Clinical image: rare localization of a giant recurrent malignant meningioma by Ibrahim Halil Türkbeyler, Mehmet Akif Sarıca, Taner Babacan, İsmail Dilli

“…Meningiomas are the most common benign brain tumors. Malignant meningioma is a rare subtype with a high recurrence rate and poor prognosis. …”
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Three-Dimensional Dosimetry by Optical-CT and Radiochromic Gel Dosimeter of a Multiple Isocenter Craniospinal Radiation Therapy Procedure by Matheus Antonio da Silveira, Juliana Fernandes Pavoni, Alexandre Colello Bruno, Gustavo Viani Arruda, Oswaldo Baffa

“…Craniospinal irradiation (CSI) is a complex radiation technique employed to treat patients with primitive neuroectodermal tumors such as medulloblastoma or germinative brain tumors with the risk of leptomeningeal spread. …”
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The Combined Use of 5-ALA and Chlorin e6 Photosensitizers for Fluorescence-Guided Resection and Photodynamic Therapy under Neurophysiological Control for Recurrent Glioblastoma in... by Elizaveta I. Kozlikina, Igor S. Trifonov, Mikhail V. Sinkin, Vladimir V. Krylov, Victor B. Loschenov

“…The treatment of glial brain tumors is an unresolved problem in neurooncology, and all existing methods (tumor resection, chemotherapy, radiotherapy, radiosurgery, fluorescence diagnostics, photodynamic therapy, etc.) are directed toward increasing progression-free survival for patients. …”
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Translational Regulation by hnRNP H/F Is Essential for the Proliferation and Survival of Glioblastoma by Morgane Le Bras, Noah Gorelick, Sylvain Pautet, Betty Tyler, Stéphane Manenti, Nicolas Skuli, Stefania Millevoi, Anne Cammas

“…Deregulation of mRNA translation is a widespread characteristic of glioblastoma (GBM), aggressive malignant brain tumors that are resistant to conventional therapies. …”
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PLGA Nanoparticle-Based Formulations to Cross the Blood–Brain Barrier for Drug Delivery: From R&D to cGMP by Kaining Zhi, Babatunde Raji, Anantha R. Nookala, Mohammad Moshahid Khan, Xuyen H. Nguyen, Swarna Sakshi, Tayebeh Pourmotabbed, Murali M. Yallapu, Harry Kochat, Erene Tadrous, Shelby Pernell, Santosh Kumar

“…The blood–brain barrier (BBB) is a natural obstacle for drug delivery into the human brain, hindering treatment of central nervous system (CNS) disorders such as acute ischemic stroke, brain tumors, and human immunodeficiency virus (HIV)-1-associated neurocognitive disorders. …”
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Intracranial Efficacy of Systemic Therapy in Patients with Asymptomatic Brain Metastases from Lung Cancer by Min-Gwan Sun, Sue Jee Park, Yeong Jin Kim, Kyung-Sub Moon, In-Young Kim, Shin Jung, Hyung-Joo Oh, In-Jae Oh, Tae-Young Jung

“…We analyzed 96 patients with asymptomatic small-sized metastatic brain tumors from lung cancer. These underwent a radiologic follow-up every 2 or 3 months without local treatment of brain metastases. …”
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Energy Metabolism in <i>IDH1</i> Wild-Type and <i>IDH1</i>-Mutated Glioblastoma Stem Cells: A Novel Target for Therapy? by Cornelis J.F. van Noorden, Vashendriya V.V. Hira, Amber J. van Dijck, Metka Novak, Barbara Breznik, Remco J. Molenaar

“…In the present review, we describe ATP production in primary brain tumors, glioblastoma, in relation to ROS production. …”
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Genetic variants in XPD gene and glioma susceptibility in Chinese children: A multicenter case–control study by Yong‐Ping Chen, Yuxiang Liao, Li Yuan, Xiao‐Kai Huang, Ji‐Chen Ruan, Hui‐Ran Lin, Lei Miao, Zhen‐Jian Zhuo

“…Abstract Background Glioma is one of the central nervous system (CNS) tumors in children, accounting for 80% of malignant brain tumors. Nucleotide excision repair (NER) is a vital pathway during DNA damage repair progression. …”
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Epigenetic-Based Therapy—A Prospective Chance for Medulloblastoma Patients’ Recovery by Agata Strejczek, Dawid Woszczyk, Helena Urbaniak, Martyna Różańska, Michał Robak, Zofia Matuszewska, Anna-Maria Barciszewska

“…Medulloblastoma (MB) is one of the most frequent and malignant brain tumors in children. The prognosis depends on the advancement of the disease and the patient’s age. …”
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The Biological and Clinical Role of the Telomerase Reverse Transcriptase Gene in Glioblastoma: A Potential Therapeutic Target? by Vincenzo Di Nunno, Marta Aprile, Stefania Bartolini, Lidia Gatto, Alicia Tosoni, Lucia Ranieri, Dario De Biase, Sofia Asioli, Enrico Franceschi

“…The telomerase reverse transcriptase gene (<i>TERT</i>) is the most frequently altered gene in solid tumors, including brain tumors and GBM <i>IDH</i>-wildtype. In particular, it can be observed in approximately 80–90% of GBM <i>IDH</i>-wildtype cases. …”
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Irigenin inhibits glioblastoma progression through suppressing YAP/β-catenin signaling by Jiayun Xu, Jiayun Xu, Shanshan Sun, Shanshan Sun, Wei Zhang, Wei Zhang, Jianhong Dong, Jianhong Dong, Changgang Huang, Changgang Huang, Xin Wang, Xin Wang, Mengxian Jia, Mengxian Jia, Hao Yang, Hao Yang, Yongjie Wang, Yongjie Wang, Yuanyuan Jiang, Yuanyuan Jiang, Liying Cao, Liying Cao, Zhihui Huang, Zhihui Huang

“…Glioblastoma (GBM) is the most malignant glioma in brain tumors with low survival and high recurrence rate. …”
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Stem Cells in Clinical Trials on Neurological Disorders: Trends in Stem Cells Origins, Indications, and Status of the Clinical Trials by Eugenia D. Namiot, Jenni Viivi Linnea Niemi, Vladimir N. Chubarev, Vadim V. Tarasov, Helgi B. Schiöth

“…The most common neurological disorders treated with stem cells were injuries of brain, spinal cord, and peripheral nerves (14%), stroke (13%), multiple sclerosis (12%), and brain tumors (11%). Mesenchymal stem cells dominated (83%) although the choice of stem cells was highly dependent on the neurological disorder. …”
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The emerging role of pyroptosis in pediatric cancers: from mechanism to therapy by Hua Wang, Xiaowen Zhou, Chenbei Li, Shuxiang Yan, Chengyao Feng, Jieyu He, Zhihong Li, Chao Tu

“…Herein, we aimed to describe the molecular mechanisms of pyroptosis, to highlight and discuss the challenges and opportunities for activating pyroptosis pathways through various oncologic therapies in multiple pediatric neoplasms, including osteosarcoma, neuroblastoma, leukemia, lymphoma, and brain tumors.…”
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A Simple 3D Cell Culture Method for Studying the Interactions between Human Mesenchymal Stromal/Stem Cells and Patients Derived Glioblastoma by Lisa Oliver, Arturo Álvarez-Arenas, Céline Salaud, Juan Jiménez-Sanchez, Gabriel F. Calvo, Juan Belmonte-Beitia, Stephanie Blandin, Luciano Vidal, Victor Pérez, Dominique Heymann, François M. Vallette

“…We have developed a 3D biosphere model using patient-derived cells (PDCs) from glioblastoma (GBM), the major form of primary brain tumors in adult, plus cancer-activated fibroblasts (CAFs), obtained by culturing mesenchymal stem cells with GBM conditioned media. …”
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Role of Notch Signaling Pathway in Glioblastoma Multiforme Pathogenesis by Riccardo Bazzoni, Angela Bentivegna

“…Therefore, genetic and functional alterations to NSCs can lead to the development of brain tumors, including glioblastoma multiforme (GBM). …”
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Advanced Pediatric Diffuse Pontine Glioma Murine Models Pave the Way towards Precision Medicine by Zirong Chen, Peng Peng, Xiaolin Zhang, Barbara Mania-Farnell, Guifa Xi, Feng Wan

“…Diffuse intrinsic pontine gliomas (DIPGs) account for ~15% of pediatric brain tumors, which invariably present with poor survival regardless of treatment mode. …”
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Emerging Pathogenic and Prognostic Significance of Paired Box 3 (PAX3) Protein in Adult Gliomas by Efthalia Angelopoulou, Yam Nath Paudel, Christina Piperi

“…Gliomas present the most common type of brain tumors in adults, characterized by high morbidity and mortality. …”
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Profiling of Carnitine Shuttle System Intermediates in Gliomas Using Solid-Phase Microextraction (SPME) by Joanna Bogusiewicz, Katarzyna Burlikowska, Karol Jaroch, Paulina Zofia Gorynska, Krzysztof Gorynski, Marcin Birski, Jacek Furtak, Dariusz Paczkowski, Marek Harat, Barbara Bojko

“…The current study aims to assess the profiles of carnitine and acylcarnitines in gliomas with respect to their grade, the presence of isocitrate dehydrogenase (IDH) mutations, and 1p/19q co-deletion. Brain tumors obtained from 19 patients were sampled on-site using solid-phase microextraction (SPME) immediately following excision. …”
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Transcranial Photosensitizer-Free Laser Treatment of Glioblastoma in Rat Brain by Oxana Semyachkina-Glushkovskaya, Sergey Sokolovski, Ivan Fedosov, Alexander Shirokov, Nikita Navolokin, Alla Bucharskaya, Inna Blokhina, Andrey Terskov, Alexander Dubrovski, Valeria Telnova, Anna Tzven, Maria Tzoy, Arina Evsukova, Daria Zhlatogosrkaya, Viktoria Adushkina, Alexander Dmitrenko, Maria Manzhaeva, Valeria Krupnova, Alessio Noghero, Denis Bragin, Olga Bragina, Ekaterina Borisova, Jürgen Kurths, Edik Rafailov

“…Over sixty years, laser technologies have undergone a technological revolution and become one of the main tools in biomedicine, particularly in neuroscience, neurodegenerative diseases and brain tumors. Glioblastoma is the most lethal form of brain cancer, with very limited treatment options and a poor prognosis. …”
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Ion Channels in Gliomas—From Molecular Basis to Treatment by Abdallah F. Elias, Bernice C. Lin, Beverly J. Piggott

“…Targeting ion channels in difficult-to-treat brain tumors such as gliomas requires an understanding of their extremely heterogenous tumor microenvironment and highly diverse molecular profiles, both representing major causes of recurrence and treatment resistance. …”
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