Activated invariant NKT cells regulate osteoclast development and function by Hu, M, Bassett, JHD, Danks, L, Howell, PGT, Xu, K, Spanoudakis, E, Kotsianidis, I, Boyde, A, Williams, GR, Horwood, N, Roberts, I, Karadimitris, A

“…Because these same progenitors give rise to osteoclasts (OCs), which also mediate the egress of hematopoietic progenitors and orchestrate bone remodeling, we hypothesized that iNKT cells would extend their myeloid cell regulatory role to the development and function of OCs. …”

Structural insights into human brachyury DNA recognition and discovery of progressible binders for cancer therapy by Newman, JA, Gavard, AE, Imprachim, N, Aitkenhead, H, Sheppard, HE, te Poele, R, Clarke, PA, Hossain, MA, Temme, L, Oh, HJ, Wells, CI, Davis-Gilbert, ZW, Workman, P, Gileadi, O, Drewry, DH

“…Brachyury is a transcription factor that plays an essential role in tumour growth of the rare bone cancer chordoma and is implicated in other solid tumours. …”

Mechanical characterization of an endoprosthesis. by Tan, Xue Yu.

“…Loss of mandibular bone as a result of trauma, inflammatory diseases and benign or malignant tumors demonstrated the need of mandibular reconstruction. …”
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Automatic knee segmentation from multi-contrast MR images by Zhang, Kunlei

“…The automatic segmentations of knee bones, cartilages and menisci are evaluated on a comprehensive multi-contrast MRI database. …”
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Clinical, genetic and omics-based biomarkers that might support the identification of the development of psoriatic arthritis in individuals with psoriasis – a narrative review of t... by Grohmann, T, Vivekanantham, A, Coates, L, Pennington, S, FitzGerald, O

“…Furthermore, there are considerable delays in diagnosis and treatment of PsA, which lead to joint and bone deformation and chronic pain. It is therefore important to develop more precise diagnostic and screening tools. …”

BMP signaling promotes zebrafish heart regeneration via alleviation of replication stress by Vasudevarao, MD, Posadas Pena, D, Ihle, M, Bongiovanni, C, Maity, P, Geissler, D, Mohammadi, HF, Rall-Scharpf, M, Niemann, J, Mommersteeg, MTM, Redaelli, S, Happ, K, Wu, C, Beisaw, A, Scharffetter-Kochanek, K, D’Uva, G, Malek Mohammadi, M, Wiesmüller, L, Geiger, H, Weidinger, G

“…Pharmacological inhibition of ATM and ATR kinases revealed that DNA damage response signaling is essential for zebrafish heart regeneration. Manipulation of Bone Morphogenetic Protein (BMP)-Smad signaling using transgenics and mutants showed that BMP signaling alleviates cardiomyocyte replication stress. …”

Tropism of subgroup J avian leukosis virus as detected by in situ hybridization by Arshad, S. S., Smith, L. M., Howes, K., Russell, P. H., Venugopal, K., Payne, L. N.

“…Viral gene expression could not be detected in the bone marrow or tumour tissues using this test. Higher levels of viral gene expression in the bursa of Fabricius infected with RAV-1, but not with HPRS-103, might help explain the inability of the latter virus to induce lymphoid leukosis.…”
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Regulation of cell migration by BMP signaling by Leong, Leslie Boon Hao

“…A morphogen is a soluble signaling molecule which instructs cellular processes in a concentration-dependent manner. Bone morphogenetic proteins (BMP) are morphogens essential for development and repair in both embryos and adults. …”
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Effects of dehydrothermal treatment on collagen by Yeo, Sherrill Yan Ling.

“…Collagen is the most fundamental unit of the extra cellular matrix and is found in most mammal tissues such as the tendon, cartilage, bone and skin. Due to its excellent biocompatibility, collagen is often used as a matrix for cell infiltration in many tissue regenerative applications. …”
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Synthesis and application of titanium dioxide nanotube and composites by Liang, Kun

“…Two different applications were explored using TiO2 nanotube structures and its composites: bone morphogenetic protein-2 (BMP-2) delivery and photocatalytic for water purification. …”
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Ontogeny of intestinal intratumoural macrophages and their contribution in cancer regulation by Soncin, Irene

“…In contrast to their LP counterparts, the intratumoural F4/80(hi) macrophages are able to self-renew and lose the bone marrow dependency. Since their depletion via CSF1R blockade diminishes the tumour burden, our data underline the potential of these tumour-promoting intestinal macrophages as an attractive target for successful cancer immunotherapies.…”
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Elucidation of the EP defect in Diamond-Blackfan anemia by characterization and prospective isolation of human EPs by Iskander, D, Psaila, B, Gerrard, G, Chaidos, A, Foong, HE, Harrington, Y, Karnik, LC, Roberts, I, de la Fuente, J, Karadimitris, A

“…By combining flow cytometry, cell-sorting, and single-cell clonogenic assays, we identified Lin(-)CD34(+)CD38(+)CD45RA(-)CD123(-)CD71(+)CD41a(-)CD105(-)CD36(-) bone marrow cells as EEP giving rise to BFU-E, and Lin(-)CD34(+/-)CD38(+)CD45RA(-)CD123(-)CD71(+)CD41a(-)CD105(+)CD36(+) cells as LEP giving rise to CFU-E, in a hierarchical fashion. …”

Glycosylphosphatidylinositol-specific, CD1d-restricted T cells in paroxysmal nocturnal hemoglobinuria by Gargiulo, L, Papaioannou, M, Sica, M, Talini, G, Chaidos, A, Richichi, B, Nikolaev, AV, Nativi, C, Layton, M, de la Fuente, J, Roberts, I, Luzzatto, L, Notaro, R, Karadimitris, A

“…The mechanism of bone marrow failure (BMF) in paroxysmal nocturnal hemoglobinuria (PNH) is not yet known. …”

A KLF2-BMPER-Smad1/5 checkpoint regulates high fluid shear stress-mediated artery remodeling by Deng, H, Zhang, J, Wang, Y, Joshi, D, Pi, X, De Val, S, Schwartz, MA

“…Here we report that high FSS suppresses Smad1/5 by elevating KLF2, which induces the bone morphogenetic protein (BMP) pathway inhibitor, BMP-binding endothelial regulator (BMPER), thereby de-inhibiting Akt. …”

Recent advancements in additively manufactured hip implant design using topology optimization technique by Noman, Abdulla All, Mohd Shamil, Shaari, Mehboob, Hassan, Abdul Hadi, Azman

“…The recent advancement of additive manufacturing (AM) offers many benefits for the medical sector, which is revolutionizing modern bone repair surgery for patients, including those with damaged hip joints. …”
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Optimisation of stamp compliance for nanoimprint lithography : an experimental and simulation investigation of deformation of Polydimethylsiloxane (PDMS) and Ultraviolet Curable Po... by Ong, Zongjue

“…This simulation is used to predict the deformation of the mold layer for nano-­‐imprint processes under variable conditions such as: 1) Different loading pressure 2) Different modulus of material 3) Different aspect ratio of structure 4) Bulging behavior with different materials For simulation to be accurate, mechanical properties of the materials are obtained by doing tensile tests on five dog-­‐bone samples of each material to acquire the engineering stress–strain curve. …”
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Electrospun composite nanofibers and their multifaceted applications by Sahay, Rahul, Kumar, Palaniswamy Suresh, Sridhar, R., Sundaramurthy, Jayaraman, Venugopal, J., Mhaisalkar, Subodh Gautam, Ramakrishna, Seeram

“…Nanofibrous materials that mimic the native extracellular matrix (ECM) and promote the adhesion of various cells are being developed as tissue-engineered scaffolds for the skin, bone, vasculature, heart, cornea, nervous system and other tissues. …”
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Selective advantage of mutant stem cells in human clonal hematopoiesis is associated with attenuated response to inflammation and aging by Jakobsen, NA, Turkalj, S, Zeng, AGX, Stoilova, B, Metzner, M, Rahmig, S, Nagree, MS, Shah, S, Moore, R, Usukhbayar, B, Angulo Salazar, M, Gafencu, G-A, Kennedy, A, Newman, S, Kendrick, BJL, Taylor, AH, Afinowi-Luitz, R, Gundle, R, Watkins, B, Wheway, K, Beazley, D, Murison, A, Aguilar-Navarro, AG, Flores-Figueroa, E, Dakin, SG, Carr, AJ, Nerlov, C, Dick, JE, Xie, SZ, Vyas, P

“…To gain insight into how CH mutations enable gradual clonal expansion, we used single-cell multi-omics with high-fidelity genotyping on human CH bone marrow (BM) samples. Most of the selective advantage of mutant cells occurs within HSCs. …”

Mycoplasma iowae infection in young Turkeys by Bradbury, Janet M., Ideris, Aini, OO, Tin Tun

“…One group was infected orally at one day of age and some birds developed bone and joint abnormalities but another group, infected via both the thoracic air sac and the foot pad, also at one day of age, developed a higher incidence of these abnormalities, which included chondrodystrophy, rotated tibia, deviated toes and, in a few cases, erosion of the articular cartilage of the hock joint. …”
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Investigating molecular vulnerabilities in TP53-mutant transformed myeloproliferative neoplasms by Paterson, A

“…To validate the selective requirement of PCBP2 in <em>TP53</em>-mutant LSC, I adopted a human bone marrow organoid model which I showed to outperform liquid culture conditions in supporting the survival and proliferation of <em>TP53</em>-sAML samples. …”