Methylation-Induced Silencing of ALDH2 Facilitates Lung Adenocarcinoma Bone Metastasis by Activating the MAPK Pathway by Mengdi Yang, Mengdi Yang, Mengdi Yang, AiTing Wang, AiTing Wang, Changcan Li, Changcan Li, Changcan Li, Jing Sun, Jing Sun, Jing Sun, Gang Yi, Gang Yi, Hao Cheng, Hao Cheng, Xueni Liu, Xueni Liu, Zhiyu Wang, Yiyi Zhou, Guangyu Yao, Shuai Wang, Rui Liang, Rui Liang, Bin Li, Bin Li, Dan Li, Dan Li, Hui Zhao

“…ALDH2 functions as a mitogen-activated protein kinase (MAPK) upstream to inhibit cell proliferation and migration, promote cell apoptosis, and alter the epithelial–mesenchymal transition (EMT) by elevating E-cadherin and attenuating vimentin. Cell proliferation and migration were inhibited after the addition of the JNK inhibitor SP600125. …”
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HIF-1α-BNIP3-mediated mitophagy in tubular cells protects against renal ischemia/reperfusion injury by Zong-Jie Fu, Zhi-Yu Wang, Lian Xu, Xiao-Hui Chen, Xiang-Xiao Li, Wei-Tang Liao, Hong-Kun Ma, Meng-Di Jiang, Ting-Ting Xu, Jing Xu, Yan Shen, Bei Song, Ping-Jin Gao, Wei-Qing Han, Wen Zhang

“…For in vivo study, we established HIF-1αflox/flox; cadherin-16-cre mice in which tubular HIF-1α was specifically knockout. …”
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Epigenetic Input Dictates the Threshold of Targeting of the Integrin-Dependent Pathway in Non-small Cell Lung Cancer by Yang Zhang, Yang Zhang, Yang Zhang, Kai Cheng, Bingwei Xu, Bingwei Xu, Junfeng Shi, Jun Qiang, Jun Qiang, Shujin Shi, Yuanqin Yi, Yuanqin Yi, Yuanqin Yi, Hongxia Li, Hongxia Li, Hongxia Li, Hongxia Li, Tengchuan Jin, Ruihua Guo, Yadi Wu, Yadi Wu, Zeyi Liu, Xiaowei Wei, Jian-An Huang, Xiuwei H. Yang, Xiuwei H. Yang

“…Meanwhile, JQ1 alone or in combination with VS-6063 attenuated cell-cell adhesion and extracellular matrix (ECM)-dependent cell spreading, which is reminiscent of phenotype induced by malfunctional E-cadherin or integrins. Paradoxically, this phenotypic impact coincided with downregulation of epithelial-mesenchymal transition (EMT)-inducting transcription factor ZEB1 or Snail. …”
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3,3',5,5'-Tetramethoxybiphenyl-4,4'diol triggers oxidative stress, metabolic changes, and apoptosis-like process by reducing the PI3K/AKT/NF-κB pathway in the NCI-H460 lung cancer... by Virginia Marcia Concato-Lopes, Taylon Felipe Silva, Mariana Barbosa Detoni, Ellen Mayara Souza Cruz, Manoela Daiele Gonçalves, Bruna Taciane da Silva Bortoleti, Fernanda Tomiotto-Pellissier, Amanda Cristina Machado Carloto, Maria Beatriz Madureira, Ana Carolina Jacob Rodrigues, Jéseka Gabriela Schirmann, Aneli M. Barbosa-Dekker, Robert F.H. Dekker, Ivete Conchon-Costa, Carolina Panis, Danielle Lazarin-Bidóia, Milena Menegazzo Miranda-Sapla, Mário Sérgio Mantovani, Wander R. Pavanelli

“…After 24-h treatment, TMBP at IC50 (154 μM) induced various morphological and ultrastructural changes in NCI-H460, reduced migration and immunofluorescence staining of N-cadherin and β-catenin, induced increased reactive oxygen species and nitric oxide with reduced superoxide radical-anion, increased superoxide dismutase activity and reduced glutathione reductase. …”
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The long noncoding RNA EMBP1 inhibits the tumor suppressor miR-9-5p and promotes renal cell carcinoma tumorigenesis by Yejing Hong, Zhongming Yuan, Rongzhong Huang, Zhiqin Wu, Yongyong Li

“…The EMBP1-miR-9-5p axis dysregulated the expression of the epithelial-to-mesenchymal transition (EMT) markers E-cadherin, claudin, and vimentin, the stemness markers KLF4 and Nanog, and the cell cycle checkpoint gene cyclin E2 (CCNE2) and its downstream mediator E2F1. miR-9-5p overexpression or EMBP1 suppression inhibited xenograft tumor growth in vivo, effects that were abrogated by CCNE2 overexpression. …”
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Plasmodium immunotherapy combined with gemcitabine has a synergistic inhibitory effect on tumor growth and metastasis in murine Lewis lung cancer models by Xiao Chen, Xiao Chen, Zhu Tao, Zhu Tao, Yun Liang, Yun Liang, Meng Ma, Meng Ma, Dickson Adah, Wenting Ding, Lili Chen, Xiaofen Li, Linglin Dai, Songwe Fanuel, Songwe Fanuel, Siting Zhao, Siting Zhao, Wen Hu, Donghai Wu, Ziyuan Duan, Fang Zhou, Li Qin, Xiaoping Chen, Xiaoping Chen, Zhaoqing Yang

“…In the mechanistic experiments, we found that the combination therapy significantly upregulated E-cadherin and downregulated Snail protein expression levels, thus inhibiting epithelial-mesenchymal transition (EMT) of tumor cells, which may be due to the blockade of CXCR2/TGF-β-mediated PI3K/Akt/GSK-3β signaling pathway.ConclusionThe combination of Pc and Gem plays a synergistic role in inhibiting tumor growth and metastasis, and prolonging mice survival in murine lung cancer models. …”
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Acute Graft-vs.-Host Disease-Associated Endothelial Activation in vitro Is Prevented by Defibrotide by Julia Martinez-Sanchez, Julia Martinez-Sanchez, Julia Martinez-Sanchez, Hannah Hamelmann, Hannah Hamelmann, Hannah Hamelmann, Marta Palomo, Marta Palomo, Marta Palomo, Enrique Mir, Enrique Mir, Enrique Mir, Ana Belen Moreno-Castaño, Sergi Torramade, Montserrat Rovira, Ginés Escolar, Steffen Cordes, Steffen Cordes, Steffen Cordes, Martina Kalupa, Martina Kalupa, Martina Kalupa, Sarah Mertlitz, Sarah Mertlitz, Sarah Mertlitz, Katarina Riesner, Katarina Riesner, Katarina Riesner, Enric Carreras, Enric Carreras, Olaf Penack, Olaf Penack, Olaf Penack, Maribel Diaz-Ricart, Maribel Diaz-Ricart

“…ECs upregulated adhesion molecules (vascular cell adhesion molecule 1, intercellular adhesion molecule 1), the adherence junction protein VE-cadherin, von Willebrand factor (VWF), and Akt phosphorylation in response to aGVHD sera. …”
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Generation and metabolomic characterization of functional ductal organoids with biliary tree networks in decellularized liver scaffolds by Jiaxian Chen, Shiwen Ma, Hui Yang, Xi Liang, Heng Yao, Beibei Guo, Deying Chen, Jing Jiang, Dongyan Shi, Jiaojiao Xin, Keke Ren, Xingping Zhou, Yun Li, Lei Geng, Jun Li

“…Basal-apical polarity was observed at day 14 with immunostaining for E-cadherin and acetylated α-tubulin. The rhodamine 123 transport assay and active collection of cholyl-lysyl-fluorescein exhibited the specific functions of bile secretion and transportation at day 14 compared to those in monolayer and hydrogel culture systems. …”
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Modulated TRPC1 Expression Predicts Sensitivity of Breast Cancer to Doxorubicin and Magnetic Field Therapy: Segue Towards a Precision Medicine Approach by Yee Kit Tai, Yee Kit Tai, Karen Ka Wing Chan, Karen Ka Wing Chan, Charlene Hui Hua Fong, Charlene Hui Hua Fong, Sharanya Ramanan, Sharanya Ramanan, Jasmine Lye Yee Yap, Jasmine Lye Yee Yap, Jocelyn Naixin Yin, Jocelyn Naixin Yin, Yun Sheng Yip, Wei Ren Tan, Angele Pei Fern Koh, Nguan Soon Tan, Nguan Soon Tan, Ching Wan Chan, Ching Wan Chan, Ruby Yun Ju Huang, Ruby Yun Ju Huang, Jing Ze Li, Jürg Fröhlich, Jürg Fröhlich, Jürg Fröhlich, Alfredo Franco-Obregón, Alfredo Franco-Obregón, Alfredo Franco-Obregón, Alfredo Franco-Obregón, Alfredo Franco-Obregón, Alfredo Franco-Obregón

“…TRPC1 channel overexpression and silencing positively correlated with markers of epithelial-mesenchymal transition (EMT), including SLUG, SNAIL, VIMENTIN, and E-CADHERIN, indicating increased and decreased EMT, respectively. …”
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DSG2 Is a Functional Cell Surface Marker for Identification and Isolation of Human Pluripotent Stem Cells by Jongjin Park, Yeonsung Son, Na Geum Lee, Kyungmin Lee, Dong Gwang Lee, Jinhoi Song, Jaemin Lee, Seokho Kim, Min Ji Cho, Ju-Hong Jang, Jangwook Lee, Jong-Gil Park, Yeon-Gu Kim, Jang-Seong Kim, Jungwoon Lee, Yee Sook Cho, Young-Jun Park, Baek Soo Han, Kwang-Hee Bae, Seungmin Han, Byunghoon Kang, Seungjoo Haam, Sang-Hyun Lee, Sang Chul Lee, Jeong-Ki Min

“…. : DSG2 is a desmosomal cadherin molecule. In this article, Min and colleagues show that DSG2 is a valuable PSC surface marker that is essential for the maintenance of PSC self-renewal and pluripotency and the acquisition of pluripotency during somatic cell reprogramming through the regulation of β-catenin-mediated EMT signaling. keywords: desmoglein-2, cell surface marker, pluripotent stem cells, monoclonal antibody, EMT…”
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Development of vascular inspired electrospun hollow fibre membranes for use in 3D tissue culture by Martin, RJ

“…Irrespective of fluid flow conditions, by day 28 of the culture period, HUVECs were shown to have flattened, flow-aligned morphologies, reached confluency, and expressed VE-cadherin cell-cell interactions. In addition, 𝜇CT image analysis revealed that HUVEC density peaked within 5000 𝜇m of the fibre inlet, after which it declined to a plateau, and that HUVEC growth was restricted to the lumen wall of the EHFM, with no cell ingress into the membrane wall.…”

Potential differentiation of human amniotic epithelial stem and mesenchymal bone marrow cells into cardiomyocytes by Motamedi, Batool

“…The antibodies against alpha-actin, connexin43, N-cadherin, desmin, nestin and vimentin were used to identify differentiated cells. …”
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Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q by Jasper E. Neggers, Brenton R. Paolella, Adhana Asfaw, Michael V. Rothberg, Thomas A. Skipper, Annan Yang, Radha L. Kalekar, John M. Krill-Burger, Neekesh V. Dharia, Guillaume Kugener, Jérémie Kalfon, Chen Yuan, Nancy Dumont, Alfredo Gonzalez, Mai Abdusamad, Yvonne Y. Li, Liam F. Spurr, Westley W. Wu, Adam D. Durbin, Brian M. Wolpin, Federica Piccioni, David E. Root, Jesse S. Boehm, Andrew D. Cherniack, Aviad Tsherniak, Andrew L. Hong, William C. Hahn, Kimberly Stegmaier, Todd R. Golub, Francisca Vazquez, Andrew J. Aguirre

“…VPS4A is essential in cancers harboring loss of VPS4B adjacent to SMAD4 on chromosome 18q and VPS4B is required in tumors with co-deletion of VPS4A and CDH1 (E-cadherin) on chromosome 16q. We demonstrate that more than 30% of cancers selectively require VPS4A or VPS4B. …”
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Carcinomas invasores triples negativosde la glándula mamaria: incidencia y características clínico-patológicas Triple-Negative Invasive Breast Carcinoma: Incidence and Clinical - P... by José L Quirós-Alpízar, Yendry Jiménez-Rodríguez, Ernesto Jiménez-Montero, Melissa Monge-Víquez, Lizbeth Salazar-Sánchez

“…In addition, in this study a high proportion of tumors were of lobular type, other tests might be indicated such as e-cadherin to verify the cases of lobular carcinomas to increase in this way the reliability of results.…”
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Circulating exosomal immuno-oncological checkpoints and cytokines are potential biomarkers to monitor tumor response to anti-PD-1/PD-L1 therapy in non-small cell lung cancer patien... by Shayista Akbar, Afsheen Raza, Afsheen Raza, Reyad Mohsin, Aladdin Kanbour, Shahnaz Qadri, Aijaz Parray, Abdul Rehman Zar Gul, Anite Philip, Suma Vijayakumar, Maysaloun Merhi, Maysaloun Merhi, Shereena Hydrose, Shereena Hydrose, Varghese Philipose Inchakalody, Varghese Philipose Inchakalody, Rajaa Al-Abdulla, Wafa Abualainin, Shaza Abu Sirriya, Issam Al-Bozom, Shahab Uddin, Shahab Uddin, Omar Muhammad Khan, Mohamed Izham Mohamed Ibrahim, Ussama Al Homsi, Said Dermime, Said Dermime, Said Dermime

“…There was a significant downregulation of exosomal PD-L1 (p=0.0156), E-Cadherin (p=0.0312), ULBP1 (p=0.0156), ULBP3 (p=0.0391), MICA (p=0.0391), MICB (p=0.0469), Siglec7 (p=0.0078) and significant upregulation of exosomal PD-1 (p=0.0156) and IFN- γ (p=0.0156) in responding patients. …”
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Cytokine signaling converging on IL11 in ILD fibroblasts provokes aberrant epithelial differentiation signatures by Miriam T. Kastlmeier, Erika Gonzalez-Rodriguez, Phoebe Cabanis, Eva M. Guenther, Ann-Christine König, Lianyong Han, Stefanie M. Hauck, Fenja See, Sara Asgharpour, Christina Bukas, Gerald Burgstaller, Marie Piraud, Mareike Lehmann, Mareike Lehmann, Rudolf A. Hatz, Jürgen Behr, Tobias Stoeger, Anne Hilgendorff, Anne Hilgendorff, Carola Voss

“…Alveolar organoids cultured with fibrotic-ILD fibroblasts further demonstrated reduced stem cell function as reflected by reduced Surfactant Protein C gene expression together with an aberrant basaloid-prone differentiation program indicated by elevated Cadherin 2, Bone Morphogenic Protein 4 and Vimentin transcription. …”
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Changes in progenitors and differentiated epithelial cells of neonatal piglets by Lanmei Yin, Jun Li, Yitong Zhang, Qing Yang, Cuiyan Yang, Zhenfeng Yi, Yuebang Yin, Qiye Wang, Jianzhong Li, Nengshui Ding, Zhigang Zhang, Huansheng Yang, Yulong Yin

“…Moreover, the mRNA expression of spheroids differed markedly from that of organoids, with low expression of intestinal differentiation gene (Lysozyme; P < 0.05), epithelial-specific markers (Villin, E-cadherin; P < 0.05), and adult ISC markers (leucine-rich repeat-containing G protein-coupled receptor 5 [Lgr5], Smoc2; P < 0.001), and up-regulation of fetal marker (connexin 43 [Cnx43]; P < 0.05). …”
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Yu-Ping-Feng Formula Ameliorates Alveolar-Capillary Barrier Injury Induced by Exhausted-Exercise via Regulation of Cytoskeleton by Di Wang, Di Wang, Di Wang, Di Wang, Di Wang, Quan Li, Quan Li, Quan Li, Quan Li, Chun-Shui Pan, Chun-Shui Pan, Chun-Shui Pan, Chun-Shui Pan, Li Yan, Li Yan, Li Yan, Li Yan, Kai Sun, Kai Sun, Kai Sun, Kai Sun, Xiao-Yi Wang, Xiao-Yi Wang, Xiao-Yi Wang, Xiao-Yi Wang, Xiao-Yi Wang, Gulinigaer Anwaier, Gulinigaer Anwaier, Gulinigaer Anwaier, Gulinigaer Anwaier, Gulinigaer Anwaier, Qian-Zan Liao, Qian-Zan Liao, Qian-Zan Liao, Qian-Zan Liao, Qian-Zan Liao, Ting-Ting Xie, Ting-Ting Xie, Ting-Ting Xie, Ting-Ting Xie, Ting-Ting Xie, Jing-Yu Fan, Jing-Yu Fan, Xin-Mei Huo, Xin-Mei Huo, Xin-Mei Huo, Xin-Mei Huo, Xin-Mei Huo, Yuan Wang, Jing-Yan Han, Jing-Yan Han, Jing-Yan Han, Jing-Yan Han, Jing-Yan Han

“…In addition, YPF increased the expression of claudin 3, claudin 18, occludin, VE-cadherin, and β-catenin, attenuated the epithelial and endothelial hyperpermeability in vivo and/or in vitro, and the stress fiber formation in PMVECs after hypoxia. …”
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QiShenYiQi Inhibits Tissue Plasminogen Activator–Induced Brain Edema and Hemorrhage after Ischemic Stroke in Mice by Yang Ye, Yang Ye, Yang Ye, Yang Ye, Yang Ye, Yang Ye, Quan Li, Quan Li, Quan Li, Quan Li, Quan Li, Chun-Shui Pan, Chun-Shui Pan, Chun-Shui Pan, Chun-Shui Pan, Chun-Shui Pan, Li Yan, Li Yan, Li Yan, Li Yan, Li Yan, Kai Sun, Kai Sun, Kai Sun, Kai Sun, Kai Sun, Xiao-Yi Wang, Xiao-Yi Wang, Xiao-Yi Wang, Xiao-Yi Wang, Xiao-Yi Wang, Xiao-Yi Wang, Shu-Qi Yao, Shu-Qi Yao, Shu-Qi Yao, Shu-Qi Yao, Shu-Qi Yao, Shu-Qi Yao, Jing-Yu Fan, Jing-Yu Fan, Jing-Yu Fan, Jing-Yu Fan, Jing-Yu Fan, Jing-Yan Han, Jing-Yan Han, Jing-Yan Han, Jing-Yan Han, Jing-Yan Han, Jing-Yan Han

“…The combination also significantly improved the survival rate, cerebral blood flow, tight and adherens junction proteins (occludin, claudin-5, junctional adhesion molecule-1, zonula occludens-1, VE-cadherin, α-catenin, β-catenin) expression, and basement membrane proteins (collagen IV, laminin) expression. …”
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Establishment and functional characterization of the reversibly immortalized mouse glomerular podocytes (imPODs) by Xinyi Yu, Liqun Chen, Ke Wu, Shujuan Yan, Ruyi Zhang, Chen Zhao, Zongyue Zeng, Yi Shu, Shifeng Huang, Jiayan Lei, Xiaojuan Ji, Chengfu Yuan, Linghuan Zhang, Yixiao Feng, Wei Liu, Bo Huang, Bo Zhang, Wenping Luo, Xi Wang, Bo Liu, Rex C. Haydon, Hue H. Luu, Tong-Chuan He, Hua Gan

“…We further demonstrate that TGFβ1 induces a podocyte injury-like response in the FLP-reverted imPOD cells by suppressing the expression of slit diaphragm-associated proteins P-Cadherin and ZO-1 and upregulating the expression of mesenchymal markers, α-SMA, Vimentin and Nestin, as well as fibrogenic factors CTGF and Col1a1. …”
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