Individual stigma in people with severe mental illness: Associations with public stigma, psychological capital, cognitive appraisal and coping orientations by Xiuxiu Shi, Xuhai Sun, Chong Zhang, Zheng Li

“…Data was provided by 422 patients with schizophrenia or bipolar disorder, from one psychiatric hospital and four community healthcare centers in China. …”
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Gilles de la Tourette syndrome: a common disease among uncommonly talented individuals? by Natalia Szejko, Piotr Janik, Tomasz Pasierski

“…Numerous famous and talented individuals were influenced by their medical conditions, for example: Fyodor Dostoevsky is claimed to have suffered from epilepsy or psychogenic seizures, Robert Schumann is suspected to have had bipolar disorder, while Russian avant-garde composer and pianist Alexander Scriabin or pianist Clara Wieck-Schumann suffered from chronic pain which probably influenced their play. …”
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Mental health, Reproductive health and contraception: pharmacological interaction, current evidence and challenges by C. Pinto Osório, P. Macedo

“…Query: Contraceptive+(psychiatric disorder, depression, anxiety, schizophrenia, bipolar disorder, psychotropic drugs). Results Based on current evidence, no statistically significant differences regarding unplanned pregnancy rates or the psychotropic treatment outcomes were found when using combined oral contraceptives and antidepressants, benzodiazepines or atypical antipsychotics (being clozapine the exception). …”
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Brain connectomes in youth at risk for serious mental illness: an exploratory analysis by Paul D. Metzak, Mohammed K. Shakeel, Xiangyu Long, Mike Lasby, Roberto Souza, Signe Bray, Benjamin I. Goldstein, Glenda MacQueen, JianLi Wang, Sidney H. Kennedy, Jean Addington, Catherine Lebel

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Valproate Use Is Associated With Posterior Cortical Thinning and Ventricular Enlargement in Epilepsy Patients by Manuela Tondelli, Anna Elisabetta Vaudano, Sanjay M. Sisodiya, Sanjay M. Sisodiya, Stefano Meletti, Stefano Meletti

“…Valproate is a drug widely used to treat epilepsy, bipolar disorder, and occasionally to prevent migraine headache. …”
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Changes in major psychiatric disorders in children and adolescents from 2001 to 2020: A retrospective single-center study by Hongyu Zheng, Xiaolu Jiang, Rong Yang, Shuo Wang, Hui Zhong, Hui Zhong

“…ObjectiveThis study aimed to determine the hospitalization rates, length of stay, age at the time of admission, and sex distribution for major psychiatric disorders in children and adolescents and provide a reference for early intervention for these diseases and distribution of medical resources in hospitals.MethodsWe screened 4,423 patients in the child and adolescent wards of the Anhui Provincial Mental Health Center from 2001 to 2020, and examined the top four (81.1%) mental health disorders that accounted for the overall proportion of patients admitted, namely schizophrenia (SCZ) (45.7%), depressive disorder (DD) (14.5%), bipolar disorder (BD) (9.3%), and childhood emotional disorder (CED) (11.6%), and for each disorder, the percentage of hospitalization, length of stay, age at admission, and sex distribution were analyzed.ResultsFrom 2001 to 2020, there was a significantly decreasing trend in the proportion of hospitalizations for SCZ (p < 0.001) and an increasing trend for depression and CED (p < 0.001). …”
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Oxcarbazepine as monotherapy of acute mania in insufficiently controlled type-1 diabetes mellitus: a case-report by Papageorgiou Charalambos, Karakatsanis Nikolaos A, Makrilakis Konstantinos, Kontoangelos Konstantinos A, Masdrakis Vasilios G, Kouzoupis Anastasios V, Karapoulios Evangelos, Oulis Panagiotis, Katsilambros Nikolaos, Soldatos Constantin R

“…<p>Abstract</p> <p>Background</p> <p>Type-1 diabetes mellitus (DM) is a lifelong serious condition which often renders the application of standard treatment options for patients' comorbid conditions, such as bipolar disorder I, risky – especially for acute manic episodes. …”
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Effect of Continuation-Maintenance Electroconvulsive Therapy on Hospitalization: A Retrospective Mirror-Image Study by Sombatcharoen-non N, Yamnim T, Jullagate S, Ittasakul P

“…The primary outcome measured the differences in admissions and admission days before and after continuation-maintenance ECT.Results: Forty-seven patients were included in the study, with diagnoses of schizophrenia (38.3%), schizoaffective disorder (21.3%), and bipolar disorder (19.1%) being the most common. The mean (standard deviation; SD) age was 44.6 (12.2) years. …”
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Electroconvulsive Therapy Practice in Thailand: A Nationwide Survey by Kittayarak K, Ittasakul P

“…The most common diagnosis was schizophrenia (5,958 patients/year), followed by bipolar disorder (982 patients/year) and major depressive disorder (869 patients/year). …”
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Effects of asenapine on depressive symptoms in patients with bipolar I disorder experiencing acute manic or mixed episodes: a post hoc analysis of two 3-week clinical trials by Nations Kari R, van Willigenburg Arjen, Zhao Jun, Szegedi Armin, Mackle Mary, Panagides John

“…Three populations were defined using baseline depressive symptoms: (1) Montgomery-Asberg Depression Rating Scale (MADRS) total score ≥20 (n = 132); (2) Clinical Global Impression for Bipolar Disorder-Depression (CGI-BP-D) scale severity score ≥4 (n = 170); (3) diagnosis of mixed episodes (n = 302) by investigative site screening. …”
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Understanding resilience among transition-age youth with serious mental illness: protocol for a scoping review by Skye Pamela Barbic, Nicole Kozloff, Catherine M Sabiston, Emily Joan Nalder, Amy E Nesbitt, Melissa L deJonge

“…Introduction Transition-age youth (16–29 years old) are disproportionately affected by the onset, impact and burden of serious mental illness (SMI; for example, depression, bipolar disorder, schizophrenia spectrum disorders). Emerging evidence has increasingly highlighted the concept of resilience in mental health promotion and treatment approaches for this population. …”
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Examining equity in the utilisation of psychiatric inpatient care among patients with severe mental illness (SMI) in Ontario, Canada by Claire de Oliveira, Joyce Mason, Rowena Jacobs

“…Abstract Background Severe mental illness (SMI) comprises a range of chronic and disabling conditions, such as schizophrenia, bipolar disorder and other psychoses. Despite affecting a small percentage of the population, these disorders are associated with poor outcomes, further compounded by disparities in access, utilisation, and quality of care. …”
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Zika virus-induced TNF-α signaling dysregulates expression of neurologic genes associated with psychiatric disorders by Po-Lun Kung, Tsui-Wen Chou, Marissa Lindman, Nydia P. Chang, Irving Estevez, Benjamin D. Buckley, Colm Atkins, Brian P. Daniels

“…Results Transcriptomic profiling of primary neuron cultures following ZIKV infection revealed altered expression of key genes associated with major psychiatric disorders, such as bipolar disorder and schizophrenia. Gene ontology enrichment analysis also revealed significant changes in gene expression associated with fundamental neurobiological processes, including neuronal development, neurotransmission, and others. …”
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Epigenetic Alterations of Brain Non-Neuronal Cells in Major Mental Diseases by Hamid Mostafavi Abdolmaleky, Marian Martin, Jin-Rong Zhou, Sam Thiagalingam

“…The tissue-specific expression and epigenetic dysregulation of many genes in cells derived from the postmortem brains of patients have been reported to provide a fundamental biological framework for major mental diseases such as autism, schizophrenia, bipolar disorder, and major depression. However, until recently, the impact of non-neuronal brain cells, which arises due to cell-type-specific alterations, has not been adequately scrutinized; this is because of the absence of techniques that directly evaluate their functionality. …”
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A selective HDAC 1/2 inhibitor modulates chromatin and gene expression in brain and alters mouse behavior in two mood-related tests. by Frederick A Schroeder, Michael C Lewis, Daniel M Fass, Florence F Wagner, Yan-Ling Zhang, Krista M Hennig, Jennifer Gale, Wen-Ning Zhao, Surya Reis, Douglas D Barker, Erin Berry-Scott, Sung Won Kim, Elizabeth L Clore, Jacob M Hooker, Edward B Holson, Stephen J Haggarty, Tracey L Petryshen

“…Psychiatric diseases, including schizophrenia, bipolar disorder and major depression, are projected to lead global disease burden within the next decade. …”
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Associations Between Brain Structural Alterations, Executive Dysfunction, and General Psychopathology in a Healthy and Cross-Diagnostic Adult Patient Sample by Adrienne L. Romer, Diego A. Pizzagalli

“…Methods: We conducted hypothesis-driven (i.e., region of interest) and exploratory whole-brain structural neuroimaging analyses using data from the Consortium for Neuropsychiatric Phenomics (CNP) study of 272 adults who met diagnostic criteria for schizophrenia, bipolar disorder, or attention-deficit/hyperactivity disorder or were healthy control subjects. …”
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Mixed effects approach to the analysis of the stepped wedge cluster randomised trial—Investigating the confounding effect of time through simulation by Nickless, A, Voysey, M, Geddes, J, Yu, L, Fanshawe, T

“…</p> <p>Methods</p> <p>Motivated by a SWCRT of self-monitoring for bipolar disorder, we conducted a simulation study to compare model formulations to analyse data from a SWCRT under 36 different scenarios in which time was related to the outcome (improvement in mood score). …”

Lithium in the prevention of suicidal behavior and all-cause mortality in patients with mood disorders: a systematic review of randomized trials. by Cipriani, A, Pretty, H, Hawton, K, Geddes, J

“…Studies selected included randomized, controlled trials comparing lithium with placebo or all other compounds used in long-term treatment for mood disorders (unipolar depression, bipolar disorder, schizoaffective disorder, dysthymia, and rapid cycling, diagnosed according to DSM or ICD criteria). …”

Factor structure and item response of psychosis symptoms among Kenyan adults by Jaguga, F, Ametaj, A, Kim, HH, Stroud, RE, Newton, CR, Kariuki, SM, Kwobah, EK, Atwoli, L, Gelaye, B, Korte, KJ

“…&lt;h4&gt;Method&lt;/h4&gt;We utilized data collected from 2738 participants with a primary psychotic or bipolar disorder. Participants were drawn from two Kenyan sites of a large multi-center neuropsychiatric genetic study. …”

Effectiveness of financial incentives to improve adherence to maintenance treatment with antipsychotics: cluster randomised controlled trial. by Priebe, S, Yeeles, K, Bremner, S, Lauber, C, Eldridge, S, Ashby, D, David, A, O'Connell, N, Forrest, A, Burns, T

“…PARTICIPANTS: Patients with a diagnosis of schizophrenia, schizoaffective disorder, or bipolar disorder, who were prescribed long acting antipsychotic (depot) injections but had received 75% or less of the prescribed injections. …”