Phosphocholine accumulation and PHOSPHO1 depletion promote adipose tissue thermogenesis by Jiang, Mengxi, Chavarria, Tony E, Yuan, Bingbing, Lodish, Harvey F, Huang, Nai-Jia

“…Here we demonstrate that the PHOSPHO1 transcript is highly enriched in mature brown adipose tissue (BAT) and is further induced by cold and isoproterenol treatments of BAT and primary brown adipocytes. …”
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Regulatory networks of non-coding RNAs in brown/beige adipogenesis by Xu, Shaohai, Chen, Peng, Sun, Lei

“…BAT (brown adipose tissue) is specialized to burn fatty acids for heat generation and energy expenditure to defend against cold and obesity. …”
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Sympathetic neuron-associated macrophages contribute to obesity by importing and metabolizing norepinephrine by Pirzgalska, R, Seixas, E, Seidman, J, Link, V, Sánchez, N, Mahú, I, Mendes, R, Gres, V, Kubasova, N, Morris, I, Arús, B, Larabee, C, Vasques, M, Tortosa, F, Sousa, A, Anandan, S, Tranfield, E, Hahn, M, Iannacone, M, Spann, N, Glass, C, Domingos, A

“…Genetic ablation of Slc6a2 in SAMs increases brown adipose tissue (BAT) content, causes browning of white fat, increases thermogenesis, and leads to substantial and sustained weight loss in obese mice. …”

Why do ABCC5 KO mice show a lean phenotype? by McKay, E

“…Despite numerous studies showing enhanced brown adipose tissue (BAT) and white adipose tissue (WAT) thermogenic capacity in the presence of elevated GLP-1 levels, data presented here do not show increased non-shivering thermogenesis occurring in our KO animals. …”

Adipocyte deletion of the oxygen-sensor PHD2 sustains elevated energy expenditure at thermoneutrality by Wang, R, Gomez Salazar, M, Pruñonosa Cervera, I, Coutts, A, French, K, Pinto, MM, Gohlke, S, García-Martín, R, Blüher, M, Schofield, CJ, Kourtzelis, I, Stimson, RH, Bénézech, C, Christian, M, Schulz, TJ, Gudmundsson, EF, Jennings, LL, Gudnason, VG, Chavakis, T, Morton, NM, Emilsson, V, Michailidou, Z

“…Enhancing thermogenic brown adipose tissue (BAT) function is a promising therapeutic strategy for metabolic disease. …”

Long non-coding RNAs as regulators of the endocrine system by Sun, Lei, Knoll, Marko, Lodish, Harvey F

“…We highlight lncRNAs that have a role in the development and function of pancreatic β cells, white and brown adipose tissue, and other endocrine organs, and discuss the involvement of these molecules in endocrine dysfunction (for example, diabetes mellitus). …”
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Liver X receptors downregulate 11beta-hydroxysteroid dehydrogenase type 1 expression and activity. by Stulnig, T, Oppermann, U, Steffensen, K, Schuster, G, Gustafsson, J

“…Moreover, long-term per os treatment with a synthetic LXR agonist downregulated 11beta-HSD-1 mRNA levels by approximately 50% in brown adipose tissue and liver of wild-type but not of LXRalpha(-/-)beta(-/-) mice and was paralleled by downregulation of hepatic PEPCK expression. …”

SYK kinase mediates brown fat differentiation and activation by Knoll, Marko, Winther, Sally, Natarajan, Anirudh, Yang, Huan, Jiang, Mengxi, Thiru, Prathapan, Shahsafaei, Aliakbar, Chavarria, Tony E., Lamming, Dudley W., Sun, Lei, Hansen, Jacob B., Lodish, Harvey F

“…Brown adipose tissue (BAT) metabolism influences glucose homeostasis and metabolic health in mice and humans. …”
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PD-L1 is an activation-independent marker of brown adipocytes by Ingram, Jessica R., Dougan, Michael, Rashidian, Mohammad, Knoll, Marko, Keliher, Edmund J., Garrett, Sarah, Garforth, Scott, Blomberg, Olga S., Espinosa, Camilo, Bhan, Atul, Almo, Steven C., Weissleder, Ralph, Dougan, Stephanie K., Lodish, Harvey F, Ploegh, Hidde

“…PET-CT imaging shows a robust and specific PD-L1 signal in brown adipose tissue (BAT). We confirm expression of PD-L1 on brown adipocytes and demonstrate that signal intensity does not change in response to cold exposure or β-adrenergic activation. …”
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Exploiting stable isotope imaging with high resolution secondary ion mass spectrometry for applications in biology by Jiang, H

“…Applying correlative BSE and NanoSIMS analysis, I also studied lipid uptake mechanisms in various mouse tissues, including brown adipose tissue, heart, intestines, liver and skeletal muscle, mainly focused on a recently discovered protein, GPIHBP1, and its function in the lipid uptake process. …”

Studies on the triglyceride - fatty acid cycle by Brooks, B, Brooks, Brian Jonathan

“…</p> <p>The use of tritiated water for estimating TG-FFA cycling is tentatively extended to brown adipose tissue. It is suggested that the rate of cycling could be used as an indicator of sympathetic activity in brown and white adipose tissue.…”

Influence of homoarginine on creatine accumulation and biosynthesis in the mouse by Lygate, CA, Lake, HA, McAndrew, DJ, Neubauer, S, Zervou, S

“…In contrast, kidney, left ventricle (LV), skeletal muscle and brown adipose tissue must rely on creatine transporter for uptake, since biosynthetic enzymes are not expressed. …”

The value of neck adipose tissue as a predictor for metabolic risk in health and type 2 diabetes by Cresswell, E, Basty, N, Pasdar, NA, Karpe, F, Pinnick, KE

“…The neck is a unique upper-body fat depot in adult humans, housing thermogenic brown adipose tissue (BAT), which is increasingly recognised to influence whole-body metabolic health. …”

IEX-1 deficiency induces browning of white adipose tissue and resists diet-induced obesity by Shahid, Mohd, Javed, Ammar A., Chandra, David, Ramsey, Haley E., Shah, Dilip, Khan, Mohammed F., Zhao, Liping, Wu, Mei X

“…We found that IEX-1 expression was highly induced in white adipose tissue (WAT) in both epidydmal and subcutaneous depots but not in interscapular brown adipose tissue (BAT) in mice fed a high fat diet (HFD). …”
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Role of the circadian clock gene Per2 in adaptation to cold temperature by Chappuis, Sylvie, Ripperger, Jürgen Alexander, Schnell, Anna, Rando, Gianpaolo, Jud, Corinne, Wahli, Walter, Albrecht, Urs

“…For instance, in brown adipose tissue (BAT) the facultative uncoupling of the proton gradient from ATP synthesis in mitochondria is used to generate systemic heat. …”
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Magnesium deficiency prevents high-fat-diet-induced obesity in mice by Kurstjens, S, Van Diepen, J, Overmars-Bos, C, Alkema, W, Bindels, R, Ashcroft, F, Tack, C, Hoenderop, J, de Baaij, J

“…Low Mg2+-HFD-fed mice had increased brown adipose tissue (BAT) Ucp1 mRNA expression and a higher body temperature. …”

Characterizing the function of the Arl15 gene and its role in the development of metabolic traits by Bai, Y

“…On an HFD KO female mice have reduced body weight, gonadal fat depot weight, brown adipose tissue weight and plasma adiponectin levels. …”

Aspects of the metabolism of the lactating rat by Agius, L, Loranne Agius

“…<p xmlns:etd="http://www.ouls.ox.ac.uk/ora/modsextensions">The effects of alterations in endocrine and nutritional state on lipogenesis <em>in vivo</em> in mammary gland, liver, white and brown adipose tissue (WAT,BAT) of the lactating rat were investigated. …”

De Novo Reconstruction of Adipose Tissue Transcriptomes Reveals Long Non-coding RNA Regulators of Brown Adipocyte Development by Bai, Zhiqiang, Xu, Dan, Yuan, Bingbing, Lo, Kinyui Alice, Yoon, Myeong Jin, Lim, Yen Ching, Knoll, Marko, Chen, Shuai, Chen, Peng, Sun, Lei, Alvarez, Juan Rene, Slavov, Nikolai G, Lodish, Harvey F

“…Brown adipose tissue (BAT) protects against obesity by promoting energy expenditure via uncoupled respiration. …”
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Rb regulates fate choice and lineage commitment in vivo by Calo, Eliezer, Quintero-Estades, Jose A., Danielian, Paul S., Nedelcu, Simona, Berman, Seth D., Lees, Jacqueline

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