Weight change following diagnosis with psychosis: a retrospective cohort study in Greater Manchester, UK by Adrian Heald, Chris Daly, John Julian Warner-Levy, Richard Williams, Cheyenne Meehan, Mark Livingston, Toby Pillinger, Lamiece Hussain, Joseph Firth

“…Conclusion The results of this real-world longitudinal cohort study suggest that the changes in BMI with treatment of non-affective psychosis vs bipolar disorder are not significantly different, while 43% maintain a healthy weight in the first 5 years following antipsychotic prescription.…”
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In silico analyses of the involvement of GPR55, CB1R and TRPV1: response to THC, contribution to temporal lobe epilepsy, structural modeling and updated evolution by Amy L. Cherry, Michael J. Wheeler, Karolina Mathisova, Mathieu Di Miceli

“…In the current study, we aim to: (i) highlight a potential link between the eCB system and neurological disorders, (ii) assess if THC exposure alters the expression of eCB-related genes, and (iii) identify evolutionary-conserved residues in CB1R or TRPV1 in light of their function.MethodsTo address this, we used several bioinformatic approaches, such as transcriptomic (Gene Expression Omnibus), protein–protein (STRING), phylogenic (BLASTP, MEGA) and structural (Phyre2, AutoDock, Vina, PyMol) analyzes.ResultsUsing RNA sequencing datasets, we did not observe any dysregulation of eCB-related transcripts in major depressive disorders, bipolar disorder or schizophrenia in the anterior cingulate cortex, nucleus accumbens or dorsolateral striatum. …”
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Trastornos del ánimo y trastornos por uso de sustancias: una comorbilidad compleja y frecuente by Carlos Ibáñez, Jorge Cáceresa, Roberto Brucher, Daniel Seijas

“…Palabras clave: Trastorno por consumo de sustancias, comorbilidad, trastorno del ánimo, patología dual, trastorno bipolar, depresión, diagnóstico, tratamiento, adicciones., Keywords: Substance use disorder, dual disorders, comorbidity, mood disorder, bipolar disorder, depression, diagnosis, treatment, addiction…”
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Do higher primary care practice performance scores predict lower rates of emergency admissions for persons with serious mental illness? An analysis of secondary panel data by Rowena Jacobs, Nils Gutacker, Anne Mason, Maria Goddard, Hugh Gravelle, Tony Kendrick, Simon Gilbody, Lauren Aylott, June Wainwright

“…Background: Serious mental illness (SMI) is a set of chronic enduring conditions including schizophrenia and bipolar disorder. SMIs are associated with poor outcomes, high costs and high levels of disease burden. …”
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Vagus Nerve Stimulation and External Defibrillation during Resuscitation; a Letter to Editor by Matthias Wittstock, Johannes Buchmann, Uwe Walter, Johannes Rösche

“…The first patient was a 66-year old female with major depression and the second one, a 57-year-old male with a history of bipolar disorder. Both had VNS for therapy refractory psychiatric illness. …”
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Haptoglobin in ultra-high risk of psychosis - findings from the longitudinal youth at risk study (LYRIKS) by Yee, Jie Yin, Chow, Si Qing, Lim, Keane, Goh, Wilson, Sng, Judy, Lee, Tih-Shin, Lee, Jimmy

“…The role of immune dysregulation in mental disorders is not new and has been investigated in acute psychosis, schizophrenia, depression, bipolar disorder, and post-traumatic stress disorder (Çakici et al., 2020; Debnath et al., 2021; Karanikas et al., 2021). …”
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Risk of Subjection to Violence and Perpetration of Violence in Persons With Psychiatric Disorders in Sweden by Sariaslan, A, Arseneault, L, Larsson, H, Lichtenstein, P, Fazel, S

“…</br> <br><strong>Exposures: </strong>Patients with common psychiatric disorders (eg, schizophrenia, bipolar disorder, depression, and anxiety) were differentiated using a hierarchical approach. …”

GSK3 beta-inhibitory activity in microfungal isolated from Sabah rainforest soils by Dg. Nur Azierah Fachyuni Abdul Aziz

“…Glycogen synthase kinase-3β (GSK-3β) is a serine/threonine kinase that has been implicated in several diseases such as diabetes, cancer, inflammation, Alzheimer and bipolar disorder. Therefore, GSK-3β has become a prior target in drug discovery. …”
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HLA-DRB1 and HLA-DQB1 genetic diversity modulates response to lithium in bipolar affective disorders by Sigrid Le Clerc, Laura Lombardi, Bernhard T. Baune, Azmeraw T. Amare, Klaus Oliver Schubert, Liping Hou, Scott R. Clark, Sergi Papiol, Micah Cearns, Urs Heilbronner, Franziska Degenhardt, Fasil Tekola-Ayele, Yi-Hsiang Hsu, Tatyana Shekhtman, Mazda Adli, Nirmala Akula, Kazufumi Akiyama, Raffaella Ardau, Bárbara Arias, Jean-Michel Aubry, Lena Backlund, Abesh Kumar Bhattacharjee, Frank Bellivier, Antonio Benabarre, Susanne Bengesser, Joanna M. Biernacka, Armin Birner, Clara Brichant-Petitjean, Pablo Cervantes, Hsi-Chung Chen, Caterina Chillotti, Sven Cichon, Cristiana Cruceanu, Piotr M. Czerski, Nina Dalkner, Alexandre Dayer, Maria Del Zompo, J. Raymond DePaulo, Bruno Étain, Stephane Jamain, Peter Falkai, Andreas J. Forstner, Louise Frisen, Mark A. Frye, Janice M. Fullerton, Sébastien Gard, Julie S. Garnham, Fernando S. Goes, Maria Grigoroiu-Serbanescu, Paul Grof, Ryota Hashimoto, Joanna Hauser, Stefan Herms, Per Hoffmann, Esther Jiménez, Jean-Pierre Kahn, Layla Kassem, Po-Hsiu Kuo, Tadafumi Kato, John R. Kelsoe, Sarah Kittel-Schneider, Ewa Ferensztajn-Rochowiak, Barbara König, Ichiro Kusumi, Gonzalo Laje, Mikael Landén, Catharina Lavebratt, Susan G. Leckband, Alfonso Tortorella, Mirko Manchia, Lina Martinsson, Michael J. McCarthy, Susan L. McElroy, Francesc Colom, Vincent Millischer, Marina Mitjans, Francis M. Mondimore, Palmiero Monteleone, Caroline M. Nievergelt, Markus M. Nöthen, Tomas Novák, Claire O’Donovan, Norio Ozaki, Urban Ösby, Andrea Pfennig, James B. Potash, Andreas Reif, Eva Reininghaus, Guy A. Rouleau, Janusz K. Rybakowski, Martin Schalling, Peter R. Schofield, Barbara W. Schweizer, Giovanni Severino, Paul D. Shilling, Katzutaka Shimoda, Christian Simhandl, Claire M. Slaney, Claudia Pisanu, Alessio Squassina, Thomas Stamm, Pavla Stopkova, Mario Maj, Gustavo Turecki, Eduard Vieta, Julia Veeh, Stephanie H. Witt, Adam Wright, Peter P. Zandi, Philip B. Mitchell, Michael Bauer, Martin Alda, Marcella Rietschel, Francis J. McMahon, Thomas G. Schulze, Jean-Louis Spadoni, Wahid Boukouaci, Jean-Romain Richard, Philippe Le Corvoisier, Caroline Barrau, Jean-François Zagury, Marion Leboyer, Ryad Tamouza

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Altered dynamic amplitude of low-frequency fluctuation between bipolar type I and type II in the depressive state by Wen Liu, Xiaowei Jiang, Zijing Deng, Linna Jia, Qikun Sun, Lingtao Kong, Feng Wu, Yanqing Tang

“…Background: Bipolar disorder is a chronic and highly recurrent mental disorder that can be classified as bipolar type I (BD I) and bipolar type II (BD II). …”
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Integrative Brain Transcriptome Analysis Reveals Region-Specific and Broad Molecular Changes in Shank3-Overexpressing Mice by Chunmei Jin, Chunmei Jin, Hyojin Kang, Jae Ryun Ryu, Jae Ryun Ryu, Shinhyun Kim, Shinhyun Kim, Yinhua Zhang, Yinhua Zhang, Yeunkum Lee, Yeunkum Lee, Yoonhee Kim, Yoonhee Kim, Kihoon Han, Kihoon Han

“…Variants of the SH3 and multiple ankyrin repeat domain 3 (SHANK3) gene, encoding excitatory postsynaptic core scaffolding proteins, are causally associated with numerous neurodevelopmental and neuropsychiatric disorders, including autism spectrum disorder (ASD), bipolar disorder, intellectual disability, and schizophrenia (SCZ). …”
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The temporal dependencies between social, emotional and physical health factors in young people receiving mental healthcare: a dynamic Bayesian network analysis by Frank Iorfino, Mathew Varidel, Roman Marchant, Sally Cripps, Jacob Crouse, Ante Prodan, Rafael Oliveria, Joanne S. Carpenter, Daniel F. Hermens, Adam Guastella, Elizabeth Scott, Jai Shah, Kathleen Merikangas, Jan Scott, Ian B. Hickie

“…Results The ‘initial network’ identified that childhood disorders tend to precede adolescent depression which itself was associated with three distinct pathways or illness trajectories; (1) anxiety disorder; (2) bipolar disorder, manic-like experiences, circadian disturbances and psychosis-like experiences; (3) self-harm and suicidality to alcohol and substance use or functioning. …”
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An exploration of the correlations between seven psychiatric disorders and the risks of breast cancer, breast benign tumors and breast inflammatory diseases: Mendelian randomizatio... by Fei Ren, Qingyao Shang, Shuangtao Zhao, Chenxuan Yang, Kexin Feng, Jiaxiang Liu, Xiyu Kang, Ruixuan Zhang, Xiang Wang, Xin Wang

“…This study aims to investigate if mental disorders influence the risks of overall breast cancer, the two subtypes of breast cancer (ER+ and ER-), breast benign tumors and breast inflammatory diseases.MethodsDuring our research, genome-wide association study (GWAS) data for seven psychiatric disorders (schizophrenia, major depressive disorder, bipolar disorder, post-traumatic stress disorder, panic disorder, obsessive-compulsive disorder and anorexia nervosa) from the Psychiatric Genomics Consortium (PGC) and the UK Biobank were selected, and single-nucleotide polymorphisms (SNPs) significantly linked to these mental disorders were identified as instrumental variables. …”
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Development and Evaluation of an FDM Printed Nasal Device for CPZ Solid Nanoparticles by Thinh To Quoc, Krisztina Bíró, Ágota Pető, Dóra Kósa, Dávid Sinka, István Lekli, Attila Kiss-Szikszai, István Budai, Mónika Béres, Miklós Vecsernyés, Pálma Fehér, Ildikó Bácskay, Zoltán Ujhelyi

“…We used chlorpromazine (CPZ), which is mainly used in the treatment of psychotic disorders such as schizophrenia and bipolar disorder. Chlorpromazine has been previously investigated by our team in other projects. …”
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A systematic review, psychometric analysis and qualitative assessment of generic preference-based measures of health in mental health populations and the estimation of mapping func... by John Brazier, Janice Connell, Diana Papaioannou, Clara Mukuria, Brendan Mulhern, Tessa Peasgood, Myfawnwy Lloyd Jones, Suzy Paisley, Alicia O’Cathain, Michael Barkham, Martin Knapp, Sarah Byford, Simon Gilbody, Glenys Parry

“…Results from the psychometric analyses in schizophrenia and bipolar disorder have been more mixed. (3) A framework analysis of 13 studies identified six major themes. (4) The interview data fitted the themes from the review well and resulted in minor modifications to the themes. …”
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Psychiatric comorbidities in women with cardiometabolic conditions with and without ADHD: a population-based study by Unnur Jakobsdottir Smari, Unnur Anna Valdimarsdottir, Thor Aspelund, Arna Hauksdottir, Edda Bjork Thordardottir, Catharina A. Hartman, Pontus Andell, Henrik Larsson, Helga Zoega

“…Women with cardiometabolic conditions and co-occurring ADHD had, compared with those without ADHD, substantially increased prevalence of (a) all measured mood and anxiety disorders, e.g., depression (PR = 2.38, 95% CI 2.19–2.58), bipolar disorder (PR = 4.81, 95% CI 3.65–6.35), posttraumatic stress disorder (PR = 2.78, 95% CI 2.52–3.07), social phobia (PR = 2.96, 95% CI 2.64–3.32); (b) moderate/severe depressive, anxiety, and PTSD symptoms with PR = 1.76 (95% CI 1.67–1.85), PR = 1.97 (95% CI 1.82–2.12), and PR = 2.01 (95% CI 1.88–2.15), respectively; (c) alcoholism/SUD, PR = 4.79 (95% CI 3.90–5.89); and (d) self-harm, PR = 1.47 (95% CI 1.29–1.67) and suicide attempts, PR = 2.37 (95% CI 2.05–2.73). …”
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Combining mHealth Technology and Pharmacotherapy to Improve Mental Health Outcomes and Reduce Human Rights Abuses in West Africa: Intervention Field Trial by Dror Ben-Zeev, Anna Larsen, Dzifa A Attah, Kwadwo Obeng, Alexa Beaulieu, Seth M Asafo, Jonathan Kuma Gavi, Arya Kadakia, Emmanuel Quame Sottie, Sammy Ohene, Lola Kola, Kevin Hallgren, Jaime Snyder, Pamela Y Collins, Angela Ofori-Atta

“…Fourteen (82%) participants had a diagnosis of schizophrenia and 2 (18%) were diagnosed with bipolar disorder. Four healers were trained to use M-Healer. …”
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Causal association of leisure sedentary behavior and cervical spondylosis, sciatica, intervertebral disk disorders, and low back pain: a Mendelian randomization study by Youjia Qiu, Xingzhou Wei, Yuchen Tao, Bingyi Song, Menghan Wang, Ziqian Yin, Minjia Xie, Aojie Duan, Zhouqing Chen, Zhong Wang

“…Multivariable MR (MVMR) was conducted to investigate the independent factor of other LSB; while two-step MR analysis was used to explore the potential mediators including Body mass index (BMI), smoking initiation, type 2 diabetes mellitus (T2DM), major depressive disorder (MDD), schizophrenia, bipolar disorder between the causal association of LSB and these diseases based on previous studies.ResultsGenetically associated TV viewing was positively associated with the risk of CS (OR = 1.61, 95%CI = 1.25 to 2.07, p = 0.002), IVDD (OR = 2.10, 95%CI = 1.77 to 2.48, p = 3.79 × 10−18), LBP (OR = 1.84, 95%CI = 1.53 to 2.21, p = 1.04 × 10−10) and sciatica (OR = 1.82, 95% CI = 1.45 to 2.27, p = 1.42 × 10−7). …”
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Perinatal depression before and during the COVID-19 pandemic in New York CityAJOG Global Reports at a Glance by Meralis Lantigua-Martinez, MD, Megan E. Trostle, MD, Anthony Melendez Torres, MD, Pournami Rajeev, BA, Alyson Dennis, BA, Jenna S. Silverstein, MD, Mahino Talib, MD

“…Several risk factors were associated with a positive screen, including being unmarried (P<.001), pulmonary disease (P=.02), depression (P<.001), anxiety (P=.01), bipolar disorder (P=.009), and use of anxiolytics (P=.04). …”
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Cariprazine’s efficacy in treating depressive symptoms – pooled data from schizophrenia, bipolar depression and major depression trials by R. S. McIntyre, R. Csehi, G. Németh

“… Introduction Depressive symptoms are a common feature of schizophrenia (SCH) and define bipolar disorder and major depressive disorder (MDD). Their emergence is related to altered neurotransmission at the serotonin receptors and potentially at dopamine D3 receptors. …”
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