Differential Gene Expression and Methylation Analysis of Melanoma in TCGA Database to Further Study the Expression Pattern of KYNU in Melanoma by Min Wang, Meng Liu, Yingjian Huang, Ziyang Wang, Yuqian Wang, Ke He, Ruimin Bai, Tingyi Ying, Yan Zheng

“…Overexpression of KYNU can promote changes in apoptotic BCL-2, metabolic KYN, 3-HAA, invasion and migration MMP9, E-cadherin, and other related proteins in melanoma. Fluorescence staining and flow analysis showed that a slower proliferation rate led to a stronger fluorescence intensity. …”
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All-trans retinoic acid reverses malignant biological behavior of hepatocarcinoma cells by regulating miR-200 family members by Jiejie Cui, Mengjia Gong, Shuyu Fang, Chaoqun Hu, Yi Wang, Jingfang Zhang, Ni Tang, Yun He

“…Antagomir specific for miR-200a-3p and 200c-3p down-regulated the expression of CK18, but only miR-200a-3p antagomir played prominent role in regulating the expression of these mesenchymal markers, N-Cadherin, Snail and Twist. The transcriptional activities of 8 transcription factors were up-regulated and 35 transcription factors were down-regulated by ATRA. …”
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Human seminal plasma stimulates the migration of CD11c+ mononuclear phagocytes to the apical side of the colonic epithelium without altering the junctional complexes in an ex vivo... by Marco Baratella, Valeria Iannone, Mariangela Cavarelli, Chiara Foglieni, Paola Viganò, Christiane Moog, Ugo Elmore, Ugo Elmore, Silvia Nozza, Massimo Alfano, Andrea Salonia, Andrea Salonia, Stefania Dispinseri, Gabriella Scarlatti

“…Mucosal exposure to human seminal plasma (HSP), rich in pro- and anti-inflammatory cytokines, chemokines and growth factors, may as well induce alterations of the colonic mucosa and recruit immune cells, hence, affecting pathogen sampling and transmission.MethodsHere, we studied the role of HSP on the paracellular intestinal permeability by analyzing the distribution of two proteins known to play a key role in controlling the intestinal barrier integrity, namely the tight junctions-associated junctional adhesion molecule (JAM-A) and the adherents junction associated protein E-cadherin (E-CAD), by immunofluorescence and confocal microscopy. …”
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AEBP1 promotes papillary thyroid cancer progression by activating BMP4 signaling by Gaoda Ju, Tao Xing, Miaomiao Xu, Xin Zhang, Yuqing Sun, Zhuanzhuan Mu, Di Sun, Sen Miao, Li Li, Jun Liang, Yansong Lin

“…In vitro experiments indicated that knockout of AEBP1 can inhibit the growth and invasion of PTC cells and reduce the expression of EMT markers including N-cadherin, TWIST1, and ZEB2. In the xenograft model, knockout of AEBP1 inhibited the growth and lung metastasis of PTC cells. …”
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YAP1/Piezo1 involve in the dynamic changes of lymphatic vessels in UVR-induced photoaging progress to squamous cell carcinoma by Yuling L. Yang, Chu Zhou, Qi Chen, Shuzhan Z. Shen, Jiandan D. Li, Xiuli L. Wang, Peiru R. Wang

“…The expression of Piezo1 whose deletion in adult lymphatics led to substantial valve degeneration, VE-cadherin that maintained the permeability of LVs, and YAP1 were evaluated by immunohistochemistry staining as well. …”
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Pericytes protect rats and mice from sepsis-induced injuries by maintaining vascular reactivity and barrier function: implication of miRNAs and microvesicles by Zi-Sen Zhang, Yi-Yan Liu, Shuang-Shuang He, Dai-Qin Bao, Hong-Chen Wang, Jie Zhang, Xiao-Yong Peng, Jia-Tao Zang, Yu Zhu, Yue Wu, Qing-Hui Li, Tao Li, Liang-Ming Liu

“…Additionally, PCMVs transferred miR-145 and miR-132 to VSMCs and VECs, respectively, exerting a protective effect on vascular reactivity and barrier function after sepsis (P < 0.05). miR-145 primarily improved the contractile response of VSMCs by activating the sphingosine kinase 2 (Sphk2)/sphingosine-1-phosphate receptor (S1PR)1/phosphorylation of myosin light chain 20 pathway, whereas miR-132 effectively improved the barrier function of VECs by activating the Sphk2/S1PR2/zonula occludens-1 and vascular endothelial-cadherin pathways. Conclusions Pericytes are protective against sepsis through regulating vascular reactivity and barrier function. …”
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Hypoxia response element-directed expression of bFGF in dental pulp stem cells improve the hypoxic environment by targeting pericytes in SCI rats by Sipin Zhu, Yibo Ying, Yan He, Xingxing Zhong, Jiahui Ye, Zhiyang Huang, Min Chen, Qiuji Wu, Yifan Zhang, Ziyue Xiang, Yurong Tu, Weiyang Ying, Jian Xiao, Xiaokun Li, Qingsong Ye, Zhouguang Wang

“…In this study, DPSCs were revealed to differentiate into CD13+ pericytes and up-regulate N-cadherin expression to promote the re-attachment of CD13+ pericytes to vascular endothelial cells. …”
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Shikonin contributes to intestinal epithelial cell differentiation through PKM2/NRF2-mediated Polyol pathway by Ling Huang, Xiufu Tang, FangYing Yang, Wenxu Pan, Xinhua Liang, Zhaohui Xu, Meiwan Cao, Junhong Zhao, Huan Chen, Jing Huang, Jiayu Chen, Lanlan Geng, Wanfu Xu, Sitang Gong

“…Moreover, both AKR1B1 and AKR1B10 expression were decreased, while PKM2 was increased in intestinal epithelial cells labeled with E-cadherin in patients with IBD, and a negative clinical relationship was observed between PKM2 and AKR1B1/AKR1B10, respectively. …”
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ANGPTL4 accelerates ovarian serous cystadenocarcinoma carcinogenesis and angiogenesis in the tumor microenvironment by activating the JAK2/STAT3 pathway and interacting with ESM1 by Yu-kun Li, An-bo Gao, Tian Zeng, Dan Liu, Qun-feng Zhang, Xiao-min Ran, Zhen-zi Tang, Yan Li, Jue Liu, Ting Zhang, Gang-qing Shi, Wen-chao Zhou, Wen-da Zou, Juan Peng, Juan Zhang, Hui Li, Juan Zou

“…In the OC microenvironment, ESM1 may interfere with the binding of ANGPTL4 to integrin and vascular-endothelial cadherin (VE-Cad), which leads to stabilization of vascular integrity and ultimately promotes angiogenesis. …”
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Hedysari Radix Praeparata Cum Melle repairs impaired intestinal barrier function and alleviates colitis-associated colorectal cancer via remodeling gut microbiota and metabolism by Yugui Zhang, Yuefeng Li, Tiantian Bian, Yujing Sun, Zhuanhong Zhang, Ting Liu, Feiyun Gao, Yanjun Wang, Rui Cao, Erdan Xin, Xingke Yan

“…Our study found that HR attenuated the pathological state, improved survival rate, diminished K-Ras, IL-1β, IL-6 and TNF-α levels, and increased the levels of the intestinal barrier function proteins including claudin-1, E-cadherin and mucin-2 in colitis-associated colorectal cancer (CAC) mice. …”
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A study on mechanism of lncRNA-mediated SNHG5/miR-26a-5p/MTDH signal axis promoting metastasis of colorectal cancer by YE Junling, ZHENG Xiaoying, GUO Xinjian, CHEN Ruihui, YANG Liu, GOU Xiaodan, JIANG Hanmei

“…Overexpression of lncRNA SNHG5 could enhance the proliferation, clone formation, migration and invasion of CRC cells, promote the growth and lung metastasis of transplanted tumor, increase the relative expression level of Ki-67 proliferation index and vimentin (P&lt;0.05), and decrease the relative expression level of E-cadherin (P&lt;0.05). However, the development of CRC cells was inhibited after inhibition of lncRNA SNHG5 expression. …”
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Regulation of connective tissue growth factor expression by miR-133b for the treatment of renal interstitial fibrosis in aged mice with unilateral ureteral obstruction by Dan Cao, Yuan Wang, Yingjie Zhang, Yinping Zhang, Qi Huang, Zhong Yin, Guangyan Cai, Xiangmei Chen, Xuefeng Sun

“…In vitro experiments were performed to evaluate mRNA and protein expression of miR-133b targets, E-cadherin, α-smooth muscle actin (SMA), fibronectin, and collagen 3A1 (Col3A1), in HK2 cells transfected with miR-133b under TGF-β1 stimulation. …”
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NOTCH1 mutation associates with impaired immune response and decreased relapse-free survival in patients with resected T1-2N0 laryngeal cancer by Xiao-yang Gong, Hai-bin Chen, Li-qing Zhang, Dong-sheng Chen, Wang Li, Dong-hui Chen, Jin Xu, Han Zhou, Le-le Zhao, Yun-jie Song, Ming-zhe Xiao, Wang-long Deng, Chuang Qi, Xue-rong Wang, Xi Chen

“…A total of 469 genomic alterations were detected in 211 distinct cancer-relevant genes, and the genes found to be mutated in more than five patients (&gt;10%) included tumor protein p53 (TP53, 78.5%), FAT atypical cadherin 1 (FAT1, 26%), LDL receptor related protein 1B (LRP1B, 19%), cyclin dependent kinase inhibitor 2A (CDKN2A, 17%), tet methylcytosine dioxygenase 2 (TET2, 17%), notch receptor 1 (NOTCH1, 12%) and neuregulin 1 (NRG1, 12%). …”
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A Chinese Prescription Yu-Ping-Feng-San Administered in Remission Restores Bronchial Epithelial Barrier to Inhibit House Dust Mite-Induced Asthma Recurrence by Kaifan Bao, Weiyuan Yuan, Yijing Zhou, Yanyan Chen, Xuerui Yu, Xiaoyu Wang, Zhirong Jia, Xi Yu, Xiaotong Wang, Lu Yao, Siqi Wang, Yifan Xu, Yuheng Zhang, Jie Zheng, Min Hong

“…Besides, we found that desmoglein 1 (DSG1) remained deficient when asthmatic responses regressed whereas tight junction (TJ) claudin 1 (CLDN1) or adherin junction (AJ) E-cadherin restored spontaneously. In vitro, DSG1 interference resulted in increased thymic stromal lymphopoietin (TSLP) secretion, and epithelial barrier compromise evidenced by significantly elevated transepithelial electrical resistance (TEER) and increased 4-kDa FITC-dextran influx. …”
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Role of Endothelial and Mesenchymal Cell Transitions in Heart Failure and Recovery Thereafter by Guangyu Wang, Guangyu Wang, Guangyu Wang, Ana Sofia Cruz, Ana Sofia Cruz, Keith Youker, Keith Youker, Hernan G. Marcos-Abdala, Hernan G. Marcos-Abdala, Rajarajan A. Thandavarayan, Rajarajan A. Thandavarayan, John P. Cooke, John P. Cooke, Guillermo Torre-Amione, Guillermo Torre-Amione, Guillermo Torre-Amione, Kaifu Chen, Kaifu Chen, Kaifu Chen, Arvind Bhimaraj, Arvind Bhimaraj

“…Human end stage HF myocardial samples showed cells with dual expressed VE-Cadherin and FSP-1 consistent with cell fate transition. …”
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Effect of bone marrow mesenchymal stem cells-derived exosomes on diabetes-induced retinal injury: Implication of Wnt/ b-catenin signaling pathway by Nesrine Ebrahim, Heba Elsayed Abd El-Halim, Omayma Kamel Helal, Nahla El-Eraky El-Azab, Omnia A.M. Badr, Amira Hassouna, Hajir A.Al Saihati, Nashwa Hassan Aborayah, Hanan Tawfeek Emam, Hend S. El-wakeel, Mohammad Aljasir, Mohamed El-Sherbiny, Naglaa A.S. Sarg, Gehan Ahmed Shaker, Ola Mostafa, Dina Sabry, Marwa Abdel Kader Fouly, Nicholas Robert Forsyth, Nehal M. Elsherbiny, Rabab F. Salim

“…Evaluation of each group was via histopathological examination, assessment of gene and/or protein expression concerned with oxidative stress (SOD1, SOD2, Nox2, Nox4, iNOS), inflammation (TNF-α, ICAM-1, NF-κB) and angiogenesis (VEGF, VE-cadherin). Results: Results demonstrated that exosomes blocked the wnt/b-catenin pathway in diabetic retina concomitant with significant reduction of features of DR as shown by downregulation of retinal oxidants, upregulation of antioxidant enzymes, suppression of retinal inflammatory and angiogenic markers. …”
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Assessing the effects of a mixed Eimeria spp. challenge on performance, intestinal integrity, and the gut microbiome of broiler chickens by Danielle Graham, Victor M. Petrone-Garcia, Xochitl Hernandez-Velasco, Makenly E. Coles, Marco A. Juarez-Estrada, Juan D. Latorre, Jianmin Chai, Stephanie Shouse, Jiangchao Zhao, Aaron J. Forga, Roberto Senas-Cuesta, Lauren Laverty, Kristen Martin, Carolina Trujillo-Peralta, Ileana Loeza, Latasha S. Gray, Billy M. Hargis, Guillermo Tellez-Isaias

“…Intestinal permeability was significantly increased in the PC group based on serum FITC-d levels. Cadherin 1 (CDH1), calprotectin (CALPR), and connexin 45 (Cx45) expression was also upregulated in the ileum of the PC group at d24 (6-day post-challenge) while villin 1 (VIL1) was downregulated in the ileum of the PC group. …”
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Antagonism between wild-type and mutant β-catenin controls hepatoblastoma differentiation via fascin-1 by Caroline Gest, Sandra Sena, Lydia Dif, Véronique Neaud, Robin Loesch, Nathalie Dugot-Senant, Lisa Paysan, Léo Piquet, Terezinha Robbe, Nathalie Allain, Doulaye Dembele, Catherine Guettier, Paulette Bioulac-Sage, Anne Rullier, Brigitte Le Bail, Christophe F. Grosset, Frédéric Saltel, Valérie Lagrée, Sabine Colnot, Violaine Moreau

“…Background &amp; Aims: β-catenin is a well-known effector of the Wnt pathway, and a key player in cadherin-mediated cell adhesion. Oncogenic mutations of β-catenin are very frequent in paediatric liver primary tumours. …”
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Necroptosis-Related Prognostic Model for Pancreatic Carcinoma Reveals Its Invasion and Metastasis Potential through Hybrid EMT and Immune Escape by Haichuan Liu, Zhenghang Li, La Zhang, Mi Zhang, Shanshan Liu, Jianwei Wang, Changhong Yang, Qiling Peng, Chengyou Du, Ning Jiang

“…A GO analysis illustrated that model genes may participate in cell–cell junction, cadherin binding, cell adhesion molecule binding, and neutrophil migration and chemotaxis, while KEGG showed involvement in PI3K-Akt signaling pathway, ECMreceptor interaction, IL-17 signaling pathway, TNF signaling pathway, etc. …”
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Papillary renal neoplasm with reverse polarity: A clinicopathological and molecular genetic characterization of 16 cases with expanding the morphologic spectrum and further support... by Miaomiao Shen, Xiaona Yin, Yanfeng Bai, Huizhi Zhang, Guoqing Ru, Xianglei He, Xiaodong Teng, Guorong Chen, Ming Zhao

“…Fourteen out of 16 tumors showed a basolateral-membranous E-cadherin expression pattern, and 12/16 cases were positive for 34βE12.The expression of AMACR, CD10, and vimentin was either absent or only weak and focal. …”
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