Mechano-responsive hydrogel for direct stem cell manufacturing to therapy by Shou, Yufeng, Liu, Ling, Liu, Qimin, Le, Zhicheng, Lee, Khang Leng, Li, Hua, Li, Xianlei, Koh, Dion Zhanyun, Wang, Yuwen, Liu, Tong Ming, Yang, Zheng, Lim, Chwee Teck, Cheung, Christine, Tay, Andy

“…Bone marrow-derived mesenchymal stem cell (MSC) is one of the most actively studied cell types due to its regenerative potential and immunomodulatory properties. …”
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Capturing the fantastic voyage of monocytes through time and space by Teh, Ye Chean, Ding, Jeak Ling, Ng, Lai Guan, Chong, Shu Zhen

“…After birth, monocytes arise from bone marrow (BM)-derived HSCs and are released into the circulation upon their maturation, where they survey peripheral tissues and maintain endothelial integrity. …”
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Chemical analysis of silica doped hydroxyapatite biomaterials consolidated by a spark plasma sintering method by Xu, Jinling, Khor, Khiam Aik

“…HA was prepared with 0, 1, 3 and 5 wt% silica, which are comparable to the measured silicon content of natural bone. After spray drying into micron sized powders, the silica doped HA (SiHA) powders were consolidated at 1000 C with a dwell time of 3 min using a spark plasma sintering (SPS) technique. …”
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Investigating molecular vulnerabilities in TP53-mutant transformed myeloproliferative neoplasms by Paterson, A

“…To validate the selective requirement of PCBP2 in <em>TP53</em>-mutant LSC, I adopted a human bone marrow organoid model which I showed to outperform liquid culture conditions in supporting the survival and proliferation of <em>TP53</em>-sAML samples. …”

Kinematic analysis of an upper extremity stroke rehabilitation orthosis by Yang, Fang

“…This method also has some deficiencies, due to lack of the actual hand anatomy data for Singapore’s stroke patient, especially the joint angle of each finger bone, some assumptions and estimations are made. …”
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Development of bioactive PCL films using low temperature solvent free method by Lim, Lynette Sihui

“…In conclusion, based on the evaluation of the results, 10% MgCl2 has the potential to be developed as a bone scaffold.…”
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Molecular genetics of Dupuytren’s contracture by Aissvarya, Shankar, Ling, King-Hwa, Arumugam, Manohar, Thilakavathy, Karuppiah

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Mechanism of damnacanthal induced apoptosis in CEM-SS cell line by Gopalsamy, Banulata, Saiful Yazan, Latifah, Abdul Hamid, Hisyam

“…Leukaemia, is cancer of organs that is responsible to produce blood specifically the lymphatic system and bone marrow. Due to the harsh effects of currently used cancer drugs, damnacanthal, an anthraquinone obtained from the roots of Morinda elliptica is tested as a potential anticancer agent. …”
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Fracture energy and mechanical properties of toughened epoxy resin with eggshell powder by Fong, Collin, Sugiman, Sugiman, Chin, Desmond, Ahmad, Hilton

“…The material properties and fracture energy of toughened epoxy with eggshell powder (TEEP) were measured and investigated. Dog-bone specimens were fabricated to investigate the mechanical properties of TEEP (i.e. elastic modulus, Poisson’s ratios and tensile strength) and tested under quasi-static tensile loading. …”
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An implantable piezoelectric ultrasound stimulator (ImPULS) for deep brain activation by Hou, Jason F, Nayeem, Md Osman Goni, Caplan, Kian A, Ruesch, Evan A, Caban-Murillo, Albit, Criado-Hidalgo, Ernesto, Ornellas, Sarah B, Williams, Brandon, Pearce, Ayeilla A, Dagdeviren, Huseyin E, Surets, Michelle, White, John A, Shapiro, Mikhail G, Wang, Fan, Ramirez, Steve, Dagdeviren, Canan

“…Ultrasound can aid in energy propagation, but transcranial ultrasound stimulation in the deep brain has limited spatial resolution caused by bone and tissue scattering. Here, we report an implantable piezoelectric ultrasound stimulator (ImPULS) that generates an ultrasonic focal pressure of 100 kPa to modulate the activity of neurons. …”
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Finite element analysis of shoulder rotator cuff by Lee, Kenneth Jun Rui.

“…Material properties and connections between the tendons and the bone have been defined using the ANSYS software. …”
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Effectiveness of supervised versus self-directed rehabilitation for adults aged 50 years and over with ankle fractures: protocol for the AFTER trial by Keene, DJ, Achten, J, Forde, C, Png, ME, Grant, R, Draper, K, Appelbe, D, Tutton, E, Peckham, N, Dutton, SJ, Lamb, SE, Costa, ML

Prevalence of complications in older adults after hip fracture surgery: a systematic review and meta-analysis by Goh, EL, Khatri, A, Costa, A, Ting, A, Steiner, K, Png, ME, Metcalfe, D, Cook, J, Costa, M

Global availability of medications and health technologies for kidney care: A multinational study from the ISN-GKHA by Kelly, DM, Jones, ESW, Barday, Z, Arruebo, S, Caskey, FJ, Damster, S, Donner, J, Jha, V, Levin, A, Nangaku, M, Saad, S, Tonelli, M, Ye, F, Okpechi, IG, Bello, AK, Johnson, DW

“…There was reduced capacity for the management of CKD mineral bone disease in low-income countries (LICs) - serum parathyroid hormone was available in only 26% (n = 5) of LICs and the ability to administer non-calcium-based phosphate binders and cinacalcet was also very limited in LICs [16% (n = 3) and 5% (n = 1), respectively]. …”

Direct reuse of electronic plastic scraps from computer monitor and keyboard to direct stem cell growth and differentiation by Shi, Pujiang, Tan, Chiew Kei, Wu, Zhuoran, Gabriel, Jean-Christophe P., Srinivasan, Madhavi, Lee, Jong-Min, Tay, Chor Yong

“…Interestingly, compared to commercial tissue-culture treated plastics and in a competitive adipogenic and osteogenic differentiation environment, ADSCs cultured on the keyboard and light diffuser plastics favoured bone cells formation while the grating-like microstructures of the prismatic sheet promoted fat cells differentiation via the process of contact guidance. …”
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Biomechanical study on arthroscopic biceps tenodesis fixation techniques by Lim, Gideon Boon Hao

“…The interference screw fixation used in the procedure is said to provide stiffer construct but fails catastrophically in osteoporotic bones. Thus, it is important to find the best repair technique among the two different techniques through biomechanical experiments. …”
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Musculoskeletal regeneration: a zebrafish perspective by Kaliya-Perumal, Arun-Kumar, Ingham, Philip William

“…Upon muscle injury, quiescent stem cells - known as satellite cells - become activated, proliferate, differentiate and fuse to form new myofibres, while bone fracture results in a phased response involving hematoma formation, inflammation, fibrocartilaginous callus formation, bony callus formation and remodelling. …”
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Optimised “green solvent” extraction of long-chain menaquinones (Vitamin K2) from wet Lactococcus lactis biomass by Lee, Sze Ying, Hu, Xiao, Stuckey, David C.

“…Menaquinone (vitamin K2) is an essential fat-soluble vitamin for bone and cardiovascular health. Long-chain menaquinones are exclusively synthesised by bacteria, and Lactococcus lactis appears promising as a microbial production platform. …”
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Hydroxyapatite nanoparticles-cell interaction: new approaches to disclose the fate of membrane-bound and internalised nanoparticles by Bonany, Mar, Pérez-Berná, Ana Joaquina, Dučić, Tanja, Pereiro, Eva, Martin-Gómez, Helena, Mas-Moruno, Carlos, van Rijt, Sabine, Zhao, Zhitong, Espanol, Montserrat, Ginebra, Maria-Pau

“…Hydroxyapatite nanoparticles are popular tools in bone regeneration, but they have also been used for gene delivery and as anticancer drugs. …”
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Evaluating the effect of rapamycin treatment in Alzheimer’s disease and aging using in vivo imaging: the ERAP phase IIa clinical study protocol by Svensson, Jonas E., Bolin, Martin, Thor, Daniel, Williams, Pete A., Brautaset, Rune, Carlsson, Marcus, Sörensson, Peder, Marlevi, David, Spin-Neto, Rubens, Probst, Monika, Hagman, Göran, Morén, Anton Forsberg, Kivipelto, Miia, Plavén-Sigray, Pontus

“…As exploratory outcomes, the study will assess change in multiple age-related pathological processes, such as periodontal inflammation, retinal degeneration, bone mineral density loss, atherosclerosis and decreased cardiac function. …”
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