LASP1 Induces Epithelial-Mesenchymal Transition in Lung Cancer through the TGF-β1/Smad/Snail Pathway by Qingming Xue, Hong Jiang, Jinjie Wang, Dongshan Wei

“…LASP1 also regulated the expression of vimentin, N-cadherin, and E-cadherin in TGF-β1-treated cells. Activity of key Smad proteins (pSmad2 and pSmad3) and protein level of Smad7 were markedly regulated through LASP1. …”
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EPAS1 siRNA inhibits the proliferation, migration and invasion of human renal clear cell carcinoma cell line HiMet-ccRCC by CHEN Hai-bin, ZHAO Jian-jun, TAN Chao

“…RT-qPCR was used to detect the EPAS1 mRNA level in HiMet-ccRCC cells; MTT method was used to detect the proliferation of HiMet-ccRCC cells; Transwell experiment was used to detect the migration and invasion ability of HiMet-ccRCC cells; Western blot was used to detect the expression of E-cadherin,N-cadherin,MMP-9,PCNA. Results Compared with Con and NC group, the expression level of EPAS1 in HiMet-ccRCC cells in the EPAS1 siRNA group was significantly reduced (P＜0.05), the proliferation inhibition rate of HiMet-ccRCC cells was significantly increased and the counting of invasion and migration cells was significantly reduced (P＜0.05), the protein expression of E-cadherin in HiMet-ccRCC cells from EPAS1 siRNA group increased (P＜0.05)and the protein expression of N-cadherin, MMP-9 and PCNA reduced(P＜0.05). …”
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Serinc2 Drives the Progression of Cervical Cancer Through Regulating Myc Pathway by Xiaoping Wang, Chen Jiang, Qing Li

“…The protein expression of c‐Myc, PDK1, HK2, PFKP, LDHA, Snail, Vimentin, N‐cadherin, and E‐cadherin was detected via western blot. …”
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RSV Inhibits Epithelial-mesenchymal Transition of MDA-MB-231 Cells by Down-regulating POLD1 Expression by WANG Mengxin, LIANG Zhijie, HUANG Donglin, WAN Yan, JIANG Hongmian, LI Hongmian, CHEN Maojian, WEI Changyuan

“…Western blot was used to detect the expression of POLD1, E-cadherin, N-cadherin and Vimentin after RSV treatment. …”
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Photoperiod-Dependent Effects of 4-tert-Octylphenol on Adherens and Gap Junction Proteins in Bank Vole Seminiferous Tubules by Anna Hejmej, Malgorzata Kotula-Balak, Katarzyna Chojnacka, Paulina Kuras, Marta Lydka-Zarzycka, Barbara Bilinska

“…We found that in bank vole testes expression and distribution of N-cadherin, β-catenin, and Cx43 were photoperiod dependent. …”
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INHBA gene silencing inhibits proliferation, migration, and invasion of osteosarcoma cells by repressing TGF-β signaling pathway activation by Hongyu Zhang, Yuemei Huang, Qiuting Wen, Yan Li, Lin Guo, Na Ge

“…Epithelial–mesenchymal transition (EMT) markers (E-cadherin and N-cadherin) were analyzed by RT-qPCR. …”
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Role of LIMK1 in trafficking of Rab5 vesicles by Lee, Michelle Jing Qi

“…To investigate the influence of LIMK1 on dynein activity, we performed time-lapse microscopy and immunofluorescence staining on LIMK1-knockdown HeLa cells to monitor Rab5 vesicle trafficking and N-cadherin localization. For cells with LIMK1 knockdown, we observed greater Rab5 vesicle movement speed and less localization of N-cadherin at the plasma membrane. …”
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Study of biomarkers in the epithelial-mesenchymal transition of triple negative breast cancers and their associations with clinicopathological parameters by Chai, Xiu Hui

“…Existing literature demonstrates that as cancer advances, the tumor cells will undergo epithelial-mesenchymal transition (EMT) to form secondary tumors at distant site. E-cadherin and Vimentin are biomarkers for epithelial and mesenchymal states respectively. β-catenin is involved in maintaining stable epithelial complex with E-cadherin and in signalling pathway implicated in tumorogenesis.…”
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EFFECT OF LONG NON-CODING RNA SMALL NUCLEOLAR RNA HOST GENE 1 ON MIGRATION, INVASION, AND EPITHELIAL-MESENCHYMAL TRANSITION OF BREAST CANCER CELLS AND ITS MECHANISM by DENG Lin, WU Qinglan, SONG Junying, GAO Xiao, XIAO Huanhuan, ZHANG Li, CAO Yi, HOU Lin

“…Compared with group C, group D had significant increases in the migration and invasion abilities of BT-549 cells and the protein expression levels of N-cadherin and Vimentin, as well as a significant reduction in the protein expression of E-cadherin (t=3.59-13.83,P<0.05). …”
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Xanthohumol Impairs the PMA-Driven Invasive Behaviour of Lung Cancer Cell Line A549 and Exerts Anti-EMT Action by Adrianna Sławińska-Brych, Magdalena Mizerska-Kowalska, Sylwia Katarzyna Król, Andrzej Stepulak, Barbara Zdzisińska

“…Furthermore, the influence of XN on the expression of EMT-associated proteins such as E-cadherin and α-E-catenin (epithelial markers), vimentin and N-cadherin (mesenchymal markers), and Snail-1 (transcriptional repressor of E-cadherin) was studied. …”
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The Correlation between Proliferative Immunohistochemical Markers and Papillary Thyroid Carcinoma Aggressiveness by Mohammad Sheikh-Ahmad, Yara Shalata, Jacob Bejar, Hila Kreizman Shefer, Majd F. Sirhan, Monica Laniado, Ibrahim Matter, Abed Agbarya, Maria Reut, Ekaterina Yovanovich, Leonard Saiegh

“…E-Cadherin staining significantly and inversely correlated with the presence of metastases.…”
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Over-expression of heparanase promotes proliferation and migration of gallbladder cancer cell line GBC-SD by LIU Zi-xiang, ZHOU Shao-bo, ZHANG Zi-yan

“…Conclusions Over-expression of heparanase promotes the proliferation and migration of gallbladder cancer cell line GBC-SD, and the mechanism may be related to its regulation of E-cadherin through FGF-2.…”
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Clear cell (glycogen rich) gastric adenocarcinoma: a distinct tubulo-papillary variant with a predilection for the cardia/gastro-oesophageal region. by Ghotli, Z, Serra, S, Chetty, R

“…The cases were stained with: CK7, CK20, CEA, AFP, cyclin D1, E-cadherin and CDX-2. RESULTS: There were nine males and three females with an age range of 62 to 82 years (mean 71.4 years). …”

Mechanism of inhibition of growth and metastasis of colon cancer by celecoxib analog OSU-03013 via wnt signaling pathway by ChunYong Yang, ZhiQiang Zhou, XueSong Wang, JianZhe Ren, Jing Qi

“…OSU-03013 had dose-dependent and time-dependent antitumor activity on SW480 cells, which can promote tumor cell apoptosis, up-regulate E-cadherin, and down-regulate β-catenin, c-myc, Wnt1, and N-cadherin. …”
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Hematopoietic stem and progenitor cells use podosomes to transcellularly cross the bone marrow endothelium by Timo Rademakers, Marieke Goedhart, Mark Hoogenboezem, Alexander García Ponce, Jos van Rijssel, Maryna Samus, Michael Schnoor, Stefan Butz, Stephan Huveneers, Dietmar Vestweber, Martijn A. Nolte, Carlijn Voermans, Jaap D. van Buul

“…We show that temporal loss of vascular endothelial-cadherin function promotes vascular permeability in BM, even upon low-dose irradiation. …”
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Selection of a MCF-7 Breast Cancer Cell Subpopulation with High Sensitivity to IL-1β: Characterization of and Correlation between Morphological and Molecular Changes Leading to Inc... by Eloy Andres Pérez-Yépez, Jorge-Tonatiuh Ayala-Sumuano, Alicia Maria Reveles-Espinoza, Isaura Meza

“…Basal expression of E-cadherin mRNA was higher, and IL-1β stimulus had no further effect at early times of cytokine exposure. …”
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PTEN inhibits epithelial mesenchymal transition of thyroid cancer cells by regulating the Wnt/β-Catenin signaling pathway by Li Wei, Qianhui Liang, Chang Zhou, Rong Liu, Yun Liu

“…The expression levels of E-Cadherin, N-Cadherin, and Vimentin in TPC-1 cells were evaluated using Western blot. …”
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Role and possible mechanism of pseudogene FMO6P in inhibiting invasion and metastasis of gastric cancer by WU Xiongyan, LI Zhen, YU Zhenjia, SU liping

“…Moreover, overexpression of FMO6P promoted the expression of E-cadherin, and inhibited the expression of N-cadherin, ZEB1, and MMP2 in gastric cancer cells. …”
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胰腺实性-假乳头状瘤的临床病理及免疫组化分析

“…【目的】 分析胰腺实性-假乳头状瘤(SPN)的临床病理特征及免疫组织化学表达情况,寻找其相对特异的免疫组化诊断标记65377; 【方法】 HE染色观察10例病例形态学特征,免疫组织化学检测其细胞角蛋白65380;波形蛋白65380;CD5665380;CD1065380;嗜铬素A65380;突触素65380;神经元特异性烯醇酶65380;α-1抗胰蛋白酶65380;孕激素受体和E-钙粘素65380;β-连环蛋白及cyclin D1的表达65377;另选5例正常胰腺组织作对照65377; 【结果】 10例SPN中6例为女性,4例为男性,年龄17 ~ 41岁,平均29岁65377;全部病例随访至今均存活,未发生复发或转移65377;肿瘤组织囊实性外观,镜下呈实性假乳头状结构65377;10例中,Vim65380;CD56及PR均弥漫阳性,9例NSE(+),7例CD10(+),6例Syn(+),5例CK及α-AT(+),4例CgA(+)65377;5例正常胰腺组织E-cadherin与β-catenin均为细胞膜表达,且cyclin D1(-);在10例SPN中,均未见E-cadherin的胞膜表达,仅2例中少数肿瘤细胞核阳性;β-catenin为核/胞浆异常表达;且cyclin D1均为阳性65377; 【结论】 在SPN中,E-cadherin为阴性或胞核阳性,而β-catenin呈异常表达;SPN中Vim65380;CD5665380;PR65380;CD10阳性以及E-cadherin与β-catenin的表达情况为该肿瘤诊断相对特异的免疫组化指标65377;…”
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Effect of dorsomorphin on the migration and invasion abilities of drug-resistant esophageal cancer cells by SHI Xiaoli, SU Zhiguo, ZHANG Ying, YANG Guoshuai, PENG Wennuan, WANG Chen, MA Lin

“…Western blotting showed that compared with the control group, the experimental group had significant reductions in the relative protein expression levels of Vimentin and N-cadherin (t=19.40,41.79,P<0.05) and a significant increase in the protein expression level of N-cadherin (t=58.12,P<0.05). …”
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