Increased intracellular cyclic di-AMP levels sensitize Streptococcus gallolyticus subsp. gallolyticus to osmotic stress and reduce biofilm formation and adherence on intestinal cel... od Teh, Wooi Keong, Dramsi, Shaynoor, Tolker-Nielsen, Tim, Yang, Liang, Givskov, Michael

“…IMPORTANCE Streptococcus gallolyticus is an opportunistic pathogen responsible for septicemia and endocarditis in the elderly and is also strongly associated with colorectal cancer. S. gallolyticus can form biofilms, express specific pili to colonize the host tissues, and produce a specific bacteriocin allowing killing of commensal bacteria in the murine colon. …”
Dokumenty pełnotekstowe
Dokumenty pełnotekstowe

Early assessment of tumor response to photodynamic therapy using combined diffuse optical and diffuse correlation spectroscopy to predict treatment outcome od Thong, Patricia, Lee, Kijoon, Toh, Hui-Jin, Dong, Jing, Tee, Chuan-Sia, Low, Kar-Perng, Chang, Pui-Haan, Bhuvaneswari, Ramaswamy, Tan, Ngian-Chye, Soo, Khee-Chee

“…Photodynamic therapy (PDT) of cancer involves the use of a photosensitizer that can be light-activated to eradicate tumors via direct cytotoxicity, damage to tumor vasculature and stimulating the body’s immune system. …”
Dokumenty pełnotekstowe
Dokumenty pełnotekstowe

NF-κB p65 repression by the sesquiterpene lactone, Helenalin, contributes to the induction of autophagy cell death od Feng, XiaoLing, Zhao, Yan, Lim, Chuan Bian, Fu, Pan You, Ky, Nung, Zhu, Hong Shuang, Li, Jinming, Srinivasan, Kandhadayar Gopalan, Hamza, Mohamed Sabry

“…To deduce the mechanistic action of helenalin, cancer cells were treated with the drug at various concentrations and time intervals. …”
Dokumenty pełnotekstowe
Dokumenty pełnotekstowe

UJI SITOTOKSIK In Vitro EKSTRAK KLOROFORM Brucea javanica L . (Meer), Ipomoea batatas Poir., Mussaenda pubescens Ait.F., DAN Portulaca oleracea L., TERHADAP SEL hela: -iii Vitro CY... od Perpustakaan UGM, i-lib

“…(Meer), have been used traditionally to treat cancer, even though the scientific base of this activity has yet been completely investigated. …”

Thrombin induces IL-8/CXCL8 expression by DCLK1-dependent RhoA and YAP activation in human lung epithelial cells od Yuliani, Fara Silvia, Chen, Jing-Yun, Cheng, Wen-Hao, Wen, Heng-Ching, Chen, Bing-Chang, Lin, Chien-Huang

“…Background: Doublecortin‑like kinase 1 (DCLK1) has been recognized as a marker of cancer stem cell in several malignancies. Thrombin is crucial in asthma severity as it can promote IL‑8/CXCL8 production in lung epithelial cells, which is a potent chemoattractant for neutrophils. …”
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Role of GDF15/MAPK14 Axis in Chondrocyte Senescence as a Novel Senomorphic Agent in Osteoarthritis od Weng, Pei-Wei, Pikatan, Narpati Wesa, Setiawan, Syahru Agung, Yadav, Vijesh Kumar, Fong, Iat-Hang, Hsu, Chia-Hung, Yeh, Chi-Tai, Lee, Wei-Hwa

“…Growth differentiation factor 15 (GDF15), a member of the tumor growth factor (TGF) superfamily, has recently been identified as a possible aging biomarker and has been linked to a variety of clinical conditions, including coronary artery disease, diabetes, and multiple cancer types. Thus, we obtained data from a publicly available single-cell sequencing RNA database and observed that GDF15, a critical protein in cellular senescence, is highly expressed in early OA. …”
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Mutagenic effect and antimutagenic potential of aqueous and methanol extracts from hydrocotoyle bonariensis and centella asiatica / Florinsiah Lorin od Lorin, Florinsiah

“…Since the mutagens are involved in the initiation and promotion of several human diseases, including cancer, the significance of novel bioactive phytocompounds in counteracting these pro-mutagenic and carcinogenics effects is now gaining attention. …”
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Rapid expansion supercritical solution (RESS) carbon dioxide as a green technology for ginger rhizome solid oil particles formation / Nur Ain Mohd Zainuddin od Mohd Zainuddin, Nur Ain

“…Many studies acknowledged the high amount of natural antioxidant content in ginger as a valuable component to replace synthetic antioxidant that can be used in anticancer activity for cancer treatment. Most of the previous researchers used Supercritical Fluid Extraction (SFE) and conventional extraction technique such as steam distillation and solvent extraction method in ginger extraction. …”
Dokumenty pełnotekstowe

Dissecting the genome-wide dynamic responses of the HIF transcriptional system od Sun, M

“…It is also important in the pathology of many human diseases such as cancer, cardiovascular and diabetic disorders. The sequence-specific, heterodimeric transcription factor HIF (Hypoxia Inducible Factor) has been shown to play a key role in cellular adaptation to hypoxia. …”

Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies. od Whitlock, G, Lewington, S, Sherliker, P, Clarke, R, Emberson, J, Halsey, J, Qizilbash, N, Collins, R, Peto, R

“…Below the range 22.5-25 kg/m(2), BMI was associated inversely with overall mortality, mainly because of strong inverse associations with respiratory disease and lung cancer. These inverse associations were much stronger for smokers than for non-smokers, despite cigarette consumption per smoker varying little with BMI. …”

Genetic and epigenetic basis of clonal advantage during the evolution of acute myeloid leukaemia od Turkalj, S

“…Overall, GTAC is a robust method applicable to a broader field of cancer evolution.</p>…”

Whole‐brain deuterium metabolic imaging via concentric ring trajectory readout enables assessment of regional variations in neuronal glucose metabolism od Niess, F, Strasser, B, Hingerl, L, Bader, V, Frese, S, Clarke, WT, Duguid, A, Niess, E, Motyka, S, Krššák, M, Trattnig, S, Scherer, T, Lanzenberger, R, Bogner, W

“…Regional differences in glucose metabolism can be observed in various brain pathologies, such as Alzheimer's disease, cancer, epilepsy or schizophrenia, but the achievable spatial resolution of conventional phase‐encoded DMI methods is limited due to prolonged acquisition times rendering submilliliter isotropic spatial resolution for dynamic whole brain DMI not feasible. …”

Endovascular versus open repair of abdominal aortic aneurysm in 15-years' follow-up of the UK endovascular aneurysm repair trial 1 (EVAR trial 1): a randomised controlled trial od Patel, R, Sweeting, M, Powell, J, Greenhalgh, R, EVAR trial investigators

“…The increased aneurysm-related mortality in the EVAR group after 8 years was mainly attributable to secondary aneurysm sac rupture (13 deaths [7%] in EVAR vs two [1%] in open repair), with increased cancer mortality also observed in the EVAR group. …”

Chemical and biological studies on human oxygenases od Thinnes, C, Dr Cyrille C. Thinnes

“…It has an effect on the post-translational modification pattern of histone H3, but not other histones, and reduces the viability of lung cancer cells, but not normal lung cells, derived from the same patient. …”

Role of the collagen receptor DDR1 in epithelial morphogenesis and polarisation od Søgaard, P

“…In contrast, loss of polarity has been associated with progression of diseases such as cancer. During epithelial tubulogenesis, the pro-invasive enzyme MT1-MMP is regulated according to apicobasal polarity. …”

A nutritional biomarker score of the Mediterranean diet and incident type 2 diabetes: integrated analysis of data from the MedLey randomised controlled trial and the EPIC-InterAct... od Sobiecki, JG, Imamura, F, Davis, CR, Sharp, SJ, Koulman, A, Hodgson, JM, Guevara, M, Schulze, MB, Zheng, J-S, Agnoli, C, Bonet, C, Colorado-Yohar, SM, Fagherazzi, G, Franks, PW, Gundersen, TE, Jannasch, F, Kaaks, R, Katzke, V, Molina-Montes, E, Nilsson, PM, Palli, D, Panico, S, Papier, K, Rolandsson, O, Sacerdote, C, Tjønneland, A, Tong, TYN, van der Schouw, YT, Danesh, J, Butterworth, AS, Riboli, E, Murphy, KJ, Wareham, NJ, Forouhi, NG

“…We applied this biomarker score in an observational study, the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct case-cohort study, to assess the association of the score with T2D incidence over an average of 9.7 years of follow-up since the baseline (1991 to 1998). …”

Association between plasma phospholipid saturated fatty acids and metabolic markers of lipid, hepatic, inflammation and glycaemic pathways in eight European countries: a cross-sect... od Zheng, J-S, Sharp, SJ, Imamura, F, Koulman, A, Schulze, MB, Ye, Z, Griffin, J, Guevara, M, Huerta, JM, Kröger, J, Sluijs, I, Agudo, A, Barricarte, A, Boeing, H, Colorado-Yohar, S, Dow, C, Dorronsoro, M, Dinesen, PT, Fagherazzi, G, Franks, PW, Feskens, EJM, Kühn, T, Katzke, VA, Key, TJ, Khaw, K-T, De Magistris, MS, Mancini, FR, Molina-Portillo, E, Nilsson, PM, Olsen, A, Overvad, K, Palli, D, Quirós, JR, Rolandsson, O, Ricceri, F, Spijkerman, AMW, Slimani, N, Tagliabue, G, Tjonneland, A, Tumino, R, Van Der Schouw, YT, Langenberg, C, Riboli, E, Forouhi, NG, Wareham, NJ

“…<br/><strong>Methods: </strong>We measured nine individual plasma phospholipid SFAs and derived three SFA groups (odd-chain: C15:0 + C17:0, even-chain: C14:0 + C16:0 + C18:0, and very-long-chain: C20:0 + C22:0 + C23:0 + C24:0) in individuals from the subcohort of the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct case-cohort study across eight European countries. …”

Geoeconomic variations in epidemiology, ventilation management, and outcomes in invasively ventilated intensive care unit patients without acute respiratory distress syndrome: a po... od Pisani, L, Algera, AG, Neto, AS, Azevedo, L, Pham, T, Paulus, F, de Abreu, MG, Pelosi, P, Dondorp, AM, Bellani, G, Laffey, JG, Schultz, MJ

“…Patients in MICs were younger, shorter and with a slightly lower body-mass index, more often had diabetes and active cancer, but less often chronic obstructive pulmonary disease and heart failure than patients from HICs. …”

Mechanistic pathways underlying altered neurovascular coupling in brain metastasis od Sarmiento Soto, M, Serres, S, Bristow, C, Economopoulos, V, Larkin, J, Escartin, C, Bonvento, G, Sibson, N

“…Astrocytic end-feet help maintain endothelial tight junctions to support the blood–brain barrier (BBB) and release vasoactive molecules that regulate vascular tone. In secondary cancer (metastasis) to the brain, astrocytes are displaced from the vasculature and become activated, and we have shown that neurovascular coupling is compromised in rat model of brain metastasis (Serres et al., abstract submitted). …”

European Society of Cardiology: cardiovascular disease statistics 2017 od Timmis, A, Townsend, N, Gale, C, Grobbee, R, Maniadakis, N, Flather, M, Wilkins, E, Wright, L, Vos, R, Bax, J, Blum, M, Pinto, F, Vardas, P

“…Declines in CVD mortality have seen cancer becoming a more common cause of death in a number of high-income member countries, but in middle-income countries declines in CVD mortality have been less consistent where CVD remains the leading cause of death. …”