Familiality of postpartum depression in unipolar disorder: results of a family study. by Forty, L, Jones, L, Macgregor, S, Caesar, S, Cooper, C, Hough, A, Dean, L, Dave, S, Farmer, A, McGuffin, P, Brewster, S, Craddock, N, Jones, I

“… OBJECTIVE: The authors previously reported strong evidence for familial aggregation of postpartum (puerperal) psychotic episodes in women with bipolar disorder. The authors here examine whether vulnerability to postpartum triggering of depressive episodes aggregates in families and assess how this aggregation varies with the definition of postpartum onset. …”

Effects of the potential lithium-mimetic, ebselen, on impulsivity and emotional processing by Masaki, C, Sharpley, A, Cooper, C, Godlewska, B, Singh, N, Vasudevan, S, Harmer, C, Churchill, G, Sharp, T, Rogers, R, Cowen, P

“…Rationale: Lithium remains the most effective treatment for bipolar disorder and also has important effects to lower suicidal behaviour, a property that may be linked to its ability to diminish impulsive, aggressive behaviour. …”

Lamotrigine for treatment of bipolar depression: independent meta-analysis and meta-regression of individual patient data from five randomised trials. by Geddes, J, Calabrese, JR, Goodwin, G

“…CONCLUSIONS: There is consistent evidence that lamotrigine has a beneficial effect on depressive symptoms in the depressed phase of bipolar disorder. The overall pool effect was modest, although the advantage over placebo was larger in more severely depressed participants.…”

Reduction in occipital cortex gamma-aminobutyric acid concentrations in medication-free recovered unipolar depressed and bipolar subjects. by Bhagwagar, Z, Wylezinska, M, Jezzard, P, Evans, J, Ashworth, F, Sule, A, Matthews, P, Cowen, P

“…METHODS: An [1H]-MRS was used to measure levels of GABA, of the combined concentration of Glu and glutamine (Gln), and of N-acetylaspartate (NAA) in occipital cortex in medication-free, fully recovered subjects with a history of recurrent unipolar depression (n = 15), bipolar disorder (n = 16), and a group of healthy controls (n = 18). …”

Reduced spinophilin but not microtubule-associated protein 2 expression in the hippocampal formation in schizophrenia and mood disorders: molecular evidence for a pathology of dend... by Law, A, Weickert, C, Hyde, T, Kleinman, J, Harrison, P

“…METHOD: Using in situ hybridization in sections of hippocampal formation from 10 patients with schizophrenia, 10 patients with mood disorders (three with bipolar disorder and seven with major depression), and 10 healthy comparison subjects, the authors examined the expression of two important dendritic genes: spinophilin, which serves as a marker of dendritic spines, and microtubule-associated protein 2 (MAP2), an overall dendritic marker. …”

No effect of parental age on risk of multiple sclerosis: a population-based study by Ramagopalan, S, Dyment, D, Guimond, C, Yee, I, Ebers, G, Sadovnick, A

“…Advanced paternal age is associated with a number of adult onset disorders including schizophrenia and bipolar disorder. In a population-based Canadian cohort, we investigated whether there is any difference in parental age at birth for MS index cases compared to spouse controls. …”

A comprehensive review and model of putative prodromal features of bipolar affective disorder. by Howes, O, Lim, S, Theologos, G, Yung, A, Goodwin, G, McGuire, P

“… BACKGROUND: Identifying prodromal features that predate the onset of bipolar disorder (BD) may enable the prevention of BD and aid early intervention. …”

Investigation of candidate risk genes for neuropsychiatric disease in vitro and in vivo using ENU mutagenesis by Hobbs, E

“…Endophenotypes associated with schizophrenia and bipolar disorder, such as anxiety, cognitive deficits and sensorimotor gating deficits, can be characterised in these mutants and, together with molecular characterisation, this can validate these genes as risk factors. …”

A comprehensive review and model of putative prodromal features of bipolar affective disorder by Howes, O, Lim, S, Theologos, G, Yung, A, Goodwin, G, McGuire, P

“…Background Identifying prodromal features that predate the onset of bipolar disorder (BD) may enable the prevention of BD and aid early intervention. …”

Psychiatric assessment of mood instability: qualitative study of patient experience. by Bilderbeck, A, Saunders, K, Price, J, Goodwin, G

“…Receiving a psychiatric diagnosis, including a diagnosis of bipolar disorder or borderline personality disorder, evoked both positive and negative responses among participants, relating to stigma, personal understanding and responsibility, prognosis and treatment. …”

Epigenetic Modifications in Stress Response Genes Associated With Childhood Trauma by Shui Jiang, Lynne Postovit, Annamaria Cattaneo, Elisabeth B. Binder, Elisabeth B. Binder, Katherine J. Aitchison, Katherine J. Aitchison

“…For example, childhood trauma has been associated with posttraumatic stress disorder (PTSD), anxiety, depression, bipolar disorder, diabetes, and cardiovascular disease. …”
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Patient-rated scales improve the classification accuracy for patients with depression and anxiety disorder: a linear discriminant analysis by Shanling Ji, Jing Zhang, Cong Zhou, Min Chen, Hao Yu

“…Methods We recruited a total of 122 subjects, comprising 24 patients with bipolar disorder (BD), 34 patients with major depressive disorder (MDD), 29 patients with anxiety disorder (AD), and 35 matched HCs. …”
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Alteration of cortical functional networks in mood disorders with resting-state electroencephalography by Sungkean Kim, Ji Hyun Baek, Se-hoon Shim, Young Joon Kwon, Hwa Young Lee, Jae Hyun Yoo, Ji Sun Kim

“…Abstract Studies comparing bipolar disorder (BD) and major depressive disorder (MDD) are scarce, and the neuropathology of these disorders is poorly understood. …”
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Adult Mild Encephalitis With Reversible Splenial Lesion Associated With Delirious Mania: A Case Report by Marcella Bellani, Marcella Bellani, Giovanni Zanette, Niccolò Zovetti, Marco Barillari, Lidia Del Piccolo, Paolo Brambilla, Paolo Brambilla

“…Little is known about neural markers of the manic state, and the corpus callosum has been described to be involved in bipolar disorder. Abnormalities in this structure may represent a marker of vulnerability for this disorder.…”
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A chemical genetic screen reveals a role for proteostasis in capsule and biofilm formation by Cryptococcus neoformans by François L. Mayer, Eddy Sánchez-León, James W. Kronstad

“…Here, we show that the bipolar disorder drug lithium inhibits formation of both virulence factors by a mechanism involving dysregulation of the ubiquitin/proteasome system. …”
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Prefronto-Cerebellar Transcranial Direct Current Stimulation Improves Sleep Quality in Euthymic Bipolar Patients: A Brief Report by Amedeo Minichino, Francesco Saverio Bersani, Francesco Spagnoli, Alessandra Corrado, Francesco De Michele, Wanda Katharina Calò, Martina Primavera, Baoran Yang, Laura Bernabei, Francesco Macrì, Lucilla Vergnani, Massimo Biondi, Roberto Delle Chiaie

“…Sleep problems are common in bipolar disorder (BD) and may persist during the euthymic phase of the disease. …”
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Involvement of Kallikrein-Related Peptidases in Nervous System Disorders by Cinthia Mella, Cinthia Mella, Cinthia Mella, Carlos D. Figueroa, Carlos D. Figueroa, Carola Otth, Carola Otth, Pamela Ehrenfeld, Pamela Ehrenfeld

“…Increased expression of KLK8 has also been implicated in schizophrenia, bipolar disorder, and depression. Also, we discuss the possible link that exists between KLKs activity and certain viral infections that can affect the nervous system. …”
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Functional single nucleotide polymorphisms in dopaminergic receptors D2 predict clinical response to Cariprazine by Marco De Pieri, Marco De Pieri, Marco De Pieri, Marco Ferrari, Franca Marino, Rafael Traber, Emilio Bolla, Marco Cosentino

“…Cariprazine (CAR) is an antipsychotic drug for the treatment of schizophrenia (SCZ) and bipolar disorder (BD), and it acts as a partial agonist on the dopamine receptors (DR), D2, and D3. …”
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Longitudinal Coupling between Eating Disorder Psychopathology and Depression in Patients with Anorexia Nervosa and Bulimia Nervosa Treated with Enhanced Cognitive Behavior Therapy:... by Emanuele Cassioli, Eleonora Rossi, Michela Martelli, Francesca Arganini, Gabriele Giuranno, Serena Siviglia, Livio Tarchi, Marco Faldi, Giovanni Castellini, Valdo Ricca

“…Methods: A total of 157 women with AN or BN and no history of childhood trauma or bipolar disorder were evaluated before treatment and after 12 months of CBT-E. …”
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Detection Study of Bipolar Depression Through the Application of a Model-Based Algorithm in Terms of Clinical Feature and Peripheral Biomarkers by Yanqun Zheng, Shen He, Tianhong Zhang, Tianhong Zhang, Zhiguang Lin, Shenxun Shi, Yiru Fang, Kaida Jiang, Xiaohua Liu, Xiaohua Liu

“…In this paper, we aimed to explore whether peripheral neurotrophic factors could be helpful for early detection of bipolar depression.Methods: A screening method combining peripheral biomarkers and clinical characteristics was applied in 30 patients with major depressive disorder (MDD) and 23 patients with depressive episode of bipolar disorder. By a model-based algorithm, some information was extracted from the dataset and used as a “model” to approach penalized regression model for stably differential diagnosis for bipolar depression.Results: A simple and efficient model of approaching the diagnosis of individuals with depressive symptoms was established with a fitting degree (90.58%) and an acceptable cross-validation error rate. …”
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