EPLIN-α and -β Isoforms Modulate Endothelial Cell Dynamics through a Spatiotemporally Differentiated Interaction with Actin by Muna Taha, Mohammed Aldirawi, Sigrid März, Jochen Seebach, Maria Odenthal-Schnittler, Olga Bondareva, Vesna Bojovic, Thomas Schmandra, Benedikt Wirth, Magdalena Mietkowska, Klemens Rottner, Hans Schnittler

“…Keywords: junction-associated intermittent lamellipodia, JAIL, junction dynamics, Arp2/3 complex, hemodynamics, actin binding proteins, VE-cadherin dynamics, lamellipodia, stress fibers, shear stress…”
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Bone marrow mesenchymal stromal cells attenuate silica-induced pulmonary fibrosis potentially by attenuating Wnt/β-catenin signaling in rats by Enguo Zhang, Ye Yang, Shangya Chen, Cheng Peng, Martin F. Lavin, Abrey J. Yeo, Chao Li, Xiaoshan Liu, Yingjun Guan, Xinjing Du, Zhongjun Du, Hua Shao

“…Treatment of BMSCs increased the expression of epithelial marker proteins including E-cadherin (E-cad) and cytokeratin19 (CK19) and reduced the expression of fibrosis marker proteins including Vimentin (Vim) and α-Smooth actin (α-SMA) after exposure to silica suspension. …”
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Lactate Induces the Expressions of MCT1 and HCAR1 to Promote Tumor Growth and Progression in Glioblastoma by Lucia Longhitano, Nunzio Vicario, Daniele Tibullo, Cesarina Giallongo, Giuseppe Broggi, Rosario Caltabiano, Giuseppe Maria Vincenzo Barbagallo, Giuseppe Maria Vincenzo Barbagallo, Roberto Altieri, Roberto Altieri, Marta Baghini, Michelino Di Rosa, Rosalba Parenti, Antonio Giordano, Maria Caterina Mione, Giovanni Li Volti

“…Moreover, lactate modulated the epithelial–mesenchymal transition protein markers E-cadherin and β-catenin. Interestingly, lactate induced mitochondrial mass and the OXPHOS gene, suggesting improved mitochondrial fitness. …”
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The Double Mutation <i>DSG2</i>-p.S363X and <i>TBX20</i>-p.D278X Is Associated with Left Ventricular Non-Compaction Cardiomyopathy: Case Report by Roman Myasnikov, Andreas Brodehl, Alexey Meshkov, Olga Kulikova, Anna Kiseleva, Greta Marie Pohl, Evgeniia Sotnikova, Mikhail Divashuk, Marina Klimushina, Anastasia Zharikova, Maria Pokrovskaya, Sergey Koretskiy, Maria Kharlap, Elena Mershina, Valentin Sinitsyn, Elena Basargina, Leila Gandaeva, Vladimir Barskiy, Sergey Boytsov, Hendrik Milting, Oxana Drapkina

“…<i>DSG2</i> encodes desmoglein–2, which is part of the cardiac desmosomes and belongs to the cadherin family. Since the identified nonsense variant (<i>DSG2</i>-p.S363X) is localized in the extracellular domain of <i>DSG2</i>, we performed in vitro cell transfection experiments. …”
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Computational approaches to elucidate the action mechanism of zerumbone towards beta catenin by Fatima, Ayesha

“…β-catenin is the key protein of the Wnt-β-catenin signaling pathway that is involved in maintaining the cell-cell adhesion by binding to the e-cadherin and β-catenin and cell proliferation by complexing with transcription factor, Lymphoid Enhancing Factor 1 (LEF1)/T-cell Factor 4 (TCF4), in the nucleus. …”
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TGF-β1 dominates stromal fibroblast-mediated EMT via the FAP/VCAN axis in bladder cancer cells by Qinrong Ping, Chunhui Wang, Xin Cheng, Yiming Zhong, Ruping Yan, Meng Yang, Yunqiang Shi, Xiangmeng Li, Xiao Li, Wenwen Huang, Liqiong Wang, Xiaofang Bi, Libing Hu, Yang Yang, Yingbao Wang, Rui Gong, Jun Tan, Rui Li, Hui Li, Jian Li, Wenju Wang, Ruhong Li

“…We revealed a new mechanism whereby TGF-β1 dominated stromal fibroblast-mediated EMT of bladder cancer cells via the FAP/VCAN axis and identified potential biomarkers (FAP, VCAN, N-cadherin, and Vimentin) of bladder cancer. These results enhance our understanding of bladder cancer invasion and metastasis and provide potential strategies for diagnosis, treatment, and prognosis.…”
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Coagulation Factor Xa Promotes Solid Tumor Growth, Experimental Metastasis and Endothelial Cell Activation by Maximiliano Arce, Mauricio P. Pinto, Macarena Galleguillos, Catalina Muñoz, Soledad Lange, Carolina Ramirez, Rafaela Erices, Pamela Gonzalez, Ethel Velasquez, Fabián Tempio, Mercedes N. Lopez, Flavio Salazar-Onfray, Kelly Cautivo, Alexis M. Kalergis, Sebastián Cruz, Álvaro Lladser, Lorena Lobos-González, Guillermo Valenzuela, Nixa Olivares, Claudia Sáez, Tania Koning, Fabiola A. Sánchez, Patricia Fuenzalida, Alejandro Godoy, Pamela Contreras Orellana, Lisette Leyton, Roberta Lugano, Anna Dimberg, Andrew F.G. Quest, Gareth I. Owen

“…Alternatively, FXa upon endothelial cells promoted cytoskeleton contraction, disrupted membrane VE-Cadherin pattern, heightened endothelial-hyperpermeability, increased inflammatory adhesion molecules and enhanced B16F10 adhesion under flow conditions. …”
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SOX2 interferes with the function of CDX2 in bile acid-induced gastric intestinal metaplasia by Ting Yuan, Zhen Ni, Chuan Han, Yali Min, Nina Sun, Caifang Liu, Miao Shi, Wenquan Lu, Na Wang, Feng Du, Qiong Wu, Ning Xie, Yongquan Shi

“…Furthermore, we demonstrated that SOX2 overexpression could significantly inhibit bile acid- and exogenous CDX2-induced IM-specific gene expression, including KLF4, cadherin 17 and HNF4α expression. In contrast, SOX2 knockdown had the opposite effect. …”
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Amphibian-derived peptide RL-RF10 ameliorates paraquat-induced pulmonary fibrosis injury by Huiling Sun, Yutong Wu, Ziqian Xiong, Yuanqi Gu, Qiuye Jia, Zeqiong Ru, Ying Peng, Zijian Kang, Yuansheng Li, Yubing Huang, Saige Yin, Kun Guo, Chengan Feng, Jing Tang, Zhenhua Gao, Ying Wang, Xinwang Yang

“…In addition, RL-RF10 down-regulated the levels of collagen I, collagen III, and vimentin, while increasing the expression of E-cadherin to inhibit epithelial-mesenchymal transition. …”
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Regulation of Activating Blood and Dredging Collate Method on Serum Bone Resorption/Angiogenesis/Osteogenic Protein in Patients with Steriod-induced Osteonecrosis of Femoral Head C... by HE Xianshun, WEI Yurou, HE Mincong, LIN Kun, TIAN Jiaqing, ZHAN Zhiwei, LIN Tianye, HE Xiaoming, HE wei, WEI Qiushi

“…Fasting serum was collected, and the expression levels of nuclear factor &#x03BA;B receptor activating factor ligand (RANKL), platelet-derived growth factor-BB (PDGF-BB), vascular endothelial growth factor A (VEGFA), osteoprotegerin (OPG) and cadherin-associated protein (CTNNB1) in serum were detected by enzyme-linked immunosorbent assay. …”
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Genistein Ameliorates Renal Fibrosis Through Regulation Snail via m6A RNA Demethylase ALKBH5 by Yichun Ning, Yichun Ning, Yichun Ning, Yichun Ning, Yichun Ning, Jing Chen, Jing Chen, Jing Chen, Jing Chen, Jing Chen, Yiqin Shi, Yiqin Shi, Yiqin Shi, Yiqin Shi, Yiqin Shi, Nana Song, Nana Song, Xiaofang Yu, Xiaofang Yu, Xiaofang Yu, Xiaofang Yu, Xiaofang Yu, Yi Fang, Yi Fang, Yi Fang, Yi Fang, Yi Fang, Xiaoqiang Ding, Xiaoqiang Ding, Xiaoqiang Ding, Xiaoqiang Ding, Xiaoqiang Ding

“…In agreement, overexpression ALKBH5 increased epithelial adhesion molecule E-cadherin and reduced snail expression. In conclusion, genistein increased renal ALKBH5 expression in UUO-induced renal fibrosis and reduced RNA m6A levels and ameliorates renal damages.…”
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Arsenic interferes with spermatogenesis involving Rictor/mTORC2-mediated blood-testis barrier disruption in mice by Xiujuan Li, Wenting Wang, Yue Hou, Gexuan Li, Huilan Yi, Shuo Cui, Juan Zhang, Xiaohong He, Hong Zhao, Zeyu Yang, Yulan Qiu, Zhizhen Liu, Jun Xie

“…Analysis of BTB junctional proteins revealed that arsenic intake downregulated Claudin-11 expression and increased protein levels of β-catenin, N-cadherin, and Connexin-43. Aberrant localization of these membrane proteins was also observed in arsenic-treated mice. …”
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Lumican is elevated in the lung in human and experimental acute respiratory distress syndrome and promotes early fibrotic responses to lung injury by Ke Wang, Youyu Wang, Yufang Cao, Hao Wang, Yongfang Zhou, Lijuan Gao, Zijian Zeng, Mengxin Cheng, Xiaodong Jin, Jun Chen, Fuqiang Wen, Tao Wang

“…In turn, lumican increased the expression of alpha-smooth muscle actin (α-SMA), COL1A1, and COL3A1 in HLF, upregulated α-SMA and COL3A1, downregulated E-cadherin, and caused spindle-shaped morphological changes in SAECs. …”
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PD-L1 Protein Expression Is Associated With Good Clinical Outcomes and Nomogram for Prediction of Disease Free Survival and Overall Survival in Breast Cancer Patients Received Neoa... by Li Chen, Li Chen, Shaolong Huang, Qiang Liu, Xiangyi Kong, Zhaohui Su, Mengliu Zhu, Yi Fang, Lin Zhang, Lin Zhang, Lin Zhang, Xingrui Li, Jing Wang

“…Univariate and multivariate analyses indicated that PD-L1, duration of neoadjuvant therapy, E-Cadherin, targeted therapy were the independent prognostic factors for patients’ DFS and OS. …”
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The Identification of Large Rearrangements Involving Intron 2 of the <i>CDH1</i> Gene in <i>BRCA1/2</i> Negative and Breast Cancer Susceptibility by Jihenne Ben Aissa-Haj, Hugo Pinheiro, François Cornelis, Molka Sebai, Didier Meseure, Adrien Briaux, Philippe Berteaux, Cedric Lefol, Gaëtan Des Guetz, Martine Trassard, Denise Stevens, François Vialard, Ivan Bieche, Catherine Noguès, Roseline Tang, Carla Oliveira, Dominique Stoppat-Lyonnet, Rosette Lidereau, Etienne Rouleau

“…E-cadherin, a <i>CDH1</i> gene product, is a calcium-dependent cell–cell adhesion molecule playing a critical role in the establishment of epithelial architecture, maintenance of cell polarity, and differentiation. …”
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Long noncoding RNA MYOSLID promotes invasion and metastasis by modulating the partial epithelial-mesenchymal transition program in head and neck squamous cell carcinoma by Hong-Gang Xiong, Hao Li, Yao Xiao, Qi-Chao Yang, Lei-Lei Yang, Lei Chen, Lin-Lin Bu, Wen-Feng Zhang, Jia-Li Zhang, Zhi-Jun Sun

“…However, the knockdown of MYOSLID had no effect on the expression levels of the EMT biomarkers E-cadherin and Vimentin. Conclusions Our study revealed that MYOSLID expression was closely related to the p-EMT program in HNSCC, and it might be a new predictive biomarker for aggressive HNSCC.…”
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Alterations of Growth and Focal Adhesion Molecules in Human Breast Cancer Cells Exposed to the Random Positioning Machine by Jayashree Sahana, Thomas J. Corydon, Thomas J. Corydon, Markus Wehland, Markus Wehland, Marcus Krüger, Marcus Krüger, Sascha Kopp, Sascha Kopp, Daniela Melnik, Stefan Kahlert, Borna Relja, Manfred Infanger, Manfred Infanger, Daniela Grimm, Daniela Grimm, Daniela Grimm

“…An interaction analysis of the examined genes involved in 3D growth and adhesion indicated a central role of fibronectin, vinculin, and E-cadherin. Live cell imaging of eGFP-vinculin in MCF-7 cells confirmed these findings. β-catenin-transfected MCF-7 cells revealed a nuclear expression in 1g and RPM-AD cells. …”
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Effects of sevoflurane on lung epithelial permeability in experimental models of acute respiratory distress syndrome by Ruoyang Zhai, Woodys Lenga Ma Bonda, Charlotte Leclaire, Cécile Saint-Béat, Camille Theilliere, Corinne Belville, Randy Coupet, Raiko Blondonnet, Damien Bouvier, Loic Blanchon, Vincent Sapin, Matthieu Jabaudon

“…Levels of zonula occludens-1, E-cadherin, and pMLC were quantified, along with F-actin immunostaining, in both models. …”
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CUL4B Promotes Breast Carcinogenesis by Coordinating with Transcriptional Repressor Complexes in Response to Hypoxia Signaling Pathway by Wei Huang, Jingyao Zhang, Miaomiao Huo, Jie Gao, Tianshu Yang, Xin Yin, Pei Wang, Shuai Leng, Dandan Feng, Yang Chen, Yang Yang, Yan Wang

“…It is demonstrated that CRL4B/NuRD(MTA1) complexes cooccupy the E‐cadherin and AXIN2 promoters, and could be recruited by transcription factors including Snail and ZEB2 to promote cell invasion and tumorigenesis both in vitro and in vivo. …”
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Effects of Montelukast on Arsenic-Induced Epithelial-Mesenchymal Transition and the Role of Reactive Oxygen Species Production in Human Bronchial Epithelial Cells by Huang-Chi Chen, Huang-Chi Chen, Hsin-Ying Clair Chiou, Hsin-Ying Clair Chiou, Mei-Lan Tsai, Mei-Lan Tsai, Szu-Chia Chen, Szu-Chia Chen, Szu-Chia Chen, Ming-Hong Lin, Ming-Hong Lin, Ming-Hong Lin, Ming-Hong Lin, Tzu-Chun Chuang, Chih-Hsing Hung, Chih-Hsing Hung, Chih-Hsing Hung, Chih-Hsing Hung, Chao-Hung Kuo, Chao-Hung Kuo, Chao-Hung Kuo

“…Furthermore, the role of reactive oxygen species (ROS) generation in arsenic-induced EMT and the effect of montelukast on this process were determined by ROS inhibitor treatment and ROS measurement, respectively.Results: Montelukast was effective at reducing arsenic-induced cell migration and mesenchymal protein (fibronectin, MMP-2, N-cadherin, β-catenin, and SMAD2/3) expression. Arsenic-induced ROS production was attenuated by pretreatment with montelukast. …”
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