Discrimination of <i>Bacillus cereus</i> Group Members by MALDI-TOF Mass Spectrometry by Viviana Manzulli, Valeria Rondinone, Alessandro Buchicchio, Luigina Serrecchia, Dora Cipolletta, Antonio Fasanella, Antonio Parisi, Laura Difato, Michela Iatarola, Angela Aceti, Elena Poppa, Francesco Tolve, Lorenzo Pace, Fiorenza Petruzzi, Ines Della Rovere, Donato Antonio Raele, Laura Del Sambro, Luigi Giangrossi, Domenico Galante

“…This could offer a critical time advantage for the diagnosis and for the clinical management of human anthrax even in case of bioterror attacks.…”
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Bacillus subtilis spore vaccines displaying protective antigen induce functional antibodies and protective potency by Yeonsu Oh, Jung Ae Kim, Chang-Hwan Kim, Soo-Keun Choi, Jae-Gu Pan

“…Abstract Background Bacillus anthracis is the causative agent of anthrax, a disease of both humans and various animal species, and can be used as a bioterror agent. Effective vaccines are available, but those could benefit from improvements, including increasing the immunity duration, reducing the shot frequency and adverse reactions. …”
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Novel small molecule retrograde transport blocker confers post-exposure protection against ricin intoxication by Xu Zhao, Haixia Li, Jia Li, Kunlu Liu, Bo Wang, Yuxia Wang, Xingzhou Li, Wu Zhong

“…Ricin is considered a potential bioterror agent and no effective antidote for ricin exists so far. …”
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Changes of Global Infectious Disease Governance in 2000s: Rise of Global Health Security and Transformation of Infectious Disease Control System in South Korea by Eun Kyung CHOI, Jong-Koo LEE

“…Moreover, global health security frame became important after 2001 bioterror and 2003 SARS outbreak. Consequently, international health regulation was fully revised in 2005, which included not only infectious disease but also public health emergency. …”
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Development of a new tacaribe arenavirus infection model and its use to explore antiviral activity of a novel aristeromycin analog. by Brian B Gowen, Min-Hui Wong, Deanna Larson, Wei Ye, Kie-Hoon Jung, Eric J Sefing, Ramona Skirpstunas, Donald F Smee, John D Morrey, Stewart W Schneller

“…They pose a public health threat as emerging viruses and because of their potential use as bioterror agents. All of the highly pathogenic New World arenaviruses (NWA) phylogenetically segregate into clade B and require maximum biosafety containment facilities for their study. …”
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Mutated and bacteriophage T4 nanoparticle arrayed F1-V immunogens from Yersinia pestis as next generation plague vaccines. by Pan Tao, Marthandan Mahalingam, Michelle L Kirtley, Christina J van Lier, Jian Sha, Linsey A Yeager, Ashok K Chopra, Venigalla B Rao

“…Pneumonic plague is a highly virulent infectious disease with 100% mortality rate, and its causative organism Yersinia pestis poses a serious threat for deliberate use as a bioterror agent. Currently, there is no FDA approved vaccine against plague. …”
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Alternative pre-approved and novel therapies for the treatment of anthrax by Breanne M. Head, Ethan Rubinstein, Adrienne F. A. Meyers

“…Abstract Background Bacillus anthracis, the causative agent of anthrax, is a spore forming and toxin producing rod-shaped bacterium that is classified as a category A bioterror agent. This pathogenic microbe can be transmitted to both animals and humans. …”
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Identification of a live attenuated vaccine candidate for tularemia prophylaxis. by Manish Mahawar, Seham M Rabadi, Sukalyani Banik, Sally V Catlett, Dennis W Metzger, Meenakshi Malik, Chandra Shekhar Bakshi

“…F. tularensis was used in bioweapon programs in the past and is now classified as a category A select agent owing to its possible use in bioterror attacks. Despite over a century since its discovery, an effective vaccine is yet to be developed. …”
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Development of Immunoassays for Detection of <i>Francisella tularensis</i> Lipopolysaccharide in Tularemia Patient Samples by Emily E. Hannah, Sujata G. Pandit, Derrick Hau, Haley L. DeMers, Kayleigh Robichaux, Teerapat Nualnoi, Anjana Dissanayaka, Jose Arias-Umana, Heather R. Green, Peter Thorkildson, Kathryn J. Pflughoeft, Marcellene A. Gates-Hollingsworth, Yasemin Ozsurekci, David P. AuCoin

“…<i>F. tularensis</i> has also garnered attention as a potential bioterror threat, as widespread dissemination could have devastating consequences on a population. …”
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Identification of novel raft marker protein, FlotP in Bacillus anthracis by Vikas Kumar Somani, Somya eAggarwal, Damini eSingh, Tulika ePrasad, Tulika ePrasad, Rakesh eBhatnagar

“…Considering the global threat of BA as the bioterror agent, it was selected as a model for further in vitro characterization of rafts in PB. …”
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A single-dose PLGA encapsulated protective antigen domain 4 nanoformulation protects mice against Bacillus anthracis spore challenge. by Manish Manish, Amit Rahi, Manpreet Kaur, Rakesh Bhatnagar, Samer Singh

“…Bacillus anthracis, the etiological agent of anthrax, is a major bioterror agent. Vaccination is the most effective prophylactic measure available against anthrax. …”
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BoHV-4-Based Vector Single Heterologous Antigen Delivery Protects STAT1(-/-) Mice from Monkeypoxvirus Lethal Challenge. by Valentina Franceschi, Scott Parker, Sarah Jacca, Ryan W Crump, Konstantin Doronin, Edguardo Hembrador, Daniela Pompilio, Giulia Tebaldi, Ryan D Estep, Scott W Wong, Mark R Buller, Gaetano Donofrio

“…For this reason, new studies on pathogenesis, prophylaxis and therapeutics are still of great interest, not only for the scientific community but also for the governments concerned that MPXV could be used as a bioterror agent. In the present study, a new vaccination strategy approach based on three recombinant bovine herpesvirus 4 (BoHV-4) vectors, each expressing different MPXV glycoproteins, A29L, M1R and B6R were investigated in terms of protection from a lethal MPXV challenge in STAT1 knockout mice. …”
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Needle-free injection nozzle geometry by Liu, John (John Hsiao-Yung)

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Nlrp3 Increases the Host’s Susceptibility to Tularemia by Ragavan V. Suresh, Elizabeth W. Bradley, Matthew Higgs, Vincenzo C. Russo, Maha Alqahtani, Wiehua Huang, Chandra Shekhar Bakshi, Meenakshi Malik

“…The CDC has classified F. tularensis as a Tier 1 Category A select agent based on its ease of aerosolization, low infectious dose, past use as a bioweapon, and the potential to be used as a bioterror agent. Francisella has a unique replication cycle. …”
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Iron-Modified Blood Culture Media Allow for the Rapid Diagnosis and Isolation of the Slow-Growing Pathogen Francisella tularensis by Efi Makdasi, Yafit Atiya-Nasagi, David Gur, Itai Glinert, Shlomo Shmaya, Elad Milrot, Theodor Chitlaru, Emanuelle Mamroud, Orly Laskar, Ofir Schuster

“…Due to the high mortality rates of the disease, as well as the low respiratory infectious dose, F. tularensis is categorized as a Tier 1 bioterror agent. The identification and isolation from clinical blood cultures of F. tularensis are complicated by its slow growth. …”
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A Monovalent and Trivalent MVA-Based Vaccine Completely Protects Mice Against Lethal Venezuelan, Western, and Eastern Equine Encephalitis Virus Aerosol Challenge by Lisa Henning, Kathrin Endt, Robin Steigerwald, Michael Anderson, Ariane Volkmann

“…Yet, no licensed vaccine for human use is available to protect against these mosquito-borne pathogens, which can be aerosolized and therefore pose a bioterror threat in addition to the risk of natural outbreaks. …”
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Generation of recombinant mAbs to vaccinia virus displaying high affinity and potent neutralization by Tal Noy-Porat, Hadas Tamir, Ron Alcalay, Ronit Rosenfeld, Eyal Epstein, Lilach Cherry, Hagit Achdout, Noam Erez, Boaz Politi, Yfat Yahalom-Ronen, Shay Weiss, Sharon Melamed, Tomer Israely, Ohad Mazor, Nir Paran, Efi Makdasi

“…We believe that these antibodies have the potential to be used for the treatment of vaccinia vaccine adverse reactions, for other orthopoxvirus infections, and in cases of unexpected bioterror scenarios.…”
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New Insights into Autoinducer-2 Signaling as a Virulence Regulator in a Mouse Model of Pneumonic Plague by Eric C. Fitts, Jourdan A. Andersson, Michelle L. Kirtley, Jian Sha, Tatiana E. Erova, Sadhana Chauhan, Vladimir L. Motin, Ashok K. Chopra

“…The organism represents a significant concern because of its potential use as a bioterror agent, beyond the several thousand naturally occurring human infection cases occurring globally each year. …”
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The production, design and application of antimicrobial peptides by Loose, Christopher (Christopher R.)

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