Triggers for violent criminality in psychotic disorders: A nationwide Swedish within-individual study of 3.1 million persons by Sariaslan, A, Fazel, S, Larsson, H, Lichtenstein, P

“…<br/><br/> Design, Setting and Patients<br/> Using a sample of all individuals born in Sweden between 1958 and 1988 (n=3,123,724), we identified patients in the National Patient Register who were diagnosed with schizophrenia-spectrum disorders (n=34,903), bipolar disorder (n=29,692) and unaffected controls (n=2,763,012). …”

Psychiatric disorders and violent reoffending: a national cohort study of convicted prisoners in Sweden by Chang, Z, Larsson, H, Lichtenstein, P, Fazel, S

“…We found some evidence of stronger eff ects on violent reoff ending of alcohol and drug use disorders and bipolar disorder than of other psychiatric disorders. Alcohol use disorder seemed to have a greater eff ect in women than in men (women 2·08 [1·66–2·60]; men 1·63 [1·56–1·71]). …”

Prevalence of multimorbidity in people living with and without severe mental illness: a systematic review and meta-analysis by Halstead, S, Cao, C, Mohr, GH, Ebdrup, BH, Pillinger, T, McCutcheon, R, Firth, J, Siskind, D, Warren, N

“…<p><strong>Background:</strong> People with severe mental illness (SMI), specifically schizophrenia-spectrum disorder (SSD) and bipolar disorder (BD), face poorer health outcomes from multiple chronic illnesses. …”

The effectiveness of a primary care based collaborative care model to improve quality of life in people with severe mental illness: the PARTNERS2 cluster randomised controlled tria... by Byng, R, Creanor, S, Jones, B, Hosking, J, Plappert, H, Bevan, S, Britten, N, Clark, M, Davies, L, Frost, J, Gask, L, Gibbons, B, Gibson, J, Hardy, P, Hobson-Merrett, C, Huxley, P, Jeffery, A, Marwaha, S, Rawcliffe, T, Siobhan, R, Richards, D, Sayers, R, Williams, L, Pinfold, V, Birchwood, M

“…</p> <p><strong>Aim:</strong> We tested whether a primary care-based Collaborative Care model (PARTNERS) would improve quality of life for people with diagnoses of schizophrenia, bipolar disorder or other psychoses compared to usual care.…”

A realist review of medication optimisation of community dwelling service users with serious mental illness by Howe, J, MacPhee, M, Duddy, C, Habib, H, Wong, G, Jacklin, S, Oduola, S, Upthegrove, R, Carlish, M, Allen, K, Patterson, E, Maidment, I

“…<p><strong>Background:</strong>&nbsp;Severe mental illness (SMI) incorporates schizophrenia, bipolar disorder, non-organic psychosis, personality disorder or any other severe and enduring mental health illness. …”

Investigating the Causal Relationship of C-Reactive Protein with 32 Complex Somatic and Psychiatric Outcomes: A Large-Scale Cross-Consortium Mendelian Randomization Study. by Bram P Prins, Ali Abbasi, Anson Wong, Ahmad Vaez, Ilja Nolte, Nora Franceschini, Philip E Stuart, Javier Guterriez Achury, Vanisha Mistry, Jonathan P Bradfield, Ana M Valdes, Jose Bras, Aleksey Shatunov, PAGE Consortium, International Stroke Genetics Consortium, Systemic Sclerosis consortium, Treat OA consortium, DIAGRAM Consortium, CARDIoGRAMplusC4D Consortium, ALS consortium, International Parkinson’s Disease Genomics Consortium, Autism Spectrum Disorder Working Group of the Psychiatric Genomics Consortium, CKDGen consortium, GERAD1 Consortium, International Consortium for Blood Pressure, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Inflammation Working Group of the CHARGE Consortium, Chen Lu, Buhm Han, Soumya Raychaudhuri, Steve Bevan, Maureen D Mayes, Lam C Tsoi, Evangelos Evangelou, Rajan P Nair, Struan F A Grant, Constantin Polychronakos, Timothy R D Radstake, David A van Heel, Melanie L Dunstan, Nicholas W Wood, Ammar Al-Chalabi, Abbas Dehghan, Hakon Hakonarson, Hugh S Markus, James T Elder, Jo Knight, Dan E Arking, Timothy D Spector, Bobby P C Koeleman, Cornelia M van Duijn, Javier Martin, Andrew P Morris, Rinse K Weersma, Cisca Wijmenga, Patricia B Munroe, John R B Perry, Jennie G Pouget, Yalda Jamshidi, Harold Snieder, Behrooz Z Alizadeh

“…We observed nominal evidence at an observed p < 0.05 using either GRSCRP or GRSGWAS-with persistence after correction for heterogeneity-for a causal relationship of elevated CRP levels with psoriatic osteoarthritis, rheumatoid arthritis, knee osteoarthritis, systolic blood pressure, diastolic blood pressure, serum albumin, and bipolar disorder. These associations remain yet to be confirmed. …”
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Investigating the causal relationship of c-reactive protein with 32 complex somatic and psychiatric outcomes: a large-scale cross-consortium mendelian randomization study by Prins, B, Abbasi, A, Wong, A, Vaez, A, Nolte, I, Franceschini, N, Stuart, P, Guterriez Achury, J, Mistry, V, Bradfield, J, Valdes, A, Bras, J, Shatunov, A, Lu, C, Han, B, Raychaudhuri, S, Bevan, S, Mayes, M, Tsoi, L, Evangelou, E, Nair, R, Grant, S, Polychronakos, C, Radstake, T, van Heel, D, Dunstan, M, Wood, N, Al-Chalabi, A, Dehghan, A, Hakonarson, H, Markus, H, Elder, J, Knight, J, Arking, D, Spector, T, Koeleman, B, van Duijn, C, Martin, J, Morris, A, Weersma, R, Wijmenga, C, Munroe, P, Perry, J, Pouget, J, Jamshidi, Y, Snieder, H, Alizadeh, B

“…We observed nominal evidence at an observed <em>p</em> &lt; 0.05 using either GRS_CRP or GRS_GWAS—with persistence after correction for heterogeneity—for a causal relationship of elevated CRP levels with psoriatic osteoarthritis, rheumatoid arthritis, knee osteoarthritis, systolic blood pressure, diastolic blood pressure, serum albumin, and bipolar disorder. These associations remain yet to be confirmed. …”

Metabolic risk factors of cognitive impairment in young women with major psychiatric disorder by Chuanjun Zhuo, Chuanjun Zhuo, Chuanjun Zhuo, Chuanjun Zhuo, Chuanjun Zhuo, Wei Liu, Ronghuan Jiang, Ranli Li, Haiping Yu, Guangdong Chen, Jianmin Shan, Jingjing Zhu, Ziyao Cai, Chongguang Lin, Langlang Cheng, Yong Xu, Sha Liu, Qinghua Luo, Shili Jin, Chuanxin Liu, Jiayue Chen, Lina Wang, Lei Yang, Qiuyu Zhang, Qianchen Li, Hongjun Tian, Xueqin Song, Xueqin Song, China multiple organs damage in the mental disorder (CMODMD) Group

“…The identification of modifiable metabolic risk factors of cognitive impairment may enable targeted improvements of patient care.ObjectiveTo investigate the relationship between MetS and cognitive impairment in young women with MPD, and to explore risk factors.MethodsWe retrospectively studied women of 18–34 years of age receiving psychotropic medications for first-onset schizophrenia (SCH), bipolar disorder (BP), or major depressive disorder (MDD). …”
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Entry of the antipsychotic drug, olanzapine, into the developing rat brain in mono- and combination therapies [version 1; peer review: 2 approved] by Mark Habgood, Katarzyna Dziegielewska, Yifan Huang, Shuai Nie, Fiona Qiu, Norman Saunders

“…Background: Olanzapine is used to treat schizophrenia and bipolar disorder in women of childbearing age. Continuation of psychotropic medications throughout pregnancy and lactation is often required as cessation could be dangerous for both mother and child. …”
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An atlas of genetic correlations between psychiatric disorders and human blood plasma proteome by Shiqiang Cheng, Fanglin Guan, Mei Ma, Lu Zhang, Bolun Cheng, Xin Qi, Chujun Liang, Ping Li, Om Prakash Kafle, Yan Wen, Feng Zhang

“…This study aims to systematically explore the potential genetic relationships between five major psychiatric disorders and more than 3,000 plasma proteins.Methods.The genome-wide association study (GWAS) datasets of attention deficiency/hyperactive disorder (ADHD), autism spectrum disorder (ASD), bipolar disorder (BD), schizophrenia (SCZ) and major depressive disorder (MDD) were driven from the Psychiatric GWAS Consortium. …”
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Polygenic risk scores across the extended psychosis spectrum by Lukasz Smigielski, Sergi Papiol, Anastasia Theodoridou, Karsten Heekeren, Miriam Gerstenberg, Diana Wotruba, Roman Buechler, Per Hoffmann, Stefan Herms, Kristina Adorjan, Heike Anderson-Schmidt, Monika Budde, Ashley L. Comes, Katrin Gade, Maria Heilbronner, Urs Heilbronner, Janos L. Kalman, Farahnaz Klöhn-Saghatolislam, Daniela Reich-Erkelenz, Sabrina K. Schaupp, Eva C. Schulte, Fanny Senner, Ion-George Anghelescu, Volker Arolt, Bernhard T. Baune, Udo Dannlowski, Detlef E. Dietrich, Andreas J. Fallgatter, Christian Figge, Markus Jäger, Georg Juckel, Carsten Konrad, Vanessa Nieratschker, Jens Reimer, Eva Reininghaus, Max Schmauß, Carsten Spitzer, Martin von Hagen, Jens Wiltfang, Jörg Zimmermann, Anna Gryaznova, Laura Flatau-Nagel, Markus Reitt, Milena Meyers, Barbara Emons, Ida Sybille Haußleiter, Fabian U. Lang, Thomas Becker, Moritz E. Wigand, Stephanie H. Witt, Franziska Degenhardt, Andreas J. Forstner, Marcella Rietschel, Markus M. Nöthen, Till F. M. Andlauer, Wulf Rössler, Susanne Walitza, Peter Falkai, Thomas G. Schulze, Edna Grünblatt

“…PRSs for schizophrenia (SZ) and bipolar disorder (BD) were computed using Bayesian regression and continuous shrinkage priors based on the latest SZ and BD genome-wide association studies (Psychiatric Genomics Consortium, third release). …”
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Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment by Hideo Hagihara, Hirotaka Shoji, Satoko Hattori, Giovanni Sala, Yoshihiro Takamiya, Mika Tanaka, Masafumi Ihara, Mihiro Shibutani, Izuho Hatada, Kei Hori, Mikio Hoshino, Akito Nakao, Yasuo Mori, Shigeo Okabe, Masayuki Matsushita, Anja Urbach, Yuta Katayama, Akinobu Matsumoto, Keiichi I Nakayama, Shota Katori, Takuya Sato, Takuji Iwasato, Haruko Nakamura, Yoshio Goshima, Matthieu Raveau, Tetsuya Tatsukawa, Kazuhiro Yamakawa, Noriko Takahashi, Haruo Kasai, Johji Inazawa, Ikuo Nobuhisa, Tetsushi Kagawa, Tetsuya Taga, Mohamed Darwish, Hirofumi Nishizono, Keizo Takao, Kiran Sapkota, Kazutoshi Nakazawa, Tsuyoshi Takagi, Haruki Fujisawa, Yoshihisa Sugimura, Kyosuke Yamanishi, Lakshmi Rajagopal, Nanette Deneen Hannah, Herbert Y Meltzer, Tohru Yamamoto, Shuji Wakatsuki, Toshiyuki Araki, Katsuhiko Tabuchi, Tadahiro Numakawa, Hiroshi Kunugi, Freesia L Huang, Atsuko Hayata-Takano, Hitoshi Hashimoto, Kota Tamada, Toru Takumi, Takaoki Kasahara, Tadafumi Kato, Isabella A Graef, Gerald R Crabtree, Nozomi Asaoka, Hikari Hatakama, Shuji Kaneko, Takao Kohno, Mitsuharu Hattori, Yoshio Hoshiba, Ryuhei Miyake, Kisho Obi-Nagata, Akiko Hayashi-Takagi, Léa J Becker, Ipek Yalcin, Yoko Hagino, Hiroko Kotajima-Murakami, Yuki Moriya, Kazutaka Ikeda, Hyopil Kim, Bong-Kiun Kaang, Hikari Otabi, Yuta Yoshida, Atsushi Toyoda, Noboru H Komiyama, Seth GN Grant, Michiru Ida-Eto, Masaaki Narita, Ken-ichi Matsumoto, Emiko Okuda-Ashitaka, Iori Ohmori, Tadayuki Shimada, Kanato Yamagata, Hiroshi Ageta, Kunihiro Tsuchida, Kaoru Inokuchi, Takayuki Sassa, Akio Kihara, Motoaki Fukasawa, Nobuteru Usuda, Tayo Katano, Teruyuki Tanaka, Yoshihiro Yoshihara, Michihiro Igarashi, Takashi Hayashi, Kaori Ishikawa, Satoshi Yamamoto, Naoya Nishimura, Kazuto Nakada, Shinji Hirotsune, Kiyoshi Egawa, Kazuma Higashisaka, Yasuo Tsutsumi, Shoko Nishihara, Noriyuki Sugo, Takeshi Yagi, Naoto Ueno, Tomomi Yamamoto, Yoshihiro Kubo, Rie Ohashi, Nobuyuki Shiina, Kimiko Shimizu, Sayaka Higo-Yamamoto, Katsutaka Oishi, Hisashi Mori, Tamio Furuse, Masaru Tamura, Hisashi Shirakawa, Daiki X Sato, Yukiko U Inoue, Takayoshi Inoue, Yuriko Komine, Tetsuo Yamamori, Kenji Sakimura, Tsuyoshi Miyakawa

“…We previously demonstrated that such alterations are commonly observed in five mouse models of schizophrenia, bipolar disorder, and autism, suggesting a shared endophenotype among these disorders rather than mere artifacts due to medications or agonal state. …”
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A unified model of shared brain structural alterations in patients with different mental disorders who experience own‐thought auditory verbal hallucinations—A pilot study by Chuanjun Zhuo, Chunxiang Wang, Xueqin Song, Xuexin Xu, Gongying Li, Xiaodong Lin, Yong Xu, Hongjun Tian, Deguo Jiang, Wenqiang Wang, Chunhua Zhou

“…Methods A cohort of 143 first‐diagnosis, nonmedicated patients with OTAVHs was enrolled: 25 with schizophrenia (FUSCH‐OTAVH), 20 with major depression disorder (FUMDD‐OTAVH), 28 with bipolar disorder (FUBD‐OTAVH), 22 patients with posttraumatic stress disorder (FUPTSD‐OTAVH), 21 with anxiety disorder (FUAD‐OTAVH), and 27 with borderline personality disorder (FUBPD‐OTAVH); 25 healthy controls (HCs) participated. …”
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Use of antidepressant medications among older adults in European long-term care facilities: a cross-sectional analysis from the SHELTER study by Silvia Giovannini, Graziano Onder, Henriëtte G. van der Roest, Eva Topinkova, Jacob Gindin, Maria Camilla Cipriani, Michael D. Denkinger, Roberto Bernabei, Rosa Liperoti, on behalf of the SHELTER Study Investigators

“…The strongest correlates of antidepressant use included reported diagnosis of anxiety, depression, bipolar disorder, pain, falls and high level of social engagement. …”
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Circulating S100B levels at birth and risk of six major neuropsychiatric or neurological disorders: a two-sample Mendelian Randomization Study by Mengyu Pan, James M. Roe, Ron Nudel, Andrew J. Schork, Olena Iakunchykova, Anders M. Fjell, Kristine B. Walhovd, Thomas Werge, Chi-hua Chen, Michael E. Benros, Yunpeng Wang

“…We applied two-sample Mendelian Randomization (MR) on the association statistics from genome-wide association studies (GWAS) for circulating S100B levels measured 5-7 days after birth (the iPSYCH sample) and in an older adult sample (mean age, 72.5 years; the Lothian sample), upon those derived from major depression disorder (MDD), schizophrenia (SCZ), bipolar disorder (BIP), autism spectral disorder (ASD), Alzheimer’s disease (AD), and Parkinson’s disease (PD). …”
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Treating repetitive suicidal intrusions using eye movements: study protocol for a multicenter randomized clinical trial by J. S. van Bentum, M. Sijbrandij, A. J. F. M. Kerkhof, A. Huisman, A. R. Arntz, E. A. Holmes, G. Franx, J. Mokkenstorm, M. J. H. Huibers

“…Growing evidence shows that the majority of suicidal patients diagnosed with major depression or bipolar disorder report repetitive suicide-related images and thoughts (suicidal intrusions). …”
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EXPERTS II - How are patient and caregiver participation in health and social care shaped by experienced burden of treatment and social inequalities? Protocol for a qualitative syn... by Katie I Gallacher, Carolyn A Chew-Graham, Frances S Mair, Ellen Nolte, Katja C Gravenhorst, Alison Richardson, Carl R May

“…Aims: With the aim of deriving policy and practice implications for service redesign, this evidence synthesis will extend our understanding of service user and caregiver workload and capacity by comparing how they are revealed in qualitative studies of lived experience of three kinds of illness trajectories: long-term conditions associated with significant disability (Parkinson’s disease, schizophrenia); serious relapsing remitting disease (Inflammatory Bowel Disease, bipolar disorder); and rapidly progressing acute disease (brain cancer, early onset dementia).  …”
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The impact of affective disorders on self-assessment of the quality of life in patients with chronic coronary artery disease by E. V. Lebedeva, E. D. Schastnyу, T. G. Nonka, E. O. Nalesnik, A. K. Surovtseva, S. N. Vasilieva, A. N. Repin

“…In 290 patients (average age 56.6 ± 6.7 years) with chronic CAD, chronic ADs (45%) were revealed; depressive episodes (DEs) were diagnosed for the first time in 24% of patients, and 24.5% of patients had recurrent DEs. Bipolar disorder was found in 6.5% of cases. Qualitative and quantitative parameters were investigated using the Mann – Whitney U test and Student’s t-test. …”
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Association between obesity and depression in patients with diabetes mellitus type 2; a study protocol [v1; ref status: indexed, http://f1000r.es/4y5] by Eduardo De la Cruz-Cano, Carlos Alfonso Tovilla-Zarate, Emilio Reyes-Ramos, Thelma Beatriz Gonzalez-Castro, Isela Juarez-Castro, Maria Lilia López-Narváez, Ana Fresan

“…Causes for exclusion will be publications that studied patients diagnosed with diabetes mellitus type 1; articles that focused on the treatment and complications of diabetes mellitus type 2; publications that have studied other clinical or psychiatric conditions (for instance, seizure disorder or history of schizophrenia, bipolar disorder, psychotic symptoms or dementia). Conclusion: The results of this study will form the basis for a better understanding of the association between obesity and depression in patients with diabetes mellitus type 2, and will allow development of prediction tools and better interventions. …”
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Discovery of suppressors of CRMP2 phosphorylation reveals compounds that mimic the behavioral effects of lithium on amphetamine-induced hyperlocomotion by Wen-Ning Zhao, Brian T. D. Tobe, Namrata D. Udeshi, Lucius L. Xuan, Cameron D. Pernia, Daniel P. Zolg, Amanda J. Roberts, Deepak Mani, Sarah R. Blumenthal, Iren Kurtser, Debasis Patnaik, Irina Gaisina, Joshua Bishop, Steven D. Sheridan, Jasmin Lalonde, Steven A. Carr, Evan Y. Snyder, Stephen J. Haggarty

“…Abstract The effective treatment of bipolar disorder (BD) represents a significant unmet medical need. …”
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