Arc Interacts with the Integral Endoplasmic Reticulum Protein, Calnexin by Craig Myrum, Craig Myrum, Jonathan Soulé, Margarethe Bittins, Kyle Cavagnini, Kevin Goff, Silje K. Ziemek, Maria S. Eriksen, Sudarshan Patil, Adrian Szum, Rajeevkumar R. Nair, Clive R. Bramham

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Calnexin, More Than Just a Molecular Chaperone by Tautvydas Paskevicius, Rabih Abou Farraj, Marek Michalak, Luis B. Agellon

“…Calnexin is a type I integral endoplasmic reticulum (ER) membrane protein with an N-terminal domain that resides in the lumen of the ER and a C-terminal domain that extends into the cytosol. …”
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The E5 protein of the human papillomavirus type 16 down-regulates HLA-I surface expression in calnexin-expressing but not in calnexin-deficient cells by Momburg Frank, Bravo Ignacio G, Gruener Myriam, Alonso Angel, Tomakidi Pascal

“…Here we show that HPV16 E5 down-regulates HLA-I surface expression in calnexin-containing but not in calnexin-deficient cells. …”
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Identification of calnexin as a diacylglycerol acyltransferase-2 interacting protein. by Curtis Brandt, Pamela J McFie, Huyen Vu, Paulos Chumala, George S Katselis, Scot J Stone

“…We found that calnexin-deficient mouse embryonic fibroblasts had reduced intracellular triacylglycerol levels and fewer large lipid droplets (>1.0 μm2 area). …”
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Structural characterisation of calnexin cycle components and assessment as antiviral targets by Hill, J

“…<p>N-glycosylated proteins that traverse the endoplasmic reticulum (ER) can make use of the calnexin cycle to attain their correct fold. The calnexin cycle modifies the N-glycan structure and allows for association of the glycoprotein with the ER lectins calnexin and calreticulin, which in turn recruit further chaperones that assist folding. …”

Genomic sequence of a calnexin homolog from Arabidopsis thaliana. by Boyce, J, Coates, D, Fricker, M, Evans, D

“…Calnexin is a membrane-bound protein of the ER in animal cells (Wada et al., 1991). …”

Calnexin-assisted biogenesis of the neuronal glycine transporter 2 (GlyT2). by Esther Arribas-González, Pablo Alonso-Torres, Carmen Aragón, Beatriz López-Corcuera

“…In this study we examined several aspects of GlyT2 biogenesis that involve the endoplasmic reticulum chaperone calnexin (CNX). CNX binds transiently to an intermediate under-glycosylated transporter precursor and facilitates GlyT2 processing. …”
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Calnexin Is Involved in Forskolin-Induced Syncytialization in Cytotrophoblast Model BeWo Cells by Hitomi Matsukawa, Midori Ikezaki, Kaho Nishioka, Naoyuki Iwahashi, Masakazu Fujimoto, Kazuchika Nishitsuji, Yoshito Ihara, Kazuhiko Ino

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Membrane Domain Localization and Interaction of the Prion-Family Proteins, Prion and Shadoo with Calnexin by Divya Teja Dondapati, Pradeep Reddy Cingaram, Ferhan Ayaydin, Antal Nyeste, Andor Kanyó, Ervin Welker, Elfrieda Fodor

“…We show that the two proteins occupy similarly raft and non-raft membrane fractions when expressed in N2a cells and that both proteins pull down the chaperone calnexin in both rafts and non-rafts. These indicate their possible binding to calnexin in both types of membrane domains, which might be a necessary requisite to aid the inherently unstable native conformation during their lifetime.…”
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Calnexin is essential for survival under nitrogen starvation and stationary phase in Schizosaccharomyces pombe. by Andrés Núñez, Dominic Dulude, Mehdi Jbel, Luis A Rokeach

“…The use of S. pombe should assist in further shedding light on the multiple roles of calnexin.…”
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Ca²⁺ Regulates ERp57-Calnexin Complex Formation by Yuya Tanikawa, Shingo Kanemura, Dai Ito, Yuxi Lin, Motonori Matsusaki, Kimiko Kuroki, Hiroshi Yamaguchi, Katsumi Maenaka, Young-Ho Lee, Kenji Inaba, Masaki Okumura

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Role of N-linked carbohydrate processing and calnexin in human hepatic lipase secretion by Jennifer C. Boedeker, Mark Doolittle, Silvia Santamarina-Fojo, Ann L. White

“…We examined the role of N-linked glycosylation and calnexin interaction in human HL secretion from Chinese hamster ovary (CHO) cells stably expressing a human HL cDNA. …”
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The role of calnexin, calreticulin and heavy chain glycosylation in MHC class I assembly by Adhikari, R, Adhikari, Raju

“…</p> <p>I have used a human calnexin-deficient cell line CEM.NK^R to study assembly of class I in the absence of calnexin. …”

Model-Driven Understanding of Palmitoylation Dynamics: Regulated Acylation of the Endoplasmic Reticulum Chaperone Calnexin. by Tiziano Dallavilla, Laurence Abrami, Patrick A Sandoz, Georgios Savoglidis, Vassily Hatzimanikatis, F Gisou van der Goot

“…This prediction guided us to find that phosphorylation actively delays calnexin palmitoylation in resting cells. Altogether this study reveals that cells synthesize 5 times more calnexin than needed under resting condition, most of which is degraded. …”
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RNF185 regulates proteostasis in Ebolavirus infection by crosstalk between the calnexin cycle, ERAD, and reticulophagy by Jing Zhang, Bin Wang, Xiaoxiao Gao, Cheng Peng, Chao Shan, Silas F. Johnson, Richard C. Schwartz, Yong-Hui Zheng

“…Here, the authors identify unexpected crosstalk between the calnexin cycle, ERAD, and reticulophagy, resulting in suppression of ebolavirus glycoprotein expression.…”
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Calnexin Depletion by Endoplasmic Reticulum Stress During Cholestasis Inhibits the Na+‐Taurocholate Cotransporting Polypeptide by Marion J.D. Robin, Monique D. Appelman, Harmjan R. Vos, Robert M. van Es, James C. Paton, Adrienne W. Paton, Boudewijn Burgering, Peter Fickert, Jarom Heijmans, Stan F.J. van de Graaf

“…Calnexin down‐regulation in vitro recapitulated the effect of ER stress on NTCP. …”
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Role of Ca2+, Calnexin and Calreticulin in Platelet from Adult Patients with Chronic Immune Thrombocytopenic Purpura by Xu DM, Zhang ZW, Yi JX, Xie L, Yu WJ, Qiu JF, Xu CW, He CL, Xu XR, Yin J

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Endoplasmic Reticulum Stress-Associated Chaperones, Bip/GRP78 and Calnexin are Overexpressed in Keratocystic Odontogenic Tumours by Maria Pavli, Elena Farmaki, Stavroula Merkourea, Helen Vastardis, Alexandra Sklavounou, Fotios Tzerbos, Ioulia Chatzistamou

“…Calnexin was expressed in 11 out of 24 KCOTs (46%) but only one out of 9 (13%) PACs, and none of the 5 FBs analyzed (P < 0.001, x2-test). …”
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N-glycosylation in the protease domain of trypsin-like serine proteases mediates calnexin-assisted protein folding by Hao Wang, Shuo Li, Juejin Wang, Shenghan Chen, Xue-Long Sun, Qingyu Wu

Subjects: “…calnexin…”
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Deficient peptide binding by MHC class I due to prolonged interaction with calnexin in a mutant cell line by Grandea, A, Townsend, A, Spies, T, Van Kaer, L, Ohlen, C