Brown adipose tissue and the take (12,13-di)HOME message to the heart by Badi, I, Antoniades, C

Peroxisome proliferator activated receptor gamma controls mature brown adipocyte inducibility through glycerol kinase by Lasar, David, Rosenwald, Matthias, Kiehlmann, Elke, Balaz, Miroslav, Tall, Bettina, Opitz, Lennart, Lidell, Martin E., Zamboni, Nicola, Krznar, Petra, Sun, Wenfei, Varga, Lukas, Stefanicka, Patrik, Ukropec, Jozef, Nuutila, Pirjo, Virtanen, Kirsi, Amri, Ez-Zoubir, Enerbäck, Sven, Wahli, Walter, Wolfrum, Christian

Subjects: “…Brown Adipose Tissue…”
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Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity by Bartelt, Alexander, Widenmaier, Scott B., Schlein, Christian, Johann, Kornelia, Goncalves, Renata L. S., Eguchi, Kosei, Fischer, Alexander W., Parlakgul, Gunes, Snyder, Nicole A., Nguyen, Truc B., Bruns, Oliver Thomas, Franke, Daniel, Bawendi, Moungi G, Lynes, Matthew D., Leiria, Luiz O., Tseng, Yu-Hua, Inouye, Karen E., Arruda, Ana Paula, Hotamisligil, Gokhan S.

“…Here we show that brown adipose tissue (BAT) thermogenic function requires an adaptive increase in proteasomal activity to secure cellular protein quality control, and we identify the ER-localized transcription factor nuclear factor erythroid 2-like 1 (Nfe2l1, also known as Nrf1) as a critical driver of this process. …”
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Brown adipose tissue influences adiponectin and thyroid hormone changes during Graves' disease therapy by Ho, Wei-En, Sun, Lijuan, Goh, Hui Jen, Tint, Mya Thway, Sun, Lei, Leow, Melvin Khee Shing

“…Thyroid hormones (TH), adiponectin and brown adipose tissue (BAT) are regulators of energy homoeostasis. …”
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A diurnal rhythm in brown adipose tissue causes rapid clearance and combustion of plasma lipids at wakening by Van Den Berg, R, Kooijman, S, Noordam, R, Ramkisoensing, A, Abreu-Vieira, G, Tambyrajah, L, Dijk, W, Ruppert, P, Mol, I, Kramar, B, Caputo, R, Puig, L, De Ruiter, E, Kroon, J, Hoekstra, M, Van Der Sluis, R, Meijer, O, Willems Van Dijk, K, Van Kerkhof, L, Christodoulides, C, Karpe, F, Gerhart-Hines, Z, Kersten, S, Meijer, J, Coomans, C, Van Heemst, D, Biermasz, N, Rensen, P

“…Many favorable metabolic effects have been attributed to thermogenic activity of brown adipose tissue (BAT). Yet, time of day has rarely been considered in this field of research. …”

The effects of propranolol and chlorisondamine on amphetamine hyperthermic action on brown adipose tissue in lean and obese zucker rats by Abdul Karim, Mohamad Nordin

“…Thermogenic capacity of brown adipose tissue was measured by [3H] GDP binding on the mitochondrial preparation of the tissue. …”
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11β-HSD1 modulates the set point of brown adipose tissue response to glucocorticoids in male mice by Doig, C, Fletcher, R, Morgan, S, McCabe, E, Larner, D, Tomlinson, J, Stewart, P, Philp, A, Lavery, G

“…Chronic GC exposure suppresses brown adipose tissue (BAT) thermogenic capacity in mice, with evidence for a similar effect in humans. …”

Capsinoids activate brown adipose tissue (BAT) with increased energy expenditure associated with subthreshold 18-fluorine fluorodeoxyglucose uptake in BAT-positive humans confirmed by positron emission tomography scan by Sun, Lijuan, Camps, Stefan G., Goh, Hui Jen, Govindharajulu, Priya, Schaefferkoetter, Joshua D., Townsend, David W., Verma, Sanjay K., Velan, S. Sendhil, Sun, Lei, Sze, Siu Kwan, Lim, Su Chi, Boehm, Bernhard Otto, Henry, Christiani Jeyakumar, Leow, Melvin Khee-Shing

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65 years of the double helix : genetics informs precision practice in the diagnosis and management of pheochromocytoma by Neumann, Hartmut P., Young, William F., Krauss, Tobias, Bayley, Jean-Pierre, Schiavi, Francesca, Opocher, Giuseppe, Boedeker, Carsten C., Tirosh, Amit, Castinetti, Frederic, Ruf, Juri, Beltsevich, Dmitry, Walz, Martin, Groeben, Harald-Thomas, von Dobschuetz, Ernst, Gimm, Oliver, Wohllk, Nelson, Pfeifer, Marija, Lourenço, Delmar M., Peczkowska, Mariola, Patocs, Attila, Ngeow, Joanne, Makay, Özer, Shah, Nalini S., Tischler, Arthur, Leijon, Helena, Pennelli, Gianmaria, Villar Gómez de Las Heras, Karina, Links, Thera P., Bausch, Birke, Eng, Charis

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Brown adipose tissues mediate the metabolism of branched chain amino acids during the transitioning from hyperthyroidism to euthyroidism (TRIBUTE) by Sun, Lijuan, Goh, Hui Jen, Verma, Sanjay, Govindharajulu, Priya, Sadananthan, Suresh Anand, Michael, Navin, Henry, Christiani Jeyakumar, Goh, Julian Park-Nam, Velan, S. Sendhil, Leow, Melvin Khee-Shing

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Substantial metabolic activity of human brown adipose tissue during warm conditions and cold-induced lipolysis of local triglycerides by Weir, G, Ramage, L, Akyol, M, Rhodes, J, Kyle, C, Fletcher, A, Craven, T, Wakelin, S, Drake, A, Gregoriades, M, Ashton, C, Weir, N, van Beek, E, Karpe, F, Walker, B, Stimson, R

“…Current understanding of in vivo human brown adipose tissue (BAT) physiology is limited by a reliance on positron emission tomography (PET)/computed tomography (CT) scanning, which has measured exogenous glucose and fatty acid uptake but not quantified endogenous substrate utilization by BAT. …”

Mitochondrial Biogenesis and Increased Uncoupling Protein 1 in Brown Adipose Tissue of Mice Fed a Ketone Ester Diet by Srivastava, S, Kashiwaya, Y, King, M, Baxa, U, Tam, J, Niu, G, Chen, X, Clarke, K, Veech, R

Mitochondrial Biogenesis and Increased Uncoupling Protein 1 in Brown Adipose Tissue of Mice Fed a Ketone Ester Diet by Srivastava, S, Kashiwaya, Y, King, M, Baxa, U, Tam, J, Niu, G, Chen, X, Clarke, K, Veech, R

Mitochondrial biogenesis and increased uncoupling protein 1 in brown adipose tissue of mice fed a ketone ester diet. by Srivastava, S, Kashiwaya, Y, King, M, Baxa, U, Tam, J, Niu, G, Chen, X, Clarke, K, Veech, R

“…Feeding the KE diet for up to 1 mo increased the number of mitochondria and doubled the electron transport chain proteins, uncoupling protein 1, and mitochondrial biogenesis-regulating proteins in the interscapular brown adipose tissue (IBAT). [(18)F]-Fluorodeoxyglucose uptake in IBAT of the KE group was twice that in IBAT of the Ctrl group. …”

Activated brown adipose tissue releases exosomes containing mitochondrial methylene tetrahydrofolate dehydrogenase (NADP dependent) 1-like protein (MTHFD1L) by Leow, Melvin Khee-Shing, Rengaraj, Anantharaj, Narasimhan, Kothandaraman, Verma, Sanjay K., Yaligar, Jadegoud, Thu, Giang Le Thi, Sun, Lijuan, Goh, Hui Jen, Govindharajulu, Priya, Sadananthan, Suresh Anand, Michael, Navin, Meng, Wei, Gallart-Palau, Xavier, Sun, Lei, Karnani, Neerja, Sze, Siu Kwan, Velan, S. Sendhil

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Immunomodulatory leptin receptor+ Sympathetic Associated Perineurial Cells protect against obesity by Haberman, E

“…Furthermore, we show that SAPC-specifc deletion of Adrb2 increases IL-33 production in the brown adipose tissue, indicating that cytokine production by SAPCs may also be regulated by the sympathetic nervous system. …”

Apelin Enhances Brown Adipogenesis and Browning of White Adipocytes by Than, Aung, He, Hui Ling, Chua, Si Hui, Xu, Dan, Sun, Lei, Leow, Melvin Khee-Shing, Chen, Peng

“…Brown adipose tissue expends energy in the form of heat via the mitochondrial uncoupling protein UCP1. …”
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The proposed systemic thermogenic metabolites succinate and 12,13-diHOME are inversely associated with adiposity and related metabolic traits: evidence from a large human cross-sec... by Vasan, SK, Noordam, R, Gowri, MS, Neville, MJ, Karpe, F, Christodoulides, C

“…</p><br /> <p><strong>Conclusions/Interpretation:</strong><br /> Our findings tentatively suggest that plasma succinate and 12,13-diHOME may play a role in the regulation of energy metabolism and brown adipose tissue activation in humans. Further studies encompassing direct assessment of brown adipose tissue activity and dietary supplementation are necessary to investigate the potential beneficial effects of these metabolites on systemic metabolism.…”

Investigating the role of apelin on brown adipogenesis by He, Huiling

“…Recently, the thermogenic activity of brown adipose tissue has become a research focus, which may provide a promising method of obesity treatment. …”
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MicroRNA networks regulate development of brown adipocytes by Trajkovski, Mirko, Lodish, Harvey F

“…Brown adipose tissue (BAT) is specialized for heat generation and energy expenditure as a defense against cold and obesity; in both humans and mice increased amounts of BAT are associated with a lean phenotype and resistance to development of the metabolic syndrome and its complications. …”
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