Understanding drug resistance through computational models of the genotype-phenotype mapping by Nichol, D

“…If we are to predict or reverse evolution, as we must to determine effective treatments for drug-resistant infections and cancers, then we must first understand the relationship between genetic and phenotypic change. …”

MicroRNA expression in multiple myeloma is associated with genetic subtype, isotype and survival. by Chi, J, Ballabio, E, Chen, X, Kušec, R, Taylor, S, Hay, D, Tramonti, D, Saunders, N, Littlewood, T, Pezzella, F, Boultwood, J, Wainscoat, J, Hatton, C, Lawrie, C

“… BACKGROUND: MicroRNAs are small RNA species that regulate gene expression post-transcriptionally and are aberrantly expressed in many cancers including hematological malignancies. However, the role of microRNAs in the pathogenesis of multiple myeloma (MM) is only poorly understood. …”

Design and synthesis of myo-inositol (1,4,5)-trisphosphate receptor antagonists by Ye, Y

“…Hence, selective blockage of Ins<em>P₃ </em>Rs will allow better understanding of Ca²⁺ signalling and might also unveil novel treatment for cancers, in the long term. There were no selective Ins<em>P₃ </em>Rs antagonists known at the start of these studies. …”

Synthesis of deuterated phosphatidylinositol phosphates by Saunders, A

“…Dysfunction of these processes has been implicated in numerous diseases including diabetes and many cancers. Some aspects of PtdInsP_n signalling have been heavily investigated; PTEN, PKC/Akt, PtdIns3K and PtdIns4K are all important therapeutic targets that have seen much attention in industrial endeavours. …”

Radionuclide imaging of angiogenesis by Patel, N

“…<p>Angiogenesis is a fundamental process in the survival, growth and spread of cancers. In recent years several therapies have been developed to interfere with this process. …”

Presentation of B-cell lymphoma in childhood and adolescence: a systematic review and meta-analysis by Saatci, D, Zhu, C, Harnden, A, Hippisley-Cox, J

“…Background: The diagnosis of B-cell lymphoma, one of the commonest cancers seen in childhood and adolescence, is challenging. …”

Unravelling the molecular and cellular mechanisms of fetal B cell lymphopoiesis to help understand childhood leukaemia by Green, J

“…<p>Childhood Leukaemia accounts for nearly one in three of all childhood cancers, with approximately 400 cases diagnosed in the UK every year. …”

Biosynthesis and characterization of silver nanoparticles from Cedrela toona leaf extracts: An exploration into their antibacterial, anticancer, and antioxidant potential by Javed, MA, Ali, B, Sarfraz, MH, Ali, S, Liaqat, E, Afzal, MS, Wang, Y, Peng, L, ur Rehman, A, Aftab, MN, Alarjani, KM, Elshikh, MS

“…The crux of this research is that AgNPs synthesized from the Cedrela toona leaf extract could be employed as antibacterial, antioxidant, and anticancer agents for the treatment of bacterial, free radical-oriented, and cancerous diseases.…”

Extracorporeal high intensity focused ultrasound for renal tumours: a 3-year follow-up. by Ritchie, R, Leslie, T, Phillips, R, Wu, F, Illing, R, ter Haar, G, Protheroe, A, Cranston, D

“…PATIENTS AND METHODS: Although surgery currently remains the standard treatment for localized renal cell carcinoma (RCC), the increasing incidence of small renal cancers has led to a shift towards nephron-sparing surgery, with associated morbidity in 20-25% of cases, and minimally invasive ablative therapies present an alternative management. …”

Arylamine N-acetyltransferases: structural and functional implications of polymorphisms. by Sim, E, Lack, N, Wang, C, Long, H, Westwood, I, Fullam, E, Kawamura, A

“…It is expressed in many tissues, particularly in oestrogen receptor positive breast cancers. Human NAT1 has an endogenous role in acetylation of a folate catabolite with in vivo evidence from transgenic mice lacking the equivalent gene. …”

Structural and computational studies of fibroblast growth factor receptor signalling complex formation by Zuniga, S

“…It has been implicated in a wide range of human pathologies such as cancers and skeletal disorders which is the reason for a particular interest over recent years. …”

Associations between food group intakes and circulating insulin-like growth factor-I in the UK Biobank: a cross-sectional analysis by Watling, CZ, Kelly, RK, Tong, TYN, Piernas, C, Watts, EL, Tin Tin, S, Knuppel, A, Schmidt, JA, Travis, RC, Key, TJ, Perez-Cornago, A

“…<p><strong>Purpose:</strong>&nbsp;Circulating insulin-like growth factor-I (IGF-I) concentrations have been positively associated with risk of several common cancers and inversely associated with risk of bone fractures. …”

Structural characterization of the Human Endogenous Retrovirus and SARS-CoV-2 by Krebs, AS

“…HERV-K (HML-2) is the most recently acquired HERV but mutations have rendered it mostly silent except in many cancers, neurological diseases, and during the aging process. …”

The spectrum of health conditions in community-based cross-sectional surveys in Southeast Asia 2010-21: a scoping review by Zhang, M, Kozlowski, H, Chew, R, Htun, NSN, Morris, SK, Akladious, C, Sarker, AR, Lubell, Y, Peto, TJ

“…However, other high-burden conditions (e.g. hearing loss, headache disorder, low back pain, chronic liver and kidney diseases, and cancers) were rarely studied. Conclusion: There were relatively few recent surveys from which to estimate representative prevalences and trends of health conditions beyond those known to be high burden. …”

"Sometimes we can't fix things": a qualitative study of health care professionals' perceptions of end of life care for patients with heart failure by Glogowska, M, Simmonds, R, McLachlan, S, Cramer, H, Sanders, T, Johnson, R, Kadam, U, Lasserson, D, Purdy, S

“…<strong>Background:</strong> Although heart failure has a worse prognosis than some cancers, patients often have restricted access to well-developed end of life (EoL) models of care. …”

Low-intensity daily smoking and cause-specific mortality in Mexico: prospective study of 150 000 adults by Thomson, B, Tapia-Conyer, R, Lacey, B, Lewington, S, Ramirez-Reyes, R, Aguilar-Ramirez, D, Gnatiuc, L, Herrington, WG, Torres, J, Trichia, E, Wade, R, Collins, R, Peto, R, Kuri-Morales, P, Alegre-Díaz, J, Emberson, JR

“…The diseases most strongly associated with daily smoking were respiratory cancers, chronic obstructive pulmonary disease and gastrointestinal and vascular diseases. …”

Proliferating cell nuclear antigen (PCNA) activity in hepatocellular carcinoma, benign peri-neoplastic and normal liver by Mun, K.S., Cheah, P.L., Baharuddin, N.B., Looi, L.M.

“…Hepatocellular carcinoma (HCC) is among the ten most common cancers in Malaysian males. As cellular proliferation is an important feature of malignant transformation, we studied the proliferation pattern of normal and benign perineoplastic liver versus hepatocellular carcinoma in an attempt to further understand the tumour transformation process. 39 HCC (21 with accompanying and 18 without cirrhosis) histologically diagnosed at the Department of Pathology, University of Malaya Medical Centre between January 1992 and December 2003 were immunohistochemically studied using a monoclonal antibody to PCNA (Clone PC10: Dako). 20 livers from cases who had succumbed to traumatic injuries served as normal liver controls (NL). …”

Xanthorrhizol inhibits cell proliferation, cellular cholesterol uptake in HT29 colon cells and adipogenesis in 3T3-L1 adipocytes by Oon, Seok Fang, Nallappan, Meenakshii, Kassim, Nur Kartinee, Shohaimi, Shamarina, Sa'ariwijaya, Mohd Shazrul Fazry, Tee, Thiam Tsui, Cheah, Yew Hoong

“…Hyperlipidemia is defined as the presence of either hypertriglyceridemia or hypercholesterolemia, which could cause atherosclerosis, cardiovascular diseases and certain cancers. Although hyperlipidemia can be treated by hypolipidemic drugs, they are limited due to lack of effectiveness and safety. …”
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Loss of interleukin17RA expression is associated with tumour progression in colorectal carcinoma by Chai, Boon Yean, Yip, Wai Kien, Dusa, Noraini, Mohtaruddin, Norhafizah, Seow, Heng Fong

“…Interleukin-17 (IL-17) is a pro-inflammatory cytokine found in various cancers. Current evidence indicates that IL-17 plays a vital role in tumour initiation and progression in colorectal carcinoma (CRC) via binding with its receptor, IL-17RA. …”
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Sonographic review of thyroid lesion based on ATA and ACR-tirads classification by Nagalindam, Deivind Kumar

“…Background: Thyroid malignancy is one of the commonest cancers among adults with prevalence rate of 3-7%. …”
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