Epstein-Barr virus LMP1 manipulates the content and functions of extracellular vesicles to enhance metastatic potential of recipient cells. by Dingani Nkosi, Li Sun, Leanne C Duke, David G Meckes

“…The LMP1 containing EVs induced transcriptome reprogramming in the recipient cells by altering gene expression of different targets including cadherins, matrix metalloproteinases 9 (MMP9), MMP2 and integrin-α5 which contribute to extracellular matrix (ECM) remodeling. …”
Get full text

Anthrax edema toxin disrupts distinct steps in Rab11-dependent junctional transport. by Annabel Guichard, Prashant Jain, Mahtab Moayeri, Ruth Schwartz, Stephen Chin, Lin Zhu, Beatriz Cruz-Moreno, Janet Z Liu, Bernice Aguilar, Andrew Hollands, Stephen H Leppla, Victor Nizet, Ethan Bier

“…As a result, cargo proteins such as cadherins fail to reach inter-cellular junctions. In the present study, we provide further mechanistic dissection of Rab11 inhibition by EF using a combination of Drosophila and mammalian systems. …”
Get full text

Issues associated with assessing nuclear localization of N-terminally unphosphorylated β-catenin with monoclonal antibody 8E7 by Russell Susan, Hartsell Alyssa M, Flozak Annette S, Maher Meghan T, Beri Rohinee, Peled Ofra N, Gottardi Cara J

“…Definitive detection of nuclear localized ABC can be confirmed through an ability of classical cadherins to sequester ABC to cell junctions. In tissues, milder antigen retrieval methods can reduce the accessibility of mAb 8E7 to this cross-reacting nuclear antigen.…”
Get full text

Bald thigh syndrome in sighthounds-Revisiting the cause of a well-known disease. by Magdalena A T Brunner, Silvia Rüfenacht, Anina Bauer, Susanne Erpel, Natasha Buchs, Sophie Braga-Lagache, Manfred Heller, Tosso Leeb, Vidhya Jagannathan, Dominique J Wiener, Monika M Welle

“…Transcriptome profiling revealed a downregulation of genes encoding 23 hair shaft keratins and 51 keratin associated proteins, as well as desmosomal cadherins and several actors of the BMP signaling pathway which is important for hair shaft differentiation. …”
Get full text

Sequencing, De Novo assembly and annotation of the Colorado Potato Beetle, Leptinotarsa decemlineata, Transcriptome. by Abhishek Kumar, Leonardo Congiu, Leena Lindström, Saija Piiroinen, Michele Vidotto, Alessandro Grapputo

“…We established a repository of genes of interest, with 101 out of the 108 diapause-specific genes described in Drosophila montana; and 621 contigs involved in insecticide resistance, including 221 CYP450, 45 GSTs, 13 catalases, 15 superoxide dismutases, 22 glutathione peroxidases, 194 esterases, 3 ADAM metalloproteases, 10 cadherins and 98 calmodulins. We found 460 putative miRNAs and we predicted a significant number of single nucleotide polymorphisms (29,205) and microsatellite loci (17,284). …”
Get full text

Plakophilin-3 catenin associates with the ETV1/ER81 transcription factor to positively modulate gene activity. by William A Munoz, Moonsup Lee, Rachel K Miller, Zamal Ahmed, Hong Ji, Todd M Link, Gilbert R Lee, Malgorzata Kloc, John E Ladbury, Pierre D McCrea

“…Members of the plakophilin-catenin sub-family (Pkp-1, -2, and -3) facilitate the linkage of desmosome junctional components to each other (e.g. desmosomal cadherins to desmoplakin) and the intermediate-filament cytoskeleton. …”
Get full text

Sec24D-dependent transport of extracellular matrix proteins is required for zebrafish skeletal morphogenesis. by Swapnalee Sarmah, Alejandro Barrallo-Gimeno, David B Melville, Jacek Topczewski, Lilianna Solnica-Krezel, Ela W Knapik

“…Bulldog chondrocytes fail to secrete type II collagen and matrilin to extracellular matrix (ECM), but membrane bound receptor beta1-Integrin and Cadherins appear to leave ER in Sec24D-independent fashion. …”
Get full text

The genomic architecture of resistance to Campylobacter jejuni intestinal colonisation in chickens by Psifidi, A, Fife, M, Howell, J, Matika, O, van Diemen, P, Kuo, R, Smith, J, Hocking, P, Salmon, N, Jones, M, Hume, D, Banos, G, Stevens, M, Kaiser, P

“…Finally, gene expression analyses were performed for some of the candidate resistance genes to support the results.Campylobacter resistance in chickens is a complex trait, possibly involving the Major Histocompatibility Complex, innate and adaptive immune responses, cadherins and other factors. Two of the QTLs for Campylobacter resistance are co-located with Salmonella resistance loci, indicating that it may be possible to breed simultaneously for enhanced resistance to both zoonoses.…”

Electron microscopic structure of purified, active gamma-secretase reveals an aqueous intramembrane chamber and two pores. by Lazarov, V, Fraering, P, Ye, W, Wolfe, MS, Selkoe, D, Li, H

“…More than two dozen additional substrates of diverse functions have been reported, including the Notch ligands Delta and Jagged, N- and E-cadherins, and a sodium channel subunit. The protease is causally implicated in Alzheimer's disease because it releases the neurotoxic amyloid beta-peptide (Abeta) from its precursor, APP. …”

Mobility gene expression differences among wild-type, Mmp20 null and Mmp20 over-expresser mice plus visualization of 3D mouse ameloblast directional movement by Masashi Shin, Aya Matsushima, Jun-ichi Nagao, Yoshihiko Tanaka, Hidemitsu Harada, Koji Okabe, John D. Bartlett

“…We previously reported that MMP20 cleaves cadherins and may regulate ameloblast movement. Here, we used an Amelx promoter driven tdTomato reporter to label mouse ameloblasts. …”
Get full text

Nectin stabilization at adherens junctions is counteracted by Rab5a-dependent endocytosis by Pasquale Cervero, Kirsten Vrenken, Matthias Klose, Kerstin Rehm, Stefan Linder

“…Indeed, transport of junctional components such as cadherins is understood in increasing depth. However, little is known about the respective pathways regulating localization of nectin at cell-cell junctions. …”
Get full text

HIF-1α Stabilization in Flagellin-Stimulated Human Bronchial Cells Impairs Barrier Function by Ivan Ramirez-Moral, Bianca L. Ferreira, Joe M. Butler, Michel van Weeghel, Natasja A. Otto, Alex F. de Vos, Xiao Yu, Menno D. de Jong, Riekelt H. Houtkooper, Tom van der Poll

“…Likewise, the cell–cell junction organization pathway was amongst the top pathways downregulated by IOX2 in flagellin-stimulated HBE cells, which included the genes encoding claudins and cadherins. This IOX2 effect was corroborated by an impaired barrier function, as measured by dextran permeability. …”
Get full text

Desmoglein 2 regulates the intestinal epithelial barrier via p38 mitogen-activated protein kinase by Hanna Ungewiß, Franziska Vielmuth, Shintaro T. Suzuki, Andreas Maiser, Hartmann Harz, Heinrich Leonhardt, Daniela Kugelmann, Nicolas Schlegel, Jens Waschke

“…This is in contrast to keratinocytes and points towards tissue-specific signalling functions of desmosomal cadherins.…”
Get full text

A role for the retinoblastoma protein as a regulator of mouse osteoblast cell adhesion: implications for osteogenesis and osteosarcoma formation. by Bernadette Sosa-García, Volkan Gunduz, Viviana Vázquez-Rivera, W Douglas Cress, Gabriela Wright, Haikuo Bian, Philip W Hinds, Pedro G Santiago-Cardona

“…Microarrays comparing pRb-expressing and pRb-deficient osteoblasts showed that pRb controls the expression of a number of cell adhesion genes, including cadherins. Furthermore, pRb knockout mice showed bone abnormalities consistent with osteoblast adhesion defects. …”
Get full text

Mechanism for the Decision of Ovarian Surface Epithelial Stem Cells to Undergo Neo-Oogenesis or Ovarian Tumorigenesis by Jiao Xu, Tuochen Zheng, Wenli Hong, Haifeng Ye, Chuan Hu, Yuehui Zheng

“…Its integrity is maintained by simple desmosomes, incomplete tight junctions, several integrins and cadherins. Recent research has found that ovarian stem cells (OSCs) exist within the OSE and may be responsible for both neo-oogenesis and ovarian cancer during adult life. …”
Get full text

Functional Role of Non-Coding RNAs during Epithelial-To-Mesenchymal Transition by Almudena Expósito-Villén, Amelia E. Aránega, Diego Franco

“…Several transcriptional factors such as Snail, Slug, Twist, Zeb1 and Zeb2 have been reported to play fundamental roles in EMT, leading in most cases to transcriptional repression of cell–cell interacting proteins such as ZO-1 and cadherins and activation of cytoskeletal markers such as vimentin. …”
Get full text

A SEMA3 Signaling Pathway-Based Multi-Biomarker for Prediction of Glioma Patient Survival by Indre Valiulyte, Giedrius Steponaitis, Deimante Kardonaite, Arimantas Tamasauskas, Arunas Kazlauskas

“…The quantitative real-time PCR method was used to evaluate mRNA expression of <i>SEMA3(A-G)</i>, neuropilins (<i>NRP1</i> and <i>NRP2</i>), plexins (<i>PLXNA2</i> and <i>PLXND1</i>), cadherins (<i>CDH1</i> and <i>CDH2</i>), integrins (<i>ITGB1, ITGB3, ITGA5,</i> and <i>ITGAV</i>), <i>VEGFA</i> and <i>KDR</i> genes in 59 II-IV grade glioma tissues. …”
Get full text

Galectin-3 determines tumor cell adaptive strategies in stressed tumor microenvironments by Ana Carolina Ferreira Cardoso, Luciana Nogueira de Sousa Andrade, Silvina Odete Bustos, Roger eChammas

“…Upon secretion, extracellular galectin-3 interacts with a variety of cell surface glycoproteins, such as growth factor receptors, integrins, cadherins and members of the Notch family, among other glycoproteins, besides different extracellular matrix molecules. …”
Get full text

Tools for engineering multicellular systems through cell sorting and cell state detection by Enghuus, Casper Nørskov

“…We use the induction of a synthetic cell state to control morphogenesis by cell state-specific expression of homotypic cadherins which controls the cell’s adhesive properties. …”
Get full text

Downregulation of γ-Catenin by miR-195-5p Inhibits Colon Cancer Progression, Regulating Desmosome Function by Emanuele Piccinno, Viviana Scalavino, Nicoletta Labarile, Giusy Bianco, Maria Teresa Savino, Raffaele Armentano, Gianluigi Giannelli, Grazia Serino

“…In this context, we recently demonstrated that miR-195-5p regulated JUP and desmosome cadherins expression. In addition, miR-195-5p gain of function indirectly modulated the expression of key effectors of the Wnt pathway involved in JUP-dependent signaling. …”
Get full text