Highly Luminescent 4<i>H</i>-1,2,4-Triazole Derivatives: Synthesis, Molecular Structure and Photophysical Properties by Monika Olesiejuk, Agnieszka Kudelko, Marcin Świątkowski

“…The described methodology allows one to conduct the coupling reaction with the use of commercially available boronic acids in the presence of conventional solvents or ionic liquids and produced excellent yields. …”
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P(III)/P(V)-Catalyzed Methylamination of Arylboronic Acids and Esters: Reductive C–N Coupling with Nitromethane as a Methylamine Surrogate by Li, Gen, Qin, Ziyang, Radosevich, Alexander T

“…This method operates by the action of a small ring organophosphorus-based catalyst (1,2,2,3,4,4-hexamethylphosphetane P-oxide) together with a mild terminal reductant hydrosilane to drive the selective installation of the methylamino group to (hetero)aromatic boronic acids and esters. This method also provides for a unified synthetic approach to isotopically labeled N-methylanilines from various stable isotopologues of nitromethane (i.e., CD3NO2, CH315NO2, and 13CH3NO2), revealing this easy-to-handle compound as a versatile precursor for the direct installation of the methylamino group.…”
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Structural basis of metallo-β-lactamase, serine-β-lactamase and penicillin-binding protein inhibition by cyclic boronates by Brem, J, Cain, R, Cahill, S, McDonough, M, Clifton, I, Jiménez-Castellanos, J, Avison, M, Spencer, J, Fishwick, C, Schofield, C

“…Pioneering work revealed that acyclic boronic acids can act as 'transition state analogue' inhibitors of nucleophilic serine enzymes, including serine-β-lactamases. …”

Structural and kinetic studies on beta-lactamase mechanism and inhibition by Cahill, S

“…In the work described herein, cyclic boronic acids were explored as a chemotype with inhibitory activity against the two mechanistic classes of beta-lactamase and are shown to be potent inhibitors of both. …”

Synthesis and Herbicidal Activity of Phenylpyridines – A New Lead by Peter Schäfer, Gerhard Hamprecht, Michael Puhl, Karl-Otto Westphalen, Cyrill Zagar

“…Their preparation follows Suzuki-type coupling conditions of reactive 2-chloro-pyridines with appropriate 2,5-substituted 4-chloro-phenyl boronic acids. Depending on the nature of substituents in the pyridine, and in particular the phenyl group, a large number of derivatives are readily accessible. …”
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The synthesis and applications of a biaryl-based asymmetric phosphine ligand by Hirai, Satoko

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Development of Facile and Simple Processes for the Heterogeneous Pd-Catalyzed Ligand-Free Continuous-Flow Suzuki–Miyaura Coupling by Tsuyoshi Yamada, Jing Jiang, Naoya Ito, Kwihwan Park, Hayato Masuda, Chikara Furugen, Moeka Ishida, Seiya Ōtori, Hironao Sajiki

“…A continuous-flow ligand-free Suzuki–Miyaura coupling reaction of (hetero)aryl iodides, bromides, and chlorides with (hetero)aryl boronic acids was developed using cartridges packed with spherical resin (tertiary amine-based chelate resin: WA30)-supported palladium catalysts (7% Pd/WA30). …”
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A Facile One-Pot Synthesis of New Poly Functionalized Pyrrolotriazoles via a Regioselective Multicomponent Cyclisation and Suzuki–Miyaura Coupling Reactions by Simon Garnier, Kévin Brugemann, Agnieszka Zak, Johnny Vercouillie, Marie Potier-Cartereau, Mathieu Marchivie, Sylvain Routier, Frédéric Buron

“…Palladium-catalyzed cross-coupling conditions were optimized and a representative library of various boronic acids was employed to establish the scope and limitations of the method.…”
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Part I: Catalytic asymmetric arylation of esters for profen synthesis. Part II: Fast Suzuki coupling of heteroaryl chlorides by Yang, Junfeng

“…Part two describes a new catalytic system for Suzuki-Miyaura coupling of heteroaryl chlorides and heteroayl boronic acids. Most of the major families of heteroaryl chlorides can reached full conversion within minutes to hours at room temperature. …”
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Rhodium-catalysed asymmetric allylic arylation of racemic halides with arylboronic acids by Sidera, M, Fletcher, SP

“…For electron-deficient, electron-rich or ortho-substituted boronic acids better results are obtained with racemic allyl bromides. …”

Asymmetric Suzuki-Miyaura coupling of heterocycles via Rhodium-catalysed allylic arylation of racemates by Schäfer, P, Palacin, T, Sidera Portela, M, Fletcher, S

“…We show that pyridine boronic acids are unsuitable, but they can be halogen-modified at the 2-position to undergo reaction, and this halogen can then be removed or used to facilitate further reactions. …”

Efficient Access to 3,5-Disubstituted 7-(Trifluoromethyl)pyrazolo[1,5-<i>a</i>]pyrimidines Involving S<i>_N</i>Ar and Suzuki Cross-Coupling Reactions by Badr Jismy, Abdellatif Tikad, Mohamed Akssira, Gérald Guillaumet, Mohamed Abarbri

“…In C-5 position, a S<i>_N</i>Ar type reaction was achieved by first activating the C–O bond of the lactam function with PyBroP (Bromotripyrrolidinophosphonium hexafluorophosphate), followed by the addition of amine or thiol giving monosubstituted derivatives, whereas in C-3 position, arylation was performed via Suzuki–Miyaura cross-coupling using the commercially available aromatic and heteroaromatic boronic acids. Moreover, trifluoromethylated analogues of potent Pim1 kinase inhibitors were designed following our concise synthetic methodology.…”
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Dioxygen compatible electron donor-acceptor catalytic system and its enabled aerobic oxygenation by Jialiang Wei, Junhong Meng, Caifang Zhang, Yameng Liu, Ning Jiao

“…Furthermore, this visible-light mediated oxidative EDA protocol is successfully applied in the aerobic oxygenation of boronic acids. We believe that this photochemical dioxygen activation strategy enabled by EDA complex not only provides a practical approach to aerobic oxygenation but also promotes the design and application of EDA photocatalysis under ambient conditions.…”
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Structure-guided design of cell wall biosynthesis inhibitors that overcome β-lactam resistance in Staphylococcus aureus (MRSA). by Contreras-Martel, C, Amoroso, A, Woon, E, Zervosen, A, Inglis, S, Martins, A, Verlaine, O, Rydzik, A, Job, V, Luxen, A, Joris, B, Schofield, C, Dessen, A

“…We have identified alkyl boronic acids that are active against pathogens including methicillin-resistant S. aureus (MRSA). …”

A ‘Defective’ Conjugated Porous Poly-Azo as Dual Photocatalyst by Ipsita Nath, Jeet Chakraborty, Sara Abednatanzi, Pascal Van Der Voort

“…Herein we report the synthesis and characterization of an azobenzene-based organic π–conjugated porous polymer (AzoCPP) as heterogeneous dual photocatalyst manifesting net-oxidative bromination of arenes and dehydroxylation of boronic acids to corresponding phenols. Hierarchical porosity and high surface area of the nano-sized AzoCPP allowed superior catalyst-substrate contact during catalyses, whereas the inherent structural defect present in the CPP backbone resulted in low-energy sinks functioning as <i>de facto</i> catalytic sites. …”
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Direct Utilization of Near-Infrared Light for Photooxidation with a Metal-Free Photocatalyst by Le Zeng, Zhonghe Wang, Tiexin Zhang, Chunying Duan

“…Herein we utilize a metal-free boron dipyrromethene (BODIPY) derivative as the photocatalyst to achieve NIR light (720 nm LED)–driven oxidation of benzylamine derivatives, sulfides, and aryl boronic acids. Compared to blue light–driven photooxidation using Ru(bpy)₃Cl₂ as a photocatalyst, NIR light–driven photooxidation exhibited solvent independence and superior performance in large-volume (20 mL) reaction, presumably thanks to the neutral structure of a BODIPY photocatalyst and the deeper penetration depth of NIR light. …”
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Regioselective Synthesis of New Family of 2-Substituted 1,2,3-Triazoles and Study of Their Fluorescent Properties by Vasiliy M. Muzalevskiy, Zoia A. Sizova, Valentine G. Nenajdenko

“…Chan–Lam reaction of the 5-aryl-4-trifluoroacetyltriazoles with boronic acids afforded 2-aryltriazoles as single isomers in up to 89% yield. …”
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N-Arylation of protected and unprotected 5-Bromo-2-aminobenzimidazole as organic material: Non-Linear Optical (NLO) properties and structural feature determination through computat... by Mumtaz, Mubeen, Rasool, Nasir, Ahmad, Gulraiz, Kosar, Naveen, Rashid, Umer

“…Here, in this study, Cu(II)-catalyzed selective N-arylation of 2-aminobenzimidazoles derivatives were achieved in the presence of different bases Et3N/TMEDA, solvents DCM/MeOH/H2O, and various aryl boronic acids under open atmospheric conditions. Two different copper-catalyzed pathways were selected for N-arylation in the presence of active nucleophilic sites, providing a unique tool for the preparation of NLO materials, C-NH (aryl) derivatives of 2-aminobenzimidazoles with protection and without protection of NH2 group. …”

High-throughput crystallography reveals boron-containing inhibitors of a penicillin-binding protein with di- and tricovalent binding modes by Newman, H, Krajnc, A, Bellini, D, Eyermann, CJ, Boyle, GA, Paterson, NG, McAuley, KE, Lesniak, R, Gangar, M, Brem, J, Schofield, CJ, von Delft, F, Chibale, K, Dowson, CG

“…Multiple crystal structures reveal that boronic acids react with PBPs to give tricovalently linked complexes bonded to Ser294, Ser349, and Lys484 of PaPBP3; benzoxaboroles react with PaPBP3 via reaction with two nucleophilic serines (Ser294 and Ser349) to give dicovalently linked complexes; and vaborbactam reacts to give a monocovalently linked complex. …”

Mechanistic investigation of Rh(i)-catalysedasymmetric Suzuki–Miyaura coupling withracemic allyl halides by Van Dijk, LL, Ardkhean, R, Sidera, M, Karabiyikoglu, S, Sari, Ö, Claridge, T, Lloyd-Jones, G, Paton, R, Fletcher, S

“…Here we propose a catalytic cycle for the highly enantioselective Rh(I)-catalysed Suzuki–Miyaura coupling of boronic acids and racemic allyl halides. Natural abundance 13C kinetic isotope effects provide quantitative information about the transition-state structures of two key elementary steps in the catalytic cycle, transmetallation and oxidative addition. …”