Long noncoding RNA MALAT1 may be a prognostic biomarker in IDH1/2 wild-type primary glioblastomas by Omer Gokay Argadal, Melis Mutlu, Secil Ak Aksoy, Hasan Kocaeli, Berrin Tunca, Muhammet Nafi Civan, Unal Egeli, Gulsah Cecener, Ahmet Bekar, Mevlut Ozgur Taskapilioglu, Cagla Tekin, Gulcin Tezcan, Sahsine Tolunay

“… Primary glioblastoma (GB) is the most aggressive type of brain tumors. While mutations in isocitrate dehydrogenase (IDH) genes are frequent in secondary GBs and correlate with a better prognosis, most primary GBs are IDH wild-type. …”
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Radiochemical Synthesis of 4-[¹⁸F]FluorobenzylAzide and Its Conjugation with EGFR-Specific Aptamers by Viktor A. Il’in, Elena V. Pyzhik, Anton B. Balakhonov, Maksim A. Kiryushin, Evgeniya V. Shcherbatova, Andrey A. Kuznetsov, Pavel A. Kostin, Andrey V. Golovin, Vladimir A. Korshun, Vladimir A. Brylev, Kseniya A. Sapozhnikova, Alexey M. Kopylov, Galina V. Pavlova, Igor N. Pronin

“…Central nervous system tumors related to gliomas are of neuroectodermal origin and cover about 30% of all primary brain tumors. Glioma is not susceptible to any therapy and surgical attack remains one of the main approaches to its treatment. …”
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A clinical case of pseudotumorous chronic parainfectious limbic encephalitis by N. A. Shnaider, Yu. S. Panina, T. E. Popova

“…It was differentially diagnosed from brain tumors (astrocytic, oligodendroglial, and mixed gliomas, ependymal, neuronal, neuroglial, and embryonal tumors, meningiomas, cholesteatomas, dermoid cysts, teratomas, and cysts), other reactive and inflammatory processes (leukemic infiltrations, systemic lupus erythematosus, multiple sclerosis, encephalomyelitis), hypoparathyroidism, Addison's disease, vitamin A intoxication, and the long-term use of glucocorticoids and contraceptives. …”
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Investigation of toxicity of TiO2 nanoparticles on glioblastoma and neuroblastoma as the most widely used nanoparticles in photocatalytic processes by Fahimeh Kazemi, Marzie Esmaeeli, Peyman Mohammadzadehjahani, Mahnaz Amiri, Parisa Vosough, Meysam Ahmadi-Zeidabadi

“…Glioblastoma and neuroblastoma are two fatal brain tumors with a high mortality rate in humans, the hope for treatment of which is weak by the common methods. …”
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Strategic Decoy Peptides Interfere with MSI1/AGO2 Interaction to Elicit Tumor Suppression Effects by Yi-Ping Yang, Andy Chi-Lung Lee, Liang-Ting Lin, Yi-Wei Chen, Pin-I Huang, Hsin-I Ma, Yi-Chen Chen, Wen-Liang Lo, Yuan-Tzu Lan, Wen-Liang Fang, Chien-Ying Wang, Yung-Yang Liu, Po-Kuei Hsu, Wen-Chang Lin, Chung-Pin Li, Ming-Teh Chen, Chian-Shiu Chien, Mong-Lien Wang

“…These striking therapeutic efficacies orchestrated by the synthetic peptides were attributed to the decoy function to C-terminal MSI1, especially in malignant brain tumors and glioblastoma.…”
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Expression pattern of MRPS18 family genes in medulloblastoma: a case report by Larysa M. Kovalevska, Valeriia M. Shcherbina, Serhii S. Kalman, Ludmila M. Verbova, Volodymyr D. Rozumenko, Tetyana A. Malysheva, Elena V. Kashuba

“… Medulloblastoma is one of the most prevalent brain tumors in children. Due to alterations in the gene expression patterns, medulloblastomas display diversity in the transcriptional, genetic, and clinical markers. …”
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Molecular Tumor Board Improves Outcomes for Hispanic Patients With Advanced Solid Tumors by Carolina Sotelo-Rodríguez, Dora Vallejo-Ardila, Alejandro Ruiz-Patiño, Diego F. Chamorro, July Rodríguez, Darwin A. Moreno-Pérez, Hernán Carranza, Jorge Otero, Carlos Vargas, Pilar Archila, Leonardo Rojas, Jairo Zuluaga, Cladelis Rubio, Camila Ordóñez-Reyes, Juan Esteban Garcia-Robledo, Sergio Mejía, Elvira Jaller, Oscar Arrieta, Andrés F. Cardona

“…Other malignancies represented 60%, 50%, and 30% of patients with soft-tissue sarcomas, brain tumors, and breast cancer, respectively.CONCLUSIONUsing an open-access virtual platform, MTBs were feasible in low- and middle-income countries on the basis of the capability to provide the benefits and access to available targeted therapies that are not standard of care. …”
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Comprehensive Commissioning and Clinical Implementation of GammaTiles STaRT for Intracranial Brain Cancer by Gregory P. Penoncello, DMP, Justin D. Gagneur, MA, Sujay A. Vora, MD, Nathan Y. Yu, MD, Mirek Fatyga, PhD, Maciej M. Mrugala, MD, Bernard R. Bendok, MD, Yi Rong, PhD

“…Purpose: To validate the dose calculation accuracy and dose distribution of GammaTiles for brain tumors, and to suggest a surgically targeted radiation therapy (STaRT) workflow for planning, delivery, radiation safety documentation, and posttreatment validation. …”
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Targeting the mDia Formin-Assembled Cytoskeleton Is an Effective Anti-Invasion Strategy in Adult High-Grade Glioma Patient-Derived Neurospheres by Krista M. Pettee, Kathryn N. Becker, Arthur S. Alberts, Kevin A. Reinard, Jason L. Schroeder, Kathryn M. Eisenmann

“…High-grade glioma (HGG, WHO Grade III–IV) accounts for the majority of adult primary malignant brain tumors. Failure of current therapies to target invasive glioma cells partly explains the minimal survival advantages: invasive tumors lack easily-defined surgical margins, and are inherently more chemo- and radioresistant. …”
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Model-Based Noninvasive Estimation of Intracranial Pressure from Cerebral Blood Flow Velocity and Arterial Pressure by Kashif, Faisal Mahmood, Verghese, George C., Heldt, Thomas, Novak, Vera, Czosnyka, Marek

“…Because ICP is also clinically important in conditions ranging from brain tumors and hydrocephalus to concussions, noninvasive determination of ICP would be desirable. …”
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Cancer immune profiling unveils biomarkers, immunological pathways, and cell type score associated with glioblastoma patients’ survival by Daniel Antunes Moreno, Luciane Sussuchi da Silva, Isabella Gomes, Letícia Ferro Leal, Gustavo Noriz Berardinelli, Gisele Melo Gonçalves, Caio Augusto Pereira, Iara Viana Vidigal Santana, Marcus de Medeiros Matsushita, Krishna Bhat, Sean Lawler, Rui Manuel Reis

“…Introduction: Glioblastoma (GBM), isocitrate dehydrogenase ( IDH ) wild-type ( IDH wt ), and grade 4 astrocytomas, IDH mutant ( IDH mut ), are the most common and aggressive primary malignant brain tumors in adults. A better understanding of the tumor immune microenvironment may provide new biomarkers and therapeutic opportunities. …”
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Dynamics of blood immunological parameters in patients with glial tumors of varying degrees of anaplasia by Mykola I. Lisianyi, Irina A. Gnedkova, Lyudmyla M. Belska, Viktoriya V. Vaslovich

“…The age of patients with brain tumors and the comparison group ranged from 35 to 65 years. …”
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Validation of an Ultraviolet Light Response Gene Signature for Predicting Prognosis in Patients with Uveal Melanoma by Carlos A. Orozco, Alejandro Mejía-García, Marcela Ramírez, Johanna González, Luis Castro-Vega, Richard B. Kreider, Silvia Serrano, Alba Lucia Combita, Diego A. Bonilla

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Radiotherapy for Pediatric Malignancies: An Experience from a Tertiary Cancer Centre by NV Vinin, Joneetha Jones, TK Jithin, KG Gopakumar, A Geethanjali, Geetha Muttath

“…Commonest malignancies which received RT treatment were ALL (30%), Brain tumors (26%) and bone and soft tissue tumors (22%). …”
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Ubiquitin Proteasome Gene Signatures in Ependymoma Molecular Subtypes by Jerry Vriend, Thatchawan Thanasupawat, Namita Sinha, Thomas Klonisch

“…Currently, a comprehensive review of the role of the UPS in ependymoma (EPN) brain tumors is lacking but may provide valuable new information on cellular networks specific to different EPN subtypes and reveal future therapeutic targets. …”
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Investigation of absorbed dose and estimation the risk of secondary thyroid cancer in whole brain radiotherapy by Mahtab Ahmadi, Mohammad Bagher Tavakoli, Alireza Amouheidari, Zahra Alirezaei

“…Background: After the surgery, radiation therapy is the most important part of treating brain tumors. Thyroid cancer is the second most prevalent malignancy, as a result of radiation therapy of head and neck. …”
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Lactic Acid Permeability of Aquaporin-9 Enables Cytoplasmic Lactate Accumulation via an Ion Trap by Katharina Geistlinger, Jana D. R. Schmidt, Eric Beitz

“…(1) Background: Human aquaporin-9 (AQP9) conducts several small uncharged metabolites, such as glycerol, urea, and lactic acid. Certain brain tumors were shown to upregulate AQP9 expression, and the putative increase in lactic acid permeability was assigned to severity. (2) Methods: We expressed AQP9 and human monocarboxylate transporter 1 (MCT1) in yeast to determine the uptake rates and accumulation of radiolabeled <span style="font-variant: small-caps;">l-</span>lactate/<span style="font-variant: small-caps;">l-</span>lactic acid in different external pH conditions. (3) Results: The AQP9-mediated uptake of <span style="font-variant: small-caps;">l-</span>lactic acid was slow compared to MCT1 at neutral and slightly acidic pH, due to low concentrations of the neutral substrate species. …”
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Construction of a prognostic classifier and prediction of the immune landscape and immunosuppressive molecules in gliomas based on combination of inflammatory response-related gene... by Chunbao Chen, Xue Du, Hongjun Liu, Xingyu Lu, Dong Li, Jian Qi

“…Introduction: Gliomas, the commonest primary brain tumors, account for about 80% of cancerous tumors in the central nervous system (CNS), featuring rapid progression, high malignancy, and extremely poor prognosis. …”
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Behavioral disorders and their correlation with nutritional status of children, complete the treatment of acute lymphoblastic leukemia and embryonic central nervous system tumors by A. Yu. Vashura, A. A. Devyaterikova, S. S. Lukina, V. N. Kasatkin, A. F. Karelin

“…As a result, it was found that a significant proportion of children have delayed effects of treatment in the form of reduced nutritional status and emotional and behavioral difficulties. Children with brain tumors have an increased risk of nutritional and emotional-behavioral disorders compared to children who have survived acute lymphoblastic leukemia. …”
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Management after initial surgery of nonfunctioning pituitary adenoma: surveillance, radiotherapy or surgery? by Thomas Charleux, Véronique Vendrely, Aymeri Huchet, Renaud Trouette, Amandine Ferrière, Antoine Tabarin, Vincent Jecko, Hugues Loiseau, Charles Dupin

“…The risk of corticotropic and thyrotropic deficiency rates were 38% and 59% after second or third surgical operation and 40% and 73% after radiotherapy. Brain tumors occurred in 4 patients: 1 meningioma present at initial surgery, and after radiotherapy, 1 neurinoma which appeared at 5 years, 1 glioblastoma at 13 years and 1 meningioma at 20 years. …”
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