Veno-Arterial Extracorporeal Membrane Oxygenation (ECMO) Impairs Bradykinin-Induced Relaxation in Neonatal Porcine Coronary Arteries by Livia Provitera, Giacomo S. Amelio, Matteo Tripodi, Genny Raffaeli, Francesco Macchini, Ilaria Amodeo, Silvia Gulden, Valeria Cortesi, Francesca Manzoni, Gaia Cervellini, Andrea Tomaselli, Gabriele Zuanetti, Caterina Lonati, Michele Battistin, Shady Kamel, Valeria Parente, Valentina Pravatà, Stefania Villa, Eduardo Villamor, Fabio Mosca, Giacomo Cavallaro

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Relationship of Bradykinin B2 Receptor Gene C-58T Variation with Total-Cholesterol and Glucose in Essential Hypertension by Belgin SÜSLEYİCİ, Meliha KOLDEMİR GÜNDÜZ, Seniyye Ülgen ZENGİN, Penbe ÇAĞATAY, Hasan Mert BOZKUŞ, Nur BAKIR, Mustafa TAŞKIN

Subjects: “…Bradykinin…”
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Bradykinin-Induced Sensitization of Transient Receptor Potential Channel Melastatin 3 Calcium Responses in Mouse Nociceptive Neurons by Marc Behrendt, Hans Jürgen Solinski, Martin Schmelz, Richard Carr

“…However, in isolated dorsal root ganglion (DRG) neurons application of inflammatory mediators like prostaglandins and bradykinin (BK) inhibit TRPM3. Therefore, the aim of this study was to examine the effect of preceding activation of cultured 1 day old mouse DRG neurons by the inflammatory mediator BK on TRPM3-mediated calcium responses. …”
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Molecular Bases of Serotonin Reuptake Inhibitor Antidepressant-Attributed Effects in COVID-19: A New Insight on the Role of Bradykinins by Ahmed S. Gouda, Bruno Mégarbane

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The bradykinin B2 receptor induces multiple cellular responses leading to the proliferation of human renal carcinoma cell lines by Kramarenko II, Morinelli TA, Bunni MA, Raymond JR Sr, Garnovskaya MN

“…Inga I Kramarenko1, Thomas A Morinelli1,2, Marlene A Bunni1,2, John R Raymond Sr3, Maria N Garnovskaya11Department of Medicine (Nephrology Division), Medical University of South Carolina, Charleston, SC, USA; 2Medical and Research Services of the Ralph H Johnson Veterans Affairs Medical Center, Charleston, SC, USA; 3Medical College of Wisconsin, Milwaukee, WI, USABackground: The vasoactive peptide bradykinin (BK) acts as a potent growth factor for normal kidney cells, but there have been few studies on the role of BK in renal cell carcinomas.Purpose: In this study, we tested the hypothesis that BK also acts as a mitogen in kidney carcinomas, and explored the effects of BK in human renal carcinoma A498 cells.Methods: The presence of mRNAs for BK B1 and BK B2 receptors in A498 cells was demonstrated by reverse transcription–polymerase chain reaction. …”
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Ameliorative effect of bee venom and its extracted bradykinin-potentiating factor on neurological alteration induced by acrylamide and chips administration by Fakhr El-Din M. Lashein, El-Sabry Abu Amra, Amin A. Seleem, Amira H. Badr

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Anti-Inflammatory Effects of Rhamnetin on Bradykinin-Induced Matrix Metalloproteinase-9 Expression and Cell Migration in Rat Brain Astrocytes by Chien-Chung Yang, Li-Der Hsiao, Ya-Fang Shih, Zih-Yao Yu, Chuen-Mao Yang

“…Bradykinin (BK) has been shown to induce matrix metalloproteinase (MMP)-9 expression and participate in neuroinflammation. …”
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Contact System Activation in Plasma from Dengue Patients Might Harness Endothelial Virus Replication through the Signaling of Bradykinin Receptors by Sharton V. A. Coelho, Naiara M. Rust, Lucas Vellasco, Michelle P. Papa, Aline S. G. Pereira, Matheus Ferreira da Silva Palazzo, Maria Aparecida Juliano, Simone M. Costa, Ada M. B. Alves, Marli T. Cordeiro, Ernesto T. A. Marques, Júlio Scharfstein, Luciana B. de Arruda

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Effects of a novel bradykinin B1 receptor antagonist and angiotensin II receptor blockade on experimental myocardial infarction in rats. by Dongmei Wu, Xinchun Lin, Christian Bernloehr, Tobias Hildebrandt, Henri Doods

“…The aim of the present study was to evaluate the cardiovascular effects of the novel bradykinin B1 receptor antagonist BI-113823 following myocardial infarction (MI) and to determine whether B1 receptor blockade alters the cardiovascular effects of an angiotensin II type 1 (AT1) receptor antagonist after MI in rats.Sprague Dawley rats were subjected to permanent occlusion of the left descending coronary artery. …”
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Additive damage in the thromboxane related vasoconstriction and bradykinin relaxation of intramural coronary resistance arterioles in a rodent model of andropausal hypertension by Attila Jósvai, Marianna Török, Judit Hetthéssy, Máté Mátrai, Anna Monori-Kiss, Jennifer Makk, Márton Vezér, Levente Sára, István Szabó, Béla Székács, György L. Nádasy, Szabolcs Várbíró

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Inhibition of bradykinin in SARS-CoV-2 infection: a randomised, double-blind trial of icatibant compared with placebo (ICASARS) by Daniel Francis McAuley, Tunde Peto, Melanie Bailey, Dermot Linden, Olivia Earley, Hong Guo Parke, Cliff Taggart, Joe Kidney

“…Methods and analysis In this study, hypoxic patients with COVID-19 with symptom onset ≤7 days will be randomised to either a bradykinin inhibitor (icatibant) or placebo. Patients and investigators will be blinded. …”
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BRADYKININ B2 RECEPTOR DELETION IN TYROSINE HYDROXYLASE NEURONS DOES NOT ALTER MOTOR AND BEHAVIORAL ASPECTS IN MALE AND FEMALE MICE. by Frederick Wasinski, Jose Donato

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Effects of Bradykinin B2 Receptor Ablation from Tyrosine Hydroxylase Cells on Behavioral and Motor Aspects in Male and Female Mice by Thaina Maquedo Franco, Mariana R. Tavares, Leonardo S. Novaes, Carolina D. Munhoz, Jose Eduardo Peixoto-Santos, Ronaldo C. Araujo, Jose Donato, Michael Bader, Frederick Wasinski

Subjects: “…bradykinin…”
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KLK12 Regulates MMP-1 and MMP-9 via Bradykinin Receptors: Biomarkers for Differentiating Latent and Active Bovine Tuberculosis by Yuanzhi Wang, Mengjin Qu, Yiduo Liu, Haoran Wang, Yuhui Dong, Xiangmei Zhou

“…KLK12 knockdown macrophages were produced by siRNA transfection. Bradykinin receptors (BR, including B1R and B2R) were blocked with specific inhibitors. …”
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Hypocomplementemic-urticarial vasculitis syndrome (hvus): by Masharib Bashar, Aqsa Farooqui, Halah

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Clinical features of angioedema induced by renin-angiotensin-aldosterone system inhibition: a retrospective analysis of 84 patients by Anja Pfaue, Patrick J. Schuler, Benjamin Mayer, Thomas K. Hoffmann, Jens Greve, Janina Hahn

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Genetic Ablation and Pharmacological Blockade of Bradykinin B1 Receptor Unveiled a Detrimental Role for the Kinin System in Chagas Disease Cardiomyopathy by Ana Carolina Oliveira, Amanda Roberta Revoredo Vicentino, Daniele Andrade, Isabela Resende Pereira, Leonardo Saboia-Vahia, Otacílio da Cruz Moreira, Carla Eponina Carvalho-Pinto, Julia Barbalho da Mota, Leonardo Maciel, Glaucia Vilar-Pereira, João B. Pesquero, Joseli Lannes-Vieira, Pierre Sirois, Antônio Carlos Campos de Carvalho, Julio Scharfstein

Subjects: “…bradykinin…”
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Analysis of Human Bradykinin Receptor Gene and Endothelial Nitric Oxide Synthase Gene Polymorphisms in End-Stage Renal Disease Among Malaysians by R. Vasudevan, P. Ismail, N.I. Jaafar, N.A. Mohamad, E. Etemad, W.S. Wan Aliaa, S. Eshkor

Subjects: “…bradykinin type 2 receptor (b2r) gene…”
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Evaluation of substance P and bradykinin levels in nasal secretions of patients with nasal polyposis with and without sensitivity to non‐steroidal anti‐inflammatory drugs by Aleksandar Perić, Svjetlana Matković, Aleksandra Barać, Tijana Vukadinović, Ljiljana Čvorović, Danilo Vojvodić

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A Robust Bioassay of the Human Bradykinin B₂ Receptor That Extends Molecular and Cellular Studies: The Isolated Umbilical Vein by François Marceau, Hélène Bachelard

Subjects: “…bradykinin…”
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