Astrocytes-Derived Small Extracellular Vesicles Hinder Glioma Growth by Carmela Serpe, Antonio Michelucci, Lucia Monaco, Arianna Rinaldi, Mariassunta De Luca, Pietro Familiari, Michela Relucenti, Erika Di Pietro, Maria Amalia Di Castro, Igea D’Agnano, Luigi Catacuzzeno, Cristina Limatola, Myriam Catalano

“…This also happens in the brain, where EVs permit the crosstalk between neuronal and non-neuronal cells, functional to homeostatic processes or cellular responses to pathological stimuli. In brain tumors, EVs are responsible for the bidirectional crosstalk between glioblastoma cells and healthy cells, and among them, astrocytes, that assume a pro-tumoral or antitumoral role depending on the stage of the tumor progression. …”
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In Vivo Brain GSH: MRS Methods and Clinical Applications by Francesca Bottino, Martina Lucignani, Antonio Napolitano, Francesco Dellepiane, Emiliano Visconti, Maria Camilla Rossi Espagnet, Luca Pasquini

“…In this context, we aimed to provide an overview of the different magnetic resonance spectroscopy (MRS) technologies introduced for in vivo human brain GSH quantification both in healthy control (HC) volunteers and in subjects affected by different neurological disorders (e.g., brain tumors, and psychiatric and degenerative disorders). …”
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Sertindole inhibits autophagic flux and glioma progression by Baiyang Liu, Yulin Shi, Bo Qin, Dating Cheng, Zhi Nie, Haoqing Zhai, Yao Li, Zhixian Jin, Jun Pu, Dongming Yan, Yongbin Chen, Cuiping Yang

“…Abstract Gliomas, the most lethal brain tumors, often exhibit resistance to conventional chemotherapy and/or radiotherapy. …”
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Development, Implementation and Application of Confocal Laser Endomicroscopy in Brain, Head and Neck Surgery—A Review by Irini Kakaletri, Maximilian Linxweiler, Serine Ajlouni, Patra Charalampaki

“…CLE of disorders, such as head, neck and brain tumors, has only recently been suggested to contribute to both immediate tumor characterization and detection. …”
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Proteomic Shotgun and Targeted Mass Spectrometric Datasets of Cerebrospinal Fluid (Liquor) Derived from Patients with Vestibular Schwannoma by Svetlana Novikova, Natalia Soloveva, Tatiana Farafonova, Olga Tikhonova, Vadim Shimansky, Ivan Kugushev, Victor Zgoda

“…Vestibular schwannomas are relatively rare intracranial tumors compared to other brain tumors. Data on the molecular features, especially on schwannoma proteome, are scarce. …”
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Epigenomic analysis of formalin-fixed paraffin-embedded samples by CUT&Tag by Steven Henikoff, Jorja G. Henikoff, Kami Ahmad, Ronald M. Paranal, Derek H. Janssens, Zachary R. Russell, Frank Szulzewsky, Sita Kugel, Eric C. Holland

“…We find that transcriptional regulatory element differences produced by FFPE-CUTAC distinguish between mouse brain tumors and identify and map regulatory element markers with high confidence and precision, including microRNAs not detectable by RNA-seq. …”
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INTRA-OPERATIVE STIMULATION OF MEDIAN NERVE REDUCES THE RISK OF POSTOPERATIVE NAUSEA AND VOMITING AFTER POSTERIOR FOSSA MASS RESECTION by А. S. Kulikov, M. I. Klyukin, I. M. Belisov, А. Yu. Lubnin

“…The article presents the results of a prospective randomized double-blind study which was investigating the efficacy of intra-operative transcutaneous stimulation of median nerve on the wrist aimed to prevent post-operative nausea and vomiting after planned resection of brain tumors located in posterior fossa.Methods. 40 patients were included into the study: 20 patients were enrolled into the stimulation group and 20 of them were enrolled into the control group, where the prevention of emetogenic reactions was limited by the use of dexamethasone and ondansetron.Results. …”
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Ketoacidosis and otitis media as a potencial cause of cerebral venous thrombosis in a 7-year-old boy by Justyna Lipińska, Łukasz Lipiński, Maria Kowalczuk, Izabela Kopeć, Joanna Mitek-Palusińska, Magdalena Woźniak

“…A large number of children have coincident local head or neck pathology, including head trauma, brain tumors, or recent intracranial surgery. Clinical symptoms are frequently nonspecific and include seizures, depressed level of consciousness, coma, lethargy, nausea, vomiting, headache, visual impairment, papilledema, and hemiparesis, which may often obscure the diagnosis and delay treatment. …”
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Emerging role of ferroptosis in glioblastoma: Therapeutic opportunities and challenges by Shenghua Zhuo, Guiying He, Taixue Chen, Xiang Li, Yunheng Liang, Wenkai Wu, Lingxiao Weng, Jigao Feng, Zhenzhong Gao, Kun Yang

“…Ferroptosis is a newly found non-apoptotic regulatory cell death process that plays a vital role in a variety of brain diseases, including cerebral hemorrhage, neurodegenerative diseases, and primary or metastatic brain tumors. Recent studies have shown that targeting ferroptosis can be an effective strategy to overcome resistance to tumor therapy and immune escape mechanisms. …”
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Exploiting 4-1BB immune checkpoint to enhance the efficacy of oncolytic virotherapy for diffuse intrinsic pontine gliomas by Virginia Laspidea, Montserrat Puigdelloses, Sara Labiano, Lucía Marrodán, Marc Garcia-Moure, Marta Zalacain, Marisol Gonzalez-Huarriz, Naiara Martínez-Vélez, Iker Ausejo-Mauleon, Daniel de la Nava, Guillermo Herrador-Cañete, Javier Marco-Sanz, Elisabeth Guruceaga, Carlos E. de Andrea, María Villalba, Oren Becher, Massimo Squatrito, Verónica Matía, Jaime Gállego Pérez-Larraya, Ana Patiño-García, Sumit Gupta, Candelaria Gomez-Manzano, Juan Fueyo, Marta M. Alonso

“…Diffuse intrinsic pontine gliomas (DIPGs) are aggressive pediatric brain tumors, and patient survival has not changed despite many therapeutic efforts, emphasizing the urgent need for effective treatments. …”
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Overview of the meningeal lymphatic vessels in aging and central nervous system disorders by Huimin Jiang, Huimin Wei, Yifan Zhou, Xuechun Xiao, Chen Zhou, Xunming Ji

“…Alterations in MLVs have been observed in aging-related neurodegenerative diseases, brain tumors, and even cerebrovascular disease. These findings reveal a new perspective on aging and CNS disorders and provide a promising therapeutic target. …”
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A case of hypogonadtropic hypogonadism due to hypophysitis discovered by secondary male infertility by Masatoshi Konishi, Yoko Maegawa, Masaru Tani, Toshihisa Asakura, Yujiro Hayashi, Yoichi Kakuta, Koichi Tsutahara, Kazuhiko Komori, Tetsuya Takao

“…The onset of hypopituitarism is often due to brain tumors, trauma, surgery, or congenital disorders. …”
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Clinical situations for which 3D printing is considered an appropriate representation or extension of data contained in a medical imaging examination: neurosurgical and otolaryngol... by Arafat Ali, Jonathan M. Morris, Summer J. Decker, Yu-hui Huang, Nicole Wake, Frank J Rybicki, David H Ballard

“…Results Evidence-based recommendations for when 3D printing is appropriate are provided for diseases of the calvaria and skull base, brain tumors and cerebrovascular disease. Recommendations are provided in accordance with strength of evidence of publications corresponding to each neurologic condition combined with expert opinion from members of the 3D printing SIG. …”
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Photodynamic Therapy for Treatment of Disease in Children—A Review of the Literature by Anna Mazur, Katarzyna Koziorowska, Klaudia Dynarowicz, David Aebisher, Dorota Bartusik-Aebisher

“…Examples of photodynamic therapy for treatment of dermatological diseases, diseases of the mucosa of the upper respiratory tract, halitosis, eye diseases and brain tumors are described. The paper describes the effectiveness of anti-cancer photodynamic therapy, including its use in antibacterial therapy. …”
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Does the functional polymorphism-1562C/T of MMP-9 gene influence brain disorders? by Sylwia Pabian-Jewuła, Marcin Rylski

“…The MMP-9 activity in the brain is strictly regulated, and any disruptions in this regulation contribute to a development of many disorders of the nervous system including multiple sclerosis, brain strokes, neurodegenerative disorders, brain tumors, schizophrenia, or Guillain-Barré syndrome. …”
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Ozone therapy for high-grade glioma: an overview by Li Yanchu, Pu Rong, Cao Rong, Zhang Li, Yang Xiaoyan, Wang Feng

“…High-grade gliomas (grades III and IV) are highly malignant and aggressive brain tumors that present significant treatment challenges. …”
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Cerebrospinal Fluid Levels of AFP and hCG: Validation of the Analytical Method and Application in the Diagnosis of Central Nervous System Germ Cell Tumors by Annamaria D'Alessandro, Domenico Ciavardelli, Anna Pastore, Germana Giannone, Giada Del Baldo, Andrea Carai, Angela Mastronuzzi, Andrea Onetti Muda, Ottavia Porzio

“…This is confirmed by the positive correlation between elevated levels of hCG or AFP and the diagnosis of brain tumors.…”
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Gangliosides as Biomarkers of Human Brain Diseases: Trends in Discovery and Characterization by High-Performance Mass Spectrometry by Mirela Sarbu, Raluca Ica, Alina D. Zamfir

“…The last part is focused on the major accomplishments of MS-based methods in the discovery of ganglioside species, which are associated with primary and secondary brain tumors and may either facilitate an early diagnosis or represent target molecules for immunotherapy oriented against brain cancers.…”
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AMPK attenuates SHH subgroup medulloblastoma growth and metastasis by inhibiting NF-κB activation by Jing Cai, Yue Wang, Xinfa Wang, Zihe Ai, Tianyuan Li, Xiaohong Pu, Xin Yang, Yixing Yao, Junping He, Steven Y. Cheng, Tingting Yu, Chen Liu, Shen Yue

“…Abstract Background Medulloblastoma (MB) is one of the most common malignant pediatric brain tumors. Metastasis and relapse are the leading causes of death in MB patients. …”
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Realistic 3D Phantoms for Validation of Microwave Sensing in Health Monitoring Applications by Mariella Särestöniemi, Daljeet Singh, Rakshita Dessai, Charline Heredia, Sami Myllymäki, Teemu Myllylä

“…The first aim of this paper is to develop realistic and adjustable 3D human-body emulation platforms that could be used for evaluating emerging microwave-based medical monitoring/sensing applications such as the detection of brain tumors, strokes, and breast cancers, as well as for capsule endoscopy studies. …”
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