Towards community-based and recovery-oriented care for severe mental disorders in Southern and Eastern Europe: aims and design of a multi-country implementation and evaluation stud... by Laura Shields-Zeeman, Ionela Petrea, Filip Smit, Bethany Hipple Walters, Jovo Dedovic, Martina Rojnic Kuzman, Vladimir Nakov, Raluca Nica, Antoni Novotni, Catharina Roth, Aleksandar Tomcuk, Ben F. M. Wijnen, Michel Wensing

“…Methods Five implementation sites were selected (Sofia, Bulgaria; Zagreb, Croatia; Skopje, North Macedonia; Kotor, Montenegro; Siret-Suceava, Romania) where hospital-based mental health services are available (care as usual, CAU) for patients with severe mental disorders (severe depression, bipolar disorder, schizophrenia). The intervention consists of the introduction of a new service delivery model in each site, consisting of community-based recovery-oriented care delivered by trained multidisciplinary community mental health teams (including a peer worker with lived experience of a severe mental disorder). …”
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Attitude regarding electroconvulsive therapy among psychiatric patients by M. Ayub

“…There were 72 (75.00%) patients were household workers, 04 (4.17%) students, 06 (5.25%) unskilled labour, 3 (3.13%) skilled labour, 10 (10.42%) professionals and just 01 (1.04%) were law enforcement worker. 19 (19.79%) patients were diagnosed with schizophrenia, 62 (64.58%) were diagnosed with unipolar depression and 15 (15.63%) were diagnosed with bipolar disorder. Source of ECT information was 11 (11.46%) electronic media, 09 (9.38%) print media, 19 (19.79%) social media and 57 (59.38%) was from health professionals. …”
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Risk Factors Associated With Nonfatal Opioid Overdose Leading to Intensive Care Unit Admission: A Cross-sectional Study by Avijit Mitra, Hiba Ahsan, Wenjun Li, Weisong Liu, Robert D Kerns, Jack Tsai, William Becker, David A Smelson, Hong Yu

“…ResultsThe strongest association with nonfatal OD was found to be drug use disorder (aOR 8.17, 95% CI 5.44-12.27), followed by bipolar disorder (aOR 2.69, 95% CI 1.68-4.29). Among others, major depressive disorder (aOR 2.57, 95% CI 1.12-5.88), being on a Medicaid health insurance program (aOR 2.26, 95% CI 1.43-3.58), history of illicit drug use (aOR 2.09, 95% CI 1.15-3.79), and current use of illicit drugs (aOR 2.06, 95% CI 1.20-3.55) were strongly associated with increased risk of nonfatal OD. …”
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Rapid tranquilization for agitated patients in emergency psychiatric rooms: a randomized trial of olanzapine, ziprasidone, haloperidol plus promethazine, haloperidol plus midazolam... by Leonardo Baldaçara, Marsal Sanches, Daniel Cruz Cordeiro, Andrea Parolin Jackowski

“…METHOD: One hundred fifty patients with agitation caused by psychotic or bipolar disorder were randomly assigned under double-blind conditions to receive olanzapine, ziprasidone, haloperidol plus midazolam, haloperidol plus promethazine or haloperidol alone. …”
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Medical conditions of primary care patients with documented cannabis use and cannabis use disorder in electronic health records: a case control study from an academic health system... by Howard Padwa, David Huang, Larissa Mooney, Christine E. Grella, Darren Urada, Douglas S. Bell, Brittany Bass, Anne E. Boustead

“…Compared to matched controls, CUD-documented patients had highest odds of other substance use disorders (OR = 21.44: 95% CI 9.43–48.73), any mental health disorder (OR = 6.99; 95% CI 5.03–9.70) social anxiety disorder (OR = 13.03; 95% CI 2.18–77.94), HIV/AIDS (OR = 7.88: 95% CI 2.58–24.08), post-traumatic stress disorder (OR = 7.74: 95% CI 2.66–22.51); depression (OR = 7.01: 95% CI 4,79–10.27), and bipolar disorder (OR = 6.49: 95% CI 2.90–14.52). Compared to matched controls, CU-documented patients had highest odds of other substance use disorders (OR = 3.64; 95% CI 2.53–5.25) and post-traumatic stress disorder (OR = 3.41; 95% CI 2.53–5.25). …”
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Abstract Number ‐ 192: Acute Ischemic Stroke in Patients with Psychiatric Disorders: Disparities in Interventions and Outcomes by Brinda Raval, Aiden K Lui, Kevin Clare, Terry Nguyen, Nicholas Mui, Anaz Uddin, Eric Feldstein, Yarden Bornovski, Gurmeen Kaur, Ji Chong, Fawaz Al‐Mufti

“…Psychiatric diagnosis included major depressive disorder, schizophrenia, bipolar disorder, and generalized anxiety disorder. Baseline demographic characteristics such as age, race, psychiatric disorder status, stroke severity, obesity, hypertension, diabetes, long term anticoagulant use, and COPD were assessed in both groups. …”
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Stigma and higher rates of psychiatric re-hospitalization: São Paulo public mental health system Estigma e frequências mais altas de re-hospitalização psiquiátrica: o sistema públi... by Alexandre Andrade Loch

“…OBJECTIVE: The aim of this study was to assess re-hospitalization rates of individuals with psychosis and bipolar disorder and to study determinants of readmission. …”
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Trastornos afectivos y salud física, implicaciones de la comorbilidad con enfermedades médicas: una revisión de la literatura by Lluc Colomer, Gerard Anmella, Iría Grande, Eduardo Vieta

“…Palabras clave: Trastorno bipolar, Trastorno depresivo mayor, Comorbilidad médica, Enfermedad cardiovascular, Obesidad, Síndrome metabólico, Keywords: Bipolar disorder, Major depressive disorder, Comorbidities, cardiovascular disease, Obesity, Metabolic syndrome…”
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A Smartphone Intervention for People With Serious Mental Illness: Fully Remote Randomized Controlled Trial of CORE by Dror Ben-Zeev, Ayesha Chander, Justin Tauscher, Benjamin Buck, Subigya Nepal, Andrew Campbell, Guy Doron

“…The sample comprised individuals with self-reported bipolar disorder (111/315, 35.2%), major depressive disorder (136/315, 43.2%), and schizophrenia or schizoaffective disorder (68/315, 21.6%) who displayed moderate to severe symptoms and disability levels at baseline. …”
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Efficacy of two intensive and spaced protocols of theta burst transcranial magnetic stimulation in treatment-resistant depression: a double-blind randomized trial by Y. Cañada, P. Navalón, P. Benavent, A. Sabater, J. Ribes, L. Livianos, P. Sierra

“…Bilateral TBS(n=4) UnilateralTBS(n=4) ShamTBS(n=5) Age [M (SD)] 55,50(5,80) 48,50(16,86) 56,40(5,86) Male: Female [n] 0:4 2:2 3:2 Depression:Bipolar disorder [n] 3:1 3:1 4:1 Length of depresive episode (months) [M (SD)] 12,00(4,08) 16,50(6,61) 15,00(5,83) Current number of antidepressants [M (SD)] 2,00(0,82) 1,75(0,50) 2,60(0,55) Maudsley score [M (SD)] 7,00(1,82) 8,75(1,5) 7,90(1,30) Basal HDRS basal [M (SD)] 16,00(1,82) 19,75(4,03) 20,40(3,21) Final HDRS [M (SD)] 5,75 (3,30) 10,75 (3,10) 17,80 (2,49) Response /Remission[n (%)] 3:3 (75%) 2:0(50:0%) 0:0 (0%) Image: Conclusions The results demonstrate the preliminary efficacy of intensive TBS protocols relative to sham. …”
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Comparing Online and On-Site Cognitive Behavior Therapy in Major Depressive Disorder: Protocol for a Noninferiority Randomized Controlled Trial by Paul Ritvo, David Gratzer, Yuliya Knyahnytska, Abigail Ortiz, Clarice Walters, Joel Katz, Judith Laposa, Christopher Baldissera, Noah Wayne, Donna Pfefer-Litman, George Tomlinson, Zafiris Daskalakis

“…Exclusion criteria are as follows: (1) receipt of weekly structured psychotherapy; (2) observation of Diagnostic and Statistical Manual of Mental Disorders (5th Edition) criteria for severe alcohol or substance use disorder (in past 3 months), borderline personality disorder, schizophrenia (or other primary psychotic disorder), bipolar disorder, or obsessive-compulsive disorder; (3) clinically significant suicidal ideation (imminent intent or attempted suicide in the past 6 months); and (4) treatment-resistant depression. …”
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Clinical effectiveness and cost-effectiveness of cognitive behavioural therapy as an adjunct to pharmacotherapy for treatment-resistant depression in primary care: the CoBalT rando... by Wiles, N, Thomas, L, Abel, A, Barnes, M, Carroll, F, Ridgway, N, Sherlock, S, Turner, N, Button, K, Odondi, L, Metcalfe, C, Owen-Smith, A, Campbell, J, Garland, A, Hollinghurst, S, Jerrom, B, Kessler, D, Kuyken, W, Morrison, J, Turner, K, Williams, C, Peters, T, Lewis, G

“…Individuals were excluded who (1) had bipolar disorder/psychosis or major alcohol/substance abuse problems; (2) were unable to complete the questionnaires; or (3) were pregnant, as were those currently receiving CBT/other psychotherapy/secondary care for depression, or who had received CBT in the past 3 years. …”

Investigating the role of the endocannabinoid system and gut-microbiome in psychotic and severe mental illness: a focus on negative symptoms by Minichino, A

“…The second meta-analysis aimed at investigating blood biomarkers of reduced microbial diversity (gut dysbiosis) in severe mental illnesses (schizophrenia, depression, and bipolar disorder) and chronic fatigue. Pooled results from 33 studies including 2,761 patients and 1,847 controls showed that blood biomarkers of gut dysbiosis were increased and positively associated with severity of negative symptoms in patients vs controls, independent of medication status and across diagnostic boundaries. …”

Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: A systematic review and network meta-analysis by Cipriani, A, Furukawa, TA, Salanti, G, Chaimani, A, Atkinson, LZ, Ogawa, Y, Leucht, S, Ruhe, HG, Turner, EH, Higgins, JPT, Egger, M, Takeshima, N, Hayasaka, Y, Imai, H, Shinohara, K, Tajika, A, Ioannidis, JPA, Geddes, JR

“…We excluded quasi-randomised trials and trials that were incomplete or included 20% or more of participants with bipolar disorder, psychotic depression, or treatment-resistant depression; or patients with a serious concomitant medical illness. …”

16th National Congress of the South African Society of Psychiatrists (SASOP) by Christer Allgulander, Orlando Alonso Betancourt, David Blackbeard, Helen Clark, Franco Colin, Sarah Cooper, Robin Emsley, Lennart Eriksson, Oye Gureje, Angelos Halaris, Sue Hawkridge, Elizabeth Howell, Bernard Janse van Rensburg, Yasmien Jeenah, Gerhard Jordaan, Andre F Joubert, Sean Kaliski, E Kinyada, N K Kirimi, Sharon Kleintjes, Liezl Kramer, Gian Lippi, Crick Lund, Dan Mkize, Povl Munk-Jorgensen, Mo Nagdee, David M Ndetei, A Parkinson, Charles Parry, Vikram Patel, Inge Petersen, Willie Pienaar, Janus Pretorius, Suvira Ramlall, Louw Roos, Shaquir Salduker, Manfred Spitzer, Christopher Szabo, Thandi van Heyningen, Jacques J M van Hoof, C W (Werdie) van Staden

“…The Psychotherapy of bipolar disorder Franco Colin 7. The Psychotherapy of bipolar disorder Franco Colin 8. …”
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IMMUNOLOGICAL RESPONSE ASSOCIATED WITH DERMATOLOGICAL LESIONS IN A PATIENT WITH MYELODYSPLASTIC NEOPLASIA by JOR Cassiano, ACP Silva, NN Kloster, CM Freitas, MM Garcia, VM Sthel, VLP Figueiredo

“…Case report: Male, 64 years old, with bipolar disorder and prolonged bicytopenia. In january/21 diagnosed with NM, myelogram: 10% of blasts with dysplastic changes in the 3 series, IPSS-R = 3.8, FISH and karyotype without abnormalities. …”
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Are there any differences in clinical and biochemical variables between bipolar patients with or without lifetime psychotic symptoms? by C. M. Esposito, A. Ceresa, M. Di Paolo, T. Surace, L. Moioli, F. Legnani, G. Nosari, V. Ciappolino, A. M. Auxilia, M. Cappellazzi, I. Tagliabue, L. Cirella, E. Capuzzi, A. Caldiroli, A. Dekanalis, M. Clerici, M. Buoli

“… Introduction Bipolar Disorder (BD) is a frequent psychiatric disorder, which can be associated with high disability. …”
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The Positive and Negative Syndrome Scale for Schizophrenia Autism Severity Scale (PAUSS) in a sample of early-onset psychosis by J. Suárez Campayo, L. Pina-Camacho, J. Merchán-Naranjo, C. Ordas, V. Cavone, R. Panadero, G. Sugranyes, I. Baeza, J. Castro-Fornieles, E. de la Serna, C. Arango, C. M. Diaz Caneja

“…Linear mixed models were performed to compare changes in PAUSS during follow-up between diagnostic subgroups [i.e., non-affective psychosis (including schizophrenia and schizophreniform disorder), affective psychosis (including bipolar disorder, schizoaffective disorder and major depressive disorder with psychotic features), and other psychosis (including brief psychotic disorder and psychosis not otherwise specified)]. …”
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Development and validation of a method for the determination of valproic acid in pharmaceutical formulations by high performance liquid chromatography with diode array detection (H... by Paulo Ricardo de Souza e Souza, Juliana Machado de Carvalho, André Luis Mazzei Albert, Josino Costa Moreira, Katia Christina Leandro

“…Valproic acid (VA) is used as an anticonvulsant and is used in the treatment of bipolar disorder and depression. The offi cial analytical method for this drug in the compendia is gas chromatography, which is unavailable in many quality control laboratories. …”
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Psychological and psychosocial interventions for cannabis cessation in adults: a systematic review short report by Katy Cooper, Robin Chatters, Eva Kaltenthaler, Ruth Wong

“…Psychiatric population studies: seven studies assessed psychiatric populations (schizophrenia, psychosis, bipolar disorder or major depression). CBT appeared to have little effect over treatment as usual (TAU) based on four small studies with design limitations (both groups received TAU and patients were referred). …”
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