ANALISIS FAKTOR-FAKTOR RISIKO YANG BERHUBUNGAN DENGAN TINGKAT DEPRESI PADA PASIEN DENGAN KEGANASAN GINEKOLOGI DI RUMAH SAKIT DR. SARDJITO YOGYAKARTA by , Selamat Widodo, , Prof. dr. H. Moh. Hakimi, Ph.D., Sp.OG(K).

“…This result shows that every patient who have been diagnosed has cancers will eventually feeling worried and afraid Conclusion: There is significant effect between risk factors toward depression. …”

Low-dose M.tb infection but not BCG or MTBVAC vaccination enhances heterologous antibody titres in non-human primates by Alvarez, MPP, Jones, H, Azema, HR, Davis, C, White, AD, Sarfas, C, Dennis, M, Li, S, Wright, D, Puentes, E, Kimuda, S, Belij-Rammerstorfer, S, Aguilo, N, Martin, C, Sharpe, S, McShane, H, Tanner, R

“…The apparent dysregulation of B cell responses associated with TB disease warrants further investigation, with potential implications for risk of B cell cancers and novel therapeutic strategies.</p>…”

How does the chromatin remodeler ATRX identify its targets in the genome? by Nguyen, DTT

“…<p>ATRX is a chromatin remodeling protein associated with X-linked Alpha-Thalassemia Mental Retardation syndrome and cancers that use the Alternative Lengthening of Telomere pathway. …”

Big brains, meat, tuberculosis and the nicotinamide switches: Co-evolutionary relationships with modern repercussions on longevity and disease? by Williams, A, Dunbar, R

“…We test this in pilot data showing that sharp declines in TB (and diarrhoea) – `environmental enteropathy' strongly correlate with increasing meat consumption and therefore nicotinamide exposure, unlike later onset cancers and Parkinson’s disease that increased in incidence, perhaps – as we propose a hypothetical hypervitaminosis B3 (to include obesity and the metabolic syndrome) – as the trade-off for increased brain power and longevity, a recently evolved human characteristic. …”

Arginine methylation in the E2F1 pathway by Zheng, S

“…Deregulation of the E2F1 pathway, which may be brought about by somatic mutations in genes such as INK4A, RB1 and CDK4, is found in a majority of cancers. The transcription factor E2F1 is able to activate genes involved in proliferation as well as apoptosis, but the mechanisms that govern these opposing biological effects remain poorly understood. …”

High proportion of PD-1 and CD39 positive CD8+ tissue resident T lymphocytes correlates with better clinical outcome in resected human oesophageal adenocarcinoma by Hill, SL, Sugiyarto, G, Harrington, J, James, E, Underwood, TJ, Elliott, T

“…Transcriptomic assessment of the PD-1 and CD39 DP TILs demonstrated enrichment for a tissue resident memory T lymphocyte (TRM) phenotype associated with improved survival in other cancers, reinforced by positivity for the canonical TRM marker CD103 by flow cytometry. …”

Matrix metalloproteinase-1 and -9 promoter polymorphisms and endometrial carcinoma risk in a Japanese population. by Sugimoto, M, Yoshida, S, Kennedy, S, Deguchi, M, Ohara, N, Maruo, T

“…Several studies have demonstrated association between MMP gene polymorphisms and various cancers. The object of this study was to investigate whether the MMP-1 and MMP-9 gene promoter polymorphisms are associated with endometrial carcinomas in a Japanese population. …”

Anthropometric measures, physical activity, and risk of glioma and meningioma in a large prospective cohort study. by Michaud, D, Bové, G, Gallo, V, Schlehofer, B, Tjønneland, A, Olsen, A, Overvad, K, Dahm, C, Teucher, B, Boeing, H, Steffen, A, Trichopoulou, A, Bamia, C, Kyrozis, A, Sacerdote, C, Agnoli, C, Palli, D, Tumino, R, Mattiello, A, Bueno-de-Mesquita, H, Peeters, P, May, A, Barricarte, A, Chirlaque, MD, Dorronsoro, M

“…Body fatness has been associated with increased risk of a number of hormone-dependent cancers. Recent studies suggest that body mass index (BMI) may be related to meningiomas, which are more common in women than men, and for which estrogens are believed to play a role. …”

Mortality in relation to smoking: 40 years' observations on male British doctors. by Doll, R, Peto, R, Wheatley, K, Gray, R, Sutherland, I

“…Positive associations with smoking were confirmed for death from cancers of the mouth, oesophagus, pharynx, larynx, lung, pancreas, and bladder; from chronic obstructive pulmonary disease and other respiratory diseases; from vascular diseases; from peptic ulcer; and (perhaps because of confounding by personality and alcohol use) from cirrhosis, suicide, and poisoning. …”

Does the use of immunohistochemistry to identify micrometastases provide useful information in the staging of node-negative non-small cell lung carcinomas? by Nicholson, A, Graham, A, Pezzella, F, Agneta, G, Goldstraw, P, Pastorino, U

“…Immunohistochemical studies using epithelial markers have recently been published which identified micrometastases in lymph nodes that had not been found on routine pathological assessment, therefore increasing the accuracy of staging of non-small cell lung cancers. The presence of these micrometastases was associated with reduced survival. …”

Towards a structure-based understanding of WNT receptor function by Hillier, J

“…<p>The highly conserved WNT signalling pathways are vital during development and throughout the lives of animals, while aberrant WNT signalling is implicated in a range of degenerative diseases, as well as cancers. Cells detect WNT signals through members of the Frizzled (FZD1- 10) family of cell-surface receptor proteins, resulting in multiple possible outcomes including changes in gene expression and cell polarity. …”

Characterisation of a New p97 Adaptor in Genome Stability by Wiseman, K

“…<p>Cells are subjected to constant genotoxic stress arising from both endogenous and exogenous sources which can drive the development of a wide range of diseases, especially cancers. Therefore, repair of these lesions is essential to maintain genomic stability and health. …”

TBX3 and its splice variant TBX3 + exon 2a are functionally similar. by Hoogaars, WM, Barnett, P, Rodriguez, M, Clout, D, Moorman, A, Goding, C, Christoffels, V

“…Both the TBX3 and the highly related TBX2 genes are also associated with several cancers, most likely as a consequence of their powerful anti-senescence properties mediated via suppression p14(Arf) and p21(CIP) expression. …”

Topological data analysis of organoids by Marsh, LM

“…The methods validate previously identified genes and detect additional genes with known involvement cancers. To study the morphology of organoids I propose DETECT, a rotationally invariant signature of dynamically changing shapes. …”

Calcium Sensing receptor expression is downregulated in gastroenteropancreatic neuroendocrine tumours via epigenetic mechanisms by English, KA, Goldsworthy, M, Willis, B, Kooblall, KG, Birla, S, Selberherr, A, Stevenson, M, Shariq, OA, Oberg, AL, Wang, T, Carmichael, J, Mavrommatis, K, Escoubet, L, Thakker, RV, Howles, SA, Lines, KE

“…The calcium sensing receptor (CASR), a G protein coupled-receptor (GPCR), is epigenetically silenced in cancers, and therefore we examined its role in GEP-NET subtypes. …”

The spectrum of p53 mutations in colorectal adenomas differs from that in colorectal carcinomas. by Hao, X, Frayling, I, Sgouros, J, Du, M, Willcocks, T, Talbot, I, Tomlinson, I

“…Adenomas harboured a spectrum of p53 mutations which was significantly different from cancers as regards the position in the gene and a higher frequency of G--&gt;C/C--&gt;G changes. …”

Big brains, meat, tuberculosis and the nicotinamide switches: co-evolutionary relationships with modern repercussions on longevity and disease? by Williams, A, Dunbar, R

“…We test this in pilot data showing that sharp declines in TB (and diarrhoea) - `environmental enteropathy' strongly correlate with increasing meat consumption and therefore nicotinamide exposure, unlike later onset cancers and Parkinson's disease that increased in incidence, perhaps - as we propose a hypothetical hypervitaminosis B3 (to include obesity and the metabolic syndrome) - as the trade-off for increased brain power and longevity, a recently evolved human characteristic.…”

The U2AF1S34F mutation induces lineage-specific splicing alterations in myelodysplastic syndromes. by Yip, B, Steeples, V, Repapi, E, Armstrong, R, Llorian, M, Roy, S, Shaw, J, Dolatshad, H, Taylor, S, Verma, A, Bartenstein, M, Vyas, P, Cross, N, Malcovati, L, Cazzola, M, Hellström-Lindberg, E, Ogawa, S, Smith, C, Pellagatti, A, Boultwood, J

“…Mutations of the splicing factor-encoding gene U2AF1 are frequent in the myelodysplastic syndromes (MDS), a myeloid malignancy, and other cancers. Patients with MDS suffer from peripheral blood cytopenias, including anemia, and an increasing percentage of bone marrow myeloblasts. …”

Design and analysis of genome-wide association studies by Barrett, J

“…Despite many years of effort, linkage and candidate gene association studies have yielded disappointingly few risk loci for common human diseases such as diabetes, auto-immune disorders and cancers. Large sample sizes, increased understanding of the patterns of correlation in genetic variation, and plunging genotyping costs have enabled genome-wide association studies, which have good power to detect common risk alleles of modest effect. …”

MRI-guided radiotherapy of the SK-N-SH neuroblastoma xenograft model using a small animal radiation research platform by Vallis, K, Corroyer-Dulmont, A, Falzone, N, Kersemans, V, Thompson, J, Hill, M, Allen, P, Beech, J, Gilchrist, S, Vojnovic, B, Kinchesh, P, Gaze, M, Tullis, I, Smart, S

“… <h4>Objective</h4> <p>Neuroblastoma has one of the lowest survival rates of all childhood cancers despite the use of intensive treatment regimens. …”