Assessment of hypoxia and oxidative-related changes in a lung-derived brain metastasis model by [64Cu][Cu(ATSM)] PET and proteomic studies by Jade Fantin, Jérôme Toutain, Elodie A. Pérès, Benoit Bernay, Sarina Maya Mehani, Charly Helaine, Mickael Bourgeois, Carole Brunaud, Laurent Chazalviel, Julien Pontin, Aurélien Corroyer-Dulmont, Samuel Valable, Michel Cherel, Myriam Bernaudin

“…Abstract Background Brain metastases (BM) are the most frequent malignant brain tumors. The aim of this study was to characterize the tumor microenvironment (TME) of BM and particularly hypoxia and redox state, known to play a role in tumor growth and treatment resistance with multimodal PET and MRI imaging, immunohistochemical and proteomic approaches in a human lung cancer (H2030-BrM3)-derived BM model in rats. …”
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Laser Interstitial Thermal Therapy in Patients with Newly Diagnosed Glioblastoma: A Systematic Review by Ilaria Viozzi, Alis Guberinic, Christiaan G. Overduin, Maroeska M. Rovers, Mark ter Laan

“…Background: Laser interstitial thermal therapy (LITT) is a minimal invasive neurosurgical technique for the treatment of brain tumors. Results of LITT have been reported in a case series of patients with deep seated and/or recurrent glioblastoma or cerebral metastases. …”
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O-Vanillin Attenuates the TLR2 Mediated Tumor-Promoting Phenotype of Microglia by Paul Triller, Julia Bachorz, Michael Synowitz, Helmut Kettenmann, Darko Markovic

“…Malignant gliomas are primary brain tumors with poor prognoses. These tumors are infiltrated by brain intrinsic microglia and peripheral monocytes which promote glioma cell invasion. …”
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<i>RYK</i> Gene Expression Associated with Drug Response Variation of Temozolomide and Clinical Outcomes in Glioma Patients by Ricardo D. Gonzalez, George W. Small, Adrian J. Green, Farida S. Akhtari, Tammy M. Havener, Julia C. F. Quintanilha, Amber B. Cipriani, David M. Reif, Howard L. McLeod, Alison A. Motsinger-Reif, Tim Wiltshire

“…Temozolomide (TMZ) chemotherapy is an important tool in the treatment of glioma brain tumors. However, variable patient response and chemo-resistance remain exceptionally challenging. …”
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Investigating the intermolecular interactions in the explicitly solvated complexes of lomustine with water and ethanol by Emmanuel E.D. Okon, Hitler Louis, Daniel Etiese, Tomsmith O. Unimuke, Gideon E. Mathias, Ededet A. Eno, Onyinye J. Ikenyirimba, Ernest C. Agwamba, Adedapo S. Adeyinka

“…Lomustine is an alkylating chemotherapy drug that is used to treat diverse types of cancer, including brain tumors, Hodgkin's lymphoma, and non-Hodgkin's lymphoma, which works by interfering with the DNA in cancer cells, preventing them from dividing and growing. …”
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A Review of Boron Neutron Capture Therapy: Its History and Current Challenges by Will H. Jin, MD, Crystal Seldon, MD, Michael Butkus, PhD, Wolfgang Sauerwein, MD, Huan B. Giap, MD, PhD

“…Early studies were promising for patients with malignant brain tumors, recurrent tumors of the head and neck, and cutaneous melanomas; however, there were certain limitations to its widespread adoption and use. …”
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Repurposing Auranofin and Evaluation of a New Gold(I) Compound for the Search of Treatment of Human and Cattle Parasitic Diseases: From Protozoa to Helminth Infections by Liwen Feng, Sébastien Pomel, Perle Latre de Late, Alexandre Taravaud, Philippe M. Loiseau, Louis Maes, Fidelis Cho-Ngwa, Christina A. Bulman, Chelsea Fischer, Judy A. Sakanari, Peter D. Ziniel, David L. Williams, Elisabeth Davioud-Charvet

“…These metal-ligand complexes are of particular interest because of their combined abilities to irreversibly target the essential dithiol/selenol catalytic pair of selenium-dependent thioredoxin reductase activity, and to kill cells from breast and brain tumors. In this work, screening of various parasites—protozoans, trematodes, and nematodes—was undertaken to determine the in vitro killing activity of GoPI-sugar compared to auranofin. …”
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Imaging biomarkers associated with extra-axial intracranial tumors: a systematic review by Navodini Wijethilake, Oscar MacCormac, Oscar MacCormac, Tom Vercauteren, Jonathan Shapey, Jonathan Shapey

“…Extra-axial brain tumors are extra-cerebral tumors and are usually benign. …”
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Assessing the Safety of Craniotomy for Resection of Primary Central Nervous System Lymphoma: A Nationwide Inpatient Sample Analysis by Jonathan Yun, Jingyan Yang, Michael Cloney, Amol Mehta, Suprit Singh, Fabio Massaiti Iwamoto, Alfred I. Neugut, Alfred I. Neugut, Alfred I. Neugut, Adam M. Sonabend

“…To challenge the traditional non-surgical paradigm, it is essential to first investigate the safety of resection for PCNSL.MethodsTo determine the operative morbidity of resection for this disease, we performed a population-based assessment of complications using the nationwide inpatient sample database for the years 1998–2013 for biopsies and open craniotomies for PCNSL and other brain tumors.ResultsAmong 95 patients who underwent biopsy and 34 patients who underwent craniotomy, we found no significant difference in complication rates between craniotomy for resection and biopsy procedures for PCNSL (23.16 versus 20.59%). …”
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The effects that secondary parkinsonian syndromes have on health status by Dawid Kościołek, Michał Urbaś, Jakub Misiak, Aleksandra Kościołek, Martyna Kępczyk, Oliwia Czekaj, Miłosz Ojdana, Kaja Surowiecka, Oliwia Kwaśniewska, Yehor Demianenko

“…Various conditions can lead to the development of secondary parkinsonism, including hydrocephalus, brain tumors, encephalitis, cerebral atherosclerosis, traumatic brain injuries, medications, and poisoning. …”
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Integrin α10, a Novel Therapeutic Target in Glioblastoma, Regulates Cell Migration, Proliferation, and Survival by Matilda Munksgaard Thorén, Katarzyna Chmielarska Masoumi, Cecilia Krona, Xiaoli Huang, Soumi Kundu, Linnéa Schmidt, Karin Forsberg-Nilsson, Marcus Floyd Keep, Elisabet Englund, Sven Nelander, Bo Holmqvist, Evy Lundgren-Åkerlund

“…New, effective treatment strategies for glioblastomas (GBMs), the most malignant and invasive brain tumors in adults, are highly needed. In this study, we investigated the potential of integrin &#945;10&#946;1 as a therapeutic target in GBMs. …”
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Bioactive peptides from venoms against glioma progression by Bernarda Majc, Bernarda Majc, Metka Novak, Tamara T. Lah, Tamara T. Lah, Igor Križaj, Igor Križaj

“…In this article, we review the mechanisms of action on these cancer cell features, focusing on bioactive peptides being developed as potential therapeutics for one of the most aggressive and deadly brain tumors, glioblastoma (GB). Novel therapeutic approaches applying bioactive peptides may contribute to multiple targeting of GB and particularly of GB stem cells. …”
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Harmaline to Human Mitochondrial Caseinolytic Serine Protease Activation for Pediatric Diffuse Intrinsic Pontine Glioma Treatment by Morena Miciaccia, Francesca Rizzo, Antonella Centonze, Gianfranco Cavallaro, Marialessandra Contino, Domenico Armenise, Olga Maria Baldelli, Roberta Solidoro, Savina Ferorelli, Pasquale Scarcia, Gennaro Agrimi, Veronica Zingales, Elisa Cimetta, Simone Ronsisvalle, Federica Maria Sipala, Paola Loguercio Polosa, Cosimo Gianluca Fortuna, Maria Grazia Perrone, Antonio Scilimati

“…DIPG is the leading cause of death for pediatric brain tumors due to its infiltrative nature and inoperability. …”
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N6-isopentenyladenosine induces cell death through necroptosis in human glioblastoma cells by Cristina Pagano, Giovanna Navarra, Laura Coppola, Giorgio Avilia, Olga Pastorino, Rosa Della Monica, Michela Buonaiuto, Giovanni Torelli, Pasquale Caiazzo, Maurizio Bifulco, Chiara Laezza

“…Abstract Targeting necroptosis is considered a promising therapeutic strategy in cancer, including Glioblastoma Multiforme (GBM), one of the most lethal brain tumors. Necroptosis is a mechanism of programmed cell death overcoming the apoptosis resistance mechanism underlying GBM tumorigenesis and malignant progression. …”
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Convection-enhanced delivery of nanoencapsulated gene locoregionally yielding ErbB2/Her2-specific CAR-macrophages for brainstem glioma immunotherapy by Lin Gao, Chongdeng Shi, Zhenmei Yang, Weiqiang Jing, Maosen Han, Jing Zhang, Cai Zhang, Chunwei Tang, Yuanmin Dong, Ying Liu, Chen Chen, Xinyi Jiang

“…Abstract Locoregional delivery of chimeric antigen receptor (CAR)-modified T (CAR-T) cells has emerged as a promising strategy for brain tumors. However, the complicated ex vivo cell manufacturing procedures and the rapid progression of the disease have limited its broader applications. …”
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Case report: Multiple brain metastases of atrial myxoma: Clinical experience and literature review by Kang Ma, Dawei Zhao, Xuegang Li, Haijun Duan, Chaojun Yan, Shi Wang, Lan Zeng, Kai Xu, Ying Lai, Beike Chen, Ning Mu, Chuanyan Yang, Yulian Quan, Zhengyang Li, Xiaoming Wang, Hua Feng, Fei Li

“…However, recurrent brain tumors and unexpected cerebral infarctions occurred frequently shortly after the treatment because the cardiac myxoma had not been treated due to the patient's personal concerns. …”
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Comparative Analysis of Amino Acid Profiles in Patients with Glioblastoma and Meningioma Using Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry (LC-ESI-MS/MS) by Piotr Kośliński, Robert Pluskota, Marcin Koba, Zygmunt Siedlecki, Maciej Śniegocki

“…Brain tumors account for 1% of all cancers diagnosed de novo. …”
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A Novel Micro Cold Atmospheric Plasma Device for Glioblastoma Both In Vitro and In Vivo by Zhitong Chen, Hayk Simonyan, Xiaoqian Cheng, Eda Gjika, Li Lin, Jerome Canady, Jonathan H. Sherman, Colin Young, Michael Keidar

“…To enhance efficiency and expand the applicability of the CAP method for brain tumors and reduce the gas flow rate and size of the plasma jet, a novel micro-sized CAP device (µCAP) was developed and employed to target glioblastoma tumors in the murine brain. …”
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Pathological and Molecular Features of Glioblastoma and Its Peritumoral Tissue by Alessio D’Alessio, Gabriella Proietti, Gigliola Sica, Bianca Maria Scicchitano

“…Glioblastoma (GBM) is one of the most aggressive and lethal human brain tumors. At present, GBMs are divided in primary and secondary on the basis of the mutational status of the isocitrate dehydrogenase (<i>IDH</i>) genes. …”
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Characterization of a bimodal multi-fibre optic clinical probe for in situ tissue diagnosis based on spectrally-and temporally-resolved autofluorescence by Mira Sibai, Hussein Mehidine, Bertrand Devaux, Bertrand Devaux, Bertrand Devaux, Darine Abi Haidar, Darine Abi Haidar

“…The unique advantage is that the sampled volume is well defined by the source-detector geometry and that the functionality of multiple optical techniques can be incorporated into one probe so that more information is gained without extra bulkiness or cost, while also mitigating the limitations of each.Methods: This advantage is utilized here to address the limited accuracy in delineating brain tumors, in situ, by simultaneously characterizing tissue based on the spectral and lifetime properties of five endogenous fluorophores commonly present in brain tissue. …”
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