Mathematical modelling of oncolytic virotherapy by Shabala, A

“…<p>This thesis is concerned with mathematical modelling of oncolytic virotherapy: the use of genetically modified viruses to selectively spread, replicate and destroy cancerous cells in solid tumours. Traditional spatially-dependent modelling approaches have previously assumed that virus spread is due to viral diffusion in solid tumours, and also neglect the time delay introduced by the lytic cycle for viral replication within host cells.…”

Wound drainage following groin dissection for malignant disease in adults. by Thomson, DR, Sadideen, H, Furniss, D

“…BACKGROUND: Groin dissection is commonly performed for the treatment of a variety of cancers, including melanoma, and squamous cell carcinoma of the skin, penis or vulva. …”

MicroRNA miR-107 is overexpressed in pituitary adenomas and inhibits the expression of aryl hydrocarbon receptor-interacting protein in vitro. by Trivellin, G, Butz, H, Delhove, J, Igreja, S, Chahal, H, Zivkovic, V, McKay, T, Patócs, A, Grossman, AB, Korbonits, M

“…In this study, we investigated the role played by miR-107, a miRNA associated with different human cancers, in sporadic pituitary adenomas and its interaction with the pituitary tumor suppressor gene aryl hydrocarbon receptor-interacting protein (AIP). miR-107 expression was evaluated in pituitary adenoma and normal pituitary samples using microRNA screen TLDA (TaqMan Low-Density Array) and RT-qPCR assays. …”

Frequent accumulation of nuclear E-cadherin and alterations in the Wnt signaling pathway in esophageal squamous cell carcinomas. by Salahshor, S, Naidoo, R, Serra, S, Shih, W, Tsao, MS, Chetty, R, Woodgett, JR

“…Nuclear expression of E-cadherin was also detected in tumors other than squamous cell carcinoma, including pancreatic and colon cancers, albeit at lower frequency. Nuclear accumulation of a portion of E-cadherin in esophageal squamous cell carcinoma and the other types of tumors indicates that, in addition to the previously implicated tumor suppressor activity of E-cadherin, modified forms of this glycoprotein might also play a role in growth promotion.…”

Big brains, meat, tuberculosis and the nicotinamide switches: Co-evolutionary relationships with modern repercussions on longevity and disease? by Williams, A, Dunbar, R

“…We test this in pilot data showing that sharp declines in TB (and diarrhoea) - 'environmental enteropathy' strongly correlate with increasing meat consumption and therefore nicotinamide exposure, unlike later onset cancers and Parkinson's disease that increased in incidence, perhaps - as we propose a hypothetical hypervitaminosis B3 (to include obesity and the metabolic syndrome) - as the trade-off for increased brain power and longevity, a recently evolved human characteristic. © 2014 Elsevier Ltd.…”

Better epitope discovery, precision immune engineering, and accelerated vaccine design using immunoinformatics tools by De Groot, AS, Moise, L, Terry, F, Gutierrez, AH, Hindocha, P, Richard, G, Hoft, DF, Ross, TM, Noe, AR, Takahashi, Y, Kotraiah, V, Silk, SE, Nielsen, CM, Minassian, AM, Ashfield, R, Ardito, M, Draper, SJ, Martin, WD

“…Tools that facilitate the in silico prediction of immune response to biothreats, emerging infectious diseases, and cancers can accelerate the design of novel and next generation vaccines and their delivery to the clinic. …”

Interactions of perihperal membrane proteins with phosphatidylinositol lipids: insights from molecular dynamics simulations by Naughton, F

“…Multiscale MD, combining coarse-grain binding simulations and atomistic refinement, was used to investigate PTEN, a tumour suppressor catalysing interconversion of PIPs and associated with many cancers and other disorders. Regions often ignored in previous studies were revealed to favour productive binding, largely via electrostatics. …”

Rational design and characterization of nitric oxide biosensors in E. coli Nissle 1917 and mini SimCells by Chen, XJ, Wang, B, Thompson, IP, Huang, WE

“…Nitric oxide (NO) is an important disease biomarker found in many chronic inflammatory diseases and cancers. A well-characterized nitric sensing system is useful to aid the rapid development of bacteria therapy and synthetic biology. …”

Mutations in Exon 1 Highlight the Role of MED12 in Uterine Leiomyomas by Kämpjärvi, K, Park, M, Mehine, M, Kim, N, Clark, A, Bützow, R, Böhling, T, Böhm, J, Mecklin, J, Järvinen, H, Tomlinson, I, van der Spuy, Z, Sjöberg, J, Boyer, T, Vahteristo, P

“…Subsequent screening studies have focused on this mutational hot spot, and mutations have been detected in uterine leiomyosarcomas, extrauterine leiomyomas and leiomyosarcomas, endometrial polyps, and colorectal cancers. All mutations have been missense changes or in-frame insertions/deletions. …”

Investigating protein-protein interactions of the Bloom Syndrome complex by Belblidia, Z

“…Patients develop a variety of developmental defects and have an increased predisposition to all cancers.</p> <p>BLM interacts with TOP3A, RMI1 and RMI2 to form the BTR complex, which functions to promote the restart of stalled forks and the dissolution of double Holliday junctions during homologous recombination repair to the prevent the formation of sister chromatid exchanges. …”

Modulating the immune system by amino acid depletion - IDO and beyond by Vallius, L

“…It therefore has a significant physiological role as a homeostatic mechanism used in mammalian organisms to dampen excessive activation of the immune system but is also used as an immune evasion mechanism by many cancers.</p><p> In this study, we investigated the IDO inhibitory properties and mechanism of action of the tryptophan metabolite 3-hydroxyanthranilic acid (3-HAA) that potentially forms a negative feedback loop in the kynurenine pathway. …”

Hypoxia. The role of hypoxia and HIF-dependent signalling events in rheumatoid arthritis. by Muz, B, Khan, M, Kiriakidis, S, Paleolog, E

“…Indeed, the idea of a therapeutic modality aimed at 'starving' tissue of blood vessels was born from the concept that blood vessel formation (angiogenesis) is central to efficient delivery of oxygen to cells and tissues, and has underpinned the development of anti-angiogenic therapies for a range of cancers. An important and well characterized 'master regulator' of the adaptive response to alterations in oxygen tension is hypoxia-inducible factor (HIF), which is exquisitely sensitive to changes in oxygen tension. …”

The origin and evolution of human glutaminases and their atypical C-terminal ankyrin repeats by Pascoal, C, Islam, Z, Adamoski, D, Ferreira, I, Righetto, R, Bettini, J, Portugal, R, Yue, W, Gonzalez, A, Dias, S, Ambrosio, A

“…We propose an evolutionary model wherein the appearance of the most active enzyme isoform, glutaminase C (GAC), which is expressed in many cancers, was a late retrotransposition event that occurred in fishes from the Chondrichthyes class. …”

Structural analysis identifies imidazo[1,2-b]pyridazines as PIM kinase inhibitors with in vitro antileukemic activity. by Pogacic, V, Bullock, A, Fedorov, O, Filippakopoulos, P, Gasser, C, Biondi, A, Meyer-Monard, S, Knapp, S, Schwaller, J

“…Much attention has recently been focused on PIM kinases as potential targets for the treatment of hematopoietic malignancies and some solid cancers. Using protein stability shift assays, we identified a family of imidazo[1,2-b]pyridazines to specifically interact with and inhibit PIM kinases with low nanomolar potency. …”

Nicotine affects bone resorption and suppresses the expression of cathepsin K, MMP-9 and vacuolar-type H(+)-ATPase d2 and actin organization in osteoclasts. by Tanaka, H, Tanabe, N, Kawato, T, Nakai, K, Kariya, T, Matsumoto, S, Zhao, N, Motohashi, M, Maeno, M

“…Tobacco smoking is an important risk factor for the development of several cancers, osteoporosis, and inflammatory diseases such as periodontitis. …”

Transforming growth factor-ß enhances invasion and metastasis in Ras-transfected human malignant epidermal keratinocytes by Paterson, I.C., Davies, M., Prime, S.S., Eveson, J.W., Price, N., Ganapathy, A., D’Mello, A.

“…Transforming growth factor-ß (TGF-ß) is known to act as a tumour suppressor early in carcinogenesis, but then switches to a pro-metastatic factor in some late stage cancers. However, the actions of TGF-ß are context dependent, and it is currently unclear how TGF-ß influences the progression of human squamous cell carcinoma(SCC). …”
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Histological, Biochemical, and Hematological Effects of Goniothalamin on Selective Internal Organs of Male Sprague-Dawley Rats by Kaid, Fahmi, Alabsi, A.M., Alafifi, Nashwan, Ali-Saeed, Rola, Al-koshab, May Ameen, Ramanathan, Anand, Ali, A.M.

“…Goniothalamin (GTN) is an isolated compound from several plants of the genus Goniothalamus, and its anticancer effect against several cancers was reported. However, there is no scientific data about effects of its higher doses on internal organs. …”

Circular RNA TFO as antiviral therapy against feline infectious peritonitis virus by Choong, Oi Kuan, Harun, Mohammad Syamsul Reza, Tejo, Bimo Ario, Omar, Abdul Rahman

“…RNA based molecular therapy such as siRNA, miRNA and RNA aptamers have been studied against various infectious diseases and cancers. Little is known on the potential of Triple Helix-Forming Oligonucleotide (TFO) RNA as anti-viral therapy. …”
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Immunohistochemical expression of hedgehog proteins in diffuse large B-cell lymphoma by Azman, Siti Nur Lina

“…In most adult tissues, this pathway remains silent and its aberrant activation has been documented in various types of malignancies including basal cell carcinoma, gastrointestinal, lung and prostate cancers. The aim of this study was to demonstrate the expression of Hh signalling pathway components in 107 DLBCL formalin fixed paraffin embedded (FFPE) tissues from Hospital Kuala Lumpur and determine their association with clinicopathological parameters. …”
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Characterisation of Plant Derived Damnacanthal and Nordamnacantbal Induced Cytotoxicity on Human HT29 Colon Adenocarcinoma Cell Line by Khor, Tin Oo

“…However both compounds were found to be less toxic against non-cancerous fibroblast 3T3 ceJJs with the ICsos of 30 /lglml (damnacanthal) and 21 /lglm] (nordamnacanthal) respectively. …”
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