Observations on the deprotection of pinanediol and pinacol boronate esters via fluorinated intermediates. by Inglis, SR, Woon, E, Thompson, A, Schofield, C

“…Methods for the deprotection of pinanediol and pinacol esters of various boronic acids via fluoroborane intermediates were evaluated. …”

A simple generic method for analyzing water sensitive pinacol boronate compounds by hydrophilic interaction liquid chromatography by Lulu Dai, Joseph Gonzalez, Kelly Zhang

“…On the other hand, boronic acids are polar compounds and difficult to be retained in RPLC. …”
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An approach to enzyme inhibition employing reversible boronate ester formation by Leung, I, Jr, B, Schofield, C, Claridge, T, Brown, T

“…NMR techniques (¹¹B NMR and ¹H waterLOGSY) were used to observe ternary complexes of boronic acids, sugars and α-chymotrypsin, and were useful for distinguishing preferentially binding combinations of boronic acids and sugars. …”

Diboron-enabled high-precision protein engineering by Mollner, T

“… <p>Boronic acids are versatile synthetic building blocks, widely applied in molecular sensing applications and have more recently attracted attention as warheads in medicinal chemistry. …”

Anticancer-active 3,4-diarylthiolated maleimides synthesis via three-component radical diarylthiolation by Limei Wang, Zhuo Li, Zhehan Ma, Kedi Xia, Wenyu Wang, Wenchang Yu

“…Herein, we report an efficient and simple copper-catalyzed oxidative diarylthiolation of maleimides with sulfur powder and aryl boronic acids, in which S powder was used as a substrate and internal oxidant. …”
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Enantio- and diastereoselective Suzuki-Miyaura coupling with racemic bicycles by Goetzke, F, Mortimore, M, Fletcher, S

“…Herein, we describe a rhodium‐catalyzed enantio‐ and diastereoselective Suzuki–Miyaura cross‐coupling between racemic fused bicyclic allylic chlorides and boronic acids. The highly stereoselective transformation allows for the coupling of aryl, heteroaryl, and alkenyl boronic acids and gives access to functionalized bicyclic cyclopentenes, which can be converted into other five‐membered‐ring scaffolds with up to five contiguous stereocenters. …”

New late-stage strategies towards difluoromethylarenes by Sap, JBI

“…In <strong>Chapter IV</strong>, a facile and robust radiochemical methodology for PET describing the synthesis of 18F-difluoromethylarenes from aryl boronic acids, ethyl bromofluoroacetate and cyclotron produced [18F]fluoride is presented. …”

Synthesis of sulfur-containing organic compounds: sulfones, sulfonamides and benzoisothiazoles by Chen, Y

“…A wide range of aryl and alkenyl boronic acids are coupled with aryl and alkenyl iodides to give the corresponding sulfones. …”

Synthesis of poly(para-phenylenevinylene) rotaxanes by aqueous Suzuki coupling. by Terao, J, Tang, A, Michels, J, Krivokapic, A, Anderson, H

“…PPV-based polyrotaxanes have been prepared by coupling vinyl boronic acids to aryl iodides in the presence of cyclodextrins, and the crystal structure of a [2]rotaxane of this type has been determined.…”

Direct copper-catalyzed three-component synthesis of sulfonamides by Chen, Y, Murray, P, Davies, A, Willis, M

“…The reaction tolerates broad variation in both coupling partners, including aryl, heteroaryl and alkenyl boronic acids, as well as cyclic and acyclic alkyl secondary amines, and primary anilines. …”

Tandem intermolecular Suzuki coupling/intramolecular vinyl triflate-arene coupling by Willis, M, Claverie, C, Mahon, M

“…Treatment of a benzyl substituted meso-ditriflate with boronic acids in the presence of palladium acetate, triphenylphosphine and caesium fluoride results in intermolecular Suzuki coupling followed by vinyl triflate-arene cyclisation to provide, in high yields, single regioisomers of tricyclic-carbocycles.…”

Tandem intermolecular Suzuki coupling/intramolecular vinyl triflate-arene coupling. by Willis, M, Claverie, C, Mahon, M

“…Treatment of a benzyl substituted meso-ditriflate with boronic acids in the presence of palladium acetate, triphenylphosphine and caesium fluoride results in intermolecular Suzuki coupling followed by vinyl triflate-arene cyclisation to provide, in high yields, single regioisomers of tricyclic-carbocycles.…”

Will morphing boron-based inhibitors beat the β-lactamases? by Krajnc, A, Lang, P, Panduwawala, T, Brem, J, Schofield, C

“…Although β-lactam and non-β-lactam inhibitors forming stable acyl-enzyme complexes with nucleophilic serine β-lactamases (SBLs) are widely used, these are increasingly susceptible to evolved SBLs and do not inhibit metallo-β-lactamases (MBLs). Boronic acids and boronate esters, especially cyclic ones, can potently inhibit both SBLs and MBLs. …”

Rewriting the bacterial glycocalyx via Suzuki-Miyaura cross-coupling by Spicer, C, Davis, B

“…Suzuki-Miyaura cross-coupling has been used to couple novel carbohydrate-based boronic acids, site-selectively, to the surface of E. coli at an unnatural amino acid. …”

Room Temperature Aryl Trifluoromethylation via Copper- Mediated Oxidative Cross-Coupling by Buchwald, Stephen Leffler, Senecal, Todd D., Parsons, Andrew

“…A method for the room temperature copper-mediated trifluoromethylation of aryl and heteroaryl boronic acids has been developed. This protocol is amenable to normal benchtop setup and reactions typically require only 1−4 h. …”
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A General Method for Suzuki–Miyaura Coupling Reactions Using Lithium Triisopropyl Borates by Buchwald, Stephen Leffler, Oberli, Matthias

“…These borate species are much more stable toward protodeboronation than the corresponding boronic acids and can conveniently be stored on benchtop at room temperature.…”
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Synthesis of 2,2-difluoro-2-arylethylamines as fluorinated analogs of octopamine and noradrenaline by Tarui Atsushi, Kamata Erika, Ebisu Koji, Kawai Yui, Araki Ryota, Yabe Takeshi, Karuo Yukiko, Sato Kazuyuki, Kawai Kentaro, Omote Masaaki

“…The syntheses of these compounds were performed by a Suzuki–Miyaura cross-coupling reaction of 4-(bromodifluoroacetyl)morpholine with aryl boronic acids to produce the intermediate 2,2-difluoro-2-arylacetamides, followed by transformation of difluoroacetamide to difluoroethylamine.…”
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Reactions of 3-amino-1,2,4-triazine with coupling reagents and electrophiles by Bvumbi Mpelegeng Victoria, Nemudzivhadi Anza Imanuel, Sengane Musiiwa Victoria, Moleele Simon Mnyakeni

“…Analogs of a new heterocyclic system were obtained from the reactions of 3-amino-1,2,4-triazine with coupling reagents such as boronic acids, and terminal alkynes in the presence of a palladium catalyst. …”
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Organophosphorus-Catalyzed Reductive Functionalization of Nitrocompounds via P(III)/P(V) Redox Couple by Li, Gen

“…With the utilization of geometric-distorted organophosphetanes as catalysts and hydrosilanes as terminal reductants, nitro compounds (nitroarenes, nitromethane and nitroalkanes) undergo reductive O-atom transfer reactions involving the conversion of P(III)/P(V)=O. With that, boronic acids were employed as coupling partners to intercept the nitrene reactivity of nitro compounds derived oxazaphosphorane intermediates for direct reductive C–N coupling. …”
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Rapid synthesis of the Taxol core by Thomas, P

“…</p> <p>The second part of this thesis builds on the Rh-catalysed asymmetric coupling of boronic acids (vinyls, benzenes and heteroaromatics) and cyclic allyl chlorides, developed in the Fletcher group. …”