Cloning, characterization and activity analysis of human choline kinase promoters by See Too, Wei Cun

“…Overexpression of CK has been reported in a variety of human cancers such as lung, colo rectal as well as prostate adenocarcinomas (Nakagami et a/., 1999, Ramirez de Molina eta/., 2002a, Ramirez de Molina eta/., 2002b). …”
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Heat distribution on abdominal aorta having aneurysm during hyperthermia therapeutic by Lee, Jun Xiong, Taib, Ishkrizat, Kamarudin, M. Saddam, Mohammad, Aswad, Asmuin, Norzelawati

“…Hyperthermia therapy is an induce heat treatment to the tumour temperature elevated with temperature 40 ̊C - 43 ̊C to cure the cancerous tissues. Hyperthermia therapy use an outer heat source to rise the temperature of the tumour to 40 ̊C -43°C for a certain period. …”
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Combating obesity through healthy eating behavior: A call for system dynamics optimization by Gonzalez-Bulnes, Antonio, Zainal Abidin, Norhaslinda, Mamat, Mustafa, Dangerfield, Brian, Zulkepli Hew, Jafri, Baten, Md Azizul, Wibowo, Antoni

“…Poor eating behavior has been identified as one of the core contributory factors of the childhood obesity epidemic.The consequences of obesity on numerous aspects of life are thoroughly explored in the existing literature.For instance, evidence shows that obesity is linked to incidences of diseases such as heart disease, type-2 diabetes, and some cancers, as well as psycho social problems.To respond to the increasing trends in the UK, in 2008 the government set a target to reverse the prevalence of obesity (POB) back to 2000 levels by 2020. …”
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Development and Application of the Metalloprotease Activity Multiplexed Bead-Based Immunoassay (MAMBI) by Chopko Ahrens, Caroline, Chiswick, Evan, Ravindra, Kodihalli C., Miller, Miles Aaron, Ramseier, Julie Y., Isaacson, Keith B., Lauffenburger, Douglas A, Griffith, Linda G

“…Metalloproteinases (MMPs) are zinc-dependent endopeptidases that cleave various proteins to regulate normal and diseased cellular functions, and as such, they play significant roles in human tissue development, homeostasis, and the pathogenesis of many diseases, including cancers, endometriosis, arthritis, etc. Most MMPs are produced as zymogenic latent enzymes that must be cleaved to activate their catalytic regions, and localized endogenous protein inhibitors further regulate activity. …”
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A DinB variant reveals diverse physiological consequences of incomplete TLS extension by a Y-family DNA polymerase by Walker, Graham C., Jarosz, Daniel F., Delaney, James C., Essigmann, John M., Cohen, Susan E., Ph. D. Massachusetts Institute of Technology

“…Y-family DNA polymerases, including DinB, have been implicated in diverse biological phenomena ranging from adaptive mutagenesis in bacteria to several human cancers. Complete TLS requires dNTP insertion opposite a replication blocking lesion and subsequent extension with several dNTP additions. …”
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A DinB variant reveals diverse physiological consequences of incomplete extension by a Y-family DNA polymerase by Jarosz, Daniel F., Cohen, Susan E., Delaney, James C., Essigmann, John M., Walker, Graham C.

“…Y-family DNA polymerases, including DinB, have been implicated in diverse biological phenomena ranging from adaptive mutagenesis in bacteria to several human cancers. Complete TLS requires dNTP insertion opposite a replication blocking lesion and subsequent extension with several dNTP additions. …”
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Improved tumor oxygenation and survival in glioblastoma patients who show increased blood perfusion after cediranib and chemoradiation by Batchelor, Tracy T., Gerstner, Elizabeth R., Emblem, Kyrre E., Duda, Dan G., Kalpathy-Cramer, Jayashree, Snuderl, Matija, Ancukiewicz, Marek, Polaskova, Pavlina, Pinho, Marco C., Jennings, Dominique, Plotkin, Scott R., Chi, Andrew S., Eichler, April F., Dietrich, Jorg, Hochberg, Fred H., Lu-Emerson, Christine, Iafrate, A. John, Ivy, S. Percy, Rosen, Bruce R., Loeffler, Jay S., Wen, Patrick Y., Sorensen, A. Greg, Jain, Rakesh K.

“…This controversy has become critical as multiple phase III trials of anti-VEGF agents combined with cytotoxics failed to show overall survival benefit in newly diagnosed glioblastoma (nGBM) patients and several other cancers. Here, we shed light on mechanisms of nGBM response to cediranib, a pan-VEGF receptor tyrosine kinase inhibitor, using MRI techniques and blood biomarkers in prospective phase II clinical trials of cediranib with chemoradiation vs. chemoradiation alone in nGBM patients. …”
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Gut Microbiome Perturbations Induced by Bacterial Infection Affect Arsenic Biotransformation by Lu, Kun, Cable, Peter Hans, Ru, Hongyu, Graffam, Michelle E., Schlieper, Katherine Ann, Bodnar, Wanda M., Wishnok, John S., Styblo, Miroslav, Swenberg, James A., Levine, Stuart S., Abo, Ryan, Fox, James G, Parry, Nicola Maria Anne, Tannenbaum, Steven R

“…Exposure to arsenic affects large human populations worldwide and has been associated with a long list of human diseases, including skin, bladder, lung, and liver cancers, diabetes, and cardiovascular disorders. In addition, there are large individual differences in susceptibility to arsenic-induced diseases, which are frequently associated with different patterns of arsenic metabolism. …”
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Highly sensitive Mach–Zehnder interferometer biosensor based on silicon nitride slot waveguide by Liu, Qing, Tu, Xiaoguang, Kim, Kyung Woo, Kee, Jack Sheng, Shin, Yong, Han, Kyungsup, Yoon, Yong-Jin, Lo, Guo-Qiang, Park, Mi Kyoung

“…Furthermore, we investigated the specific detection and quantification of the methylation of DAPK (Death-associated protein kinase) gene, which is a widely used biomarker for human cancers. We have shown that methylation sequences of DAPK gene of various methylation densities (100%, 50%, and 0% of methylation sites) can be quantified and discriminated even at a concentration as low as 1 fmol/μl or 1 nM.…”
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Alternative polyadenylation expands the mRNA isoform repertoire of human CD46 by Ly, Phuong Thao, Tang, Sze Jing, Roca, Xavier

“…Intronic PolyAdenylation could add to the source of soluble CD46 isoforms in fluids and tissues, which increase in cancers and autoimmune syndromes. Furthermore, 3′RACE identified three PolyAdenylation Sites within the last intron and exon, whose transcripts with shortened 3′UTRs could support higher CD46 expression. …”
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JAK2V617F promotes replication fork stalling with disease-restricted impairment of the intra-S checkpoint response. by Chen, E, Ahn, J, Massie, C, Clynes, D, Godfrey, A, Li, J, Park, H, Nangalia, J, Silber, Y, Mullally, A, Gibbons, R, Green, A

“…Cancers result from the accumulation of genetic lesions, but the cellular consequences of driver mutations remain unclear, especially during the earliest stages of malignancy. …”

Effects of different light intensities on total phenolics and flavonoids synthesis and anti-oxidant activities in young ginger varieties (Zingiber officinale Roscoe). by Ghasemzadeh, Ali, Jaafar, Hawa Z. E., Rahmat, Asmah, Megat Wahab, Puteri Edaroyati, Abd Halim, Mohd Ridzwan

“…Phenolics and flavonoids are known for their health-promoting properties due to protective effects against cardiovascular disease, cancers and other disease. Ginger (Zingiber officinale) is one of the traditional folk medicinal plants and it is widely used in cooking in Malaysia. …”
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Increased expression of phosphatidylinositol 3-kinase p110α and gene amplification of PIK3CA in nasopharyngeal carcinoma by Yip, Wai Kien, He, Pei Yuan, Abdullah, Maizaton Atmadini, Yusoff, Suryati, Seow, Heng Fong

“…Molecular alterations in PIK3CA oncogene that encodes the p110α catalytic subunit of phosphatidylinositol 3-kinase (PI3K p110α) are commonly found in human cancers. In this study, we examined the expression of PI3K p110α and PIK3CA gene amplification in 74 nasopharyngeal carcinoma (NPC) cases. …”
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Regulation of microtubule attachment at the kinetochore and cell cortex by Kern, David M. (David Matthew)

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Multiplexed Single-Cell Leukocyte Enzymatic Secretion Profiling from Whole Blood Reveals Patient-Specific Immune Signature by Zeming, Kerwin Kwek, Lu, Ri, Woo, Kai Lee, Sun, Guoyun, Quek, Kai Yun, Cheow, Lih Feng, Chen, Chia-Hung, Han, Jongyoon, Lim, Shir Lynn

“…Enzymatic secretion of immune cells (leukocytes) plays a dominant role in host immune responses to a myriad of biological triggers, including infections, cancers, and cardiovascular diseases. Current tools to probe these leukocytes inadequately profile these vital biomarkers; the need for sample preprocessing steps of cell lysis, labeling, washing, and pipetting inevitably triggers the cells, changes its basal state, and dilutes the individual cell secretion in bulk assays. …”
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Cavitation methods in therapeutic ultrasound : techniques, mechanisms, and system design by Sokka, Shunmugavelu D. (Shunmugavelu Doraivelu), 1975-

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The germline- and tissue-specific effects of endogenous point-mutant p53 by Olive, Kenneth P

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Development of an integrated microfluidic platform for oxygen sensing and delivery by Vollmer, Adam P

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The role of ras signaling associative learning and memory in Drosophila by Sakamoto, Toshimasa

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Engineering design of a fission converter-based epithermal beam for neutron capture therapy by Sutharshan, Balendra, 1966-

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