Microstructural imaging and transcriptomics of the basal forebrain in first-episode psychosis by Min Tae M. Park, Peter Jeon, Leon French, Kara Dempster, M. Mallar Chakravarty, Michael MacKinley, Julie Richard, Ali R. Khan, Jean Théberge, Lena Palaniyappan

“…Abstract Cholinergic dysfunction has been implicated in the pathophysiology of psychosis and psychiatric disorders such as schizophrenia, depression, and bipolar disorder. The basal forebrain (BF) cholinergic nuclei, defined as cholinergic cell groups Ch1-3 and Ch4 (Nucleus Basalis of Meynert; NBM), provide extensive cholinergic projections to the rest of the brain. …”
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The Collaborative Lithium Trials (CoLT): specific aims, methods, and implementation by Hooper Stephen R, Hlastala Stefanie, Sikich Linmarie, Pavuluri Mani, McClellan Jon, Kowatch Robert, Kafantaris Vivian, Frazier Jean A, Findling Robert L, Demeter Christine A, Bedoya Denise, Brownstein Bernard, Taylor-Zapata Perdita

“…</p> <p>Conclusion</p> <p>These innovative studies will not only provide data to inform the labeling of lithium in children and adolescents with bipolar disorder, but will also enhance clinical decision-making regarding the use of lithium treatment in pediatric bipolar illness.…”
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Survey of Health Literacy Among Japanese Outpatients with Mental Illness by Sato Y, Sugawara N, Kawamata Y, Shimoda K, Yasui-Furukori N

“…Among patients with mood disorders, there were no differences between those with major depressive disorder and those with bipolar disorder. Anxiety disorders were associated with higher health literacy than schizophrenia and mood disorders (odds ratio (OR) 1.85, 95% confidence interval (95% CI) 1.07, 3.34), and in terms of personality, neuroticism (OR 0.85, 95% CI 0.75, 0.97) and openness (OR 0.85, 95% CI 0.74, 0.98) were associated with limited health literacy, while agreeableness (OR 1.36, 95% CI 1.18, 1.57) and extraversion OR 1.34, 95% CI 1.17, 1.52) were associated with higher health literacy.Conclusion: The results of this study indicate limited health literacy in patients with mental illness, in particular, limited health literacy in outpatients with schizophrenia and mood disorders. …”
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Development and initial evaluation of a behavioural intervention to support weight management for people with serious mental illness: an uncontrolled feasibility and acceptability... by Charlotte Lee, Felicity Waite, Carmen Piernas, Paul Aveyard

“…Abstract Background The rates of obesity and associated health problems are higher in people with serious mental illness (SMI), such as schizophrenia and bipolar disorder, than the general population. A primary care referral to a behavioural weight management programme can be an effective intervention, but people with SMI have reported barriers to engaging with them and bespoke options are rarely provided in routine practice. …”
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Optimization of Processing Parameters of Nanoemulsion Containing Aripiprazole Using Response Surface Methodology by Samiun WS, Ashari SE, Salim N, Ahmad S

“…Wan Sarah Samiun,1 Siti Efliza Ashari,1,2 Norazlinaliza Salim,1,2 Syahida Ahmad3 1Integrated Chemical Biophysics Research, Faculty of Science, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia; 2Centre of Foundation Studies for Agricultural Sciences, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia; 3Department of Biochemistry, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, Serdang 43400, Selangor, MalaysiaCorrespondence: Wan Sarah Samiun; Siti Efliza AshariIntegrated Chemical Biophysics Research, Faculty of Science, Universiti Putra Malaysia, Serdang 43400, Selangor, MalaysiaTel +603-8946 6997Email ctefliza@upm.edu.my; wansarahsamiun@yahoo.comBackground: Aripiprazole, which is a quinolinone derivative, has been widely used to treat schizophrenia, major depressive disorder, and bipolar disorder.Purpose: A Central Composite Rotatable Design (CCRD) of Response Surface Methodology (RSM) was used purposely to optimize process parameters conditions for formulating nanoemulsion containing aripiprazole using high emulsification methods.Methods: This design is used to investigate the influences of four independent variables (overhead stirring time (A), shear rate (B), shear time (C), and the cycle of high-pressure homogenizer (D)) on the response variable namely, a droplet size (Y) of nanoemulsion containing aripiprazole.Results: The optimum conditions suggested by the predicted model were: 120 min of overhead stirring time, 15 min of high shear homogenizer time, 4400 rpm of high shear homogenizer rate and 11 cycles of high-pressure homogenizer, giving a desirable droplet size of nanoemulsion containing aripiprazole of 64.52 nm for experimental value and 62.59 nm for predicted value. …”
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A Cognitive Rehabilitation Program for Psychoses: Origins, Development and Perspectives by Dimitrios Kontis, Eirini Theochari, Angeliki Andreopoulou, Spyridoula Vassilouli, Dimitra Giannakopoulou, Eleni Siettou, Maria Kouloumbi, Antonios Tsichlakis, Eleftheria Tsaltas

“…Objective: To present the origins, process of development and characteristics of a CRT program for individuals with psychoses (schizophrenia and other psychotic disorders, bipolar disorder with psychotic features and bipolar depression, etc.), along with the experience of its pilot implementation and its perspectives under limited financial and human resources. …”
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Differential acute impact of therapeutically effective and overdose concentrations of lithium on human neuronal single cell and network function by Julia Izsak, Henrik Seth, Margarita Iljin, Stephan Theiss, Hans Ågren, Keiko Funa, Ludwig Aigner, Eric Hanse, Sebastian Illes

“…Abstract Lithium salts are used as mood-balancing medication prescribed to patients suffering from neuropsychiatric disorders, such as bipolar disorder and major depressive disorder. Lithium salts cross the blood-brain barrier and reach the brain parenchyma within few hours after oral application, however, how lithium influences directly human neuronal function is unknown. …”
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Historical developments, hotspots, and trends in tardive dyskinesia research: a scientometric analysis of 54 years of publications by Anuradha Baminiwatta, Christoph U. Correll, Christoph U. Correll, Christoph U. Correll

“…During the 1990s, research diverged into pathophysiological studies, especially oxidative stress, and clinical trials on atypical antipsychotics, with a focus on clozapine and bipolar disorder. In the 1990–2000s, pharmacogenetics emerged. …”
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Psychotic-like Experiences during COVID-19 Outbreak: A survey from Pakistan by I. Ullah, F. Arain, A. Tohid, A. Ahmad, M. Jawad, A. Awan, A. Javaid

“…Psychiatric disorder other than bipolar disorder or psychosis (p<0.001 for CAPE-frequency and stress), family history of psychiatric disorders (p<0.001 for CAPE-frequency and stress), chronic medical disease (p=0.021 CAPE-frequency and p=0.026 CAPE-stress), illegal drug usage (p<0.001 for CAPE-frequency and stress) were associated with CAPE-Frequency and CAPE-stress. …”
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Comparison of health-related quality of life among patients using atypical antipsychotics for treatment of depression: results from the National Health and Wellness Survey by Kalsekar Iftekhar, Wagner Jan-Samuel, DiBonaventura Marco, Bates Jay, Forbes Robert, Hebden Tony

“…Patients taking an atypical antipsychotic for less than 2 months or who reported being diagnosed with bipolar disorder or schizophrenia were excluded. Patients taking aripiprazole were compared with patients taking other atypical antipsychotics. …”
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Human factors evaluation of a novel digital medicine system in psychiatry by Peters-Strickland T, Hatch A, Adenwala A, Atkinson K, Bartfeld B

“…Keywords: digital medicine system, drug&ndash;device combination, schizophrenia, bipolar disorder, major depressive disorder, aripiprazole, serious mental illness, usability…”
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Prevalence of bipolar spectrum disorder in Korean college students according to the K-MDQ by Bae SO, Kim MD, Lee JG, Seo JS, Won SH, Woo YS, Seok JH, Kim W, Kim SJ, Min KJ, Jon DI, Shin YC, Bahk WM, Yoon BH

“…There were significant relationships between BSD and gender, age, and socioeconomic status.Conclusion: The prevalence of BSD found in the present study is higher than that reported by other epidemiological studies in Korea and in international studies.Keywords: general population, bipolar disorder, epidemiological study, Mood Disorder Questionnaire…”
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Risk assessment and prediction of TD incidence in psychiatric patients taking concomitant antipsychotics: a retrospective data analysis by Oscar Patterson-Lomba, Rajeev Ayyagari, Benjamin Carroll

“…Methods Adult patients with schizophrenia, major depressive disorder, or bipolar disorder taking oral antipsychotics were identified in a Medicaid claims database (covering six US states from 1997 to 2016) and divided into cohorts based on whether they developed TD within 1 year after the first observed claim for antipsychotics. …”
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Mortality risk of antipsychotic augmentation for adult depression by Tobias Gerhard, T. Scott Stroup, Christoph U. Correll, Soko Setoguchi, Brian L. Strom, Cecilia Huang, Zhiqiang Tan, Stephen Crystal, Mark Olfson, James M. Wright

“…Patients with alternative indications for antipsychotic medications, such as schizophrenia, psychotic depression, or bipolar disorder, were excluded. Exposure Augmentation treatment for depression with a newer antipsychotic or with a second antidepressant. …”
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Use of an Interactive Obesity Treatment Approach in Individuals With Severe Mental Illness: Feasibility, Acceptability, and Proposed Engagement Criteria by Ginger Nicol, Madeline Jansen, Rita Haddad, Amanda Ricchio, Michael D Yingling, Julia A Schweiger, Katie Keenoy, Bradley A Evanoff, John W Newcomer

“…ObjectiveWe tested the feasibility and usability of a 12-week interactive obesity treatment approach (iOTA) to adults with chronic SMIs (depression, bipolar disorder and schizophrenia spectrum disorder) receiving treatment in community settings. …”
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Therapeutic update in the treatment of disruptive disorder with emotional dysregulation in children and adolescents : review of the literature by H. Belhadga, Z. Elmaataoui, H. Kisra

“… Introduction Disruptive Mood Dysregulation Disorder (DMDD) is a new disorder that has been added to the category of mood disorders in the fifth Diagnostic and Statistical Manual of Mental Disorders to distinguish chronic non-periodic irritability from the periodic irritability of bipolar disorder. The main characteristic of DMDD is chronic and severe irritability. …”
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MEDICAL FITNESS IN WORKERS WITH PSYCHIATRIC DISORDERS by L. Ben Afia, G. Bahri, I. Youssef, N. Mechergui, S. Ernez, D. Brahim, M. Mersni, N. Ladhari

“…These included 21 cases of bipolar disorder, 21 cases of schizophrenia, two cases of chronic hallucinatory psychosis and 3 cases of delusional psychosis. …”
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Psychiatric presentation of patients with acute SARS-CoV-2 infection: a retrospective review of 50 consecutive patients seen by a consultation-liaison psychiatry team by Yousaf Iqbal, Majid Ali Al Abdulla, Sultan Albrahim, Javed Latoo, Rajeev Kumar, Peter M. Haddad

“…Cases of psychosis and mania represented relapses in people with schizophrenia and bipolar disorder and also new onset cases.…”
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Development and validation of the analytical method by high performance liquid chromatography (HPLC) for Lamotrigine raw material = Desenvolvimento e validação do método analítico... by Guilherme Nobre Lima do Nascimento, Keila Carla de Freitas Pereira, Hisao Nishijo, Tales Alexandre Aversi-Ferreira

“…This study aimed to analyze the main aspects of the validation of analytical methods for Lamotrigine, new drug for bipolar disorder with wide use today. In conclusion, the proposed analytical method for determination of the lamotrigine content in raw materials is adequate, effective and capable of reproducing reliable results during analysis. …”
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An analytical method for the identification of cell type-specific disease gene modules by Jinting Guan, Yiping Lin, Yang Wang, Junchao Gao, Guoli Ji

“…We also study the similarity and dissimilarity in cell type-specific disease gene modules among autism spectrum disorder, schizophrenia and bipolar disorder. The functions of neurons-specific disease gene modules are associated with synapse for all three diseases, while those in glia cells are different. …”
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