Bradykinin does not mediate remote ischaemic preconditioning or ischaemia-reperfusion injury in vivo in man. by Pedersen, C, Schmidt, MR, Barnes, G, Bøtker, H, Kharbanda, R, Newby, D, Cruden, N

“…OBJECTIVE: To examine whether endogenous bradykinin mediates the endothelium-dependent vasomotor dysfunction induced by ischaemia-reperfusion injury, or the protection afforded by remote ischaemic preconditioning in vivo in man. …”

Can’t Intubate, Can’t Oxygenate: A Rare Case of a Difficult Airway due to Nonhereditary Angioedema by Điđi Delalić, Vinko Borčić, Ingrid Prkačin

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Autocrine Bradykinin Release Promotes Ischemic Preconditioning-Induced Cytoprotection in Bovine Aortic Endothelial Cells by Alessandro Bellis, Daniela Sorriento, Antonella Fiordelisi, Raffaele Izzo, Junichi Sadoshima, Ciro Mauro, Federica Cerasuolo, Costantino Mancusi, Emanuele Barbato, Emanuele Pilato, Bruno Trimarco, Carmine Morisco

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In vitro comparison of bradykinin degradation by aliskiren, a renin inhibitor, and an inhibitor of angiotensin-converting enzyme by Kusumam Joseph, Tracy E Tholanikunnel, Allen P Kaplan

“…We determined whether aliskiren, a renin inhibitor, has an effect on the rate of bradykinin degradation. Methods: The ability of renin to metabolize bradykinin was studied and the rate of bradykinin degradation compared in the presence or absence of aliskiren. …”
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The des-Arg9-bradykinin/B1R axis: Hepatic damage in COVID-19 by Gabriel Moreira de M Mendes, Gabriel Moreira de M Mendes, Israel Júnior Borges Do Nascimento, Israel Júnior Borges Do Nascimento, Paulo HS. Marazzi-Diniz, Izabela B. Da Silveira, Izabela B. Da Silveira, Matheus F. Itaborahy, Matheus F. Itaborahy, Luiz E. Viana, Luiz E. Viana, Filipe A. Silva, Monique F Santana, Rebecca AA. Pinto, Bruna G. Dutra, Marcus Vinicius G. Lacerda, Stanley A. Araujo, David Wanderley, Paula VT. Vidigal, Paulo HC Diniz, Thiago Verano-Braga, Robson AS. Santos, M Fatima Leite

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Bradykinin enhances membrane electrical activity of pancreatic beta cells in the presence of low glucose concentrations by A.S. Moura

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Bradykinin and adenosine receptors mediate desflurane induced postconditioning in human myocardium: role of reactive oxygen species by Gérard Jean-Louis, Massetti Massimo, Babatasi Gérard, Ivascau Calin, Rouet René, Buléon Clément, Lemoine Sandrine, Hanouz Jean-Luc

“…We investigated the role of adenosine and bradykinin receptors, and generation of radical oxygen species in desflurane-induced postconditioning in human myocardium.…”
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Redox Regulation of Microvascular Permeability: IL-1β Potentiation of Bradykinin-Induced Permeability Is Prevented by Simvastatin by Felipe Freitas, Eduardo Tibiriçá, Mita Singh, Paul A. Fraser, Giovanni E. Mann

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A Systematic Review of Molecular Imaging Agents Targeting Bradykinin B1 and B2 Receptors by Joseph Lau, Julie Rousseau, Daniel Kwon, François Bénard, Kuo-Shyan Lin

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A mechanistic model and therapeutic interventions for COVID-19 involving a RAS-mediated bradykinin storm by Michael R Garvin, Christiane Alvarez, J Izaak Miller, Erica T Prates, Angelica M Walker, B Kirtley Amos, Alan E Mast, Amy Justice, Bruce Aronow, Daniel Jacobson

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Effect of 3-substituted 1,4-benzodiazepin-2-ones on bradykinin-induced smooth muscle contraction by P. A. Virych, O. V. Shelyuk, T. A. Kabanova, E. I. Khalimova, V. S. Martynyuk, V. I. Pavlovsky, S. A. Andronati

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Discovery of a Bradykinin B2 Partial Agonist Profile of Raloxifene in a Drug Repurposing Campaign by Patricia Gomez-Gutierrez, Juan J. Perez

Subjects: “…nonpeptide bradykinin partial agonist…”
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Reduced hepatic bradykinin degradation accounts for cold-induced BAT thermogenesis and WAT browning in male mice by Fei Xiao, Haizhou Jiang, Zi Li, Xiaoxue Jiang, Shanghai Chen, Yuguo Niu, Hanrui Yin, Yousheng Shu, Bo Peng, Wei Lu, Xiaoying Li, Zhigang Li, Shujue Lan, Xiaoyan Xu, Feifan Guo

“…A bolus of anti-bradykinin antibodies reduces body temperature during acute cold exposure, whereas bradykinin has the opposite effect. …”
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Hypersensitivity Induced by Intrathecal Bradykinin Administration Is Enhanced by N-oleoyldopamine (OLDA) and Prevented by TRPV1 Antagonist by Eva Uchytilova, Diana Spicarova, Jiri Palecek

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Bixa orellana leaves extract inhibits bradykinin-induced inflammation through suppression of nitric oxide production by Yong, Yoke Keong, Abdul Kadir, Arifah, Sukardi, Sabrina, Abd Hamid @ Abdul Razak, Roslida, Somchit, Muhammad Nazrul, Ahmad, Zuraini

“…Results: Pretreatment with AEBO for 4 consecutive days exhibited significant inhibitory activity against inflammatory models, the bradykinin-induced hind paw edema model and bradykinin-induced increased peritoneal vascular permeability at both doses in dose-dependent manner. …”
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Effect of valsartan and captopril in rabbit carotid injury. Possible involvement of bradykinin in the antiproliferative action of the renin-angiotensin blockade by Tong Chuang Feng, Wang Yui Ying, Ren Jang Hua, Yale Y Ji, Marc de Gasparo

“…In untreated animals, 6-keto-PGF 1 -alpha levels decreased slightly after injury, but for both the captopril and valsartan groups, there were significant increases in levels of this prostaglandin derivative, effects attributed to the action of bradykinins. Levels were highest in the captopril-treated animals. …”
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Over diagnosis of bradykinin angioedema in patients treated with angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers by Marie Douillard, MD, Zineb Deheb, MD, Agathe Bozon, MD, Nadia Raison-Peyron, MD, Olivier Dereure, MD, PhD, Lionel Moulis, MD, Angèle Soria, MD, PhD, Aurélie Du-Thanh, MD, PhD

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Role of Bradykinin and Mas Receptor Blockade in Renal Vascular Responses to Angiotensin 1-7 in Adult Female Rats by Shadan Saberi, Mehdi Nematbakhsh, Aghdas Dehghani

“…Materials and methods: Female Wistar rats were divided into three groups (control, Bradykinine, and Bradykinin + MasR antagonist (A779)). …”
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Novel Bradykinin Receptor Inhibitors Inhibit Proliferation and Promote the Apoptosis of Hepatocellular Carcinoma Cells by Inhibiting the ERK Pathway by Yiou Wang, Bingxue Zhang, Yibing Huang, Wenjun Yao, Fei Tao, Yuxin Chen

Subjects: “…bradykinin receptor inhibitor…”
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Endoplasmic Reticulum Is a Key Organella in Bradykinin-Triggered ATP Release From Cultured Smooth Muscle Cells by Yumei Zhao, Keisuke Migita, Chiemi Sato, Sadaharu Usune, Takahiro Iwamoto, Takeshi Katsuragi

“…It was found that bradykinin also increased the production of Ins(1,4,5)P3 and 2-APB-inhibitable [Ca2+]i. …”
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