Multi-class disease detection using deep learning and human brain medical imaging by Yousaf, Fatima, Iqbal, Sajid, Fatima, Nosheen, Kousar, Tanzeela, Mohd. Rahim, Mohd. Shafry

“…Machine learning methods especially neural-network based algorithms have shown huge success in medical image analysis for variety of tasks including the detection, segmentation and classification of brain tumors and Ischemic stroke. Usually, these models address one problem at a time which is considered as Artificial Weak Intelligence (AWI). …”

Deep-learning-enabled brain hemodynamic mapping using resting-state fMRI by Xirui Hou, Pengfei Guo, Puyang Wang, Peiying Liu, Doris D. M. Lin, Hongli Fan, Yang Li, Zhiliang Wei, Zixuan Lin, Dengrong Jiang, Jin Jin, Catherine Kelly, Jay J. Pillai, Judy Huang, Marco C. Pinho, Binu P. Thomas, Babu G. Welch, Denise C. Park, Vishal M. Patel, Argye E. Hillis, Hanzhang Lu

“…The deep-learning network is trained with CVR and BAT maps obtained with a reference method of CO2-inhalation MRI, which includes data from young and older healthy subjects and patients with Moyamoya disease and brain tumors. We demonstrate the performance of deep-learning cerebrovascular mapping in the detection of vascular abnormalities, evaluation of revascularization effects, and vascular alterations in normal aging. …”
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Importance of the Role of ω-3 and ω-6 Polyunsaturated Fatty Acids in the Progression of Brain Cancer by Mayra Montecillo-Aguado, Belen Tirado-Rodriguez, Zhen Tong, Owen M. Vega, Mario Morales-Martínez, Shaheen Abkenari, José Pedraza-Chaverri, Sara Huerta-Yepez

“…We highlight our current understanding of the role of PUFAs and its metabolites (oxylipins) in different brain tumors, proliferation, apoptosis, invasion, angiogenesis, and immunosuppression by focusing on recent research in vitro and in vivo.…”
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Long-Term Effects of Ionizing Radiation on the Hippocampus: Linking Effects of the Sonic Hedgehog Pathway Activation with Radiation Response by Francesca Antonelli, Arianna Casciati, Montserrat Belles, Noemi Serra, Maria Victoria Linares-Vidal, Carmela Marino, Mariateresa Mancuso, Simonetta Pazzaglia

“…Radiation therapy represents one of the primary treatment modalities for primary and metastatic brain tumors. Although recent advances in radiation techniques, that allow the delivery of higher radiation doses to the target volume, reduce the toxicity to normal tissues, long-term neurocognitive decline is still a detrimental factor significantly affecting quality of life, particularly in pediatric patients. …”
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Expression of the Human Serotonin 5-HT₇ Receptor Rescues Phenotype Profile and Restores Dysregulated Biomarkers in a <i>Drosophila melanogaster</i> Glioma Model by Florestan Courant, Marion Maravat, Wanyin Chen, David Gosset, Lauren Blot, Nadège Hervouet-Coste, Vincent Sarou-Kanian, Séverine Morisset-Lopez, Martine Decoville

“…Gliomas are the most common primary brain tumors in adults. Significant progress has been made in recent years in identifying the molecular alterations involved in gliomas. …”
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The effect of Azo-dyes on glioblastoma cells in vitro by Ani-Simona Sevastre, Carina Baloi, Oana Alexandru, Ligia Gabriela Tataranu, Oana Stefana Popescu, Anica Dricu

“…Conclusions: Our research represents a novelty, by offering unique valuable data regarding the azo-dye cyototoxic effects in high grade brain tumors. This study may focus the attention on azo-dye agents that may represent an insufficient exploited source of agents for cancer treatment.…”
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Pharmacological Modulation of Blood–Brain Barrier Permeability by Kinin Analogs in Normal and Pathologic Conditions by Dina Sikpa, Lisa Whittingstall, Martin Savard, Réjean Lebel, Jérôme Côté, Stephen McManus, Sylvain Chemtob, David Fortin, Martin Lepage, Fernand Gobeil

“…Moreover, a systemic single dose of B2R agonist did not increase the incidence of metastatic brain tumors originating from circulating breast cancer cells. …”
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A Targeted Next-Generation Sequencing Panel to Genotype Gliomas by Maria Guarnaccia, Laura Guarnaccia, Valentina La Cognata, Stefania Elena Navone, Rolando Campanella, Antonella Ampollini, Marco Locatelli, Monica Miozzo, Giovanni Marfia, Sebastiano Cavallaro

“…Gliomas account for the majority of primary brain tumors. Glioblastoma is the most common and malignant type. …”
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Pre- and Post-Zygotic TP53 De Novo Mutations in SHH-Medulloblastoma by Jacopo Azzollini, Elisabetta Schiavello, Francesca Romana Buttarelli, Carlo Alfredo Clerici, Laura Tizzoni, Giovanna De Vecchi, Fabio Capra, Federica Pisati, Veronica Biassoni, Letterio Runza, Giorgio Carrabba, Felice Giangaspero, Maura Massimino, Valeria Pensotti, Siranoush Manoukian

“…Li-Fraumeni syndrome (LFS) is an autosomal dominant disorder caused by mutations in the <i>TP53</i> gene, predisposing to a wide spectrum of early-onset cancers, including brain tumors. In medulloblastoma patients, the role of TP53 has been extensively investigated, though the prevalence of de novo mutations has not been addressed. …”
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Safeness of sodium fluorescein administration in neurosurgery: Case-report of an erroneous very high-dose administration and review of the literature by Francesco Restelli, Giulio Bonomo, Emanuele Monti, Giovanni Broggi, Francesco Acerbi, Morgan Broggi

“…Discussion and conclusions: The good clinical and laboratory outcome of this patient further strengthens the idea that fluorescein-guided removal of brain tumors may be considered safe, beyond effective. …”
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The Application of DTCWT on MRI-Derived Radiomics for Differentiation of Glioblastoma and Solitary Brain Metastases by Wen-Feng Wu, Chia-Wei Shen, Kuan-Ming Lai, Yi-Jen Chen, Eugene C. Lin, Chien-Chin Chen

“…Background: While magnetic resonance imaging (MRI) is the imaging modality of choice for the evaluation of patients with brain tumors, it may still be challenging to differentiate glioblastoma multiforme (GBM) from solitary brain metastasis (SBM) due to their similar imaging features. …”
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Multiparametric Longitudinal Profiling of RCAS-tva-Induced PDGFB-Driven Experimental Glioma by Hannes Becker, Salvador Castaneda-Vega, Kristin Patzwaldt, Justyna M. Przystal, Bianca Walter, Filippo C. Michelotti, Denis Canjuga, Marcos Tatagiba, Bernd Pichler, Susanne C. Beck, Eric C. Holland, Christian la Fougère, Ghazaleh Tabatabai

“…Glioblastomas are incurable primary brain tumors harboring a heterogeneous landscape of genetic and metabolic alterations. …”
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Identification of differentially expressed key genes between glioblastoma and low-grade glioma by bioinformatics analysis by Yang Xu, Rongxin Geng, Fan’en Yuan, Qian Sun, Baohui Liu, Qianxue Chen

“…Gliomas are a very diverse group of brain tumors that are most commonly primary tumor and difficult to cure in central nervous system. …”
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Glioblastoma Tissue Slice Tandem-Cultures for Quantitative Evaluation of Inhibitory Effects on Invasion and Growth by Vasile Sidorcenco, Luisa Krahnen, Marion Schulz, Janina Remy, Donat Kögel, Achim Temme, Ute Krügel, Heike Franke, Achim Aigner

“…Glioblastomas (GBMs) are the most malignant brain tumors and are essentially incurable even after extensive surgery, radiotherapy, and chemotherapy, mainly because of extensive infiltration of tumor cells into the adjacent normal tissue. …”
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Effects of Multi-Shell Free Water Correction on Glioma Characterization by Lea Starck, Fulvio Zaccagna, Ofer Pasternak, Ferdia A. Gallagher, Renate Grüner, Frank Riemer

“…Diffusion MRI is a useful tool to investigate the microstructure of brain tumors. However, the presence of fast diffusing isotropic signals originating from non-restricted edematous fluids, within and surrounding tumors, may obscure estimation of the underlying tissue characteristics, complicating the radiological interpretation and quantitative evaluation of diffusion MRI. …”
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Validation Study for Non-Invasive Prediction of <i>IDH</i> Mutation Status in Patients with Glioma Using In Vivo ¹H-Magnetic Resonance Spectroscopy and Machine Learning by Elisabeth Bumes, Claudia Fellner, Franz A. Fellner, Karin Fleischanderl, Martina Häckl, Stefan Lenz, Ralf Linker, Tim Mirus, Peter J. Oefner, Christian Paar, Martin Andreas Proescholdt, Markus J. Riemenschneider, Katharina Rosengarth, Serge Weis, Christina Wendl, Sibylle Wimmer, Peter Hau, Wolfram Gronwald, Markus Hutterer

“…The <i>isocitrate dehydrogenase</i> (<i>IDH</i>) mutation status is an indispensable prerequisite for diagnosis of glioma (astrocytoma and oligodendroglioma) according to the WHO classification of brain tumors 2021 and is a potential therapeutic target. …”
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ERK Phosphorylation Regulates the Aml1/Runx1 Splice Variants and the TRP Channels Expression during the Differentiation of Glioma Stem Cell Lines by Giorgio Santoni, Massimo Nabissi, Consuelo Amantini, Matteo Santoni, Lucia Ricci-Vitiani, Roberto Pallini, Federica Maggi, Maria Beatrice Morelli

“…The identification of cancer stem cells in brain tumors paved the way for new therapeutic approaches. …”
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Glioma Tumors’ Classification Using Deep-Neural-Network-Based Features with SVM Classifier by Ghazanfar Latif, Ghassen Ben Brahim, D. N. F. Awang Iskandar, Abul Bashar, Jaafar Alghazo

“…The complexity of brain tissue requires skillful technicians and expert medical doctors to manually analyze and diagnose Glioma brain tumors using multiple Magnetic Resonance (MR) images with multiple modalities. …”
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Nanotechnology prospects in brain therapeutics concerning gene-targeting and nose-to-brain administration by Dong-Dong Wu, Yasmine Ahmed Salah, Ebenezeri Erasto Ngowi, Yan-Xia Zhang, Saadullah Khattak, Nazeer Hussain Khan, Yan Wang, Tao Li, Zi-Hua Guo, Yan-Mei Wang, Xin-Ying Ji

“…Adding to this mind-blowing nanotechnology, the revolutionizing gene-altering biologics can have the best of both worlds, and pave the way for the long-awaited cure to many diseases, among those diseases thus far are Alzheimer’s disease (AD), brain tumors (glioma and glioblastoma), Down syndrome, stroke, and even cases with HIV. …”
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Prognostic value of mutations in isocitrate dehydrogenase 1 (IDH1) and reverse telomerase transcriptase (TERT) in Argentine patients` gliomas by Pedro Tomás Funes, Daniela Moggia, Diana Lidia Parma, Marcela Ferrer, Florencia Giliberto, Irene Szijan

“… Background and aim: Gliomas are the most common primary brain tumors, and they are classified according to their histopathological and genetic features. …”
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