Sociodemographic and Clinical Correlates Associated with the Frequent Service Users in an Italian Psychiatric Emergency Department by Andrea Aguglia, Giovanni Pietro Corsini, Alessandra Costanza, Andrea Berti, Edoardo Bruno, Andrea Escelsior, James Sanvi, Alice Trabucco, Eleonora Vai, Andrea Amerio, Gianluca Serafini, Mario Amore

“…Results: On average, FSUs were more likely to be single (75.0% vs. 64.0, <i>p</i> = 0.001), younger (38.79 years ± 14.68 vs. 45.94 years ± 16.94, <i>p</i> = 0.028), with an earlier onset (20.15 years ± 7.22 vs. 29.33 years ± 15.96, <i>p</i> < 0.001), and longer length of hospitalisation (13.65 days ± 12.40 vs. 9.89 ± 10.15, <i>p</i> = 0.006) compared to non-FSUs. While bipolar disorder was the most common primary diagnosis in both FSUs and non-FSUs, cluster B personality disorder was particularly elevated in FSUs (30.3% vs. 10.4%, <i>p</i> < 0.001). …”
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Promotion of mental health in young adults via mobile phone app: study protocol of the ECoWeB (emotional competence for well-being in Young adults) cohort multiple randomised trial... by A. Newbold, F. C. Warren, R. S. Taylor, C. Hulme, S. Burnett, B. Aas, C. Botella, F. Burkhardt, T. Ehring, J. R. J. Fontaine, M. Frost, A. Garcia-Palacios, E. Greimel, C. Hoessle, A. Hovasapian, VEI Huyghe, J. Lochner, G. Molinari, R. Pekrun, B. Platt, T. Rosenkranz, K. R. Scherer, K. Schlegel, G. Schulte-Korne, C. Suso, V. Voigt, E. R. Watkins

“…In total, 2142 participants aged 16 to 22 years, with no current or past history of major depression, bipolar disorder or psychosis will be recruited across UK, Germany, Spain, and Belgium. …”
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Genetic Deletion of P2Y2 Receptor Offers Long-Term (5 Months) Protection Against Lithium-Induced Polyuria, Natriuresis, Kaliuresis, and Collecting Duct Remodeling and Cell Prolifer... by Yue Zhang, Yue Zhang, Yue Zhang, Anne Riquier-Brison, Anne Riquier-Brison, Tao Liu, Tao Liu, Yufeng Huang, Noel G. Carlson, Noel G. Carlson, Noel G. Carlson, János Peti-Peterdi, János Peti-Peterdi, Bellamkonda K. Kishore, Bellamkonda K. Kishore, Bellamkonda K. Kishore, Bellamkonda K. Kishore

“…Chronic lithium administration for the treatment of bipolar disorder leads to nephrogenic diabetes insipidus (NDI), characterized by polyuria, natriuresis, kaliuresis, and collecting duct remodeling and cell proliferation among other features. …”
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Prevalence, time trends, and correlates of major depressive episode and other psychiatric conditions among young people amid major social unrest and COVID-19 in Hong Kong: a repres... by Stephanie M.Y. Wong, Eric Y.H. Chen, Y.N. Suen, Corine S.M. Wong, W.C. Chang, Sherry K.W. Chan, Patrick D. McGorry, Craig Morgan, Jim van Os, David McDaid, Peter B. Jones, T.H. Lam, Linda C.W. Lam, Edwin H.M. Lee, Eric Y.H. Tang, Charlie H. Ip, Winky W.K. Ho, Sarah M. McGhee, P.C. Sham, Christy L.M. Hui

“…MDE, generalised anxiety disorder (GAD), panic disorder (PD), and bipolar disorder (BD) were assessed using the Composite International Diagnostic Interview–Screening Scales in 3340 young people. …”
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Predicting unipolar and bipolar depression using inflammatory markers, neuroimaging and neuropsychological data: a machine learning study by L. Raffaelli, F. Colombo, F. Calesella, L. Fortaner-Uya, I. Bollettini, C. Lorenzi, E. Maggioni, E. Tassi, S. Poletti, R. Zanardi, F. Attanasio, F. Benedetti, B. Vai

“… Introduction About 60% of bipolar disorder (BD) cases are initially misdiagnosed as major depressive disorder (MDD), preventing BD patients from receiving appropriate treatment. …”
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Chronic pain diagnoses and opioid dispensings among insured individuals with serious mental illness by Ashli Owen-Smith, Christine Stewart, Musu M. Sesay, Sheryl M. Strasser, Bobbi Jo Yarborough, Brian Ahmedani, Lisa R. Miller-Matero, Stephen C. Waring, Irina V. Haller, Beth E. Waitzfelder, Stacy A. Sterling, Cynthia I. Campbell, Rulin C. Hechter, John E. Zeber, Laurel A. Copeland, Jeffrey F. Scherrer, Rebecca Rossom, Greg Simon

“…Abstract Background Individuals with major depressive disorder (MDD) and bipolar disorder (BD) have particularly high rates of chronic non-cancer pain (CNCP) and are also more likely to receive prescription opioids for their pain. …”
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Integrated therapist and online CBT for depression in primary care (INTERACT): study protocol for a multi-centre randomised controlled trial by Debbie Tallon, Laura Thomas, Sally Brabyn, Brian Chi Fung Ching, Jane Sungmin Hahn, Berry Jude, Mekeda X Logan, Alex Burrage, Fiona Fox, Simon Gilbody, Paul Lanham, Glyn Lewis, Jinshuo Li, Stephanie J. MacNeill, Irwin Nazareth, Steve Parrott, Tim J. Peters, Roz Shafran, Katrina Turner, Chris Williams, David Kessler, Nicola Wiles

“…Exclusion criteria: alcohol or substance dependency in the past year; bipolar disorder; schizophrenia; psychosis; dementia; currently under psychiatric care for depression (including those referred but not yet seen); cannot complete questionnaires unaided or requires an interpreter; currently receiving CBT/other psychotherapy; received high-intensity CBT in the past four years; participating in another intervention trial; unwilling/unable to receive CBT via computer/laptop/smartphone. …”
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Implementing guidelines on physical health in the acute mental health setting: a quality improvement approach by Stuart Green, Ed Beveridge, Liz Evans, Jenny Trite, Sandra Jayacodi, Rachel Evered, Caroline Parker, Luca Polledri, Emily Tabb, John Green, Anton Manickam, Joanna Williams, Rebecca Deere, Bill Tiplady

“…Abstract Background In the UK, life expectancy for people living with a serious mental illness, such as schizophrenia and bipolar disorder, is reduced by 15–20 years compared with the general population. …”
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Polygenic Heterogeneity Across Obsessive-Compulsive Disorder Subgroups Defined by a Comorbid Diagnosis by Nora I. Strom, Nora I. Strom, Nora I. Strom, Nora I. Strom, Jakob Grove, Jakob Grove, Jakob Grove, Sandra M. Meier, Marie Bækvad-Hansen, Marie Bækvad-Hansen, Judith Becker Nissen, Thomas Damm Als, Thomas Damm Als, Thomas Damm Als, Matthew Halvorsen, Merete Nordentoft, Merete Nordentoft, Merete Nordentoft, Preben B. Mortensen, Preben B. Mortensen, Preben B. Mortensen, Preben B. Mortensen, David M. Hougaard, David M. Hougaard, Thomas Werge, Thomas Werge, Thomas Werge, Thomas Werge, Ole Mors, Ole Mors, Anders D. Børglum, Anders D. Børglum, Anders D. Børglum, James J. Crowley, Jonas Bybjerg-Grauholm, Jonas Bybjerg-Grauholm, Manuel Mattheisen, Manuel Mattheisen, Manuel Mattheisen

“…We found that PRS of all traits but BMI were significantly associated with OCD across all subgroups (neuroticism: p = 1.19 × 10−32, bipolar disorder: p = 7.51 × 10−8, anorexia nervosa: p = 3.52 × 10−20, age at first birth: p = 9.38 × 10−5, educational attainment: p = 1.56 × 10−4, OCD: p = 1.87 × 10−6, insomnia: p = 2.61 × 10−5, BMI: p = 0.15). …”
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Additive effects of adjunctive app-based interventions for mental disorders - A systematic review and meta-analysis of randomised controlled trials by Lukas M. Fuhrmann, Kiona K. Weisel, Mathias Harrer, Jennifer K. Kulke, Harald Baumeister, Pim Cuijpers, David D. Ebert, Matthias Berking

“…No significant effects were found on symptoms of depression within a bipolar disorder (g = -0.07; 95 % CI -0.37 to 0.23, k = 4) and eating disorders (g = -0.02; 95 % CI -0.44 to 0.4, k = 3). …”
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The Role of Attitudes Toward Medication and Treatment Adherence in the Clinical Response to LAIs: Findings From the STAR Network Depot Study by Andrea Aguglia, Andrea Aguglia, Laura Fusar-Poli, Andrea Amerio, Andrea Amerio, Valeria Placenti, Valeria Placenti, Carmen Concerto, Giovanni Martinotti, Giuseppe Carrà, Giuseppe Carrà, Francesco Bartoli, Armando D'Agostino, Gianluca Serafini, Gianluca Serafini, Mario Amore, Mario Amore, Eugenio Aguglia, Giovanni Ostuzzi, Corrado Barbui, The STAR Network Investigators

“…Background: Long-acting injectable (LAI) antipsychotics are efficacious in managing psychotic symptoms in people affected by severe mental disorders, such as schizophrenia and bipolar disorder. The present study aimed to investigate whether attitude toward treatment and treatment adherence represent predictors of symptoms changes over time.Methods: The STAR Network “Depot Study” was a naturalistic, multicenter, observational, prospective study that enrolled people initiating a LAI without restrictions on diagnosis, clinical severity or setting. …”
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How ambient temperature affects mood: an ecological momentary assessment study in Switzerland by Marvin Bundo, Martin Preisig, Kathleen Merikangas, Jennifer Glaus, Julien Vaucher, Gérard Waeber, Pedro Marques-Vidal, Marie-Pierre F. Strippoli, Thomas Müller, Oscar Franco, Ana Maria Vicedo-Cabrera

“…A higher association was found in participants with bipolar disorder (-23%; OR: 0.77: 95% CI 0.51, 1.17) and in participants with a high neuroticism (-13%; OR: 0.87 95% CI 0.80, 0.95), whereas the association was reversed for participants with anxiety (20%; OR: 1.20: 95% CI 0.90, 1.59), depression (18%; OR: 1.18 95% CI 0.94, 1.48) and schizophrenia (193%; OR: 2.93 95% CI 1.17, 7.73). …”
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Local neuroanatomical and tract-based proxies of optimal subcallosal cingulate deep brain stimulation by Gavin J.B. Elias, Jürgen Germann, Alexandre Boutet, Michelle E. Beyn, Peter Giacobbe, Ha Neul Song, Ki Sueng Choi, Helen S. Mayberg, Sidney H. Kennedy, Andres M. Lozano

“…A smaller cohort (n = 22) of SCC-DBS patients with differing primary indications (bipolar disorder/anorexia nervosa) was utilized as an out-of-sample validation cohort. …”
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Mental health problems and socioeconomic disadvantage: a controlled household study in rural Ethiopia by Yohannes Hailemichael, Charlotte Hanlon, Kebede Tirfessa, Sumaiyah Docrat, Atalay Alem, Girmay Medhin, Abebaw Fekadu, Crick Lund, Dan Chisholm, Damen Hailemariam

“…The aim of the study was to explore the socio-economic status of households with a person with severe mental disorder (SMD; psychosis or bipolar disorder) or depression compared to households without an affected person. …”
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Instituto Nacional de Ciência e Tecnologia em Medicina Translacional (INCT-TM): abordagens metodológicas National Science and Technology Institute for Translational Medicine (INCT-... by Jaime E. C. Hallak, José Alexandre S. Crippa, João Quevedo, Rafael Roesler, Nadja Schröder, Antonio Egidio Nardi, Flávio Kapczinski

“…METHOD: In this manuscript, we describe some of the approaches used to attain the main objectives of the National Science and Technology Institute for Translational Medicine, which include the development of 1) animal models for bipolar disorder; 2) strategies to investigate neurobehavioral function and cognitive dysfunction associated with brain disorders; 3) experimental models of brain function and behavior, neuropsychiatric disorders, cell proliferation, and cancer; 4) Simulated Public Speaking and 5) Virtual reality simulation for inducing panic disorder and agoraphobia. …”
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Abuso de cannabis em pacientes com transtornos psiquiátricos: atualização para uma antiga evidência Cannabis abuse in patients with psychiatric disorders: an update to old evidence... by Alessandra Diehl, Daniel Cruz Cordeiro, Ronaldo Laranjeira

“…Cannabis seems to be one of the drugs of choice of individuals with bipolar disorder, despite evidence that manic states can be induced by its use. …”
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4333 The role of the L-type calcium channel, Cav1.3, in motor and associative learning by Aislinn Joanmarie Williams, Marisol Lauffer, Hsiang Wen, Bryn Myers

“…OBJECTIVES/GOALS: Genetic variation in L-type voltage-gated calcium channels, including CaV1.3, is associated with increased risk for psychiatric disorders including bipolar disorder and schizophrenia. Additionally, rare mutations in CaV1.3 have been linked to epilepsy, developmental delay, and autism. …”
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Does intensive home treatment change treatment trajectories of psychiatric disorders? by A. Martín-Blanco, A. González-Fernández, A. Farré, S. Vieira, P. Alvaro, C. Isern, D. Giménez, C. Torres, V. de la Cruz, C. Martín, N. Moll, O. Castro, M. Sagué-Vilavella

“…Clinical characteristics of the whole sample (N=1000) mean SD Age (years) 47.07 17.02 CGI-s at admission * 5 4-5 N % Sex (female) 548 54.8% Psychotic disorders 463 46.3% Affective disorder 257 25.7% Bipolar disorder 128 12.8% Other disorders 152 15.2% Hospital admission in the previous 5 years 313 31.3% CGI-s: clinical global impression - severity. * median and IQR Image: Image 2: Conclusions Patients that used to require inward management can now be treated at home when suffering an acute episode. …”
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Severe mental illnesses and mortality following COVID-19 infection: Data linkage study using the Clinical Practice Research Database (CPRD). by Jayati Das-Munshi, Alex Dregan, Robert Stewart, Matthew Hotopf, Ioannis Bakolis, Laia Becares, Josephine Ocloo, Ruth Stuart, Elisa Impara

“…Exposures SMI defined as the presence of schizophrenia, schizoaffective disorder, bipolar disorder, or affective disorders with psychosis, according to the International Classification of Mental Disorders (ICD-10). …”
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Pharmacological Treatments for Cocaine Craving: What Is the Way Forward? A Systematic Review by Dângela Layne Silva Lassi, André Malbergier, André Brooking Negrão, Lígia Florio, João P. De Aquino, João Maurício Castaldelli-Maia

“…Further, the majority of the studies considered abstinence and retention in treatment as the main outcomes, whereas craving was a secondary outcome and some of the studies evaluated patients with cocaine use disorder with comorbidities such as opioid or alcohol use disorder, schizophrenia, bipolar disorder or attention deficit hyperactivity. Lastly, most of the studies also included non-pharmacological treatments, such as counseling or psychotherapy. …”
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