CBP-HSF2 structural and functional interplay in Rubinstein-Taybi neurodevelopmental disorder by Aurélie de Thonel, Johanna K. Ahlskog, Kevin Daupin, Véronique Dubreuil, Jérémy Berthelet, Carole Chaput, Geoffrey Pires, Camille Leonetti, Ryma Abane, Lluís Cordón Barris, Isabelle Leray, Anna L. Aalto, Sarah Naceri, Marine Cordonnier, Carène Benasolo, Matthieu Sanial, Agathe Duchateau, Anniina Vihervaara, Mikael C. Puustinen, Federico Miozzo, Patricia Fergelot, Élise Lebigot, Alain Verloes, Pierre Gressens, Didier Lacombe, Jessica Gobbo, Carmen Garrido, Sandy D. Westerheide, Laurent David, Michel Petitjean, Olivier Taboureau, Fernando Rodrigues-Lima, Sandrine Passemard, Délara Sabéran-Djoneidi, Laurent Nguyen, Madeline Lancaster, Lea Sistonen, Valérie Mezger

“…Moreover, we unravel a CBP/EP300-HSF2-N-cadherin cascade that is also active in neurodevelopmental contexts, and show that its deregulation disturbs neuroepithelial integrity in 2D and 3D organoid models of cerebral development, generated from RSTS patient-derived iPSC cells, providing a molecular reading key for this complex pathology.…”
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Diminished Expression of Corticotropin-Releasing Hormone Receptor 2 in Human Colon Cancer Promotes Tumor Growth and Epithelial-to-Mesenchymal Transition via Persistent Interleukin-... by Jorge A. Rodriguez, Sara Huerta-Yepez, Ivy Ka Man Law, Guillermina J. Baay-Guzman, Belen Tirado-Rodriguez, Jill M. Hoffman, Dimitrios Iliopoulos, Daniel W. Hommes, Hein W. Verspaget, Lin Chang, Charalabos Pothoulakis, Stavroula Baritaki

“…In patients, CRHR2 mRNA expression was inversely correlated with IL-6R and vimentin levels and metastasis occurrence, while positively associated with E-cadherin expression and overall survival. Conclusions: CRHR2 down-regulation in CRC supports tumor expansion and spread through maintaining persistent inflammation and constitutive Stat3 activation. …”
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Case report: Preclinical efficacy of NEDD8 and proteasome inhibitors in patient-derived models of signet ring high-grade mucinous colorectal cancer from a Lynch syndrome patient by Erica Torchiaro, Consalvo Petti, Sabrina Arena, Sabrina Arena, Francesco Sassi, Giorgia Migliardi, Alfredo Mellano, Roberta Porporato, Marco Basiricò, Loretta Gammaitoni, Enrico Berrino, Enrico Berrino, Monica Montone, Giorgio Corti, Giovanni Crisafulli, Caterina Marchiò, Caterina Marchiò, Alberto Bardelli, Alberto Bardelli, Enzo Medico, Enzo Medico

“…Indeed, sensitivity to bortezomib was observed in mucinous adenocarcinoma of the lung, and we previously found that HGM CRC is preferentially sensitive to pevonedistat in models with low or absent expression of cadherin 17 (CDH17), a differentiation marker. We therefore performed IHC on the tumor and models, and observed no CDH17 expression, suggesting sensitivity to pevonedistat. …”
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Heparanase 1 Upregulation Promotes Tumor Progression and Is a Predictor of Low Survival for Oral Cancer by André A. Nimtz Rodrigues, André A. Nimtz Rodrigues, Lucilene Lopes-Santos, Pammela A. Lacerda, Mariana F. Juste, Bruno Augusto Mariz, Débora C. Cajazeiro, Victoria Giacobbe, Rafael Borges, André Casarim, Giovanna De Sanctis Callegari, Giovanna De Sanctis Callegari, Fernando Antônio M. Claret Arcadipane, Ivan Aprahamian, Tuula Anneli Salo, Carine Ervolino De Oliveira, Ricardo D. Coletta, Ricardo D. Coletta, Taize M. Augusto, Taize M. Augusto, Nilva K. Cervigne, Nilva K. Cervigne, Nilva K. Cervigne

“…Moreover, abrogation of HPSE1 in OSCC cells significantly promoted apoptosis and inhibited proliferation, migration, invasion, and epithelial–mesenchymal transition by significantly decreasing the expression of N-cadherin and vimentin. Furthermore, a conditioned medium of HPSE1-downregulated cells resulted in reduced vascular endothelial growth.Conclusion: Our results confirm the overexpression of HPSE1 in OSCCs, suggest that HPSE1 expression correlates with disease progression as it is associated with several important biological processes for oral tumorigenesis, and can be managed as a prognostic marker for patients with OSCC.…”
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Inhibition of murine colorectal cancer metastasis by targeting M2-TAM through STAT3/NF-kB/AKT signaling using macrophage 1-derived extracellular vesicles loaded with oxaliplatin, r... by Thaís Gomes de Carvalho, Pablo Lara, Carla Jorquera-Cordero, Cícero Flávio Soares Aragão, Artur de Santana Oliveira, Vinicius Barreto Garcia, Shirley Vitória de Paiva Souza, Timo Schomann, Luiz Alberto Lira Soares, Paulo Marcos da Matta Guedes, Raimundo Fernandes de Araújo Júnior

“…Furthermore, malignant cells showed overexpression of FADD, APAF-1, caspase-3, and E-cadherin, and decreased expression of MDR1, survivin, vimentin, and PD-L1 after treatment with systems of M1EVs. …”
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Association of CLDN18 Protein Expression with Clinicopathological Features and Prognosis in Advanced Gastric and Gastroesophageal Junction Adenocarcinomas by Antonio Pellino, Stefano Brignola, Erika Riello, Monia Niero, Sabina Murgioni, Maria Guido, Floriana Nappo, Gianluca Businello, Marta Sbaraglia, Francesca Bergamo, Gaya Spolverato, Salvatore Pucciarelli, Stefano Merigliano, Pierluigi Pilati, Francesco Cavallin, Stefano Realdon, Fabio Farinati, Angelo Paolo Dei Tos, Vittorina Zagonel, Sara Lonardi, Fotios Loupakis, Matteo Fassan

“…In this work, we evaluated the immunohistochemical (IHC) profile of CLDN18 and its correlation with clinical and histopathological features including p53, E-cadherin, MSH2, MSH6, MLH1, PMS2, HER2, EBER and PD-L1 combined positive score, in a large real-world and mono-institutional series of advanced GCs (<i>n</i> = 280) and GECs (<i>n</i> = 70). …”
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Exploration and identification of anoikis-related genes in polycythemia vera by Wufuer Aini, Wufuer Aini, Wufuer Aini, Limin Xie, Limin Xie, Limin Xie, Wanyu Hu, Wanyu Hu, Wanyu Hu, Yuan Tang, Yuan Tang, Yuan Tang, Hongling Peng, Hongling Peng, Hongling Peng, Guangsen Zhang, Tuo Deng, Tuo Deng, Tuo Deng

“…The significant enrichment of the apoptosis and cell adhesion pathways (i.e., cadherin binding) were shown in functional enrichment analysis. …”
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Overexpression of Mena is associated with tumor progression and poor prognosis in oral squamous cell carcinoma via EMT by Sijia Na, Sijia Na, Hao Cui, Hao Cui, Zhichen Guo, Zhichen Guo, Xiang Liang, Xiang Liang, Karim Ahmed Sakran, Karim Ahmed Sakran, Xiaomei Guo, Xiaomei Guo, Xingqiang Li, Xingqiang Li, Linyang Xie, Linyang Xie, Yifei Zhu, Yifei Zhu, Hong Qi, Hong Qi, Junbo Tu, Junbo Tu

“…IHC staining revealed that high expression of Mena in OSCC was correlated with Lymphatic metastasis, TNM stage, E-cadherin, Vimentin, and MMP-2, but insignificantly Ki67. …”
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TGF-β1, pSmad-2/3, Smad-7, and β-Catenin Are Augmented in the Pulmonary Arteries from Patients with Idiopathic Pulmonary Fibrosis (IPF): Role in Driving Endothelial-to-Mesenchymal... by Archana Vijay Gaikwad, Mathew Suji Eapen, Surajit Dey, Prem Bhattarai, Affan Mahmood Shahzad, Collin Chia, Jade Jaffar, Glen Westall, Darren Sutherland, Gurpreet Kaur Singhera, Tillie-Louise Hackett, Wenying Lu, Sukhwinder Singh Sohal

“…Intimal TGF-β1 and β-catenin percentage expression showed a strong correlation with the percentage expression of intimal vimentin (r′ = 0.54, <i>p</i> = 0.05 and r′ = 0.61, <i>p</i> = 0.02, respectively) and intimal N-cadherin (r′ = 0.62, <i>p</i> = 0.03 and r′ = 0.70, <i>p</i> = 0.001, respectively). …”
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Ribosomal DNA copy number is associated with P53 status and levels of heavy metals in gastrectomy specimens from gastric cancer patients by Lingfang Feng, Jing Du, Chunji Yao, Zhaoqiang Jiang, Tao Li, Quan Zhang, Xinnian Guo, Min Yu, Hailing Xia, Li Shi, Junlin Jia, Yan Tong, Li Ju, Jiaqi Liu, Jianlin Lou, Bernardo Lemos

“…Immunohistochemistry was used to assess HER-2, E-cadherin, EGFR, CK (pan), CK20, CK7, TopoⅡ, CAM5.2, P53, and Ki-67 expression. …”
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Blocking Connexin-43 mediated hemichannel activity protects against early tubular injury in experimental chronic kidney disease by Gareth W. Price, Christos E. Chadjichristos, Panagiotis Kavvadas, Sydney C. W. Tang, Wai Han Yiu, Colin R. Green, Joe A. Potter, Eleftherios Siamantouras, Paul E. Squires, Claire E. Hills

“…Video Abstract Graphical abstract In proximal tubular epithelial cells (PTECs), tight junction proteins, including zona occuludens-1 (ZO-1), contribute to epithelial integrity, whilst the adherens junction protein epithelial (E)-cadherin (ECAD) maintains cell-cell coupling, facilitating connexin 43 (Cx43) gap junction-mediated intercellular communication (GJIC) and the direct transfer of small molecules and ions between cells. …”
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Inhibition of calpain9 attenuates peritoneal dialysis-related peritoneal fibrosis by Fang Li, Yu Wang, Jianwei Tian, Zhanmei Zhou, Wei Yin, Xianhui Qin, Huizhen Wang, Tao Zeng, Aiqing Li, Jianping Jiang

“…In addition, compared with the control group, when primary rat peritoneal mesothelial cells or human peritoneal mesothelial cells were treated with transforming growth factor beta, down-regulation of calpain activity inhibited the expression of Fibronectin and Collagen I, and increased the expression of E-cadherin. These changes could be adjusted after silencing calpain9. …”
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Hepatocyte growth factor protects pulmonary endothelial barrier against oxidative stress and mitochondria-dependent apoptosis by Shanshan Meng, Feiping Xia, Jingyuan Xu, Xiwen Zhang, Ming Xue, Mingyuan Gu, Fengmei Guo, Yingzi Huang, Haibo Qiu, Yi Yang, Yanjie Yin, Xiuyuan Hao

“…Our study demonstrated that HGF protected the endothelium via the suppression of ROS production and intracellular calcium uptake, which lead to increased mitochondrial membrane potential (JC-1 and mitochondria tracker green detection) and specific proteins (complex I), raised anti-apoptosis Messenger Ribonucleic Acid level (B-cell lymphoma 2 and Bcl-xL), and increased endothelial junction proteins (VE-cadherin and occludin). Reversely, mTOR inhibitor rapamycin and STAT3 inhibitor S3I-201 could raise oxidative stress and mitochondria-dependent apoptosis even with HGF treatment in LPS-induced endothelial cells. …”
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Mediastinal lymph node dissection effectiveness in patients with I stage of non-small cell lung cancer by A. P. Kolesnik

“…Immunohistochemical study was performed on paraffin sections of lung tumors using monoclonal antibodies to Ki-67, CD31, p53 , E-Cadherin, EGFR, c-erbB-2 , pantcytokeratin and visualization system EnVision FLEX. …”
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Afadin Downregulation by Helicobacter pylori Induces Epithelial to Mesenchymal Transition in Gastric Cells by Miguel Sardinha Marques, Miguel Sardinha Marques, Miguel Sardinha Marques, Joana Melo, Joana Melo, Joana Melo, Bruno Cavadas, Bruno Cavadas, Bruno Cavadas, Nuno Mendes, Nuno Mendes, Luísa Pereira, Luísa Pereira, Luísa Pereira, Fátima Carneiro, Fátima Carneiro, Fátima Carneiro, Fátima Carneiro, Ceu Figueiredo, Ceu Figueiredo, Ceu Figueiredo, Marina Leite, Marina Leite, Marina Leite

“…H. pylori infection of cell lines recapitulated several EMT features, displacing and downregulating multiple proteins from cell–cell junctions, and increasing the expression of ZEB1, Vimentin, Slug, N-cadherin, and Snail. Silencing of Afadin by RNAi promoted delocalization of junctional proteins from the cell–cell contacts, increased paracellular permeability, and decreased transepithelial electrical resistance, all compatible with impaired junctional integrity. …”
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CDH6 as a prognostic indicator and marker for chemotherapy in gliomas by Ming Meng, Ming Meng, Hongshu Zhou, Hongshu Zhou, Ye He, Ye He, Ye He, Lu Chen, Lu Chen, Lu Chen, Wanpeng Wang, Wanpeng Wang, Wanpeng Wang, Liting Yang, Liting Yang, Liting Yang, Zeyu Wang, Zeyu Wang, Liyang Zhang, Liyang Zhang, Liyang Zhang, Sha Wang, Sha Wang, Sha Wang

“…This study examined the cadherin-6 (CDH6) expression in gliomas using The Cancer Genome Atlas and Chinese Glioma Genome Atlas datasets. …”
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Long non-coding RNA LINC01554 overexpression suppresses viability, migration, and invasion of liver cancer cells through regulating miR-148b-3p/EIF4E3 by Xiaojing Ren, Xiaoxiao Wang, Huangqin Song, Chao Zhang, Junlong Yuan, Jiefeng He, Jianguo Li, Zhuangqiang Wang

“…Besides, LINC01554 overexpression also significantly increased the levels of BAX, BCL2/BAX, P53, cleaved-Caspase3, TIMP3, E-cadherin and EIF4E3 (P < 0.05). Through bioinformatics and dual-luciferase reporter gene assay, LINC01554, miR-148b-3p and EIF4E3 were proved to interact with each other. …”
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Modulated TRPC1 expression predicts sensitivity of breast cancer to doxorubicin and magnetic field therapy: segue towards a precision medicine approach by Tai, Yee Kit, Chan, Karen Ka Wing, Fong, Charlene Hui Hua, Ramanan, Sharanya, Yap, Jasmine Lye Yee, Yin, Jocelyn Naixin, Yip, Yun Sheng, Tan, Wei Ren, Koh, Angele Pei Fern, Tan, Nguan Soon, Chan, Ching Wan, Huang, Ruby Yun Ju, Li, Jing Ze, Fröhlich, Jürg, Franco-Obregón, Alfredo

“…TRPC1 channel overexpression and silencing positively correlated with markers of epithelial-mesenchymal transition (EMT), including SLUG, SNAIL, VIMENTIN, and E-CADHERIN, indicating increased and decreased EMT, respectively. …”
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Investigation into the Role of Forkhead Box A1 (FOXA1) in Late-Onset Preeclampsia of a Prospective Cohort Study and Its Actions on Trophoblast Invasion and Migration by Juan Zhu, Yunjian Wei, Zhen Wang, Qiuling Jie, Ping Long, Huamei Yang, Hui Ke, Zaijia Yang, Yanlin Ma

“…However, FOXA1 overexpression did not affect the mRNA expression levels of N-cadherin, vimentin, and fibronectin in trophoblast cells. …”
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MicroRNA-33b Suppresses Epithelial–Mesenchymal Transition Repressing the MYC–EZH2 Pathway in HER2+ Breast Carcinoma by Birlipta Pattanayak, Iris Garrido-Cano, Anna Adam-Artigues, Eduardo Tormo, Eduardo Tormo, Begoña Pineda, Begoña Pineda, Begoña Pineda, Paula Cabello, Elisa Alonso, Elisa Alonso, Begoña Bermejo, Begoña Bermejo, Begoña Bermejo, Cristina Hernando, Cristina Hernando, María Teresa Martínez, María Teresa Martínez, Ana Rovira, Ana Rovira, Joan Albanell, Joan Albanell, Joan Albanell, Federico Rojo, Federico Rojo, Octavio Burgués, Octavio Burgués, Juan Miguel Cejalvo, Juan Miguel Cejalvo, Ana Lluch, Ana Lluch, Ana Lluch, Ana Lluch, Pilar Eroles, Pilar Eroles, Pilar Eroles

“…The upregulation of miR-33b suppressed proliferation, induced apoptosis, reduced invasion, migration and regulated EMT by an increase of E-cadherin and a decrease of ß-catenin and vimentin. …”
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