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Role of Cadherins in Cancer—A Review
Published 2020-10-01Subjects: “…cadherin…”
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Trim28 contributes to EMT via regulation of E-cadherin and N-cadherin in lung cancer cell lines.
Published 2014-01-01“…Silencing Trim28 with inhibitory RNAs alters the expression of numerous EMT markers, such as E-cadherin and N-cadherin, whereas overexpression of Trim28 has an opposite effect. …”
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NEDD9 and BCAR1 negatively regulate E-cadherin membrane localization, and promote E-cadherin degradation.
Published 2011-01-01“…We here establish that Cas proteins negatively regulate E-cadherin expression in human mammary cells. Cas proteins do not affect E-cadherin transcription, but rather, BCAR1 and NEDD9 signal through SRC to promote E-cadherin removal from the cell membrane and lysosomal degradation. …”
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The Scribble polarity protein stabilizes E-cadherin/p120-catenin binding and blocks retrieval of E-cadherin to the Golgi.
Published 2012-01-01“…Several polarity proteins, including Scribble (Scrb) have been implicated in control of vesicle traffic, and in particular the endocytosis of E-cadherin, but through unknown mechanisms. We now show that depletion of Scrb enhances endocytosis of E-cadherin by weakening the E-cadherin-p120catenin interaction. …”
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E-Cadherin Immunostaining in Equine Melanocytic Tumors
Published 2023-07-01Subjects: Get full text
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Revisiting the multiple roles of T-cadherin in health and disease
Published 2021-09-01Subjects: “…T-cadherin…”
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Cadherin Expression and EMT: A Focus on Gliomas
Published 2021-09-01Subjects: “…cadherins…”
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N-cadherin, spine dynamics, and synaptic function
Published 2008-12-01Subjects: Get full text
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Regulation of α-catenin conformation at cadherin adhesions
Published 2018-03-01Subjects: Get full text
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Nucleation of cadherin clusters on cell-cell interfaces
Published 2022-11-01“…Abstract Cadherins mediate cell-cell adhesion and help the cell determine its shape and function. …”
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Cadherin-11 Regulates Macrophage Development and Function
Published 2022-02-01Subjects: “…Cadherin-11…”
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Interactions and Feedbacks in E-Cadherin Transcriptional Regulation
Published 2021-06-01“…The transmembrane protein E-cadherin is the major protein that mediates homophilic adhesion between neighbouring cells and is, therefore, one of the critical components for epithelial integrity. …”
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The Cross-Talk Between EGFR and E-Cadherin
Published 2022-01-01“…Epidermal growth factor receptor (EGFR) and adhesion protein E-cadherin are major regulators of proliferation and differentiation in epithelial cells. …”
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Gastrulation EMT Is Independent of P-Cadherin Downregulation.
Published 2016-01-01“…Here we investigate the relationship between E-cadherin and P-cadherin expression and localization, Snail function and EMT during gastrulation in chicken embryos. …”
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Regulation of α-catenin conformation at cadherin adhesions
Published 2018“…Here, I describe an updated view of the mechanical regulation of α-catenin in the context of cellular adhesion, including the role of cadherin clustering in its activation.…”
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E-cadherin loss of function in the murine intestine
Published 2012“…<p>E-cadherin (<em>Cdh1</em>), is a major component of epithelial adherens junctions, binds the Wnt pathway effector β-catenin and is lost at the invasive edge of colon cancers. …”
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E-cadherin and Snail gene analysis in ameloblastoma
Published 2016Get full text
Conference or Workshop Item