Meta-analysis of expression of l(3)mbt tumor-associated germline genes supports the model that a soma-to-germline transition is a hallmark of human cancers. by Feichtinger, J, Larcombe, L, McFarlane, R

“…Here, we have meta-analyzed gene expression profiles of the human orthologs of Drosophila melanogaster germline genes that are ectopically expressed in l(3)mbt brain tumors using gene expression datasets derived from a large cohort of human tumors. …”

circSMARCA5 Is an Upstream Regulator of the Expression of miR-126-3p, miR-515-5p, and Their mRNA Targets, <i>Insulin-like Growth Factor Binding Protein 2</i> (<i>IGFBP2</i>) and <i... by Aurora Eliana Merulla, Michele Stella, Cristina Barbagallo, Rosalia Battaglia, Angela Caponnetto, Giuseppe Broggi, Roberto Altieri, Francesco Certo, Rosario Caltabiano, Marco Ragusa, Giuseppe Maria Vincenzo Barbagallo, Cinzia Di Pietro, Michele Purrello, Davide Barbagallo

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Polymeric Nanoparticles—Tools in a Drug Delivery System in Selected Cancer Therapies by Marcel Madej, Natalia Kurowska, Barbara Strzalka-Mrozik

“…With their application, it is possible to precisely deliver medicinal substances to the tumor structure, to overcome the blood–brain barrier in the case of brain tumors, to reduce the side effects of anticancer agents on normal cells and to achieve a therapeutic effect with a lower drug dose. …”
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Anatomical Targeting of Anticancer Drugs to Solid Tumors Using Specific Administration Routes: Review by Akira Saito, Joji Kitayama, Ryozo Nagai, Kenichi Aizawa

“…This strategy is most commonly used for liver and brain tumors, as well as pleural or peritoneal malignancies. …”
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MicroRNAs at the Crossroad of the Dichotomic Pathway Cell Death vs. Stemness in Neural Somatic and Cancer Stem Cells: Implications and Therapeutic Strategies by Andrea Diana, Giuseppe Gaido, Cristina Maxia, Daniela Murtas

“…This event implies controlling the expression of pro/anti-apoptotic target genes, which is crucial for the management of neural/neural crest-derived CSCs in brain tumors, neuroblastoma, and melanoma. From a translational point of view, the current progress on the emerging miRNA-based neuropathology therapeutic applications and antitumor strategies will be disclosed and their advantages and shortcomings discussed.…”
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The role of 18F-FDG PET/CT in evaluation of Primary CNS lymphoma: The path less travelled by Sharjeel Usmani, Anjali Jain, Khulood Al Riyami, Shah P Naumani, Rashid Al-Sukaiti, Muhammad Shahzad Shamim

“…Keywords: 18F-FDG PET/CT; CNS lymphoma; brain tumors. …”
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Immunotherapy in Glioblastoma: Current Shortcomings and Future Perspectives by Bas Weenink, Pim J. French, Peter A.E. Sillevis Smitt, Reno Debets, Marjolein Geurts

“…Glioblastomas are aggressive, fast-growing primary brain tumors. After standard-of-care treatment with radiation in combination with temozolomide, the overall prognosis of newly diagnosed patients remains poor, with a 2-year survival rate of less than 20%. …”
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Nucleic acid delivery by ionizable nanocarriers for brain disease treatment by Ruru Xiong, Guixia Ling, Yuqi Zhang, Jibin Guan, Peng Zhang

“…However, gene therapy faces great challenges in treating brain diseases such as brain tumors, infections, and strokes because the limitations of the blood‐brain barrier make it difficult for nucleic acid drugs to be delivered safely and effectively into the brain. …”
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Discovering Glioma Tissue through Its Biomarkers’ Detection in Blood by Raman Spectroscopy and Machine Learning by Denis Vrazhnov, Anna Mankova, Evgeny Stupak, Yury Kistenev, Alexander Shkurinov, Olga Cherkasova

“…The most commonly occurring malignant brain tumors are gliomas, and among them is glioblastoma multiforme. …”
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Low-Grade Gliomas: Histological Subtypes, Molecular Mechanisms, and Treatment Strategies by Corneliu Toader, Lucian Eva, Daniel Costea, Antonio Daniel Corlatescu, Razvan-Adrian Covache-Busuioc, Bogdan-Gabriel Bratu, Luca Andrei Glavan, Horia Petre Costin, Andrei Adrian Popa, Alexandru Vlad Ciurea

“…Low-Grade Gliomas (LGGs) represent a diverse group of brain tumors originating from glial cells, characterized by their unique histopathological and molecular features. …”
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Targeting SOX2 as a therapeutic strategy in glioblastoma by Ander Matheu, laura garros

“…Therefore, SOX2 silencing might be a novel therapeutic approach to combat cancer and particularly brain tumors.In this review, we will summarize the current knowledge about SOX2 in glioblastoma and recapitulate several strategies, which have been recently described targeting SOX2 in this malignancy.…”
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Pituitary Adenoma in the Philippines: A Scoping Review on the Treatment Gaps, Challenges, and Current State of Care by Mykha Marie B. Tabuzo, Mary Angeline Luz U. Hernandez, Annabell E. Chua, Patricia D. Maningat, Harold Henrison C. Chiu, Roland Dominic G. Jamora

“…Background: Pituitary adenomas are benign brain tumors that impose a heavy burden on patients worldwide. …”
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Notch Signaling & Micro RNAs - two tumblers of neurogenesis and Gliomas by Zeeshan Javed, Qamar Raza, Faiez Ahmad Shah, Haleema Sadia, Ayesha Alam, Faiza Anum, Mushtaq Ahmad Saleem, Shahid Raza

“… Abstract Gliomas are one of the most annihilating types of brain tumors having a high rate of annual incidence worldwide. …”
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Photodynamic therapy in brain cancer: mechanisms, clinical and preclinical studies and therapeutic challenges by Wojciech Domka, Dorota Bartusik-Aebisher, Izabela Rudy, Klaudia Dynarowicz, Karolina Pięta, David Aebisher

“…Gliomas are the most common primary intracranial tumor, accounting for 81% of malignant brain tumors. Although relatively rare, they cause significant mortality. …”
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Pathological implications of metabolic reprogramming and its therapeutic potential in medulloblastoma by Veronica Marabitti, Manuela Giansanti, Francesca De Mitri, Francesca Gatto, Angela Mastronuzzi, Francesca Nazio

“…Medulloblastoma (MB) is one of the most heterogeneous malignant pediatric brain tumors, divided into four molecular subgroups (Wingless, Sonic Hedgehog, Group 3 and Group 4). …”
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Magnetic resonance elastography of malignant tumors by Gwenaël Pagé, Philippe Garteiser, Bernard E. Van Beers, Bernard E. Van Beers

“…Generally, malignant tumors, except brain tumors, have high stiffness and high visco-elastic ratio or fluidity. …”
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Imaging and multi-omics datasets converge to define different neural progenitor origins for ATRT-SHH subgroups by María-Jesús Lobón-Iglesias, Mamy Andrianteranagna, Zhi-Yan Han, Céline Chauvin, Julien Masliah-Planchon, Valeria Manriquez, Arnault Tauziede-Espariat, Sandrina Turczynski, Rachida Bouarich-Bourimi, Magali Frah, Christelle Dufour, Thomas Blauwblomme, Liesbeth Cardoen, Gaelle Pierron, Laetitia Maillot, Delphine Guillemot, Stéphanie Reynaud, Christine Bourneix, Célio Pouponnot, Didier Surdez, Mylene Bohec, Sylvain Baulande, Olivier Delattre, Eliane Piaggio, Olivier Ayrault, Joshua J. Waterfall, Nicolas Servant, Kevin Beccaria, Volodia Dangouloff-Ros, Franck Bourdeaut

“…Here, we investigate the imaging of human ATRT at diagnosis and the precise anatomic origin of brain tumors in the Rosa26-CreERT2::Smarcb1flox/flox model. …”
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A Review on Lactoferrin and Central Nervous System Diseases by Yu-Qi Li, Chuang Guo

“…This review highlights recent advances in the understanding of the major pharmacological effects of Lf in CNS diseases, including neurodegenerative diseases, cerebrovascular disease, developmental delays in children, and brain tumors.…”
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Glioblastoma and the significance of MGMT gene methylation by Payam Izadpanahi, Kazem Anvari, Mitra Fazl Ersi

“…In this research Glioblastoma has been studied as one of the most common brain tumors and a short review of the available therapeutic methods have presented including surgery, radiotherapy, chemotherapy and particularly adjuvant chemotherapy with temozolomide, as the most effective developed treatment. …”
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An image-based modeling framework for predicting spatiotemporal brain cancer biology within individual patients by Kamila M. Bond, Kamila M. Bond, Lee Curtin, Sara Ranjbar, Ariana E. Afshari, Leland S. Hu, Leland S. Hu, Joshua B. Rubin, Kristin R. Swanson

“…Imaging is central to the clinical surveillance of brain tumors yet it provides limited insight into a tumor’s underlying biology. …”
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