Targeting MAPK (Ras/ERK) and PI3K/Akt pathways in pituitary tumorigenesis. by Cakir, M, Grossman, AB

“… BACKGROUND: Pituitary adenomas are common intracranial neoplasms, comprising 10 - 15% of all brain tumors. Data from autopsy studies suggest that pituitary adenomas develop in 17 - 25% of the population. …”

Effect of 5-Aminolevulinic Acid and Sodium Fluorescein on the Extent of Resection in High-Grade Gliomas and Brain Metastasis by Lasse Cramer Ahrens, Mathias Green Krabbenhøft, Rasmus Würgler Hansen, Nikola Mikic, Christian Bonde Pedersen, Frantz Rom Poulsen, Anders Rosendal Korshoej

“…Here, we give an update and review the latest literature on fluorescence-guided surgery with 5-ALA and SF for brain tumors with emphasis on fluorescence-guided surgery in HGG and brain metastases. …”
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Dose-Dependent Transcriptional Response to Ionizing Radiation Is Orchestrated with DNA Repair within the Nuclear Space by Garima Chaturvedi, Avital Sarusi-Portuguez, Olga Loza, Ariel Shimoni-Sebag, Orly Yoron, Yaacov Richard Lawrence, Leor Zach, Ofir Hakim

“…Radiation therapy is commonly used to treat glioblastoma multiforme (GBM) brain tumors. Ionizing radiation (IR) induces dose-specific variations in transcriptional programs, implicating that they are tightly regulated and critical components in the tumor response and survival. …”
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Paradoxical role of high mobility group box 1 in glioma: a suppressor or a promoter? by Richard A. Seidu, Min Wu, Zhaoliang Su, Huaxi Xu

“…Gliomas represent 60% of primary intracranial brain tumors and 80% of all malignant types, with highest morbidity and mortality worldwide. …”
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Transcription Factors with Targeting Potential in Gliomas by Angeliki-Ioanna Giannopoulou, Dimitrios S. Kanakoglou, Christina Piperi

“…A variety of TFs have been detected to be aberrantly expressed in brain tumors, being highly implicated in critical pathological aspects and progression of gliomas. …”
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Review: therapeutic approaches for circadian modulation of the glioma microenvironment by Ella A. Nettnin, Thien Nguyen, Sophia Arana, Maria Isabel Barros Guinle, Cesar A. Garcia, Erin M. Gibson, Laura M. Prolo, Laura M. Prolo

“…High-grade gliomas are malignant brain tumors that are characteristically hard to treat because of their nature; they grow quickly and invasively through the brain tissue and develop chemoradiation resistance in adults. …”
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vNARs as Neutralizing Intracellular Therapeutic Agents: Glioblastoma as a Target by Alejandro Manzanares-Guzmán, Pavel H. Lugo-Fabres, Tanya A. Camacho-Villegas

“…Glioblastoma is the most prevalent and fatal form of primary brain tumors. New targeted therapeutic strategies for this type of tumor are imperative given the dire prognosis for glioblastoma patients and the poor results of current multimodal therapy. …”
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Advanced immunotherapies for glioblastoma: tumor neoantigen vaccines in combination with immunomodulators by Berta Segura-Collar, Sara Hiller-Vallina, Olaya de Dios, Marta Caamaño-Moreno, Lucia Mondejar-Ruescas, Juan M. Sepulveda-Sanchez, Ricardo Gargini

“…Abstract Glial-origin brain tumors, including glioblastomas (GBM), have one of the worst prognoses due to their rapid and fatal progression. …”
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Bisphenol A: Unveiling Its Role in Glioma Progression and Tumor Growth by Liang Niu, Juan Jia, Hu Yang, Shangyu Liu, Hongyu Wang, Yunji Yan, Qiao Li, Qiang Dong, He Zhang, Guoming Zhao, Junqiang Dai, Guoqiang Yuan, Yawen Pan

“…Gliomas represent the most common and lethal category of primary brain tumors. Bisphenol A (BPA), a widely recognized endocrine disruptor, has been implicated in the progression of cancer. …”
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Case Report: Detailed Clinical Course and Management Plan for Status Epilepticus Pediatric Patient with Resected Choroid Plexus Papilloma: A Case Report and a Single Center Experie... by Fahad Alotibi, Osama Muthaffar, Anas Alyazidi

“…It accounts for 0.4–0.6% of all brain tumors. Usually seen in patients who are young children. …”
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Flaviviruses in AntiTumor Therapy by Alina S. Nazarenko, Mikhail F. Vorovitch, Yulia K. Biryukova, Nikolay B. Pestov, Ekaterina A. Orlova, Nickolai A. Barlev, Nadezhda M. Kolyasnikova, Aydar A. Ishmukhametov

“…The key advantages of flaviviruses include their reproduction cycle occurring entirely within the cytoplasm (avoiding genome integration) and their ability to cross the blood–brain barrier, facilitating the systemic delivery of oncolytics against brain tumors. So far, the direct lytic effects and immunomodulatory activities of many flaviviruses have been widely studied in experimental animal models across various types of tumors. …”
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A feasible strategy of fabricating camptothecin (SN38)-loaded holmium ferrite nanocarrier delivery for glioma treatment by Yu Zeng, Huihui Chen, Fan Yang, Huiyong Li, Pengxiang Yang

“…Malignant gliomas are the most prevalent and deadly primary brain tumors. The life expectancy of people with gliomas only slightly increases through surgical procedures, radiation, and chemotherapy. …”
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Automated temporalis muscle quantification and growth charts for children through adulthood by Anna Zapaishchykova, Kevin X. Liu, Anurag Saraf, Zezhong Ye, Paul J. Catalano, Viviana Benitez, Yashwanth Ravipati, Arnav Jain, Julia Huang, Hasaan Hayat, Jirapat Likitlersuang, Sridhar Vajapeyam, Rishi B. Chopra, Ariana M. Familiar, Ali Nabavidazeh, Raymond H. Mak, Adam C. Resnick, Sabine Mueller, Tabitha M. Cooney, Daphne A. Haas-Kogan, Tina Y. Poussaint, Hugo J.W.L. Aerts, Benjamin H. Kann

“…We validate iTMT across multiple demographic groups and in children with brain tumors and demonstrate feasibility for individualized longitudinal monitoring. …”
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Curcumin, inflammation, and neurological disorders: How are they linked? by Prachi Garodia, Mangala Hegde, Ajaikumar B. Kunnumakkara, Bharat B. Aggarwal

“…The effects of curcumin on neurodegenerative diseases such as Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), brain tumors, epilepsy, Huntington's disorder (HD), ischemia, Parkinson's disease (PD), multiple sclerosis (MS), and traumatic brain injury (TBI) with a major focus on associated signalling pathways have been thoroughly discussed. …”
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Olaparib Is a Mitochondrial Complex I Inhibitor That Kills Temozolomide-Resistant Human Glioblastoma Cells by Luca X. Zampieri, Martina Sboarina, Andrea Cacace, Debora Grasso, Léopold Thabault, Loïc Hamelin, Thibaut Vazeille, Elodie Dumon, Rodrigue Rossignol, Raphaël Frédérick, Etienne Sonveaux, Florence Lefranc, Pierre Sonveaux

“…Glioblastoma represents the highest grade of brain tumors. Despite maximal resection surgery associated with radiotherapy and concomitant followed by adjuvant chemotherapy with temozolomide (TMZ), patients have a very poor prognosis due to the rapid recurrence and the acquisition of resistance to TMZ. …”
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Mutational signatures of synchronous and metachronous brain metastases from lung adenocarcinoma by Jianing Chen, Hainan Yang, Chao Zhao, Tao Lin, Da Liu, Weiping Hong, Changguo Shan, Cheng Zhou, Ling Bao, Caicun Zhou, Linbo Cai, Chunxia Su, Zhaoming Zhou, Lei Wen

“…The difference in their genomic characterization is unclear. 96 lung adenocarcinoma patients were enrolled in our study. 53 patients (55%) had synchronous metastatic brain tumors. 43 (45%) patients had metachronous brain metastases. …”
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Schinzel-Giedion syndrome: a rare cause of psychomotor delay and refractory seizures by Gordana Kovačević, Ružica Kravljanac, Biljana Vučetić Tadić, Slavica Ostojić, Seung Woo Ryu

“…Affected children have increased risk of developing neuroepithelial brain tumors.We are reporting a case of a 20 months-old boy with profound psychomotor delay, distinctive facial features, congenital cardiac defect and renal malformation, associated with drug-resistant seizures and progressive brain atrophy. …”
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Mapping and Quantification of Non-Coding RNA Originating from the rDNA in Human Glioma Cells by Anastasia A. Sadova, Natalia S. Kupriyanova, Galina V. Pavlova

“…In this study, we demonstrate that the region ~2 kb upstream of the rDNA promoter is transcriptionally active in one type of the most malignant human brain tumors, and we compare its expression rate to that of healthy human tissues and cell cultures. …”
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Oculomotor nerve palsy in neurofibromatosis type 2 by Aymen Shahab, MBBS, Hafsa Sardar, MBBS, Samaa Akhtar, MD, MSc, Anam Safdar, MBBS,FCPS, Muhammad Ismail Safi, MD, Izaz Ahmad, Faheemullah Khan, MBBS,MD

“…We describe a 20-year-old patient, with a family history of brain tumors, with symptoms of left sided third nerve palsy. …”
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The experience of stereotactic radiosurgery and radiotherapy use in combined treatment of pituitary adenomas by Andrey Gryazov, Olga Chuvashova, Nikolay Guk, Aleksandr Guk, Yuliya Medvedovskaya, Elena Andriychenko, Vitaliy Zakordonets

“…Pituitary tumors take the third place in a structure of CNS neoplasms and ranged from 4 to 17% of all brain tumors.The purpose. To study features of stereotactic ray methods in treatment of pituitary adenomas, to estimate efficacy of stereotactic radiosurgery and stereotactic radiotherapy in pituitary adenomas combined treatment.Materials and methods. …”
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