Ssa1-targeted antibody prevents host invasion by Candida albicans by Xi-Ran Qiu, Chen-Rui Shen, Li-Wen Jiang, Peng Ji, Yu Zhang, Wei-Tong Hou, Wen Zhang, Hui Shen, Mao-Mao An

“…Heat shock protein Ssa1, a conserved member of the Hsp70 family in yeast, is a novel invasin that binds to host cell cadherins, induces host cell endocytosis, and enables C. albicans to cause maximal damage to host cells and induces disseminated and oropharyngeal disease.ResultHere we discovered a mouse monoclonal antibody (mAb 13F4) that targeting C. albicans Ssa1 with high affinity (EC50 = 39.78 ng/mL). mAb 13F4 prevented C. albicans from adhering to and invading human epithelial cells, displayed antifungal activity, and synergized with fluconazole in proof of concept in vivo studies. mAb 13F4 significantly prolonged the survival rate of the hematogenous disseminated candidiasis mice to 75%. …”
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Proteome of larval metamorphosis induced by epinephrine in the Fujian oyster Crassostrea angulata by Guilan Di, Xiaohuo Xiao, Ming Him Tong, Xinhua Chen, Li Li, Miaoqin Huang, Long Zhou, Caihuan Ke

“…Hepatic lectin-like proteins, cadherins, calmodulin, calreticulin, and cytoskeletal proteins were involved in metamorphosis. …”
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The Study for Diagnostic Value of β-Catenin Immunohistochemistry Marker in Distinction of Aggressive and Non-Aggressive Basal Cell Carcinoma by Parvin Rajabi, Mitra Hydarpoor, Ahmadreza Maghsoudi, Fatemeh Mohaghegh, Maryam Dehghani Mobarakeh

“…It has a critical role in cell-to-cell adhesion by linking cadherins to the actin cytoskeleton and has a central role in transcriptional regulation in the Wnt signaling pathway. …”
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Alpha5beta1 integrin-fibronectin interactions specify liquid to solid phase transition of 3D cellular aggregates. by Carlos E Caicedo-Carvajal, Troy Shinbrot, Ramsey A Foty

“…Cells achieve these contradictory tasks by regulating either cell-cell adhesive bonds, mediated by cadherins, or cell-extracellular matrix (ECM) connections, regulated by integrins. …”
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Urinary proteome of dogs with kidney injury during babesiosis by D. Winiarczyk, K. Michalak, L. Adaszek, M. Winiarczyk, S. Winiarczyk

“…Conclusions It was hypothesized that epithelial-mesenchymal transition might play an important role in the mechanisms underlying pathological changes in renal tissue during babesiosis, as indicated by a causal relationship network built by combining 5 of the 10 selected metabolic pathways, and 4 of the 8 proteins associated with these pathways; this network included cadherins, gonadotropin releasing hormone receptors, inflammatory responses mediated by chemokine and cytokine signalling pathways, integrins, interleukins, and TGF-β (transforming growth factor β) pathways. …”
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HLA class II antigens in Croatian patients with pemphigus vulgaris and their correlation with anti-desmoglein antibodies by Ines Lakoš Jukić, Ines Lakoš Jukić, Mislav Mokos, Branka Marinović, Branka Marinović

“…Pemphigus vulgaris (PV) is an acquired autoimmune blistering disease characterized by the production of autoantibodies targeting desmosomal cadherins, primarily desmoglein 1 and desmoglein 3, leading to acantholysis. …”
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Structural disruption of BAF chromatin remodeller impairs neuroblastoma metastasis by reverting an invasiveness epigenomic program by Carlos Jiménez, Roberta Antonelli, Mariona Nadal-Ribelles, Laura Devis-Jauregui, Pablo Latorre, Carme Solé, Marc Masanas, Adrià Molero-Valenzuela, Aroa Soriano, Josep Sánchez de Toledo, David Llobet-Navas, Josep Roma, Francesc Posas, Eulàlia de Nadal, Soledad Gallego, Lucas Moreno, Miguel F. Segura

“…Genome-wide chromatin remodelling and transcriptomic analyses revealed that BAF disruption results in the epigenetic repression of an extensive invasiveness-related expression program involving integrins, cadherins, and key mesenchymal regulators, thereby reducing adhesion to the extracellular matrix and the subsequent invasion in vitro and drastically inhibiting the initiation and growth of neuroblastoma metastasis in vivo. …”
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Myosin VII, USH1C, and ANKS4B or USH1G Together Form Condensed Molecular Assembly via Liquid-Liquid Phase Separation by Yunyun He, Jianchao Li, Mingjie Zhang

“…Summary: Hair cell stereocilia tip-links function to sense mechanical forces generated by sound waves and maintain the structure of stereocilia by rooting the tail of cadherins to highly dense structures known as tip-link densities. …”
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Integrated miRNA and mRNA expression profiling in inflamed colon of patients with ulcerative colitis. by Jan Van der Goten, Wiebe Vanhove, Katleen Lemaire, Leentje Van Lommel, Kathleen Machiels, Willem-Jan Wollants, Vicky De Preter, Gert De Hertogh, Marc Ferrante, Gert Van Assche, Paul Rutgeerts, Frans Schuit, Séverine Vermeire, Ingrid Arijs

“…IL8) and barrier integrity (e.g. cadherins). MicroRNAs (miRNAs) are regulators of gene expression and are involved in various immune-related diseases. …”
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Gene expression during testis development in Duroc boars by S. Lervik, A.B. Kristoffersen, L.N. Conley, I.C. Oskam, J. Hedegaard, E. Ropstad, I. Olsaker

“…Prominent pathways in the prepubertal testis were associated with tissue renewal, cell respiration and increased endocytocis. E-cadherines may be associated with the onset of pubertal development. …”
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Desmoplakin Maintains Transcellular Keratin Scaffolding and Protects From Intestinal InjurySummary by Annika Gross, Biaohuan Zhou, Lisa Bewersdorf, Nicole Schwarz, Gabriel M. Schacht, Peter Boor, Konrad Hoeft, Bernd Hoffmann, Elaine Fuchs, Rafael Kramann, Rudolf Merkel, Rudolf E. Leube, Pavel Strnad

“…Background & Aims: Desmosomes are intercellular junctions connecting keratin intermediate filaments of neighboring cells. The cadherins desmoglein 2 (Dsg2) and desmocollin 2 mediate cell–cell adhesion, whereas desmoplakin (Dsp) provides the attachment of desmosomes to keratins. …”
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Control of stereocilia length during development of hair bundles. by Jocelyn F Krey, Paroma Chatterjee, Julia Halford, Christopher L Cunningham, Benjamin J Perrin, Peter G Barr-Gillespie

“…Cdh23v2J/v2J and Pcdh15av3J/av3J bundles had adjacent stereocilia in the same row that were not matched in length, revealing that a major role of these cadherins is to synchronize lengths of side-by-side stereocilia. …”
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Network assessment of demethylation treatment in melanoma: Differential transcriptome-methylome and antigen profile signatures. by Zhijie Jiang, Caterina Cinti, Monia Taranta, Elisabetta Mattioli, Elisa Schena, Sakshi Singh, Rimpi Khurana, Giovanna Lattanzi, Nicholas F Tsinoremas, Enrico Capobianco

“…Overall, the non-metastatic SKMEL-2 map reveals post-treatment re-activation of a richer pathway landscape, involving cadherins and integrins as signatures of cell adhesion and proliferation. …”
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The lhfpl5 Ohnologs lhfpl5a and lhfpl5b Are Required for Mechanotransduction in Distinct Populations of Sensory Hair Cells in Zebrafish by Timothy Erickson, Timothy Erickson, Itallia V. Pacentine, Alexandra Venuto, Rachel Clemens, Teresa Nicolson

“…Using a stably integrated GFP-Lhfpl5a transgene, we show that the tip link cadherins Pcdh15a and Cdh23, along with the Myo7aa motor protein, are required for correct Lhfpl5a localization at the tips of stereocilia. …”
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Extracellular Control of Radial Glia Proliferation and Scaffolding During Cortical Development and Pathology by Julien Ferent, Julien Ferent, Julien Ferent, Donia Zaidi, Donia Zaidi, Donia Zaidi, Fiona Francis, Fiona Francis, Fiona Francis

“…Classical short range factors include cell to cell signaling, adhesion molecules and mechano-transduction mechanisms (e.g., TAG1, Notch, cadherins, mechanical tension). Changes in one or several of these components influencing the RG extracellular environment can disrupt the development or maintenance of RG architecture on which neuronal migration relies, leading to a range of cortical malformations. …”
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Structure and function of CD31 by Newton, J

“…A novel zipper model of homophilic adhesion involving CD31 lateral association analogous to that seen amongst cadherins is proposed on the basis of these results.…”

Innovative mouse models for the tumor suppressor activity of Protocadherin-10 isoforms by Irene Kleinberger, Ellen Sanders, Katrien Staes, Marleen Van Troys, Shinji Hirano, Tino Hochepied, Kelly Lemeire, Liesbet Martens, Christophe Ampe, Frans van Roy

“…Abstract Background Nonclustered mouse protocadherin genes (Pcdh) encode proteins with a typical single ectodomain and a cytoplasmic domain with conserved motifs completely different from those of classic cadherins. Alternative splice isoforms differ in the size of these cytoplasmic domains. …”
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