DIAGNOSIS OF PLEOMORPHIC XANTHOASTROCYTOMA by Eryk Mikos, Joanna Dmochowska, Karol Kanon, Sara Moqbil, Wanesa Góralczyk

“…It accounts for 1% of primary brain tumors. It is mainly located in the temporal lobe and belongs to a group of tumors called long-term epilepsy associated tumors. …”
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Leptomeningeal metastasis from extracranial solid tumors by Dilip Harindran Vallathol, Vijay Maruti Patil, Vanita Noronha, Amit Joshi, Nandini Menon, Kumar Prabhash

“…The articles related to hematological malignancies and brain tumors were excluded. Results and Discussion: LM usually requires a strong suspicion based on the natural history of the disease and symptoms for diagnosis. …”
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Association Between Gene Polymorphisms and Glioma Susceptibility in Chinese Children by Huiqin Guo BA, Yuxiang Liao MD, Ao Lin MS, Huiran Lin MS, Xiaokai Huang MS, Jichen Ruan MD, Li Yuan PhD, Zhenjian Zhuo PhD

“…Gliomas are the most prevalent brain tumors among children and adolescents. The occurrence and development of various malignant tumors is closely related with LIN28A gene, but its relationship with glioma susceptibility has not been widely discovered. …”
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Short Term Outcomes of Gamma Knife Radiosurgery for Skull Base Meningiomas in Iran by Bitaraf M. A. Alikhani M., Shariftabrizi A.

“…Introduction: Skull base meningiomas constitute a large proportion of the meningiomas, which are the most common benign brain tumors. The treatment of skull base meningiomas is specially challenging and controversial due to the proximity of these tumors to the vital brain structures. …”
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The Multiple Roles of Peptidyl Prolyl Isomerases in Brain Cancer by Stefano Stifani

“…This review will discuss studies providing evidence for multiple roles of PIN1 and other PPIases in glioblastoma and medulloblastoma, the most frequent adult and pediatric primary brain tumors.…”
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Glioblastoma and MiRNAs by Swalih P. Ahmed, Javier S. Castresana, Mehdi H. Shahi

“…Glioblastoma (GB) is one of the most common types of lethal brain tumors. Although several treatment options are available including surgery, along with adjuvant chemo and radiotherapy, the disease has a poor prognosis and patients generally die within 14 months of diagnosis. …”
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The Transient Receptor Potential Vanilloid Type-2 (TRPV2) Ion Channels in Neurogenesis and Gliomagenesis: Cross-Talk between Transcription Factors and Signaling Molecules by Giorgio Santoni, Consuelo Amantini

“…Recently, the finding of cancer stem cells in brain tumors has increased the possibilitiesfor advancing new therapeutic approaches with the aim to overcome the limits of current availabletreatments. …”
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Loss of wild-type ATRX expression in somatic cell hybrids segregates with activation of Alternative Lengthening of Telomeres. by Kylie Bower, Christine E Napier, Sara L Cole, Rebecca A Dagg, Loretta M S Lau, Emma L Duncan, Elsa L Moy, Roger R Reddel

“…Alternative Lengthening of Telomeres (ALT) is a non-telomerase mechanism of telomere lengthening that occurs in about 10% of cancers overall and is particularly common in astrocytic brain tumors and specific types of sarcomas. Somatic cell hybridization analyses have previously shown that normal telomerase-negative fibroblasts and telomerase-positive immortalized cell lines contain repressors of ALT activity, indicating that activation of ALT results from loss of one or more unidentified repressors. …”
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Short Term Outcomes of Gamma Knife Radiosurgery for Skull Base Meningiomas in Iran by M. A Bitaraf, A Shariftabrizi

“…Introduction: Skull base meningiomas constitute a large proportion of the meningiomas, which are the most common benign brain tumors. The treatment of skull base meningiomas is specially challenging and controversial due to the proximity of these tumors to the vital brain structures. …”
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Engineering risk assessment of electromagnetic situation in the area of Rostov-on-Don television center by A. I. Kuhta, N. S. Mamatchenko

“…The result of this may be degenerative diseases of the central nervous system, blood cancer (leukemia), brain tumors, hormonal diseases, and malfunctions of certain organs and the human body as a whole. …”
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Comparison of hypothesis- and a novel hybrid data/hypothesis-driven method of functional MR imaging analysis in patients with brain gliomas. by Caulo, M, Esposito, R, Mantini, D, Briganti, C, Sestieri, C, Mattei, P, Colosimo, C, Romani, G, Tartaro, A

“…CONCLUSIONS: We suggest the use of the ICA-GLM as a valid alternative to the classic GLM method for presurgical mapping in patients with brain tumors and to replicate the present results in a broader sample of patients.…”

Noninvasive Quantification of 2-Hydroxyglutarate in Human Gliomas with IDH1 and IDH2 Mutations by Emir, U, Larkin, S, de Pennington, N, Voets, N, Plaha, P, Stacey, R, Al-Qahtani, K, Mccullagh, J, Schofield, C, Clare, S, Jezzard, P, Cadoux-Hudson, T, Ansorge, O

“…In this study, we address this need by presenting a proton magnetic resonance spectroscopy (1H-MRS) acquisition scheme that uses an ultrahigh magnetic field (≥7T) capable of noninvasively detecting 2-HG with quantitative measurements sufficient to differentiate mutant cytosolic IDH1 and mitochondrial IDH2 in human brain tumors. Untargeted metabolomics analysis of in vivo 1H-MRS spectra discriminated between IDH-mutant tumors and healthy tissue, and separated IDH1 from IDH2 mutations. …”

Stochastic growth pattern of untreated human glioblastomas predicts the survival time for patients by Ma, Z, Niu, B, Phan, TA, StensjØen, AL, Ene, C, Woodiwiss, T, Wang, T, Maini, P, Holland, EC, Tian, JP

“…Glioblastomas are highly malignant brain tumors. Knowledge of growth rates and growth patterns is useful for understanding tumor biology and planning treatment logistics. …”

Role of inflammatory mediators, macrophages, and neutrophils in glioma maintenance and progression: mechanistic understanding and potential therapeutic applications by Basheer, Abdul Samad, Abas, Faridah, Othman, Iekhsan, Naidu, Rakesh

“…Gliomas are the most common, highly malignant, and deadliest forms of brain tumors. These intra-cranial solid tumors are comprised of both cancerous and non-cancerous cells, which contribute to tumor development, progression, and resistance to the therapeutic regimen. …”

Slow Off-Rate Modified Aptamer (SOMAmer) Proteomic Analysis of Patient-Derived Malignant Glioma Identifies Distinct Cellular Proteomes by Thatchawan Thanasupawat, Aleksandra Glogowska, Christopher Pascoe, Sai Nivedita Krishnan, Maliha Munir, Farhana Begum, Jason Beiko, Jerry Krcek, Marc R. Del Bigio, Marshall Pitz, Yaoqing Shen, Victor Spicer, Kevin M. Coombs, John Wilkins, Sabine Hombach-Klonisch, Thomas Klonisch

“…Malignant gliomas derive from brain glial cells and represent >75% of primary brain tumors. This includes anaplastic astrocytoma (grade III; AS), the most common and fatal glioblastoma multiforme (grade IV; GBM), and oligodendroglioma (ODG). …”
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Involvement of Long Non-Coding RNAs (lncRNAs) in Tumor Angiogenesis by Julia Teppan, Dominik A. Barth, Felix Prinz, Katharina Jonas, Martin Pichler, Christiane Klec

“…Further, angiogenic lncRNAs occurring in several cancer types such as liver, gastrointestinal cancer, or brain tumors are summarized. Growing evidence on the influence of lncRNAs on tumor angiogenesis verified these transcripts as potential predictive or diagnostic biomarkers or therapeutic targets of anti-angiogenesis treatment. …”
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Remdesivir inhibits the progression of glioblastoma by enhancing endoplasmic reticulum stress by Yujia Chen, Yuduo Guo, Shenglun Li, Jiacheng Xu, Weihai Ning, Chao Zhao, Jun Wang, Yanming Qu, Mingshan Zhang, Wanlu Zhou, Qinghua Cui, Hongwei Zhang

“…Glioblastoma (GBM) is one of the most aggressive primary malignant brain tumors. The major challenge is the lack of effective therapeutic drugs due to the blood–brain barrier (BBB) and tumor heterogeneity. …”
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Secreted PGK1 and IGFBP2 contribute to the bystander effect of miR-10b gene editing in glioma by Yanhong Zhang, Rosalia Rabinovsky, Zhiyun Wei, Rachid El Fatimy, Evgeny Deforzh, Bai Luan, Leonid Peshkin, Erik J. Uhlmann, Anna M. Krichevsky

“…However, therapeutic gene editing in patients’ brain tumors may be hampered, among other factors, by the imperfect delivery and distribution of targeting vectors. …”
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Lentiviral Vectors as Tools for the Study and Treatment of Glioblastoma by Claudia Del Vecchio, Arianna Calistri, Cristina Parolin, Carla Mucignat-Caretta

“…Glioblastoma (GBM) has the worst prognosis among brain tumors, hence basic biology, preclinical, and clinical studies are necessary to design effective strategies to defeat this disease. …”
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Friends with Benefits: Chemokines, Glioblastoma-Associated Microglia/Macrophages, and Tumor Microenvironment by Elena Codrici, Ionela-Daniela Popescu, Cristiana Tanase, Ana-Maria Enciu

“…Glioma is the most common primary intracranial tumor and has the greatest prevalence of all brain tumors. Treatment resistance and tumor recurrence in GBM are mostly explained by considerable alterations within the tumor microenvironment, as well as extraordinary cellular and molecular heterogeneity. …”
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