Fractalkine/CX3CL1 in Neoplastic Processes by Jan Korbecki, Donata Simińska, Klaudyna Kojder, Szymon Grochans, Izabela Gutowska, Dariusz Chlubek, Irena Baranowska-Bosiacka

“…We present the role of CX3CL1 in the development of active human cytomegalovirus (HCMV) infection in glioblastoma multiforme (GBM) brain tumors. Finally, we discuss the possible use of CX3CL1 in immunotherapy.…”
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Mast Cell Infiltration in Human Brain Metastases Modulates the Microenvironment and Contributes to the Metastatic Potential by Ananya Roy, Ananya Roy, Sylwia Libard, Holger Weishaupt, Ida Gustavsson, Lene Uhrbom, Göran Hesselager, Fredrik J. Swartling, Fredrik Pontén, Fredrik Pontén, Irina Alafuzoff, Elena Tchougounova

“…Metastatic brain tumors continue to be a clinical problem, despite new therapeutic advances in cancer treatment. …”
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GPX8 as a Novel Prognostic Factor and Potential Therapeutic Target in Primary Glioma by Zhao-shou Yang, Qin Yang, Xiao-xiao Sun, Kui Xiong, Xiao-ting Zhu, Yi-chen Wang, Qian-yao Ren, Guo-hui Wu, Shi-min Wang, Xu-qin Cao, Xiao-rong Yang, Wen-gong Jiang

“…One of the most prevalent malignant primary brain tumors is primary glioma. Although glutathione peroxidase 8 (GPX8) is intimately associated with carcinogenesis, its function in primary gliomas has not yet been thoroughly understood. …”
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Transfer Learning Approach for Classification of Histopathology Whole Slide Images by Shakil Ahmed, Asadullah Shaikh, Hani Alshahrani, Abdullah Alghamdi, Mesfer Alrizq, Junaid Baber, Maheen Bakhtyar

“…Deep learning (DL) has made significant advances in the medical industry, including the use of magnetic resonance imaging (MRI) scans, computerized tomography (CT) scans, and electrocardiograms (ECGs) to detect life-threatening diseases, including heart disease, cancer, and brain tumors. However, more advancement in the field of pathology is needed, but the main hurdle causing the slow progress is the shortage of large-labeled datasets of histopathology images to train the models. …”
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Novel Insights into the Role of the Mineralocorticoid Receptor in Human Glioblastoma by Paula Aldaz, Amaya Fernández-Celis, Natalia López-Andrés, Imanol Arozarena

“…However, while GR signaling is well studied in GBM, little is known about the MR in brain tumors. We examined the implication of the MR in GBM considering its interplay with DEXA. …”
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Advances in computational and translational approaches for malignant glioma by Adip G. Bhargav, Joseph S. Domino, Anthony M. Alvarado, Chad A. Tuchek, David Akhavan, David Akhavan, David Akhavan, Paul J. Camarata

“…Gliomas are the most common primary brain tumors in adults and carry a dismal prognosis for patients. …”
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Tumor-to-Tumor Metastasis of Multiple Meningiomas and Clear Cell Renal Cell Carcinoma Metastasis as First Clinical Appearance of Kidney Cancer: A Case Report and Analysis by Johannes Dietterle, Clara Frydrychowicz, Wolf Müller, Karl-Titus Hoffmann, Katja Jähne, Jürgen Meixensberger

“…Background Meningioma accounts for more than 35% of all diagnosed brain tumors of the central nervous system and, moreover, it is the most common benign recipient of tumor-to-tumor metastasis. …”
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Intestinal Mucosa-Associated Lymphoid Tissue Lymphoma Transforming into Diffuse Large B-Cell Lymphoma in a Young Adult Patient with Neurofibromatosis Type 1: A Case Report by Hideki Kosako, Yusuke Yamashita, Ken Tanaka, Hiroyuki Mishima, Ryuta Iwamoto, Akira Kinoshita, Shin-ichi Murata, Koichi Ohshima, Koh-ichiro Yoshiura, Takashi Sonoki, Shinobu Tamura

“…Lymphoproliferative malignancies associated with NF1 are limited, although the most common are brain tumors. <i>Case presentation</i>: A 22-year-old woman with NF1 was admitted due to abdominal pain and bloody diarrhea. …”
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H2A.Z histone variants facilitate HDACi-dependent removal of H3.3K27M mutant protein in pediatric high-grade glioma cells by Katarzyna B. Leszczynska, Amanda Freitas-Huhtamäki, Chinchu Jayaprakash, Monika Dzwigonska, Francisca N.L. Vitorino, Cynthia Horth, Kamil Wojnicki, Bartlomiej Gielniewski, Paulina Szadkowska, Beata Kaza, Javad Nazarian, Maciej K. Ciolkowski, Joanna Trubicka, Wieslawa Grajkowska, Benjamin A. Garcia, Jacek Majewski, Bozena Kaminska, Jakub Mieczkowski

“…Summary: Diffuse intrinsic pontine gliomas (DIPGs) are deadly pediatric brain tumors, non-resectable due to brainstem localization and diffusive growth. …”
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A novel BRAF::PTPRN2 fusion in meningioma: a case report by Nishanth S. Sadagopan, Khizar R. Nandoliya, Mark W. Youngblood, Craig M. Horbinski, Jared T. Ahrendsen, Stephen T. Magill

“…Fusions involving B-raf proto-oncogene, serine/threonine kinase (BRAF) are subtypes of oncogenic BRAF genetic abnormalities that have been reported in certain cases of brain tumors, such as pilocytic astrocytomas. However, BRAF fusions have not been recognized in meningioma. …”
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Medulloblastoma, macrocephaly, and a pathogenic germline PTEN variant: Cause or coincidence? by Jussi‐Pekka Tolonen, Anne Hekkala, Outi Kuismin, Hannu Tuominen, Maria Suo‐Palosaari, Olli Tynninen, Riitta Niinimäki

“…Abstract Background Medulloblastomas (MBs) are a heterogeneous group of childhood brain tumors with four consensus subgroups, namely MBSHH, MBWNT, MBGroup 3, and MBGroup 4, representing the second most common type of pediatric brain cancer after high‐grade gliomas. …”
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Targeted Sensitization of Glioblastoma Multiforme Using AAAPT Technology by Megan Mendieta, Naze G. Avci, Raghu Pandurangi, Yasemin M. Akay, Metin Akay

“…Glioblastoma Multiforme (GBM) is the most malignant type of all brain tumors. Current GBM treatment options include surgery, followed by radiation and chemotherapy. …”
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Computer-Aided Discovery of Small Molecule Inhibitors of Transcriptional Activity of TLX (NR2E1) Nuclear Receptor by Evgenia Dueva, Kriti Singh, Anastasia Kalyta, Eric LeBlanc, Paul S. Rennie, Artem Cherkasov

“…Orphan nuclear receptor TLX (NR2E1) plays a critical role in the regulation of neural stem cells (NSC) as well as in the development of NSC-derived brain tumors. In the last years, new data have emerged implicating TLX in prostate and breast cancer. …”
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Renal cell carcinoma metastasis to meningioma: A case report by Ka Hyen Ko, Kihwan Hwang, Ji-Eyon Kwon, Yujun Park, Gheeyoung Choe

“…Background: Meningiomas are the most common primary intracranial tumors that account for about 35% of all brain tumors. Tumor-to-tumor metastasis (TTM) refers to a rare phenomenon in which a malignant tumor metastasizes to another tumor of totally different origin. …”
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Role of Inflammatory Mediators, Macrophages, and Neutrophils in Glioma Maintenance and Progression: Mechanistic Understanding and Potential Therapeutic Applications by Abdul Samad Basheer, Faridah Abas, Iekhsan Othman, Rakesh Naidu

“…Gliomas are the most common, highly malignant, and deadliest forms of brain tumors. These intra-cranial solid tumors are comprised of both cancerous and non-cancerous cells, which contribute to tumor development, progression, and resistance to the therapeutic regimen. …”
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An integrated genetic analysis of epileptogenic brain malformed lesions by Atsushi Fujita, Mitsuhiro Kato, Hidenori Sugano, Yasushi Iimura, Hiroharu Suzuki, Jun Tohyama, Masafumi Fukuda, Yosuke Ito, Shimpei Baba, Tohru Okanishi, Hideo Enoki, Ayataka Fujimoto, Akiyo Yamamoto, Kentaro Kawamura, Shinsuke Kato, Ryoko Honda, Tomonori Ono, Hideaki Shiraishi, Kiyoshi Egawa, Kentaro Shirai, Shinji Yamamoto, Itaru Hayakawa, Hisashi Kawawaki, Ken Saida, Naomi Tsuchida, Yuri Uchiyama, Kohei Hamanaka, Satoko Miyatake, Takeshi Mizuguchi, Mitsuko Nakashima, Hirotomo Saitsu, Noriko Miyake, Akiyoshi Kakita, Naomichi Matsumoto

“…In this study, we performed a genetic analysis of epileptogenic brain malformed lesions from 64 patients with focal cortical dysplasia, hemimegalencephy, brain tumors, or hippocampal sclerosis. Targeted sequencing, whole-exome sequencing, and single nucleotide polymorphism microarray detected four germline and 35 somatic variants, comprising three copy number variants and 36 single nucleotide variants and indels in 37 patients. …”
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LINC02774 inhibits glycolysis in glioma to destabilize HIF‐1α dependent on transcription factor RP58 by Yuanbing Chen, Yating Liu, Jianbing Xiong, Lianlian Ouyang, Miao Tang, Chao Mao, Liling Li, Desheng Xiao, Shuang Liu, Zhen Yang, Jun Huang, Yongguang Tao

“…Abstract Glioma, the most common of malignant tumors in the brain, is responsible for the majority of deaths from primary brain tumors. The regulation of long noncoding RNAs (lncRNAs) in HIF‐1α‐driven tumor development remains unclear. …”
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Therapeutic Potential of Resveratrol for Glioma: A Systematic Review and Meta-Analysis of Animal Model Studies by Ângelo Luís, Helena Marcelino, Fernanda Domingues, Luísa Pereira, José Francisco Cascalheira

“…Gliomas are aggressive malignant brain tumors, with poor prognosis despite available therapies, raising the necessity for finding new compounds with therapeutic action. …”
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Identification of transcriptome signature for predicting clinical response to bevacizumab in recurrent glioblastoma by Seung Won Choi, Hyemi Shin, Jason K. Sa, Hee Jin Cho, Harim Koo, Doo‐Sik Kong, Ho Jun Seol, Do‐Hyun Nam

“…Abstract Glioblastomas are among the most fatal brain tumors. Although no effective treatment option is available for recurrent glioblastomas (GBMs), a subset of patients evidently derived clinical benefit from bevacizumab, a monoclonal antibody against vascular endothelial growth factor. …”
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HDAC Class I Inhibitor Domatinostat Preferentially Targets Glioma Stem Cells over Their Differentiated Progeny by Yurika Nakagawa-Saito, Shinichi Saitoh, Yuta Mitobe, Asuka Sugai, Keita Togashi, Shuhei Suzuki, Chifumi Kitanaka, Masashi Okada

“…We aimed in this study to discover novel drugs targeting such Achilles’ heels of GSCs as anti-GSC drug candidates to be used for the treatment of glioblastoma, the most therapy-resistant form of brain tumors. Here we report that domatinostat (4SC-202), a class I HDAC inhibitor, is one such candidate. …”
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