Regulation of PGC1α on SiO2-induced lipid accumulation in macrophages and fibrosis in pulmonary fibroblasts by Hailan HE, Yuhui ZHOU, Jie CUI, Jiahui CAO, Mingming LIU, Bo GUAN, Yufan ZHOU, Hongli WANG, Heliang LIU

“…The expression of collagen Ι (COL Ι), E-cadherin (Eca), and fibronectin (FN) were detected by cell immunofluorescence and Western blot to further evaluate the effect of silencing PGC1α on fibrosis. …”
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Hyperglycolysis in endothelial cells drives endothelial injury and microvascular alterations in peritoneal dialysis by Zekun Si, Wenyan Su, Zhuoyu Zhou, Jinjin Li, Cailing Su, Ying Zhang, Zuoyu Hu, Zhijie Huang, Hong Zhou, Ansheng Cong, Zhanmei Zhou, Wei Cao

“…Mechanistically, endothelial PFKFB3 deficiency induced the protective effects in part by inhibiting cell proliferation, VE‐cadherin endocytosis and monocyte‐adhesion molecule expression. …”
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Phosphorylation inhibition of protein-tyrosine phosphatase 1B tyrosine-152 induces bone regeneration coupled with angiogenesis for bone tissue engineering by Yong Tang, Keyu Luo, Yin Chen, Yueqi Chen, Rui Zhou, Can Chen, Jiulin Tan, Moyuan Deng, Qijie Dai, Xueke Yu, Jian Liu, Chengmin Zhang, Wenjie Wu, Jianzhong Xu, Shiwu Dong, Fei Luo

“…A close relationship has been reported to exist between cadherin-mediated cell–cell adhesion and integrin-mediated cell mobility, and protein tyrosine phosphatase 1B (PTP1B) may be involved in maintaining this homeostasis. …”
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Recombinant VEGF-C (Cys156Ser) improves mesenteric lymphatic drainage and gut immune surveillance in experimental cirrhosis by Pinky Juneja, Syed Nazrin Ruhina Rahman, Deepika Jakhar, Akash Kumar Mourya, Dinesh M. Tripathi, Impreet Kaur, Vaibhav Tiwari, Sumati Rohilla, Abhishek Gupta, Preety Rawal, Sukriti Baweja, Archana Rastogi, V.G.M. Naidu, Shiv K. Sarin, Subham Banerjee, Savneet Kaur

“…E-VEGF-C treatment upregulated the expression of vascular endothelial-cadherin in LyECs and functionally improved the permeability of these cells. …”
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Establishment of an experimental model of canine malignant mesothelioma organoid culture using a three-dimensional culture method by Yomogi Sato, Mohamed Elbadawy, Kazuhiko Suzuki, Ryouichi Tsunedomi, Hiroaki Nagano, Yusuke Ishihara, Haru Yamamoto, Daigo Azakami, Tsuyoshi Uchide, Rina Nabeta, Ryuji Fukushima, Amira Abugomaa, Masahiro Kaneda, Hideyuki Yamawaki, Yuta Shinohara, Tatsuya Usui, Kazuaki Sasaki

“…Among these genes, the expression level of E-cadherin was drastically higher in the organoids than that in the 2D cells. …”
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Digitoxin Inhibits Epithelial-to-Mesenchymal-Transition in Hereditary Castration Resistant Prostate Cancer by Bette S. Pollard, Mark. A. Suckow, William R. Wolter, Joshua M. Starr, Ofer Eidelman, Clifton L. Dalgard, Clifton L. Dalgard, Parameet Kumar, Sharmistha Battacharyya, Meera Srivastava, Meera Srivastava, Roopa Biswas, Matthew D. Wilkerson, Matthew D. Wilkerson, Xijun Zhang, Xijun Zhang, Qingfeng Yang, Harvey B. Pollard, Harvey B. Pollard

“…Here we show, in vitro, that digitoxin inhibits NFκB-driven TGFBR2 expression, as well as Vimentin, while elevating E-cadherin expression. Digitoxin also significantly reduces HSPB1 mRNA and the HSPB1/RBFOX2 mRNA ratio in PC3 cells. …”
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Emodin ameliorates renal injury and fibrosis via regulating the miR-490-3p/HMGA2 axis by Liulin Wang, Liulin Wang, Liulin Wang, Xuerui Wang, Xuerui Wang, Xuerui Wang, Gang Li, Gang Li, Gang Li, Shanshan Zhou, Shanshan Zhou, Shanshan Zhou, Rui Wang, Rui Wang, Rui Wang, Qi Long, Qi Long, Qi Long, Min Wang, Min Wang, Min Wang, Liang Li, Liang Li, Liang Li, Hai Huang, Hai Huang, Hai Huang, Yuanming Ba, Yuanming Ba, Yuanming Ba

“…Emodin decreased the expression levels of TGF-β1 and fibrotic-related proteins, including alpha-smooth muscle actin, Collagen IV, and Fibronectin, and increased the expression of E-cadherin. Furthermore, miR-490-3p was decreased in UUO mice and negatively correlated with increased expression of high migration protein A2 (HMGA2). …”
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miR-1303 regulates BBB permeability and promotes CNS lesions following CA16 infections by directly targeting MMP9 by Jie Song, Yajie Hu, Hongzhe Li, Xing Huang, Huiwen Zheng, Yunguang Hu, Jingjing Wang, Xi Jiang, Jiaqi Li, Zening Yang, Haitao Fan, Lei Guo, Haijing Shi, Zhanlong He, Fengmei Yang, Xi Wang, Shaozhong Dong, Qihan Li, Longding Liu

“…Further experiments revealed that CA16 infection promoted the degradation of junctional complexes (Claudin4, Claudin5, VE-Cadherin, and ZO-1), likely by downregulating miR-1303 and upregulating MMP9. …”
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PIWI-interacting RNA-36712 restrains breast cancer progression and chemoresistance by interaction with SEPW1 pseudogene SEPW1P RNA by Liping Tan, Dongmei Mai, Bailin Zhang, Xiaobing Jiang, Jialiang Zhang, Ruihong Bai, Ying Ye, Mei Li, Ling Pan, Jiachun Su, Yanfen Zheng, Zexian Liu, Zhixiang Zuo, Qi Zhao, Xiaoxing Li, Xudong Huang, Jie Yang, Wen Tan, Jian Zheng, Dongxin Lin

“…We also found that higher SEPW1 expression due to downregulation of piRNA-36,712 in breast cancer may suppress P53, leading to the upregulated Slug but decreased P21 and E-cadherin levels, thus promoting cancer cell proliferation, invasion and migration. …”
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Cystathionine-γ-lyase overexpression modulates oxidized nicotinamide adenine dinucleotide biosynthesis and enhances neovascularization by Kevin Kiesworo, MS, Michael R. MacArthur, PhD, Peter Kip, MD, PhD, Thomas Agius, MS, Diane Macabrey, MS, Martine Lambelet, BS, Lauriane Hamard, PhD, C.-Keith Ozaki, MD, James R. Mitchell, PhD, Sébastien Déglise, MD, Sarah J. Mitchell, PhD, Florent Allagnat, PhD, Alban Longchamp, MD, PhD

“…Leg perfusion was measured by laser Doppler imaging and vascular endothelial-cadherin immunostaining. To examine the angiogenic potential, aortic ring sprouting assay and postnatal mouse retinal vasculature development studies were performed. …”
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Brusatol suppresses STAT3-driven metastasis by downregulating epithelial-mesenchymal transition in hepatocellular carcinoma by Jong Hyun Lee, Chakrabhavi Dhananjaya Mohan, Amudha Deivasigamani, Young Yun Jung, Shobith Rangappa, Salundi Basappa, Arunachalam Chinnathambi, Tahani Awad Alahmadi, Sulaiman Ali Alharbi, Manoj Garg, Zhi-Xiu Lin, Kanchugarakoppal S. Rangappa, Gautam Sethi, Kam Man Hui, Kwang Seok Ahn

“…Results: We found that BT treatment restored the expression of Occludin, E-cadherin (epithelial markers) while suppressing the levels of different mesenchymal markers in HCC cells and tumor tissues. …”
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Migration and invasion of NSCLC suppressed by the downregulation of Src/focal adhesion kinase using single, double and tetra domain anti- CEACAM6 antibodies by Shang-Jung Wu, Arivajiagane Arundhathi, Hsiang-Ching Wang, Chiao-Yun Chen, Tsai-Mu Cheng, Shyng-Shiou F. Yuan, Yun-Ming Wang

“…Meanwhile, overall protein analysis revealed that 2Ab and 4Ab potently inhibited the phosphorylation of pSRC, pERK, pFAK, pAKT, MMP-2, MMP-9 and N-cadherin. Anti-tumor effect was observed in an A549 NSCLC xenograft model treated with 2Ab or 4Ab compared with doxorubicin. …”
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Integrated Single-Cell RNA-Sequencing Analysis of Aquaporin 5-Expressing Mouse Lung Epithelial Cells Identifies GPRC5A as a Novel Validated Type I Cell Surface Marker by Masafumi Horie, Alessandra Castaldi, Mitsuhiro Sunohara, Hongjun Wang, Yanbin Ji, Yixin Liu, Fan Li, Thomas A. Wilkinson, Long Hung, Hua Shen, Hidenori Kage, Ite A. Offringa, Crystal N. Marconett, Per Flodby, Beiyun Zhou, Zea Borok

“…Following enzymatic digestion, CD31^-CD45^-E-cadherin⁺tdTomato⁺ cells were subjected to fluorescence-activated cell sorting (FACS) followed by scRNA-seq. …”
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Effects of Immunoglobulins G From Systemic Sclerosis Patients in Normal Dermal Fibroblasts: A Multi-Omics Study by Aurélien Chepy, Aurélien Chepy, Solange Vivier, Fabrice Bray, Camille Ternynck, Jean-Pascal Meneboo, Martin Figeac, Alexandre Filiot, Lucile Guilbert, Lucile Guilbert, Manel Jendoubi, Christian Rolando, David Launay, David Launay, Sylvain Dubucquoi, Sylvain Dubucquoi, Guillemette Marot, Guillemette Marot, Guillemette Marot, Vincent Sobanski, Vincent Sobanski, Vincent Sobanski

“…IgG from ATA positive SSc patients induced enrichment in proteins involved in focal adhesion, cadherin binding, cytosolic part, or lytic vacuole. …”
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MiR-125b-5p Is Involved in Sorafenib Resistance through Ataxin-1-Mediated Epithelial-Mesenchymal Transition in Hepatocellular Carcinoma by Akihiro Hirao, Yasushi Sato, Hironori Tanaka, Kensei Nishida, Tetsu Tomonari, Misato Hirata, Masahiro Bando, Yoshifumi Kida, Takahiro Tanaka, Tomoyuki Kawaguchi, Hironori Wada, Tatsuya Taniguchi, Koichi Okamoto, Hiroshi Miyamoto, Naoki Muguruma, Toshihito Tanahashi, Tetsuji Takayama

“…PLC/PRF5-miR125b showed lower E-cadherin and higher Snail and vimentin expression—findings similar to those for PLC/PRF5-R2—which suggests the induction of EMT in those cells. …”
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Identification of Blood-Based Biomarkers for the Prediction of the Response to Neoadjuvant Chemoradiation in Rectal Cancer by Delphine Dayde, Jillian Gunther, Yutaka Hirayama, David C. Weksberg, Adam Boutin, Gargy Parhy, Clemente Aguilar-Bonavides, Hong Wang, Hiroyuki Katayama, Yuichi Abe, Kim-Anh Do, Kazuo Hara, Takashi Kinoshita, Koji Komori, Yasuhiro Shimizu, Masahiro Tajika, Yasumasa Niwa, Y. Alan Wang, Ronald DePinho, Samir Hanash, Sunil Krishnan, Ayumu Taguchi

“…In addition, we explored whether four tissue protein biomarkers previously shown to predict response to nCRT (Epidermal growth factor receptor [EGFR], Ki-67, E-cadherin, and Prostaglandin G/H synthase 2 [COX2]) also act as potential blood biomarkers. …”
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Deletion of tetraspanin CD151 alters the Wnt oncogene-induced mammary tumorigenesis: A cell type-linked function and signaling by Hongxia Li, Jieming Li, Rongbo Han, Xinyu Deng, Junfong Shi, Huanhuan Huang, Nevean Hamad, Abigail McCaughley, Jinpeng Liu, Chi Wang, Kuey Chen, Dongping Wei, Jun Qiang, Sean Thatcher, Yadi Wu, Chunming Liu, Olivier Thibault, Xiaowei Wei, Song Chen, Hai Qian, Binhua P. Zhou, Pao Xu, Xiuwei H. Yang

“…Mechanistically, the CD151-deficient tumors were largely ER+, and exhibited hyperactivation of the Wnt pathway as reflected by a marked upregulation in β-catenin and Cyclin D1, and their target genes. In addition, E-cadherin displayed a cytosolic distribution and transcription factor Snail was markedly upregulated. …”
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Modulation of the hippo-YAP pathway by cyclic stretch in rat type 2 alveolar epithelial cells—a proof-of-concept study by Xi Ran, Xi Ran, Sabine Müller, Coy Brunssen, Robert Huhle, Martin Scharffenberg, Christian Schnabel, Thea Koch, Marcelo Gama de Abreu, Marcelo Gama de Abreu, Marcelo Gama de Abreu, Henning Morawietz, Jorge M. C. Ferreira, Jakob Wittenstein

“…The cytoskeleton remodeling and cell junction integrity were evaluated by F-actin and Pan-cadherin immunofluorescence, respectively. The gene expression and protein levels of IL-6, Yes-associated protein, Cysteine-rich angiogenic inducer 61 (Cyr61/CCN1), and connective tissue growth factor (CTGF/CCN2) were studied by real-time polymerase chain reaction (RT-qPCR) and Western blot, respectively. …”
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A Comprehensive Analysis of Fibroblast Growth Factor Receptor 2b Signaling on Epithelial Tip Progenitor Cells During Early Mouse Lung Branching Morphogenesis by Matthew R. Jones, Matthew R. Jones, Salma Dilai, Arun Lingampally, Cho-Ming Chao, Cho-Ming Chao, Soula Danopoulos, Gianni Carraro, Regina Mukhametshina, Jochen Wilhelm, Eveline Baumgart-Vogt, Denise Al Alam, Chengshui Chen, Parviz Minoo, Jin San Zhang, Jin San Zhang, Jin San Zhang, Saverio Bellusci, Saverio Bellusci, Saverio Bellusci, Saverio Bellusci, Saverio Bellusci

“…Loss of FGF10 signaling did not impact proliferation or survival, but affected both adherens junctions (up-regulation of E-cadherin), and basement membrane organization (increased laminin). …”
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Acinetobacter baumannii Outer Membrane Protein A Induces Pulmonary Epithelial Barrier Dysfunction and Bacterial Translocation Through The TLR2/IQGAP1 Axis by Wang Zhang, Wang Zhang, Wang Zhang, Hua Zhou, Yan Jiang, Yan Jiang, Yan Jiang, Jintao He, Jintao He, Jintao He, Yue Yao, Yue Yao, Yue Yao, Jianfeng Wang, Xiaochen Liu, Xiaochen Liu, Xiaochen Liu, Sebastian Leptihn, Sebastian Leptihn, Sebastian Leptihn, Xiaoting Hua, Xiaoting Hua, Xiaoting Hua, Yunsong Yu, Yunsong Yu, Yunsong Yu

“…TLR2/NF-κB signaling was involved in OmpA-induced inflammation, IQGAP1-mediated OmpA-induced opening of the pulmonary epithelial barrier via cytoskeleton dynamic remodeling, and cellular redistribution of the major AJ protein, E-cadherin. These observations indicate that A. baumannii uses OmpA to overcome epithelial defences and cross the pulmonary epithelial barrier.…”
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