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37481
Noncovalent hyaluronan crosslinking by TSG-6: Modulation by heparin, heparan sulfate, and PRG4
Published 2022-10-01“…Connections formed between two end-biotinylated 50 kDa HA (bHA) chains can be detected by signal arising from streptavidin-coated donor and acceptor beads being brought into close proximity when the bHA chains are bridged by proteins. We observed that incubation of bHA with the protein TSG-6 (tumor necrosis factor alpha stimulated gene/protein 6, TNFAIP/TSG-6) leads to dimerization or higher order multimerization of HA chains in solution. …”
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37482
The XBB.1.5 slightly increase the binding affinity for host receptor ACE2 and exhibit strongest immune escaping features: molecular modeling and free energy calculation
Published 2023-05-01“…Moreover, the interaction network analysis also revealed significant variations in the number of hydrogen bonds, salt-bridges, and non-bonded contacts. These findings were further validated by computing the dissociation constant (KD). …”
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37483
Viscosity Estimation of TiO<sub>2</sub>-Bearing Blast Furnace Slag with High Al<sub>2</sub>O<sub>3</sub> at 1500 °C
Published 2023-03-01“…With the increase in <i>N<sub>w</sub></i> and <i>R<sub>w</sub></i><sub>2</sub>, the peak values of the symmetrical stretching vibration of non-bridging oxygen in the Si–O tetrahedral structure of slag decrease, and the slag structures depolymerize, which leads to the decrease in the viscosity of the slag.…”
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37484
Gemtuzumab ozogamicin for relapsed or primary refractory acute myeloid leukemia in children—the Polish Pediatric Leukemia and Lymphoma Study Group experience
Published 2023-12-01“…Sinusoidal obstruction syndrome occurred in two children.ConclusionsThe use of GO in severely pretreated children, including those under 15 years of age, with previous failure of AML treatment is a feasible and effective bridging therapy to allo-HSCT with an acceptable toxicity profile.…”
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37485
Metadata stewardship in nanosafety research: learning from the past, preparing for an “on-the-fly” FAIR future
Published 2023-08-01“…By mapping the available tools for nanomaterials safety research (including nanomaterials characterisation, nonstandard (mechanistic-focussed) methods, measurement principles and experimental setup, environmental fate and requirements from new research foci such as safe and sustainable by design), a strategy for integration and bridging between silos is presented. The NanoCommons KnowledgeBase has shown how data from different sources can be integrated into a one-stop shop for searching, browsing and accessing data (without copying), and thus how to break the boundaries between data silos.Discussion: The next steps are to generalise the approach by defining a process to build consensus (meta)data standards, develop solutions to make (meta)data more machine actionable (on the fly ontology development) and establish a distributed FAIR data ecosystem maintained by the community beyond specific projects. …”
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37486
Preparation of supramolecular viscoelastic polymers with shear, temperature, and salt resistance/sensitivity by amphiphilic functional monomer modification
Published 2022-12-01“…Finally, by X-ray diffraction, the particle size test in solution, and scanning electron microscopy, the higher the number of oxyethylene groups in the amphiphilic functional monomers, the higher the mixing entropy of copolymers, and the particle size in solution and multi-peak distribution were higher, as well as more clear linear entanglement between copolymers; all of these factors were conducive to the formation of large-scale supramolecular structures of super-bridged copolymers.…”
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37487
Ex Vivo Activation of Red Blood Cell Senescence by Plasma from Sickle-Cell Disease Patients: Correlation between Markers and Adhesion Consequences during Acute Disease Events
Published 2021-06-01“…RESULTS: Senescence markers on AA RBCs, together with their in-flow adhesion to the plasma-bridging protein thrombospondin, were associated with the clinical status of the SCD patients from whom plasma was obtained. …”
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37488
Novel, thalidomide-like, non-cereblon binding drug tetrafluorobornylphthalimide mitigates inflammation and brain injury
Published 2023-03-01“…However, the classical glutarimide ring was replaced by a bridged ring structure. TFBP/TFNBP were hence designed to retain beneficial anti-inflammatory properties of IMiDs but, importantly, hinder cereblon binding that underlies the adverse action of thalidomide-like drugs. …”
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37489
Real-life monocentric experience of venetoclax-based regimens for acute myeloid leukemia
Published 2023-03-01“…Despite a limited number of patients, the association of venetoclax and HMAs proved to be also a feasible bridging therapy to transplantation.…”
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37490
A Chain of Vertex-Sharing {Co<sup>III</sup><sub>2</sub>Co<sup>II</sup><sub>2</sub>}<sub>n</sub> Squares with Single-Ion Magnet Behavior
Published 2023-05-01“…The structural analysis shows the formation of a neutral 4,2-ribbon-like chain of vertex-sharing cyanido-bridged {Co<sup>III</sup><sub>2</sub>Co<sup>II</sup><sub>2</sub>} squares in which the metalloligand underwent an oxidation process and a reorganization to form {Co<sup>III</sup>(dmphen)(CN)<sub>4</sub>}<sup>−</sup> linkers that coordinate to the [Co<sup>II</sup>(MeOH)<sub>2</sub>]<sup>2+</sup> units through single cyanido ligands. …”
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37491
Genome-wide characterization of the MBF1 gene family and its expression pattern in different tissues and stresses in Zanthoxylum armatum
Published 2022-09-01“…Abstract Background Multiprotein bridging factor 1 (MBF1) is a crucial transcriptional coactivator in animals, plants, and some microorganisms, that plays a necessary role in growth development and stress tolerance. …”
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37492
Genetic evidence strengthens the bidirectional connection between gut microbiota and periodontitis: insights from a two-sample Mendelian randomization study
Published 2023-09-01“…Intestinal dysbiosis may play a pivotal bridging role in extra-oral inflammatory comorbidities caused by periodontitis. …”
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37493
Mining the nanotube-forming Bacillus amyloliquefaciens MR14M3 genome for determining anti-Candida auris and anti-Candida albicans potential by pathogenicity and comparative genomic...
Published 2023-01-01“…Bacillus amyloliquefaciens MR14M3 establishes bridges of intercellular nanotubes (L 258.56 ± 35.83 nm; W 25.32 ± 6.09 nm) connecting neighboring cells. …”
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37494
The Sialic Acid-Dependent Nematocyst Discharge Process in Relation to Its Physical-Chemical Properties Is a Role Model for Nanomedical Diagnostic and Therapeutic Tools
Published 2019-08-01“…Especially, the role of nematogalectins is of interest because these bridging proteins contribute as well as special collagen fibers to the elastic band properties. …”
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37495
Structural Elucidation of a Protective B Cell Epitope on Outer Surface Protein C (OspC) of the Lyme Disease Spirochete, Borreliella burgdorferi
Published 2023-04-01“…In addition, B5’s complementarity-determining region (CDR) H3 bridged the OspC-OspC′ homodimer interface, revealing the quaternary nature of the protective epitope. …”
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37496
Promotion of self-directed learning abilities among Chinese medical students through preparing for career calling and enhancing teaching competencies in medical education: a cross-...
Published 2024-04-01“…Educators play a crucial role in bridging the gap between career calling education and SDL ability enhancement, highlighting the significance of optimal teaching competencies. …”
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37497
Quality of Life Following Urgent LVAD Implantation for ECMO Therapy in Cardiogenic Shock: A Long-Term Follow-Up
Published 2021-07-01“…Successful weaning of VA-ECMO may not be possible, and bridging with further mechanical circulatory support (MCS), such as urgent implantation of a left ventricular assist device (LVAD), may represent the only means to sustain the patient haemodynamically. …”
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37498
Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond
Published 2017“…But the interface could especially be bridged through a scale-up of open sharing of physical compounds, which would accelerate the finding of new starting points for drug discovery. …”
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37499
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37500
The chemistry of [h]-cycloheptatrienyl derivatives of molybdenum and tungsten
Published 1993“…Second part of this chapter describes the new bridging-imido compound [(η-C<sub>7</sub>H<sub>7</sub>)Mo(μ-NAr)<sub>2</sub>Mo(η-C<sub>7</sub>H<sub>7</sub>)] (Ar = 2,6- diisopropylphenyl).…”
Thesis