Abnormal cell cycle regulation in primary human uveal melanoma cultures. by Pardo, M, Piñeiro, A, de la Fuente, M, García, A, Prabhakar, S, Zitzmann, N, Dwek, R, Sánchez-Salorio, M, Domínguez, F, Capeans, C

“…The cellular events leading to neoplasic transformation of normal uveal melanocytes are not well known when compared to other cancers. In this study, we investigated the role of G1 and G1/S regulatory proteins of the cell cycle in human uveal melanoma (UM) primary cell cultures, since these proteins are common targets in tumor development. …”

Zinc presence in invasive ductal carcinoma of the breast and its correlation with oestrogen receptor status. by Farquharson, M, Al-Ebraheem, A, Geraki, K, Leek, R, Jubb, A, Harris, A

“…However, the non-tumour tissue regions of the samples contained on average the same levels of zinc in both types of breast cancers. The relative levels of zinc in tumour areas of the tissue were compared with levels in areas of non-tumour surrounding tissue. …”

Biological optimization for mediastinal lymphoma radiotherapy – a preliminary study by Aznar, M

“…We used published data to model recurrence and radiation-induced mortality from coronary heart disease and secondary lung and breast cancers. Patient-specific doses to the heart, lung, breast, and target were incorporated in the models as well as age, sex, and cardiac risk factors (CRFs). …”

Management of heart failure: evidence versus practice. Does current prescribing provide optimal treatment for heart failure patients? by Hobbs, F

“…Heart failure is an increasingly common and costly chronic disorder, with a rising prevalence of at least 2% in populations over the age of 45 years, mortality rates that are as poor as common solid cancers, and very high health care utilisation costs. …”

Attitude towards diabetes and social and family support among type 2 diabetes patients attending a tertiary-care hospital in Bangladesh: a cross-sectional study by Shawon, M, Hossain, F, Adhikary, G, Gupta, R, Hashan, M, Rabbi, M, Ahsan, G

“…<p>Background: Bangladesh has been suffering from an epidemiological transition from infectious and maternal diseases to non-communicable lifestyle-related diseases like diabetes, cardiovascular diseases, cancers etc. The burden of diabetes has been increasing rapidly due to high incidence as well as poor glycemic control leading to various macro and micro-vascular complications. …”

Enasidenib induces acute myeloid leukemia cell differentiation to promote clinical response by Amatangelo, MD, Quek, L, Shih, A, Stein, EM, Roshal, M, David, MD, Marteyn, B, Farnoud, NR, De Botton, S, Bernard, OA, Wu, B, Yen, KE, Tallman, MS, Papaemmanuil, E, Penard-Lacronique, V, Thakurta, A, Vyas, P, Levine, RL

“…Recurrent mutations at R140 and R172 in isocitrate dehydrogenase 2 (IDH2) occur in many cancers, including ∼12% of acute myeloid leukemia (AML). …”

p53 alterations in sequential biopsies of Asian follicular lymphoma: a study of immunohistochemical staining pattern and gene mutations by PCR-SSCP in paraffin-embedded tissues by Shaminie, J., Peh, S.C., Tan, J.

“…Aim: Tumour suppressor gene p53 is a common target in carcinogenesis, reported to be altered and functionally inactive in 70 of human cancers. Although p53 mutations are less commonly present in haematological malignancies when compared with other solid tumours, they have been reported in histological transformation of follicular lymphoma. …”
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Immunolocalization of notch signaling protein molecules in a maxillary chondrosarcoma and its recurrent tumor by Siar, C.H., Ha, K.O., Aung, L.O., Nakano, K., Tsujigiwa, H., Nagatsuka, H., Ng, K.H., Kawakami, T.

“…Aberrant Notch activity has been implicated in numerous human diseases including cancers; however its role in chondrogenic tumors has not been clarified. …”
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Molecular detection of Helicobacter pylori resistance to clarithromycin isolated from Sabah by Nurul Ashira Azman

“…Helicobacter pylori is a pathogenic bacterium that has been associated with peptic ulcer disease and cancers of human gastrointestinal tract. Currently, c1arithromycin has remained as one of the most powerful antibiotics used as first line treatment for H. pylori infection. …”
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The impact of multimodality integrated positron emission tomography-computed tomography on improving the staging and management of head and neck malignancy: a cross- sectional stud... by Subha, Sethu Thakachy, Nordin, Abdul Jalil

“…Background: Clinical assessment of head and neck cancers is highly challenging owing to the complexity of regional anatomy and wide range of lesions. …”

Bioaccumulation of arsenic(As) and phosphorous by transplanting Aman rice in arsenic-contaminated clay soils. by Rauf, M.A., Hakim, M.A., Hanafi, M.M., Islam, M.M., Rahman, G.K.M.M., Panaullah, G.M.

“…Inorganic species of arsenic are associated with various internal cancers and create other health problems. An experiment was conducted to investigate the effect of soil arsenic (As) concentration on arsenic and phosphorous accumulation in root, straw, husk and grain of rice (Oryza sativa). …”
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Prevalence and factors associated with overweight and obesity among Malaysian post graduate students in a public university by Abba, Shaima’u Kabir, Md Said, Salmiah, Ismail, Suriani

“…Overweight and obesity is a major public health problem globally because they increase the burden of non-communicable diseases such as cardiovascular diseases, and cancers. Many studies on overweight and obesity in the universities focused on the undergraduate students and there is little information on post-graduate students. …”

A classical genetic solution to enhance the biosynthesis of anticancer phytochemicals in Andrographis paniculata nees by Valdiani, Alireza, Talei, Daryush, Tan, Soon Guan, Abdul Kadir, Mihdzar, Mahmood, Maziah, Yusop, Mohd Rafii, Sagineedu, Sreenivasa Rao

“…A number of such compounds namely andrographolide (AG), neoandrographolide (NAG), and 14-deoxy-11,12-didehydroandrographolide (DDAG) have already attracted a great deal of attention due to their potential therapeutic effects in hard-to-treat diseases such as cancers and HIV. Recently, they have also been considered as substrates for the discovery of novel pharmaceutical compounds. …”
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Image segmentation method for boundary detection of breast thermography using random walkers by Moghbel, Mehrdad

“…Although almost half of all breast cancers occur in the upper outer region of the breast known as the tail of the breast, most of the segmentation methods cannot segment the upper outer region of the breast with the adequate accuracy. …”
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Pharmacological modulation of oncogenic Ras by natural products and their derivatives: renewed hope in the discovery of novel anti-Ras drugs by Quah, Shun Ying, Tan, Michelle Siying, Teh, Yuan Han, Stanslas, Johnson

“…Oncogenic rat sarcoma (Ras) is linked to the most fatal cancers such as those of the pancreas, colon, and lung. …”
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Stem cells differentiation and probing their therapeutic applications in hematological disorders: a critical review by Ali, Faisal, Taresh, S., Al-Nuzaily, M., Mok, Pooi Ling, Ismail, Amin, Ahmad, S.

“…Numerous lines of evidence support that bone marrow is a rich source of stem cells that can be used for research purposes and to treat some complex blood diseases and cancers. Stem cells are a potential source for regenerative medicine and tissue replacement after injury or disease, and mother cells that possess the capacity to become any type of cell in the body. …”
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Utilization of the ethyl acetate fraction of Zanthoxylum rhetsa bark extract as an active ingredient in natural sunscreen formulations by Santhanam, Ramesh Kumar, Akhtar, Muhammad Tayyab, Ahmad, Syahida, Abas, Faridah, Ismail, Intan Safinar, Rukayadi, Yaya, Shaari, Khozirah

“…Sunburn, premature skin aging, skin cancers and suppression of the immune system are linked to exposure of the skin to UV light. …”
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K-ras peptide mimotope induces antigen specific Th1 and B-cell immune responses against G12A-mutated K-Ras antigen in balb/c mice by Siak, Pui Yan, Wong, Kuan Yee, Song, Adelene Ai Lian, Abdul Rahim, Raha, Lian, Lionel Aun In

“…In this study, a modified G12A-K-ras epitope (139A) with sequence-specific modifications to improve immunogenicity was developed as a potential vaccine against G12A-mutant KRAS cancers. Additionally, coupling of the 139A epitope with a tetanus toxoid (TTD) universal T-cell epitope to improve antigenicity was also reported. …”

Moringa oleifera hydorethanolic leaf extract induced acute and sub-acute hepato-nephrotoxicity in female ICR-mice by Aliyu, Abdullahi, Shaari, Mohd Rosly, Ahmad Sayuti, Nurul Syahirah, Reduan, Farhan Hanif, Sithambaram, Shanmugavelu, Mohamed Mustapha, Noordin, Shaari, Khozirah, Hamzah, Hazilawati

“…It is an important multipurpose tree that is largely distributed globally and has been used almost in every aspect of traditional medicine for the treatment of various illnesses including cancers, diabetes mellitus, asthma, arthritis, etc. …”

Health risk associated with nitrate exposure from groundwater intake among respondents of Keting Village, Bachok District, Kelantan State, Malaysia by Mat Yusof, Muhammad Azri, Mohd Sham, Shaharuddin

“…The increased use of nitrate fertilizers has a possible risk factor associated to health problems such as methemoglobinemia and cancers. Health risk assessment can be conducted to quantify the probability of harmful effects of nitrate to individuals or populations from certain human activities. …”
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