The Atacama Desert in Northern Chile as an Analog Model of Mars by Armando Azua-Bustos, Armando Azua-Bustos, Carlos González-Silva, Alberto G. Fairén, Alberto G. Fairén

“…The thorough study of the Atacama has allowed us to understand how life has adapted to its extreme conditions, the specific habitats that life occupies in each case (thus suggesting the most likely places in which to search for evidence for life on Mars), and the number of biosignatures detected across this desert. Also, the characterization of west-to-east transects across this desert has shown to be of significant value to understand the potential adaptations that Martian microorganisms may have followed in an ever-drying planet. …”
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Hierarchical clustering by patient-reported pain distribution alone identifies distinct chronic pain subgroups differing by pain intensity, quality, and clinical outcomes. by Benedict J Alter, Nathan P Anderson, Andrea G Gillman, Qing Yin, Jong-Hyeon Jeong, Ajay D Wasan

“…In the future, algorithmic clustering by pain distribution may be an important facet in chronic pain biosignatures developed for the personalization of pain management.…”
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Exploratory evidence for differences in GABAergic regulation of auditory processing in autism spectrum disorder by Qiyun Huang, Hester Velthuis, Andreia C. Pereira, Jumana Ahmad, Samuel F. Cooke, Claire L. Ellis, Francesca M. Ponteduro, Nicolaas A. J. Puts, Mihail Dimitrov, Dafnis Batalle, Nichol M. L. Wong, Lukasz Kowalewski, Glynis Ivin, Eileen Daly, Declan G. M. Murphy, Gráinne M. McAlonan

“…As part of a study of potential biosignatures of GABA function in ASD to inform future clinical trials, we evaluated the role of GABA in auditory repetition suppression in 66 adults (n = 28 with ASD). …”
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Combined Genomic and Imaging Techniques Show Intense Arsenic Enrichment Caused by Detoxification in a Microbial Mat of the Dead Sea Shore by C. Thomas, M. Filella, D. Ionescu, S. Sorieul, C. G. L. Pollier, A. M. Oehlert, P. Zahajská, N. Gedulter, A. Agnon, D. Ferreira Sanchez, D. Ariztegui

“…Arsenic signatures in Precambrian organic matter and carbonate rocks may host biosignatures, including evidence for extracellular polymeric substances, As‐binding and detoxification processes, without supporting arsenotrophy. …”
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Exploration of Potential Biomarker Genes and Pathways in Kawasaki Disease: An Integrated in-Silico Approach by Priyanka Srivastava, Chitra Bamba, Rakesh Kumar Pilania, Anu Kumari, Rajni Kumrah, Archan Sil, Surjit Singh

“…These findings could significantly aid in identifying therapeutic targets and understanding KD biosignatures to design a biomarker panel for early diagnosis and severity of the disease.…”
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Neuroimaging alterations of the suicidal brain and its relevance to practice: an updated review of MRI studies by Matthew Dobbertin, Matthew Dobbertin, Karina S. Blair, Erin Carollo, James R. Blair, Ahria Dominguez, Sahil Bajaj

“…However, more recent studies have started to shed light on complex biosignatures using MRI techniques, including task-based and resting-state functional MRI, brain morphometry, and diffusion tensor imaging. …”
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Spices Volatilomic Fingerprinting—A Comprehensive Approach to Explore Its Authentication and Bioactive Properties by Sergio Izcara, Rosa Perestrelo, Sonia Morante-Zarcero, Isabel Sierra, José S. Câmara

“…Volatile organic metabolites (VOMs) present in different spices can provide distinct analytical biosignatures related to organoleptic properties and health benefits. …”
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Prebiosignature Molecules Can Be Detected in Temperate Exoplanet Atmospheres with JWST by A. B. Claringbold, P. B. Rimmer, S. Rugheimer, O. Shorttle

“…The search for biosignatures on exoplanets connects the fields of biology and biochemistry to astronomical observation, with the hope that we might detect evidence of active biological processes on worlds outside the solar system. …”
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Biota and Biomolecules in Extreme Environments on Earth: Implications for Life Detection on Mars by Joost W. Aerts, Wilfred F.M. Röling, Andreas Elsaesser, Pascale Ehrenfreund

“…The search for organic material and biosignatures on Mars is particularly challenging due to the hostile environment and its effect on organic compounds near the surface. …”
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The Molecular Profile of Soil Microbial Communities Inhabiting a Cambrian Host Rock by Ting Huang, Daniel Carrizo, Laura Sánchez-García, Qitao Hu, Angélica Anglés, David Gómez-Ortiz, Liang-Liang Yu, David C. Fernández-Remolar

“…Furthermore, findings highlight the ability of contemporary soil microbiota to inhabit rocky substrates actively, requiring strict contamination controls when evaluating ancient molecular biosignatures or extraterrestrial materials collected.…”
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FLUORESCENT ANALYSIS OF PHOTOSYNTHETIC MICROBES AND POLYCYCLIC AROMATIC HYDROCARBONS LINKED TO OPTICAL REMOTE SENSING by D. Zhang, J.-P. Muller, S. Lavender, D. Walton, L. R. Dartnell

“…The aim of the study was to find fluorescent biosignatures of cyanobacteria (initially a species specific to the Baltic Sea) and the fingerprints of crude oil; oil spills can be difficult to differentiate from biogenic films when using Synthetic Aperture Radar (SAR) or sunglint contaminated optical imagery. …”
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In situ microbial community succession on mild steel in estuarine and marine environments: exploring the role of iron-oxidizing bacteria by Joyce Margaret Mcbeth, Joyce Margaret Mcbeth, David eEmerson

“…Iron oxyhydroxide stalk biosignatures were observed on the steel and in earlier enrichment culture studies; this is evidence that the Zetaproteobacteria identified in the qPCR, pyrosequencing, and single cell data were likely FeOB. …”
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Water is a preservative of microbes by John E. Hallsworth

“…Implications of this role are discussed with reference to the ecology of halophiles, human pathogens and other microbes; food science; biotechnology; biosignatures for life and other aspects of astrobiology; and the large‐scale release/reactivation of preserved microbes caused by global climate change.…”
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Reward Behavior Disengagement, a Neuroeconomic Model-Based Objective Measure of Reward Pathology in Depression: Findings from the EMBARC Trial by Michael A. Giles, Crystal M. Cooper, Manish K. Jha, Cherise R. Chin Fatt, Diego A. Pizzagalli, Taryn L. Mayes, Christian A. Webb, Tracy L. Greer, Amit Etkin, Joseph M. Trombello, Henry W. Chase, Mary L. Phillips, Melvin G. McInnis, Thomas Carmody, Phillip Adams, Ramin V. Parsey, Patrick J. McGrath, Myrna Weissman, Benji T. Kurian, Maurizio Fava, Madhukar H. Trivedi

“…Data were gathered as part of the Establishing Moderators and Biosignatures of Antidepressant Response in Clinical Care (EMBARC) study, a double-blind, placebo-controlled clinical trial of antidepressant response. …”
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Protein networks in induced sputum from smokers and COPD patients by Baraniuk JN, Casado B, Pannell LK, McGarvey PB, Boschetto P, Luisetti M, Iadarola P

“…Conclusion: The proteomes were interpreted as complex “biosignatures” that suggest distinct pathophysiological mechanisms for mucin 5AC hypersecretion, airflow obstruction, and inflammatory emphysema phenotypes. …”
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Current Understanding of the Mechanisms Underlying Immune Evasion From PD-1/PD-L1 Immune Checkpoint Blockade in Head and Neck Cancer by Victor C. Kok, Victor C. Kok

“…Several potential biomarkers or biosignatures, which could predict the response or resistance to the PD-1/PD-L1 checkpoint immunotherapy, are also discussed.…”
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Multi-factor regulatory network and different clusters in hypertrophic obstructive cardiomyopathy by Xianyu Qin, Lei Huang, Sicheng Chen, Shaoxian Chen, Pengju Wen, Yueheng Wu, Jian Zhuang

“…Abstract Background Practical biosignatures and thorough understanding of regulatory processes of hypertrophic obstructive cardiomyopathy (HOCM) are still lacking. …”
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Exploratory data analysis (EDA) machine learning approaches for ocean world analog mass spectrometry by Victoria Da Poian, Victoria Da Poian, Victoria Da Poian, Bethany Theiling, Lily Clough, Brett McKinney, Jonathan Major, Jingyi Chen, Sarah Hörst

“…Our driving science goal is to determine whether the mass spectra of volatile gases could contain information about the composition of the seawater and potential biosignatures. We implement data science and ML techniques to investigate what inherent information the spectra contain and determine whether a data science pipeline could be designed to quickly analyze data from future ocean worlds missions. …”
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Cerebellar and multi-system metabolic reprogramming associated with trauma exposure and post-traumatic stress disorder (PTSD)-like behavior in mice by Graeme Preston, Tim Emmerzaal, Silvia Radenkovic, Ian R. Lanza, Devin Oglesbee, Eva Morava, Tamas Kozicz

“…Notably, several transformed metabolic pathways observed in the cerebellum were also reflected in plasma, connecting central and peripheral biosignatures of PTSD-like behavior. These preliminary findings could direct further mechanistic studies and offer insights into potential metabolic interventions, either pharmacological or dietary, to improve PTSD resilience.…”
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Intact polar lipidome and membrane adaptations of microbial communities inhabiting serpentinite-hosted fluids by Kaitlin R. Rempfert, Emily A. Kraus, Daniel B. Nothaft, Nadia Dildar, John R. Spear, John R. Spear, Julio Sepúlveda, Alexis S. Templeton

“…These data contribute new insights into the complexity of lipid structures generated in actively serpentinizing environments and provide valuable context to aid in the reconstruction of past microbial activity from fossil lipid records of terrestrial serpentinites and the search for biosignatures elsewhere in our solar system.…”
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