High-Dose Chemotherapy in Children with Newly Diagnosed Medulloblastoma by Lucie Lafay-Cousin, Christelle Dufour

“…High-dose chemotherapy with stem cell rescue has been used as an adjuvant therapy or as salvage therapy to treat pediatric patients with brain tumors, and to avoid deleterious side effects of radiotherapy in infants and very young children. …”
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Possible novel therapy for malignant gliomas with secretable trimeric TRAIL. by Moonsup Jeong, Yong-Sam Kwon, Soon-Hye Park, Chae-Young Kim, Sin-Soo Jeun, Kang-Won Song, Yong Ko, Paul D Robbins, Timothy R Billiar, Byong-Moon Kim, Dai-Wu Seol

“…Malignant gliomas are the most common primary brain tumors. Despite intensive clinical investigation and many novel therapeutic approaches, average survival for the patients with malignant gliomas is only about 1 year. …”
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Cannabis Biomolecule Effects on Cancer Cells and Cancer Stem Cells: Cytotoxic, Anti-Proliferative, and Anti-Migratory Activities by Hadar Peeri, Hinanit Koltai

“…Gliomas are primary brain tumors that account for ~80% of all malignant brain tumors. …”
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Hippo Signaling Pathway in Gliomas by Konstantin Masliantsev, Lucie Karayan-Tapon, Pierre-Olivier Guichet

“…This pathway was recently shown to be involved in tumorigenesis and metastasis in several cancers such as lung, breast, or colorectal cancers but is still poorly investigated in brain tumors. Gliomas are the most common and the most lethal primary brain tumors representing about 80% of malignant central nervous system neoplasms. …”
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Diagnostic Dilemma: An Atypical Case of Astrocytoma in a Patient with Relapsing–Remitting Multiple Sclerosis by Chantal Kahovec, Aman Saini, Michael C. Levin

“…Distinguishing between tumefactive demyelinating lesions (TDLs) and brain tumors in multiple sclerosis (MS) can be challenging. …”
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Stereotactic Iodine-125 Brachytherapy for Low-Grade Glioma Treatment: A Monte Carlo study by Shahrzad Valizadeh, Elham Saeedzadeh, Alireza Zali, Hasanali Nedaei, Saeed Zare Ganjaroodi

“…Background: Stereotactic brachytherapy is an appropriate method that has been used for brain tumors and metastases treatment for more than 40 years for many patients in the world. …”
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Modulation of Blood–Brain Barrier Permeability by Activating Adenosine A2 Receptors in Oncological Treatment by Kamila Wala, Wojciech Szlasa, Jolanta Saczko, Julia Rudno-Rudzińska, Julita Kulbacka

“…However, in the case of neurological diseases or primary brain tumors, i.e., gliomas, the higher permeability of the blood-derived substances in the brain tissue is necessary. …”
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<i>EGFR</i> Amplification Is a Phenomenon of <i>IDH</i> Wildtype and <i>TERT</i> Mutated High-Grade Glioma: An Integrated Analysis Using Fluorescence In Situ Hybridization and DNA... by Dorothee Hölzl, Georg Hutarew, Barbara Zellinger, Beate Alinger-Scharinger, Hans U. Schlicker, Christoph Schwartz, Karl Sotlar, Theo F. J. Kraus

“…Gliomas are the most common intrinsic brain tumors in adults, and in accordance with their clinical behavior and patients’ outcome, they are graded by the World Health Organization (WHO) classification of brain tumors. …”
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CCR2 and CCR5 co-inhibition modulates immunosuppressive myeloid milieu in glioma and synergizes with anti-PD-1 therapy by Ayush Pant, Brandon Hwa-Lin Bergsneider, Siddhartha Srivastava, Timothy Kim, Aanchal Jain, Sadhana Bom, Pavan Shah, Nivedha Kannapadi, Kisha Patel, John Choi, Kwang Bog Cho, Rohit Verma, Caren Yu-Ju Wu, Henry Brem, Betty Tyler, Drew M. Pardoll, Christina Jackson, Michael Lim

“…Moreover, the treatment specifically reduced the infiltration of monocytic-MDSCs (M-MDSCs) into brain tumors and increased lymphocyte abundance and cytokine secretion by tumor-infiltrating CD8 T cells. …”
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A Preliminary Study of the Effect of Quercetin on Cytotoxicity, Apoptosis, and Stress Responses in Glioblastoma Cell Lines by Magdalena Kusaczuk, Rafał Krętowski, Monika Naumowicz, Anna Stypułkowska, Marzanna Cechowska-Pasko

“…However, little is known yet about their activity in brain tumors. Here we investigated the interaction of dietary flavonoid quercetin (QCT) with the human glioblastoma A172 and LBC3 cell lines. …”
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Clinical Management of Embryonal Tumor with Multilayered Rosettes: The CCMC Experience by Zengyan Li, Zhiming Wu, Youhong Dong, Dongdong Zhang

“…Objective: Embryonal tumors with multilayered rosettes (ETMRs) are highly aggressive pediatric brain tumors with poor prognosis. No standard treatment strategy for them exists because of their rarity. …”
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Nanoparticles: a New Approach to the Diagnosis and Treatment of Cerebral Glial Tumours by I. F. Gareev, O. A. Beylerli, V. N. Pavlov, Shiguang Zhao, Xin Chen, Zhixing Zheng, Chen Shen, Jinxian Sun

“…Glial tumors, and in particular anaplastic astrocytomas and glioblastoma multiforme (GBM), are aggressive brain tumors with poor prognosis and high recurrence rates. …”
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Liposome Consolidated with Cyclodextrin Provides Prolonged Drug Retention Resulting in Increased Drug Bioavailability in Brain by En-Yi Lin, Yu-Shuan Chen, Yuan-Sheng Li, Syuan-Rong Chen, Chia-Hung Lee, Mao-Hsuan Huang, Hong-Meng Chuang, Horng-Jyh Harn, Hsueh-Hui Yang, Shinn-Zong Lin, Dar-Fu Tai, Tzyy-Wen Chiou

“…Although butylidenephthalide (BP) is an efficient anticancer drug, its poor bioavailability renders it ineffective for treating drug-resistant brain tumors. However, this problem is overcome through the use of noninvasive delivery systems, including intranasal administration. …”
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Differentiating High-Grade Gliomas from Brain Metastases at Magnetic Resonance: The Role of Texture Analysis of the Peritumoral Zone by Csaba Csutak, Paul-Andrei Ștefan, Lavinia Manuela Lenghel, Cezar Octavian Moroșanu, Roxana-Adelina Lupean, Larisa Șimonca, Carmen Mihaela Mihu, Andrei Lebovici

“…Forty-two patients with pathology-proven brain tumors who underwent conventional pretreatment MRIs were retrospectively included (HGGs, <i>n</i> = 16; BMs, <i>n</i> = 26). …”
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Heme Oxygenase-1 in Central Nervous System Malignancies by Giuseppe Sferrazzo, Michelino Di Rosa, Eugenio Barone, Giovanni Li Volti, Nicolò Musso, Daniele Tibullo, Ignazio Barbagallo

“…Several lines of evidence suggest that brain tumors show altered redox homeostasis that triggers the activation of various survival pathways, leading to disease progression and chemoresistance. …”
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Uterine Leiomyosarcoma: Infrequent Cardiac and Brain Metastasis A Case Report by Jorge Rodríguez Delgado, Margarito Morales Cruz, Christopher López Hernández, Maximiliano Rodríguez Morales, Jairo Viscarra León, María Torres Álvarez, Guillermo Díaz Quiroz, José Aceves Chimal

“…By cardiac and brain symptomatology, this patient was diagnosed with cardiac and brain tumors in imaging studies. The patient underwent tumors resection by cardiac surgery and stereotaxic procedure and subsequent chemo and radiotherapy, without neurological and cardiac symptoms in her evolution.…”
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Nucleolin promotes angiogenesis and endothelial metabolism along the oncofetal axis in the human brain vasculature by Marc Schwab, Ignazio de Trizio, Moheb Ghobrial, Jau-Ye Shiu, Oguzkan Sürücü, Francesco Girolamo, Mariella Errede, Murat Yilmaz, Johannes Haybaeck, Alessandro Moiraghi, Philippe P. Monnier, Sean E. Lawler, Jeffrey P. Greenfield, Ivan Radovanovic, Karl Frei, Ralph Schlapbach, Viola Vogel, Daniela Virgintino, Katrien De Bock, Thomas Wälchli

“…Angiogenesis is dynamic during brain development, almost quiescent in the adult brain but reactivated in vascular-dependent CNS pathologies, including brain tumors. The oncofetal axis describes the reactivation of fetal programs in tumors, but its relevance in endothelial and perivascular cells of the human brain vasculature in glial brain tumors is unexplored. …”
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Radiation-induced meningioma following radiation therapy for pituitary adenoma: a case report by Muhammed Nordin, Ellyda, Jalaludin, Win Mar @ Salmah

“…It is well known that ionozing radiation has an onco-genetic activity and has been implicated in the causation of brain tumors. However, when a new growth appears adjacent to the site of previous tumor, the diagnosis is more toward recurrence. …”
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Microglia-Based Gene Expression Signature Highly Associated with Prognosis in Low-Grade Glioma by Evelien Schaafsma, Chongming Jiang, Thinh Nguyen, Kenneth Zhu, Chao Cheng

“…Gliomas make up ~80% of malignant brain tumors in adults and are responsible for the majority of deaths from primary brain tumors. …”
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Revealing Pan-Histology Immunomodulatory Targets in Pediatric Central Nervous System Tumors by Robert T. Galvin, Sampreeti Jena, Danielle Maeser, Robert Gruener, R. Stephanie Huang

“…The aim of this study was to uncover the mechanisms of immune suppression common among pediatric brain tumors. Methods: We apply an immunologic clustering algorithm validated by The Cancer Genome Atlas Project to an independent pediatric CNS transcriptomic dataset. …”
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