca–derived chemical fossils (biomarkers) is interpreted to suggest an ecological relationship between methanotrophs and G. prisca. …”
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PHOTOCHEMISTRY IN TERRESTRIAL EXOPLANET ATMOSPHERES. I. PHOTOCHEMISTRY MODEL AND BENCHMARK CASES by Hu, Renyu, Seager, Sara, Bains, William

“…The atmospheric scenarios presented in this paper can serve as the benchmark atmospheres for quickly assessing the lifetime of trace gases in reducing, weakly oxidizing, and highly oxidizing atmospheres on terrestrial exoplanets for the exploration of possible biosignature gases.…”
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Characterising exoplanets in reflected light: a pathway towards Earth-like worlds by Vaughan, SR

“…If the focal plane mask were to be shrunk or offset then I show that biosignature detection on Proxima b could be possible with around 40 hours of observation.…”

Prognostic Risk Assessment and Prediction of Radiotherapy Benefit for Women with Ductal Carcinoma In Situ (DCIS) of the Breast, in a Randomized Clinical Trial (SweDCIS) by Fredrik Wärnberg, Per Karlsson, Erik Holmberg, Kerstin Sandelin, Pat W. Whitworth, Jess Savala, Todd Barry, Glen Leesman, Steven P. Linke, Steven C. Shivers, Frank Vicini, Chirag Shah, Sheila Weinmann, Gregory Bruce Mann, Troy Bremer

“…The aim was to validate a biosignature, DCISionRT^®, in the SweDCIS randomized trial. …”
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Venus Life Finder Habitability Mission: Motivation, Science Objectives, and Instrumentation by Sara Seager, Janusz J. Petkowski, Christopher E. Carr, Sarag J. Saikia, Rachana Agrawal, Weston P. Buchanan, David H. Grinspoon, Monika U. Weber, Pete Klupar, Simon P. Worden, Iaroslav Iakubivskyi, Mihkel Pajusalu, Laila Kaasik, on behalf of the Venus Life Finder Mission Team

“…We envision an instrument suite to measure not only the acidity and water content of the droplets (and their variability) but additionally to confirm the presence of metals and other non-volatile elements required for life’s metabolism, verify the existence of organic material, and search for biosignature gases as signs of life. We present an astrobiology-focused mission, science goals, and instruments that can be used on both a large atmospheric probe with a parachute lasting about one hour in the cloud layers (40 to 60 km) or a fixed-altitude balloon operating at about 52 km above the surface. …”
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Urinary metabolic characterization of advanced tuberculous meningitis cases in a South African paediatric population by Simon Isaiah, Du Toit Loots, Mari van Reenen, Regan Solomons, Sabine van Elsland, Sabine van Elsland, A. Marceline Tutu van Furth, Martijn van der Kuip, Shayne Mason

“…We also provide original biological insights into this biosignature of urinary metabolites that can be used to characterize paediatric TBM patients in a South African cohort.…”
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Methylation Status of Corticotropin-Releasing Factor (CRF) Receptor Genes in Colorectal Cancer by Maria Panagopoulou, Antonia Cheretaki, Makrina Karaglani, Ioanna Balgkouranidou, Eirini Biziota, Kyriakos Amarantidis, Nikolaos Xenidis, Stylianos Kakolyris, Stavroula Baritaki, Ekaterini Chatzaki

“…AutoML analysis based on <i>CRFRs</i> methylation status revealed a three-feature high-performing biosignature for CRC diagnosis with an estimated AUC of 0.929. …”
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Additive and Interactive Genetically Contextual Effects of HbA1c on cg19693031 Methylation in Type 2 Diabetes by Kelsey Dawes, Willem Philibert, Benjamin Darbro, Ronald L. Simons, Robert Philibert

“…Despite the identification of well over a hundred genetic variants and CpG sites that associate with T2D, a robust biosignature that could be used to prevent or forestall clinical disease has not been developed. …”
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Standardization of the assessment protocol of mitochondrial respiration in human platelets by Rațiu D. Corina, Petruș T. Alexandra1,3, Lighezan Rodica2,3, Oana M. Duicu1,3, Muntean M. Danina1,3

“…Increased platelet mitochondrial respiration after cardiac arrest and resuscitation as a potential peripheral biosignature of cerebral bioenergetic dysfunction. J Bioenerg Biomembr. 2016;48:269- 279. 2. …”
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Prenatal transcript levels and metabolomics analyses reveal metabolic changes associated with intrauterine growth restriction and sex by Siriluck Ponsuksili, Eduard Murani, Frieder Hadlich, Muhammad Arsalan Iqbal, Beate Fuchs, Christina E. Galuska, Alvaro Perdomo-Sabogal, Fabio Sarais, Nares Trakooljul, Henry Reyer, Michael Oster, Klaus Wimmers

“…Our multi-omics network analysis reveals interactions and changes in the metabolic system associated with IUGR and identified an important biosignature that differs between IUGR and AGA piglets.…”
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Vitamin D, d-dimer, Interferon γ, and sCD14 Levels are Independently Associated with Immune Reconstitution Inflammatory Syndrome: A Prospective, International Study by Laura W. Musselwhite, Bruno B. Andrade, Susan S. Ellenberg, Ann Tierney, Pablo F. Belaunzaran-Zamudio, Adam Rupert, Michael M. Lederman, Ian Sanne, Juan G. Sierra Madero, Irini Sereti

“…TB-IRIS cases exhibited a distinct biosignature from IRIS related to other pathogens, with increased levels of C-reactive protein (CRP), sCD14, IFNγ, and lower levels of Hb that could be captured by a composite risk score. …”
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The Potential microRNA Prognostic Signature in HNSCCs: A Systematic Review by Mario Dioguardi, Francesca Spirito, Giovanna Iacovelli, Diego Sovereto, Enrica Laneve, Luigi Laino, Giorgia Apollonia Caloro, Ari Qadir Nabi, Andrea Ballini, Lorenzo Lo Muzio, Giuseppe Troiano

“…All survival index data were extracted, and the three miRs (miR-21, miR-155, and miR-375) most investigated and presenting the largest number of patients included in the studies were selected in a molecular biosignature. The difference between high and low tissue expression levels of miR-21, miR-155, and miR-375 for OS had an HR = 1.28, with 95% CI: [0.95, 1.72]. …”
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A Review of Super-Resolution Single-Molecule Localization Microscopy Cluster Analysis and Quantification Methods by Ismail M. Khater, Ivan Robert Nabi, Ghassan Hamarneh

“…Researchers have been actively exploring new computational methods for SMLM data analysis to extract biosignatures of various biological structures and functions. …”
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Evidence for an association of serum microanalytes and myofascial pain syndrome by Aishwarya Pradeep, Aybike Birerdinc, Travis Branigan, Vy Phan, Hailey Morris, Jay Shah, Secili DeStefano, Siddhartha Sikdar, John Srbely, Dinesh Kumbhare, Antonio Stecco, James Paik, Lynn H. Gerber

“…Diagnostic criteria include physical findings which are often unreliable or not universally accepted. A precise biosignature may improve diagnosis and treatment effectiveness. …”
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Immunologic and vascular biomarkers of mortality in critical COVID-19 in a South African cohort by Jane Alexandra Shaw, Maynard Meiring, Candice Snyders, Frans Everson, Lovemore Nyasha Sigwadhi, Veranyay Ngah, Gerard Tromp, Gerard Tromp, Gerard Tromp, Brian Allwood, Coenraad F. N. Koegelenberg, Elvis M. Irusen, Usha Lalla, Nicola Baines, Annalise E. Zemlin, Rajiv T. Erasmus, Zivanai C. Chapanduka, Tandi E. Matsha, Gerhard Walzl, Hans Strijdom, Nelita du Plessis, Alimuddin Zumla, Alimuddin Zumla, Novel Chegou, Stephanus T. Malherbe, Peter S. Nyasulu, Peter S. Nyasulu

“…A clinically relevant biosignature including PCT, pH and lymphocyte percentage on differential count, had an 84.8% sensitivity for mortality, and outperformed the Luminex-derived biosignature.…”
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