The Impact of Spaceflight and Simulated Microgravity on Cell Adhesion by Xiao Lin, Kewen Zhang, Daixu Wei, Ye Tian, Yongguang Gao, Zhihao Chen, Airong Qian

“…In this review, we summarize the four major classes of adhesion molecules that regulate cell adhesion, including integrins, immunoglobulin superfamily (Ig-SF), cadherins, and selectin. Moreover, we discuss the effects of spaceflight and simulated microgravity on the adhesion of endothelial cells, immune cells, tumor cells, stem cells, osteoblasts, muscle cells, and other types of cells. …”
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Annexin A2 in Inflammation and Host Defense by Valentina Dallacasagrande, Katherine A. Hajjar

“…In acute inflammation, the interaction of AnxA2 with actin and adherens junction VE-cadherins underlies its role in regulating vascular integrity. …”
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Regression of atherosclerosis is characterized by broad changes in the plaque macrophage transcriptome. by Jonathan E Feig, Yuliya Vengrenyuk, Vladimir Reiser, Chaowei Wu, Alexander Statnikov, Constantin F Aliferis, Michael J Garabedian, Edward A Fisher, Oscar Puig

“…In CD68+ cells from regressing plaque we observed that genes associated with the contractile apparatus responsible for cellular movement (e.g. actin and myosin) were up-regulated whereas genes related to cell adhesion (e.g. cadherins, vinculin) were down-regulated. In addition, CD68+ cells from regressing plaque were characterized by enhanced expression of genes associated with an anti-inflammatory M2 macrophage phenotype, including arginase I, CD163 and the C-lectin receptor. …”
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Nanotechnology-based drug delivery systems by Singh Baljit, Fenniri Hicham, Suri Sarabjeet

“…The use of nanomaterials including peptide-based nanotubes to target the vascular endothelial growth factor (VEGF) receptor and cell adhesion molecules like integrins, cadherins and selectins, is a new approach to control disease progression.…”
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Discrete Element Framework for Modelling Extracellular Matrix, Deformable Cells and Subcellular Components. by Bruce S Gardiner, Kelvin K L Wong, Grand R Joldes, Addison J Rich, Chin Wee Tan, Antony W Burgess, David W Smith

“…Simple particle to particle interaction laws are used to simulate and control complex physical interaction types (e.g. cell-cell adhesion via cadherins, integrin basement membrane attachment, cytoskeletal mechanical properties). …”
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EGFR may couple moderate alcohol consumption to increased breast cancer risk by Christopher P Mill, Julia A Chester, David J Riese II

“…Studies using cultured human tumor cell lines have identified signaling molecules that may contribute to the effects of alcohol, including reactive oxygen species and other ethanol metabolites, matrix metalloproteases, the ErbB2/Her2/Neu receptor tyrosine kinase, cytoplasmic protein kinases, adenylate cyclase, E-cadherins, estrogen receptor, and a variety of transcription factors. …”
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Mechanotransduction Mechanisms in Mitral Valve Physiology and Disease Pathogenesis by Leah A. Pagnozzi, Jonathan T. Butcher

“…Specialized cell receptors, such as adherens junctions, cadherins, integrins, primary cilia, ion channels, caveolae, and the glycocalyx, convert mechanical cues into biochemical responses via a complex of mechanoresponsive elements, shared signaling modalities, and integrated frameworks. …”
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Cell-cell adhesion regulates Merlin/NF2 interaction with the PAF complex. by Anne E Roehrig, Kristina Klupsch, Juan A Oses-Prieto, Selim Chaib, Stephen Henderson, Warren Emmett, Lucy C Young, Silvia Surinova, Andreas Blees, Anett Pfeiffer, Maha Tijani, Fabian Brunk, Nicole Hartig, Marta Muñoz-Alegre, Alexander Hergovich, Barbara H Jennings, Alma L Burlingame, Pablo Rodriguez-Viciana

“…Merlin interacts with the PAFC in a cell density-dependent manner and we identify a role for FAT cadherins in regulating the Merlin-PAFC interaction. …”
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Toll-Like Receptor 2 mediates in vivo pro- and anti-inflammatory effects of Mycobacterium tuberculosis and modulates autoimmune encephalomyelitis by Alessia ePiermattei, Giuseppe eMigliara, Giuseppe eMigliara, Gabriele eDi Sante, Gabriele eDi Sante, Maria eFoti, Soren Bohos Hayrabedyan, Angela ePapagna, Maria Concetta eGeloso, Maddalena eCorbi, Mariagrazia eValentini, Alessandro eSgambato, Giovanni eDelogu, Gabriela eConstantin, Francesco eRia

“…In silico, we showed that Tlr2 variant Met82Ile modified the binding pocket for peptidoglycans and participate directly to a putative binding pocket for sugars and Cadherins. The distinct pro- and anti-inflammatory actions impacted on severity, extent of remission and distribution of the lesions within the Central Nervous System of Experimental Autoimmune Encephalomyelitis. …”
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Aspects of neurodevelopment between autism spectrum disorders and epilepsy by Paola Núñez-Contreras, Daniela Granado-Rocha, Maritza Carvajal-Game, Ana M. Torres-Perez

“…There are anomalies in different proteins that modulate the first phase of synaptogenesis, mutations in protocadherins, cadherins, and abnormalities in glutamatergic and GABAergic systems that affect the brain. …”
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A synthetic planar cell polarity system reveals localized feedback on Fat4-Ds1 complexes by Olga Loza, Idse Heemskerk, Nadav Gordon-Bar, Liat Amir-Zilberstein, Yunmin Jung, David Sprinzak

“…The atypical cadherins Fat and Dachsous (Ds) have been found to underlie planar cell polarity (PCP) in many tissues. …”
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Emergence of slip-ideal-slip behavior in tip-links serve as force filters of sound in hearing by Nisha Arora, Jagadish P. Hazra, Sandip Roy, Gaurav K. Bhati, Sarika Gupta, K. P. Yogendran, Abhishek Chaudhuri, Amin Sagar, Sabyasachi Rakshit

“…Here, we present evidence that tip-links (collectively as heterotetrameric complexes of cadherins) function as force filters during mechanotransduction. …”
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Engineered Dynamic Hydrogel Niches for the Regulation of Redox Homeostasis in Osteoporosis and Degenerative Endocrine Diseases by Weihao Yuan, Jiankun Xu, Na Yang, Han Wang, Jinteng Li, Mengyao Zhang, Meiling Zhu

“…Mechanotransduction-dependent redox signaling is initiated by cell surface protein assemblies, cadherins for cell–cell junctions, and integrins for cell–ECM interactions. …”
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Desmoglein 3: A Help or a Hindrance in Cancer Progression? by Louise Brown, Hong Wan

“…Desmoglein 3 is one of seven desmosomal cadherins that mediate cell-cell adhesion in desmosomes. …”
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Regulation of ADAM10 by the TspanC8 Family of Tetraspanins and Their Therapeutic Potential by Neale Harrison, Chek Ziu Koo, Michael G. Tomlinson

“…ADAM10 is known to have over 100 substrates including Notch, amyloid precursor protein, cadherins, and growth factors, and is important in health and implicated in diseases such as cancer and Alzheimer’s. …”
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Increased Frequency of T Follicular Helper Cells and Elevated Interleukin-27 Plasma Levels in Patients with Pemphigus. by Tina Hennerici, Robert Pollmann, Thomas Schmidt, Maria Seipelt, Björn Tackenberg, Christian Möbs, Kamran Ghoreschi, Michael Hertl, Rüdiger Eming

“…Pemphigus is an autoimmune disease in which IgG auto-antibodies (auto-ab) against the desmosomal cadherins desmoglein (Dsg) 3 and Dsg1 cause loss of epidermal keratinocyte adhesion. …”
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Neuronal influence behind the central nervous system regulation of the immune cells by ANAHI eCHAVARRIA, Graciela eCárdenas

“…Contact-dependent mechanisms are provided by several membrane immune modulating molecules such as Sema-7A, CD95L, CD22, CD200, CD47, NCAM, ICAM-5 and cadherins; which can inhibit the expression of microglial inflammatory cytokines, induce apoptosis or inactivate infiltrated T-cells. …”
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The molecular pathogenesis of corticotroph tumours. by Dworakowska, D, Grossman, AB

“…CONCLUSIONS: We would expect that over the next 5 years, more detailed analysis of inter-cellular communication pathways between pituitary cells, including the cadherins and integrins, and their interactions with other signalling pathways such as the β-catenin cascade will help elucidate what exactly goes awry in the formation of a benign corticotroph adenoma. …”

The Molecular Architecture of Cell Adhesion: Dynamic Remodeling Revealed by Videonanoscopy by Arnauld eSergé

“…Adhesion proteins such as integrins and cadherins also constitute receptors for inside-out and outside-in signaling within proteolipidic platforms. …”
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Four whole-istic aspects of schistosome granuloma biology: fractal arrangement, internal regulation, autopoietic component and closure by HL Lenzi, W de S Romanha, RM Zorzenon dos Santos, A Rosas, EM Mota, PPA Manso, LFG Caputo, M Pelajo-Machado

“…Fourth, the granulomas cells are intimately connected by pan-cadherins, occludin and connexin-43, building a state of closing (granuloma closure). …”
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