Noncovalent hyaluronan crosslinking by TSG-6: Modulation by heparin, heparan sulfate, and PRG4 by Yun Jin Ashley Sin, Rebecca MacLeod, Adam P. Tanguay, Andrew Wang, Olivia Braender-Carr, Teraesa M. Vitelli, Gregory D. Jay, Tannin A. Schmidt, Mary K. Cowman, Mary K. Cowman

“…Connections formed between two end-biotinylated 50 kDa HA (bHA) chains can be detected by signal arising from streptavidin-coated donor and acceptor beads being brought into close proximity when the bHA chains are bridged by proteins. We observed that incubation of bHA with the protein TSG-6 (tumor necrosis factor alpha stimulated gene/protein 6, TNFAIP/TSG-6) leads to dimerization or higher order multimerization of HA chains in solution. …”
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The XBB.1.5 slightly increase the binding affinity for host receptor ACE2 and exhibit strongest immune escaping features: molecular modeling and free energy calculation by Muhammad Suleman, Aneela Murtaza, Maria, Haji Khan, Farooq Rashid, Abdulrahman Alshammari, Liaqat Ali, Abbas Khan, Abbas Khan, Dong-Qing Wei, Dong-Qing Wei, Dong-Qing Wei

“…Moreover, the interaction network analysis also revealed significant variations in the number of hydrogen bonds, salt-bridges, and non-bonded contacts. These findings were further validated by computing the dissociation constant (KD). …”
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Viscosity Estimation of TiO₂-Bearing Blast Furnace Slag with High Al₂O₃ at 1500 °C by Haiyan Zheng, Shifa Zhou, Shen Zhang, Yang Li, Baozhi Zhang, Fengman Shen, Zhonghua Wang, Tao Han

“…With the increase in <i>N_w</i> and <i>R_w</i>₂, the peak values of the symmetrical stretching vibration of non-bridging oxygen in the Si–O tetrahedral structure of slag decrease, and the slag structures depolymerize, which leads to the decrease in the viscosity of the slag.…”
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Gemtuzumab ozogamicin for relapsed or primary refractory acute myeloid leukemia in children—the Polish Pediatric Leukemia and Lymphoma Study Group experience by Katarzyna Pawinska-Wasikowska, Katarzyna Pawinska-Wasikowska, Malgorzata Czogala, Malgorzata Czogala, Szymon Skoczen, Szymon Skoczen, Marta Surman, Monika Rygielska, Teofila Ksiazek, Agnieszka Pac, Aleksandra Wieczorek, Aleksandra Wieczorek, Jolanta Skalska-Sadowska, Magdalena Samborska, Jacek Wachowiak, Radoslaw Chaber, Radoslaw Chaber, Renata Tomaszewska, Tomasz Szczepanski, Karolina Zielezinska, Tomasz Urasinski, Malgorzata Moj-Hackemer, Krzysztof Kalwak, Marta Kozlowska, Ninela Irga-Jaworska, Walentyna Balwierz, Walentyna Balwierz, Karolina Bukowska-Strakova

“…Sinusoidal obstruction syndrome occurred in two children.ConclusionsThe use of GO in severely pretreated children, including those under 15 years of age, with previous failure of AML treatment is a feasible and effective bridging therapy to allo-HSCT with an acceptable toxicity profile.…”
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Metadata stewardship in nanosafety research: learning from the past, preparing for an “on-the-fly” FAIR future by Thomas E. Exner, Anastasios G. Papadiamantis, Anastasios G. Papadiamantis, Georgia Melagraki, Jaleesia D. Amos, Nathan Bossa, Nathan Bossa, Georgios P. Gakis, Costas A. Charitidis, Geert Cornelis, Anna L. Costa, Philip Doganis, Lucian Farcal, Steffi Friedrichs, Irini Furxhi, Frederick C. Klaessig, Vladimir Lobaskin, Dieter Maier, John Rumble, John Rumble, Haralambos Sarimveis, Blanca Suarez-Merino, Socorro Vázquez, Mark R. Wiesner, Antreas Afantitis, Antreas Afantitis, Iseult Lynch, Iseult Lynch

“…By mapping the available tools for nanomaterials safety research (including nanomaterials characterisation, nonstandard (mechanistic-focussed) methods, measurement principles and experimental setup, environmental fate and requirements from new research foci such as safe and sustainable by design), a strategy for integration and bridging between silos is presented. The NanoCommons KnowledgeBase has shown how data from different sources can be integrated into a one-stop shop for searching, browsing and accessing data (without copying), and thus how to break the boundaries between data silos.Discussion: The next steps are to generalise the approach by defining a process to build consensus (meta)data standards, develop solutions to make (meta)data more machine actionable (on the fly ontology development) and establish a distributed FAIR data ecosystem maintained by the community beyond specific projects. …”
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Preparation of supramolecular viscoelastic polymers with shear, temperature, and salt resistance/sensitivity by amphiphilic functional monomer modification by Meiling Fan, Lei Wang, Jing Li, Ping He, Xiaojuan Lai, Jinhao Gao, Guiru Liu, Xin Wen

“…Finally, by X-ray diffraction, the particle size test in solution, and scanning electron microscopy, the higher the number of oxyethylene groups in the amphiphilic functional monomers, the higher the mixing entropy of copolymers, and the particle size in solution and multi-peak distribution were higher, as well as more clear linear entanglement between copolymers; all of these factors were conducive to the formation of large-scale supramolecular structures of super-bridged copolymers.…”
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Ex Vivo Activation of Red Blood Cell Senescence by Plasma from Sickle-Cell Disease Patients: Correlation between Markers and Adhesion Consequences during Acute Disease Events by Philippe Chadebech, Gwellaouen Bodivit, Gaétana Di Liberto, Alicia Jouard, Corinne Vasseur, France Pirenne, Pablo Bartolucci

“…RESULTS: Senescence markers on AA RBCs, together with their in-flow adhesion to the plasma-bridging protein thrombospondin, were associated with the clinical status of the SCD patients from whom plasma was obtained. …”
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Novel, thalidomide-like, non-cereblon binding drug tetrafluorobornylphthalimide mitigates inflammation and brain injury by Daniela Lecca, Shih-Chang Hsueh, Weiming Luo, David Tweedie, Dong Seok Kim, Abdul Mannan Baig, Neil Vargesson, Yu Kyung Kim, Inho Hwang, Sun Kim, Barry J. Hoffer, Yung-Hsiao Chiang, Nigel H. Greig

“…However, the classical glutarimide ring was replaced by a bridged ring structure. TFBP/TFNBP were hence designed to retain beneficial anti-inflammatory properties of IMiDs but, importantly, hinder cereblon binding that underlies the adverse action of thalidomide-like drugs. …”
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Real-life monocentric experience of venetoclax-based regimens for acute myeloid leukemia by Mariarita Sciumè, Alessandro Bosi, Marta Canzi, Giusy Ceparano, Fabio Serpenti, Pasquale De Roberto, Sonia Fabris, Elena Tagliaferri, Francesca Cavallaro, Francesco Onida, Francesco Onida, Nicola Stefano Fracchiolla

“…Despite a limited number of patients, the association of venetoclax and HMAs proved to be also a feasible bridging therapy to transplantation.…”
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A Chain of Vertex-Sharing {Co^III₂Co^II₂}_n Squares with Single-Ion Magnet Behavior by Maria-Gabriela Alexandru, Diana Visinescu, Sergiu Shova, Joan Cano, Nicolás Moliner, Francesc Lloret, Miguel Julve

“…The structural analysis shows the formation of a neutral 4,2-ribbon-like chain of vertex-sharing cyanido-bridged {Co^III₂Co^II₂} squares in which the metalloligand underwent an oxidation process and a reorganization to form {Co^III(dmphen)(CN)₄}⁻ linkers that coordinate to the [Co^II(MeOH)₂]²⁺ units through single cyanido ligands. …”
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Genome-wide characterization of the MBF1 gene family and its expression pattern in different tissues and stresses in Zanthoxylum armatum by Wenkai Hui, Hao Zheng, Jiangtao Fan, Jingyan Wang, Tahseen Saba, Kai Wang, Jiaojiao Wu, Han Wu, Yu Zhong, Gang Chen, Wei Gong

“…Abstract Background Multiprotein bridging factor 1 (MBF1) is a crucial transcriptional coactivator in animals, plants, and some microorganisms, that plays a necessary role in growth development and stress tolerance. …”
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Genetic evidence strengthens the bidirectional connection between gut microbiota and periodontitis: insights from a two-sample Mendelian randomization study by Xinjian Ye, Bin Liu, Yijing Bai, Yue Cao, Sirui Lin, Linshuoshuo Lyu, Haohao Meng, Yuwei Dai, Ding Ye, Weiyi Pan, Zhiyong Wang, Yingying Mao, Qianming Chen

“…Intestinal dysbiosis may play a pivotal bridging role in extra-oral inflammatory comorbidities caused by periodontitis. …”
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Mining the nanotube-forming Bacillus amyloliquefaciens MR14M3 genome for determining anti-Candida auris and anti-Candida albicans potential by pathogenicity and comparative genomic... by J. Francis Borgio, Rahaf Alhujaily, Rahaf Alquwaie, Maryam Jawad Alabdullah, Eman AlHasani, Wojod Alothman, Rawan Khalid Alaqeel, Aqeelah Salman Alfaraj, Ayidah Kaabi, Norah F. Alhur, Sultan Akhtar, Reem AlJindan, Sarah Almofty, Noor B. Almandil, Sayed AbdulAzeez

“…Bacillus amyloliquefaciens MR14M3 establishes bridges of intercellular nanotubes (L 258.56 ± 35.83 nm; W 25.32 ± 6.09 nm) connecting neighboring cells. …”
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The Sialic Acid-Dependent Nematocyst Discharge Process in Relation to Its Physical-Chemical Properties Is a Role Model for Nanomedical Diagnostic and Therapeutic Tools by Ruiyan Zhang, Li Jin, Ning Zhang, Athanasios K. Petridis, Thomas Eckert, Georgios Scheiner-Bobis, Martin Bergmann, Axel Scheidig, Roland Schauer, Mingdi Yan, Samurdhi A. Wijesundera, Bengt Nordén, Barun K. Chatterjee, Hans-Christian Siebert

“…Especially, the role of nematogalectins is of interest because these bridging proteins contribute as well as special collagen fibers to the elastic band properties. …”
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Structural Elucidation of a Protective B Cell Epitope on Outer Surface Protein C (OspC) of the Lyme Disease Spirochete, Borreliella burgdorferi by Michael J. Rudolph, Simon A. Davis, H. M. Emranul Haque, David D. Weis, David J. Vance, Carol Lyn Piazza, Monir Ejemel, Lisa Cavacini, Yang Wang, M. Lamine Mbow, Robert D. Gilmore, Nicholas J. Mantis

“…In addition, B5’s complementarity-determining region (CDR) H3 bridged the OspC-OspC′ homodimer interface, revealing the quaternary nature of the protective epitope. …”
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Promotion of self-directed learning abilities among Chinese medical students through preparing for career calling and enhancing teaching competencies in medical education: a cross-... by Chen-xi Zhao, Zi-jiao Wang, Xiao-jing Yang, Xing Ma, Ying Cui, Yan-xin Zhang, Xin-hui Cheng, Shu-e Zhang, Qing-feng Guo, De-pin Cao

“…Educators play a crucial role in bridging the gap between career calling education and SDL ability enhancement, highlighting the significance of optimal teaching competencies. …”
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Quality of Life Following Urgent LVAD Implantation for ECMO Therapy in Cardiogenic Shock: A Long-Term Follow-Up by Rafal Berger, Hasan Hamdoun, Rodrigo Sandoval Boburg, Medhat Radwan, Metesh Acharya, Reiner Markus Waeschle, Christian Schlensak, Aron-Frederik Popov, Petar Risteski

“…Successful weaning of VA-ECMO may not be possible, and bridging with further mechanical circulatory support (MCS), such as urgent implantation of a left ventricular assist device (LVAD), may represent the only means to sustain the patient haemodynamically. …”
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Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond by Van Voorhis, Wesley C., Adams, John H., Adelfio, Roberto, Ahyong, Vida, Akabas, Myles H., Alano, Pietro, Alday, Aintzane, Yesmalie, Alemán Resto, Alsibaee, Aishah, Alzualde, Ainhoa, Andrews, Katherine T., Avery, Simon V., Avery, Vicky M., Ayong, Lawrence, Baker, Mark, Baker, Stephen, Ben Mamoun, Choukri, Bickle, Quentin, Bounaadja, Lotfi, Bowling, Tana, Bosch, Jürgen, Boucher, Lauren E., Boyom, Fabrice F., Brea, Jose, Brennan, Marian, Burton, Audrey, Caffrey, Conor R., Camarda, Grazia, Carrasquilla, Manuela, Carter, Dee, Cassera, Maria Belen, Ken, Chih-Chien Cheng, Chindaudomsate, Worathad, Chubb, Anthony, Colon, Beatrice L., Colón-López, Daisy D., Corbett, Yolanda, Crowther, Gregory J., Cowan, Noemi, D’Alessandro, Sarah, Le Dang, Na, Delves, Michael, DeRisi, Joseph L., Du, Alan Y., Duffy, Sandra, Abd El-Salam El-Sayed, Shimaa, Ferdig, Michael T., Fernández Robledo, José A., Fidock, David A., Florent, Isabelle, Fokou, Patrick V. T., Galstian, Ani, Gamo, Francisco Javier, Gokool, Suzanne, Gold, Ben, Golub, Todd, Goldgof, Gregory M., Guha, Rajarshi, Guiguemde, W. Armand, Gural, Nil, Guy, R. Kiplin, Hansen, Michael A. E., Hanson, Kirsten K., Hemphill, Andrew, Hooft van Huijsduijnen, Rob, Horii, Takaaki, Horrocks, Paul, Hughes, Tyler B., Huston, Christopher, Igarashi, Ikuo, Ingram-Sieber, Katrin, Itoe, Maurice A., Jadhav, Ajit, Naranuntarat Jensen, Amornrat, Jensen, Laran T., Jiang, Rays H. Y., Kaiser, Annette, Keiser, Jennifer, Ketas, Thomas, Kicka, Sebastien, Kim, Sunyoung, Kirk, Kiaran, Kumar, Vidya P., Kyle, Dennis E., Lafuente, Maria Jose, Landfear, Scott, Lee, Nathan, Lee, Sukjun, Lehane, Adele M., Li, Fengwu, Little, David, Liu, Liqiong, Llinás, Manuel, Loza, Maria I., Lubar, Aristea, Lucantoni, Leonardo, Lucet, Isabelle, Maes, Louis, Mancama, Dalu, Mansour, Nuha R., March, Sandra, McGowan, Sheena, Medina Vera, Iset, Meister, Stephan, Mercer, Luke, Mestres, Jordi, Mfopa, Alvine N., Misra, Raj N., Moon, Seunghyun, Moore, John P., Morais Rodrigues da Costa, Francielly, Müller, Joachim, Muriana, Arantza, Nakazawa Hewitt, Stephen, Nare, Bakela, Nathan, Carl, Narraidoo, Nathalie, Nawaratna, Sujeevi, Ojo, Kayode K., Ortiz, Diana, Panic, Gordana, Papadatos, George, Parapini, Silvia, Patra, Kailash, Pham, Ngoc, Prats, Sarah, Plouffe, David M., Poulsen, Sally-Ann, Pradhan, Anupam, Quevedo, Celia, Quinn, Ronald J., Rice, Christopher A., Ruecker, Andrea, St. Onge, Robert, Salgado Ferreira, Rafaela, Samra, Jasmeet, Robinett, Natalie G., Schlecht, Ulrich, Schmitt, Marjorie, Silva Villela, Filipe, Silvestrini, Francesco, Sinden, Robert, Smith, Dennis A., Soldati, Thierry, Spitzmüller, Andreas, Stamm, Serge Maximilian, Sullivan, David J., Sullivan, William, Suresh, Sundari, Suzuki, Brian M., Suzuki, Yo, Swamidass, S. Joshua, Taramelli, Donatella, Tchokouaha, Lauve R. Y., Theron, Anjo, Thomas, David, Tonissen, Kathryn F., Townson, Simon, Tripathi, Abhai K., Trofimov, Valentin, Udenze, Kenneth O., Ullah, Imran, Vallieres, Cindy, Vigil, Edgar, Vinetz, Joseph M., Voong Vinh, Phat, Vu, Hoan, Watanabe, Nao-aki, Weatherby, Kate, White, Pamela M., Wilks, Andrew F., Winzeler, Elizabeth A., Wojcik, Edward, Wree, Melanie, Wu, Wesley, Yokoyama, Naoaki, Zollo, Paul H. A., Abla, Nada, Blasco, Benjamin, Burrows, Jeremy, Laleu, Benoît, Leroy, Didier, Spangenberg, Thomas, Wells, Timothy, Willis, Paul A., Bhatia, Sangeeta N

“…But the interface could especially be bridged through a scale-up of open sharing of physical compounds, which would accelerate the finding of new starting points for drug discovery. …”
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Synthesis and small molecule chemistry of the niobaziridine-hydride functional group by Figueroa, Joshua S

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The chemistry of [h]-cycloheptatrienyl derivatives of molybdenum and tungsten by Ng, K, Ng, Kee-Pui Dennis

“…Second part of this chapter describes the new bridging-imido compound [(η-C₇H₇)Mo(μ-NAr)₂Mo(η-C₇H₇)] (Ar = 2,6- diisopropylphenyl).…”