IMPlementation of A Relatives’ Toolkit (IMPART study): an iterative case study to identify key factors impacting on the implementation of a web-based supported self-management inte... by Fiona Lobban, Victoria Appleton, Duncan Appelbe, Johanna Barraclough, Julie Bowland, Naomi R Fisher, Sheena Foster, Sonia Johnson, Elizabeth Lewis, Céu Mateus, Barbara Mezes, Elizabeth Murray, Puffin O’Hanlon, Vanessa Pinfold, Jo Rycroft-Malone, Ron Siddle, Jo Smith, Chris J. Sutton, Andrew Walker, Steven H. Jones

“…The aim of this study is to identify critical factors impacting on the implementation of an online supported self-management intervention for relatives of people with recent onset psychosis or bipolar disorder into routine clinical care and to use this information to inform an implementation plan to facilitate widespread use and inform wider implementation of digital health interventions. …”
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Factors associated with lifetime history of eating disorder in non-psychotic patients with suicidal ideation by George V. Kustov, Mikhail S. Zinchuk, Sofya B. Popova, Ilya N. Mishin, Nadezhda I. Voinova, Alexander A. Yakovlev, Renat G. Akzhigitov

“…CONCLUSION: Lifetime ED in NPMD patients with SI is associated with younger age, being assigned female at birth, having an alternative gender identity, having same-sex experience, having more than one psychiatric diagnosis, having been diagnosed with bipolar disorder, experiencing severe depression and anxiety, being exposed to multiple traumatic experiences, having various body modifications, practicing NSSI, and having a lifetime story of suicide attempts.…”
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Brain Versus Blood: A Systematic Review on the Concordance Between Peripheral and Central Kynurenine Pathway Measures in Psychiatric Disorders by Katrien Skorobogatov, Katrien Skorobogatov, Livia De Picker, Livia De Picker, Robert Verkerk, Violette Coppens, Violette Coppens, Marion Leboyer, Marion Leboyer, Marion Leboyer, Marion Leboyer, Norbert Müller, Manuel Morrens, Manuel Morrens

“…We also included 32 articles reporting associations between peripheral KP markers and symptom severity, CNS pathology or treatment response in schizophrenia, bipolar disorder or major depressive disorder.ResultsFor kynurenine and 3-hydroxykynurenine, moderate to strong concordance was found between peripheral and central concentrations not only in psychiatric disorders, but also in other (patho)physiological conditions. …”
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Genome-Wide Association Study of Circadian Rhythmicity in 71,500 UK Biobank Participants and Polygenic Association with Mood InstabilityResearch in context by Amy Ferguson, Laura M. Lyall, Joey Ward, Rona J. Strawbridge, Breda Cullen, Nicholas Graham, Claire L. Niedzwiedz, Keira J.A. Johnston, Daniel MacKay, Stephany M. Biello, Jill P. Pell, Jonathan Cavanagh, Andrew M. McIntosh, Aiden Doherty, Mark E.S. Bailey, Donald M. Lyall, Cathy A. Wyse, Daniel J. Smith

“…Disrupted rhythms of rest and activity are recognised as risk factors for major depressive disorder and bipolar disorder. Methods: We conducted a genome-wide association study (GWAS) of low relative amplitude (RA), an objective measure of rest-activity cycles derived from the accelerometer data of 71,500 UK Biobank participants. …”
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A Selective HDAC 1/2 Inhibitor Modulates Chromatin and Gene Expression in Brain and Alters Mouse Behavior in Two Mood-Related Tests by Schroeder, Frederick A., Lewis, Michael C., Fass, Daniel M., Wagner, Florence F., Zhang, Yan-Ling, Hennig, Krista M., Gale, Jennifer, Zhao, Wen-Ning, Reis, Surya, Barker, Douglas D., Berry-Scott, Erin, Kim, Sung Won, Clore, Elizabeth L., Hooker, Jacob M., Holson, Edward B., Haggarty, Stephen J., Petryshen, Tracey

“…Psychiatric diseases, including schizophrenia, bipolar disorder and major depression, are projected to lead global disease burden within the next decade. …”
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Investigation of G72 (DAOA) expression in the human brain by Hirsch Steven, de Belleroche Jacqueline, Kelly Fiona, Viknaraja Ramya, Kew James NC, Benzel Isabel, Sanderson Thirza H, Maycox Peter R

“…<p>Abstract</p> <p>Background</p> <p>Polymorphisms at the G72/G30 locus on chromosome 13q have been associated with schizophrenia or bipolar disorder in more than ten independent studies. …”
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Determinants of Revolving Door in an Acute Psychiatric Ward for Prison Inmates by Isabella D'Orta, François R. Herrmann, Panteleimon Giannakopoulos, Panteleimon Giannakopoulos

“…In contrast, depressive episodes (7%) and bipolar disorder (4.5%) were rare. Group comparison showed that the presence of court-ordered treatments, suicidal behavior, personality and psychotic disorders was associated with significantly increased frequency of RD use. …”
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Schizophrenia: the announcement of the diagnosis by F. Azraf, M. Chtibi, F. Laboudi, A. Ouanass

“…All participants considered schizophrenia to be the most difficult pathology to announce, followed by personality disorders and bipolar disorder. 74.2 of the participants considered it “rather” or “completely” essential to inform the patient of his or her psychiatric diagnosis. 77.4% of the participants considered it necessary to announce the diagnosis of schizophrenia and 80.7 often or systematically announce this diagnosis. …”
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How is city living associated with psychosis? Findings from a novel data linkage of 612,988 people from an urban and ethnically diverse area by Rosanna Hildersley, Jayati Das-Munshi, Peter Schofield, Lukasz Cybulski, Milena Wuerth

“…Cases with clinical diagnoses of non-affective (schizophrenia-spectrum) and affective psychoses (bipolar disorder, depression with psychosis) were identified. …”
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Clinical Characteristics of Asymptomatic Thromboembolism in Psychiatric Inpatients: A Retrospective Study by Geng Y, Zhang P, Pan Y, Wang H, Chen Y, Lai J, Hu S

“…Significantly higher D-dimer levels were observed in patients diagnosed with severe mental disorders (SMD), such as schizophrenia and bipolar disorder, compared to those with mild mental disorders (MMD), including depression and anxiety disorders (p = 0.007). …”
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Effect of acute lithium administration on penile erection: involvement of nitric oxide system by Saleh Sandoughdaran, Hamed Sadeghipour, Hamid Reza Sadeghipour

“…Background: Lithium has been the treatment of choice for bipolar disorder (BD) for many years. Although erectile dysfunction is a known adverse effect of this drug, the mechanism of action by which lithium affects erectile function is still unknown. …”
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Physical Comorbidities are Independently Associated with Higher Rates of Psychiatric Readmission in a Chinese Han Population by Yang C, Zhong X, Zhou H, Wu Z, Zhang M, Ning Y

“…We aimed to investigate the association between physical comorbidities and psychiatric readmission in Han Chinese patients with psychiatric disorders.Methods: We used administrative data for January 1, 2009 to December 31, 2018 from the headquarters of the Affiliated Brain Hospital of Guangzhou Medical University to identify adults with schizophrenia, unipolar depression or bipolar disorder discharged from hospital. Data were extracted on sociodemographic and clinical characteristics. …”
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Quality of clinical trials for selected priority mental and neurological disorders in sub-Saharan Africa: a systematic review by Mulugeta A, Medhin G, Yimer G, Jemal R, Fekadu A

“…Both randomized and nonrandomized clinical trials for the treatment of schizophrenia, depression, maternal depression, bipolar disorder, and epilepsy/seizure disorders that involve pharmacotherapy, psychotherapy, and physical therapy were included. …”
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Web-Based Graphic Representation of the Life Course of Mental Health: Cross-Sectional Study Across the Spectrum of Mood, Anxiety, Eating, and Substance Use Disorders by Aupperle, Robin Leora, Paulus, Martin P, Kuplicki, Rayus, Touthang, James, Victor, Teresa, Yeh, Hung-Wen, Khalsa, Sahib S

“…However, the implementation of these assessments is limited by the exclusive focus on specific mental illnesses (ie, bipolar disorder) and the lack of intuitive graphical interfaces for data collection and visualization. …”
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Association of the 5-HTT gene-linked promoter region (5-HTTLPR) polymorphism with psychiatric disorders: review of psychopathology and pharmacotherapy by Kenna GA, Roder-Hanna N, Leggio L, Zywiak WH, Clifford J, Edwards S, Kenna JA, Shoaff J, Swift RM

“…Decreased transcriptional activity of the S allele (&amp;ldquo;risk allele&amp;rdquo;) may be associated with a heightened amygdala response leading to anxiety-related personality traits, major depressive disorder, suicide attempts, and bipolar disorder. By contrast, increased transcriptional activity of the L allele is considered protective for depression but is also associated with completed suicide, nicotine dependence, and attention deficit hyperactivity disorder. …”
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Health and social care professionals' views and experiences of supporting parents with serious mental illness by Lucy Oakes, Lauren Wolfenden, Richard J. Drake, Richard J. Drake, Rachel Calam, Lynsey Gregg

“…IntroductionA significant number of individuals with a serious mental illness (SMI) such as schizophrenia or bipolar disorder are also parents of dependent children. …”
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Impact of COVID-19 pandemic on emergency psychiatry-Millcreek community hospital, Erie, PA by Alexis Janoczkin, Spencer Kiers, Naga Edara, Ping He, Yueling Li

“…Concerning primary psychiatric disorders, there was increased ED prevalence in chief complaint of total mood disorders (PR = 1.21) with major depressive disorder (PR = 1.23) and bipolar disorder (PR = 1.47), neurodevelopment disorders (PR = 1.25) with attention deficit hyperactivity disorder (ADHD) (PR = 1.19) and intellectual disability (PR = 1.52), trauma- and stressor-related disorders (PR = 1.56) with post-traumatic stress disorder (PTSD) (PR = 1.39) and adjustment disorder (PR = 1.73), substance abuse and addiction disorders (PR = 1.29), and personality disorders (PR = 1.56). …”
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Mental disorders, functional impairment, and nerve growth factor by Salles FHM, Soares PSM, Wiener CD, Mondin TC, da Silva PM, Jansen K, de Mattos Souza LD, da Silva RA, Oses JP

“…Several studies have evaluated functionality in bipolar disorder; however, no studies have evaluated the functionality in other mental disorders. …”
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Acute mania following COVID-19 in a woman with no past psychiatric history case report by Steven Sprenger, J. Pilar Bare, Rahul Kashyap, Luigi Cardella

“…She reported a family history of bipolar disorder but no past manic or depressive episodes. …”
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Genetics of psycho-emotional well-being: genome-wide association study and polygenic risk score analysis by Anna Yurievna Yakovchik, Darya V. Tolynyova, Daria A. Kashtanova, Ekaterina R. Sutulova, Mikhail V. Ivanov, Alexandra A. Mamchur, Veronika V. Erema, Lorena R. Matkava, Mikhail V. Terekhov, Antonina M. Rumyantseva, Olga I. Blinova, Aleksandra I. Akinshina, Sergey I. Mitrofanov, Vladimir S. Yudin, Valentin V. Makarov, Anton А. Keskinov, Sergey A. Kraevoy, Sergey M. Yudin

“…New single-nucleotide polymorphisms (SNPs) with genome-wide significance were discovered, which had not been associated with anxiety or other stress-related conditions but were located in genes previously associated with bipolar disorder, schizophrenia, or emotional instability. …”
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